Semaglutide and its Impurities
Semaglutide, sold under the brand name Ozempic among others, is an antidiabetic medication used for the treatment of type 2 diabetes and long-term weight management. Reference standards of Semaglutide API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
(R)-13-(tert-Butoxycarbonyl)-34,34-dimethyl-10,15,32-trioxo-3,6,33-trioxa-9,14-diazapentatriacontanoic Acid
(R)-13-(tert-Butoxycarbonyl)-34,34-dimethyl-10,15,32-trioxo-3,6,33-trioxa-9,14-diazapentatriacontanoic Acid
Catalogue No.:PA 19 1851020
CAS :
NA
Molecular Formula : C37H68N2O10
Molecular Weight : 700.96
(R)-22-(tert-Butoxycarbonyl)-43,43-dimethyl-10,19,24,41-tetraoxo-3,6,12,15,42-pentaoxa-9,18,23-triazatetratetracontanoic Acid
(R)-22-(tert-Butoxycarbonyl)-43,43-dimethyl-10,19,24,41-tetraoxo-3,6,12,15,42-pentaoxa-9,18,23-triazatetratetracontanoic Acid
Catalogue No.:PA 19 1851021
CAS :
NA
Molecular Formula : C43H79N3O13
Molecular Weight : 846.11
tert-Butyl (R)-1-amino-22-(tert-butoxycarbonyl)-1,10,19,24-tetraoxo-3,6,12,15-tetraoxa-9,18,23-triazahentetracontan-41-oate
tert-Butyl (R)-1-amino-22-(tert-butoxycarbonyl)-1,10,19,24-tetraoxo-3,6,12,15-tetraoxa-9,18,23-triazahentetracontan-41-oate
Catalogue No.:PA 19 1851022
CAS :
NA
Molecular Formula : C43H80N4O12
Molecular Weight : 845.13
(R)-31-(tert-Butoxycarbonyl)-52,52-dimethyl-10,19,28,33,50-pentaoxo-3,6,12,15,21,24,51-heptaoxa-9,18,27,32-tetraazatripentacontanoic Acid
(R)-31-(tert-Butoxycarbonyl)-52,52-dimethyl-10,19,28,33,50-pentaoxo-3,6,12,15,21,24,51-heptaoxa-9,18,27,32-tetraazatripentacontanoic Acid
Catalogue No.:PA 19 1851023
CAS :
NA
Molecular Formula : C49H90N4O16
Molecular Weight : 991.27
(S)-(2-(2-(((Benzyloxy)carbonyl)amino)-2-methylpropanamido)-5-(tert-butoxy)-5-oxopentanoyl)glycine
(S)-(2-(2-(((Benzyloxy)carbonyl)amino)-2-methylpropanamido)-5-(tert-butoxy)-5-oxopentanoyl)glycine
Catalogue No.:PA 19 1851025
CAS :
NA
Molecular Formula : C23H33N3O8
Molecular Weight : 479.53
Methyl (6S,12S)-12-(3-(tert-butoxy)-3-oxopropyl)-2,2,9,9-tetramethyl-4,7,10,13-tetraoxo-6-((1-trityl-1H-imidazol-4-yl)methyl)-3-oxa-5,8,11,14-tetraazahexadecan-16-oate
Methyl (6S,12S)-12-(3-(tert-butoxy)-3-oxopropyl)-2,2,9,9-tetramethyl-4,7,10,13-tetraoxo-6-((1-trityl-1H-imidazol-4-yl)methyl)-3-oxa-5,8,11,14-tetraazahexadecan-16-oate
Catalogue No.:PA 19 1851027
CAS :
NA
Molecular Formula : C46H58N6O9
Molecular Weight : 839
(6S,12S)-12-(2-Carboxyethyl)-2,2,9,9-tetramethyl-4,7,10,13-tetraoxo-6-((1-trityl-1H-imidazol-4-yl)methyl)-3-oxa-5,8,11,14-tetraazahexadecan-16-oic Acid
(6S,12S)-12-(2-Carboxyethyl)-2,2,9,9-tetramethyl-4,7,10,13-tetraoxo-6-((1-trityl-1H-imidazol-4-yl)methyl)-3-oxa-5,8,11,14-tetraazahexadecan-16-oic Acid
Catalogue No.:PA 19 1851028
CAS :
NA
Molecular Formula : C41H48N6O9
Molecular Weight : 768.87
((S)-5-(tert-Butoxy)-2-(2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-5-oxopentanoyl)glycine
((S)-5-(tert-Butoxy)-2-(2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-5-oxopentanoyl)glycine
Catalogue No.:PA 19 1851029
CAS :
2377584-78-4
Molecular Formula : C26H42N6O9
Molecular Weight : 582.66
((R)-5-(tert-Butoxy)-2-(2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-5-oxopentanoyl)glycine
((R)-5-(tert-Butoxy)-2-(2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-5-oxopentanoyl)glycine
Catalogue No.:PA 19 1851030
CAS :
NA
Molecular Formula : C45H56N6O9
Molecular Weight : 824.98
((S)-5-(tert-Butoxy)-2-(2-(2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-2-methylpropanamido)-5-oxopentanoyl)glycine
((S)-5-(tert-Butoxy)-2-(2-(2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-2-methylpropanamido)-5-oxopentanoyl)glycine
Catalogue No.:PA 19 1851031
CAS :
NA
Molecular Formula : C49H63N7O10
Molecular Weight : 910.08
tert-Butyl (S)-4-(((benzyloxy)carbonyl)amino)-5-((2-methoxy-2-oxoethyl)amino)-5-oxopentanoate
tert-Butyl (S)-4-(((benzyloxy)carbonyl)amino)-5-((2-methoxy-2-oxoethyl)amino)-5-oxopentanoate
Catalogue No.:PAI 19 185001
CAS :
63276-51-7
Molecular Formula : C20H28N2O7
Molecular Weight : 408.45
Methyl (S)-8-(3-(tert-butoxy)-3-oxopropyl)-5,5-dimethyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oate
Methyl (S)-8-(3-(tert-butoxy)-3-oxopropyl)-5,5-dimethyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oate
Catalogue No.:PAI 19 185002
CAS :
2377584-75-1
Molecular Formula : C24H35N3O8
Molecular Weight : 493.56
(S)-9,18,23-Trioxo-2,5,11,14-tetraoxa-8,17,22-triazanonatriacontane-1,21,39-tricarboxylic Acid
(S)-9,18,23-Trioxo-2,5,11,14-tetraoxa-8,17,22-triazanonatriacontane-1,21,39-tricarboxylic Acid
Catalogue No.:PA 19 1851057
CAS :
1335440-44-2
Molecular Formula : C35H63N3O13
Molecular Weight : 733.9
(S)-2-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-imidazol-5-yl)propanamido)-2-methylpropanoic Acid
(S)-2-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-imidazol-5-yl)propanamido)-2-methylpropanoic Acid
Catalogue No.:PA 19 1851058
CAS :
1446013-07-5
Molecular Formula : C25H26N4O5
Molecular Weight : 462.51
(2S,5S,8S,11S,14S,17S,20S,26S,29S,32S,35S,62R)-35-(((6S,12S,15S,18S,21S,24S,27S,30S,33S)-21-((1H-Indol-3-yl)methyl)-1-amino-30-benzyl-27-((S)-sec-butyl)-35-carboxy-6-((carboxymethyl)carbamoyl)-12-(3-guanidinopropyl)-1-imino-18-isobutyl-15-isopropyl-24-methyl-8,11,14,17,20,23,26,29,32-nonaoxo-2,7,10,13,16,19,22,25,28,31-decaazapentatriacontan-33-yl)carbamoyl)-2-((2S)-2-((3R)-2-(2-((S)-2-amino-3-(1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-3-hydroxybutanamido)-3-hydroxypropanamido)-26-(3-amino-3-oxopropyl)-20-(2-carboxyethyl)-14-(4-hydroxybenzyl)-8,11-bis(hydroxymethyl)-17-isobutyl-5-isopropyl-29,32-dimethyl-3,6,9,12,15,18,21,24,27,30,33,41,50,59,64-pentadecaoxo-43,46,52,55-tetraoxa-4,7,10,13,16,19,22,25,28,31,34,40,49,58,63-pentadecaazaoctacontane-1,62,80-tricarboxylic Acid
(2S,5S,8S,11S,14S,17S,20S,26S,29S,32S,35S,62R)-35-(((6S,12S,15S,18S,21S,24S,27S,30S,33S)-21-((1H-Indol-3-yl)methyl)-1-amino-30-benzyl-27-((S)-sec-butyl)-35-carboxy-6-((carboxymethyl)carbamoyl)-12-(3-guanidinopropyl)-1-imino-18-isobutyl-15-isopropyl-24-methyl-8,11,14,17,20,23,26,29,32-nonaoxo-2,7,10,13,16,19,22,25,28,31-decaazapentatriacontan-33-yl)carbamoyl)-2-((2S)-2-((3R)-2-(2-((S)-2-amino-3-(1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-3-hydroxybutanamido)-3-hydroxypropanamido)-26-(3-amino-3-oxopropyl)-20-(2-carboxyethyl)-14-(4-hydroxybenzyl)-8,11-bis(hydroxymethyl)-17-isobutyl-5-isopropyl-29,32-dimethyl-3,6,9,12,15,18,21,24,27,30,33,41,50,59,64-pentadecaoxo-43,46,52,55-tetraoxa-4,7,10,13,16,19,22,25,28,31,34,40,49,58,63-pentadecaazaoctacontane-1,62,80-tricarboxylic Acid
Catalogue No.:PA PEP 004977
CAS :
NA
Molecular Formula : C167H265N41O52
Molecular Weight : 3679.19
(2S,5S,8S,11S,14S,17S,20S,26S,29S,32S,35S,62R)-35-(((6S,12S,15S,18S,21S,24S,27S,30S,33S)-21-((1H-Indol-3-yl)methyl)-1-amino-30-benzyl-27-((S)-sec-butyl)-35-carboxy-6-((carboxymethyl)carbamoyl)-12-(3-guanidinopropyl)-1-imino-18-isobutyl-15-isopropyl-24-methyl-8,11,14,17,20,23,26,29,32-nonaoxo-2,7,10,13,16,19,22,25,28,31-decaazapentatriacontan-33-yl)carbamoyl)-2-((S)-2-(2-((S)-2-amino-3-(1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-3-hydroxypropanamido)-26-(3-amino-3-oxopropyl)-20-(2-carboxyethyl)-14-(4-hydroxybenzyl)-8,11-bis(hydroxymethyl)-17-isobutyl-5-isopropyl-29,32-dimethyl-3,6,9,12,15,18,21,24,27,30,33,41,50,59,64-pentadecaoxo-43,46,52,55-tetraoxa-4,7,10,13,16,19,22,25,28,31,34,40,49,58,63-pentadecaazaoctacontane-1,62,80-tricarboxylic Acid
(2S,5S,8S,11S,14S,17S,20S,26S,29S,32S,35S,62R)-35-(((6S,12S,15S,18S,21S,24S,27S,30S,33S)-21-((1H-Indol-3-yl)methyl)-1-amino-30-benzyl-27-((S)-sec-butyl)-35-carboxy-6-((carboxymethyl)carbamoyl)-12-(3-guanidinopropyl)-1-imino-18-isobutyl-15-isopropyl-24-methyl-8,11,14,17,20,23,26,29,32-nonaoxo-2,7,10,13,16,19,22,25,28,31-decaazapentatriacontan-33-yl)carbamoyl)-2-((S)-2-(2-((S)-2-amino-3-(1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-3-hydroxypropanamido)-26-(3-amino-3-oxopropyl)-20-(2-carboxyethyl)-14-(4-hydroxybenzyl)-8,11-bis(hydroxymethyl)-17-isobutyl-5-isopropyl-29,32-dimethyl-3,6,9,12,15,18,21,24,27,30,33,41,50,59,64-pentadecaoxo-43,46,52,55-tetraoxa-4,7,10,13,16,19,22,25,28,31,34,40,49,58,63-pentadecaazaoctacontane-1,62,80-tricarboxylic Acid
Catalogue No.:PA PEP 004978
CAS :
NA
Molecular Formula : C163H258N40O50
Molecular Weight : 3578.09
