saxagliptin and its Impurities
Saxagliptin is used as monotherapy or in combination with other drugs for the treatment of type 2 diabetes. It is an oral hypoglycemic SaxagliptinIt, it is sold under the brand name Onglyza.Reference standards of Saxagliptin API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
 
	
			                                   
																				(1S,3S,5S)-2-((S)-2-amino-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic Acid
(1S,3S,5S)-2-((S)-2-amino-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic Acid
- Catalogue No.:PA 19 40740 
- CAS : - 1802786-89-5
- Molecular Formula : C18H26N2O4 
- Molecular Weight : 334.41 
 
	
			                                  ![N-((S)-2-((1S,3S,5S)-3-Cyano-2-azabicyclo[3.1.0]he PA 19 40750](https://www.pharmaffiliates.com/pimages/PA1940750.jpg) 
																				N-((S)-2-((1S,3S,5S)-3-Cyano-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)acetamide
N-((S)-2-((1S,3S,5S)-3-Cyano-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)acetamide
- Catalogue No.:PA 19 40750 
- CAS : - NA
- Molecular Formula : C20H28N2O5 
- Molecular Weight : 376.45 
 
	
			                                   
																				(1S,3S,5S)-2-((2S)-2-Amino-2-(3-(trichloromethoxy)adamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile
(1S,3S,5S)-2-((2S)-2-Amino-2-(3-(trichloromethoxy)adamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile
- Catalogue No.:PA 19 40760 
- CAS : - NA
- Molecular Formula : C19H24Cl3N3O2 
- Molecular Weight : 432.77 
 
	
			                                   
																				(R)-2-((S)-2-((1S,3S,5S)-3-Cyano-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)succinic Acid
(R)-2-((S)-2-((1S,3S,5S)-3-Cyano-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)succinic Acid
- Catalogue No.:PA 19 40780 
- CAS : - NA
- Molecular Formula : C22H28N2O6 
- Molecular Weight : 416.47 
 
	
			                                   
																				(1S,3R,5S)-2-((2S)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carboxamide
(1S,3R,5S)-2-((2S)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carboxamide
- Catalogue No.:PA 19 40830 
- CAS : - NA
- Molecular Formula : C18H27N3O3 
- Molecular Weight : 333.43 
 
	
			                                   
																				3-((S)-1-Amino-2-((1S,3R,5S),-3-cyano-2-aza-biclyclo[3.1.0]hexan-2-yl)-2-oxoethyl)adamantan-1-yl-2,2,2-trichloroacetate
3-((S)-1-Amino-2-((1S,3R,5S),-3-cyano-2-aza-biclyclo[3.1.0]hexan-2-yl)-2-oxoethyl)adamantan-1-yl-2,2,2-trichloroacetate
- Catalogue No.:PA 19 40840 
- CAS : - NA
- Molecular Formula : C20H24Cl3N3O3 
- Molecular Weight : 460.78 
 
	
			                                   
																				(1aS,4S,6aR,7aS)-6-Amino-4-(3,5-dihydroxytricyclo[3.3.1.13,7]dec-1-yl)-1,1a,4,6a,7,7a-hexahydro-3H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-3-one
(1aS,4S,6aR,7aS)-6-Amino-4-(3,5-dihydroxytricyclo[3.3.1.13,7]dec-1-yl)-1,1a,4,6a,7,7a-hexahydro-3H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-3-one
- Catalogue No.:PA 19 40920 
- CAS : - 1429782-93-3
- Molecular Formula : C18H25N3O3 
- Molecular Weight : 331.41 
 
	
			                                   
																				(1S,3S,5S)-2-((R)-2-Amino-2-((1r,3S,5R,7S)-3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride
(1S,3S,5S)-2-((R)-2-Amino-2-((1r,3S,5R,7S)-3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride
- Catalogue No.:PA 19 0401003 
- CAS : - NA
- Molecular Formula : C18H26ClN3O2 
- Molecular Weight : 351.88 
 
	
			                                   
																				(1S,3R,5S)-2-((2S)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride
(1S,3R,5S)-2-((2S)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride
- Catalogue No.:PA 19 0401004 
- CAS : - NA
- Molecular Formula : C18H26ClN3O2 
- Molecular Weight : 351.88 
 
	
			                                   
																				(E)-4-(((1S)-2-((1S,3S,5S)-3-Cyano-2-azabicyclo[3.1.0]hexan-2-yl)-1-((3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)amino)-4-oxobut-2-enoic acid
(E)-4-(((1S)-2-((1S,3S,5S)-3-Cyano-2-azabicyclo[3.1.0]hexan-2-yl)-1-((3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)amino)-4-oxobut-2-enoic acid
- Catalogue No.:PA 19 0401017 
- CAS : - NA
- Molecular Formula : C22H27N3O5 
- Molecular Weight : 413.47 
 
	
			                                   
																				(1S,3S,5S)-2-((2S)-2-(((3R,4R,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-(((3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)amino)-2-((3R,5R,7S)-3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile
(1S,3S,5S)-2-((2S)-2-(((3R,4R,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-(((3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)amino)-2-((3R,5R,7S)-3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile
- Catalogue No.:PA 19 0401018 
- CAS : - NA
- Molecular Formula : C30H45N3O12 
- Molecular Weight : 639.3 
 
	
			                                   
																				(1R,3S,5R)-2-((2S)-2-(3-Hydroxyadamantan-1-yl)-2-(tritylamino)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile
(1R,3S,5R)-2-((2S)-2-(3-Hydroxyadamantan-1-yl)-2-(tritylamino)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile
- Catalogue No.:PA 19 0401026 
- CAS : - NA
- Molecular Formula : C37H39N3O2 
- Molecular Weight : 557.74 
 
	
			                                   
																				(1R,3r,5R,7S)-3-((S)-1-((tert-Butoxycarbonyl)amino)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)adamantan-1-yl 2,2,2-trifluoroacetate
(1R,3r,5R,7S)-3-((S)-1-((tert-Butoxycarbonyl)amino)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)adamantan-1-yl 2,2,2-trifluoroacetate
- Catalogue No.:PA 19 0401028 
- CAS : - 1194836-75-3
- Molecular Formula : C25H32F3N3O5 
- Molecular Weight : 511.54 
 
	
			                                   
																				(1aS,4S,7aS)-4-((1r,3R,5R,7S)-3-Hydroxyadamantan-1-yl)-6-imino-5-nitrosooctahydro-3H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-3-one
(1aS,4S,7aS)-4-((1r,3R,5R,7S)-3-Hydroxyadamantan-1-yl)-6-imino-5-nitrosooctahydro-3H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-3-one
- Catalogue No.:PA 19 0401029 
- CAS : - NA
- Molecular Formula : C18H24N4O3 
- Molecular Weight : 344.42 

 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				![2-Azabicyclo[3.1.0]hexane-3-carboxamide Methanesul PA 19 40600](https://www.pharmaffiliates.com/pimages/PA1940600.jpg) 
																				 
																				 
																				 
																				 
																				 
																				![(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide PA 19 40660](https://www.pharmaffiliates.com/pimages/PA1940660.jpg) 
																				 
																				 
																				![(1S,3R,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide PA 19 40690](https://www.pharmaffiliates.com/pimages/PA1940690.jpg) 
																				![(1R,3S,5R)-2-Azabicyclo[3.1.0]hexane-3-carboxamide PA 19 40700](https://www.pharmaffiliates.com/pimages/PA1940700.jpg) 
																				 
																				 
																				![(1S,5S)-2-Azabicyclo[3.1.0]hexane-3-carbonitrile PA 19 40730](https://www.pharmaffiliates.com/pimages/PA1940730.jpg) 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				![(1R,3R,5R)-2-Azabicyclo[3.1.0]hexane-3-carboxamide PA 19 0401000](https://www.pharmaffiliates.com/pimages/PA190401000.jpg) 
																				![(1R,3S,5R)-2-Azabicyclo[3.1.0]hexane-3-carboxamide PA 19 0401001](https://www.pharmaffiliates.com/pimages/PA190401001.jpg) 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				![(1S,3S,5S)-2-Boc-2-azabicyclo[3.1.0]hexane-3-carbo PA 19 0401016](https://www.pharmaffiliates.com/pimages/PA190401016.jpg) 
																				![(1R,3R,5R)-2-Azabicyclo[3.1.0]hexane-3-carboxamide PA 19 0401019](https://www.pharmaffiliates.com/pimages/PA190401019.jpg) 
																				![(1S,3R,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide PA 19 0401020](https://www.pharmaffiliates.com/pimages/PA190401020.jpg) 
																				 
																				 
																				![(1R,3R,5R)-2-Azabicyclo[3.1.0]hexane-3-carboxamide PA 19 0401023](https://www.pharmaffiliates.com/pimages/PA190401023.jpg) 
																				![(1R,3R,5R)-2-Nitroso-2-azabicyclo[3.1.0]hexane-3-c PA 19 0401024](https://www.pharmaffiliates.com/pimages/PA190401024.jpg) 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				![tert-Butyl (1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]h PAI 19 040009](https://www.pharmaffiliates.com/pimages/PAI19040009.jpg) 
																				 
																				![tert-Butyl (1S,3R,5S)-3-cyano-2-azabicyclo[3.1.0]h PAI 19 040011](https://www.pharmaffiliates.com/pimages/PAI19040011.jpg) 
																				 
																				 
																				 
																				 
																				 
																				![tert-Butyl (1R,3R,5R)-3-cyano-2-azabicyclo[3.1.0]h PAI 19 040017](https://www.pharmaffiliates.com/pimages/PAI19040017.jpg) 
																				![(1R,3R,5R)-2-Azabicyclo[3.1.0]hexane-3-carbonitril PAI 19 040018](https://www.pharmaffiliates.com/pimages/PAI19040018.jpg) 
																				![(1S,3R,5S)-2-Azabicyclo[3.1.0]hexane-3-carbonitril PAI 19 040019](https://www.pharmaffiliates.com/pimages/PAI19040019.jpg) 
																				 
																				 
																				 
 
 
 
