Semaglutide and its Impurities
Semaglutide, sold under the brand name Ozempic among others, is an antidiabetic medication used for the treatment of type 2 diabetes and long-term weight management. Reference standards of Semaglutide API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


(R)-13-(tert-Butoxycarbonyl)-34,34-dimethyl-10,15,32-trioxo-3,6,33-trioxa-9,14-diazapentatriacontanoic Acid
(R)-13-(tert-Butoxycarbonyl)-34,34-dimethyl-10,15,32-trioxo-3,6,33-trioxa-9,14-diazapentatriacontanoic Acid
Catalogue No.:PA 19 1851020
CAS :
NA
Molecular Formula : C37H68N2O10
Molecular Weight : 700.96


(R)-22-(tert-Butoxycarbonyl)-43,43-dimethyl-10,19,24,41-tetraoxo-3,6,12,15,42-pentaoxa-9,18,23-triazatetratetracontanoic Acid
(R)-22-(tert-Butoxycarbonyl)-43,43-dimethyl-10,19,24,41-tetraoxo-3,6,12,15,42-pentaoxa-9,18,23-triazatetratetracontanoic Acid
Catalogue No.:PA 19 1851021
CAS :
NA
Molecular Formula : C43H79N3O13
Molecular Weight : 846.11


tert-Butyl (R)-1-amino-22-(tert-butoxycarbonyl)-1,10,19,24-tetraoxo-3,6,12,15-tetraoxa-9,18,23-triazahentetracontan-41-oate
tert-Butyl (R)-1-amino-22-(tert-butoxycarbonyl)-1,10,19,24-tetraoxo-3,6,12,15-tetraoxa-9,18,23-triazahentetracontan-41-oate
Catalogue No.:PA 19 1851022
CAS :
NA
Molecular Formula : C43H80N4O12
Molecular Weight : 845.13


(R)-31-(tert-Butoxycarbonyl)-52,52-dimethyl-10,19,28,33,50-pentaoxo-3,6,12,15,21,24,51-heptaoxa-9,18,27,32-tetraazatripentacontanoic Acid
(R)-31-(tert-Butoxycarbonyl)-52,52-dimethyl-10,19,28,33,50-pentaoxo-3,6,12,15,21,24,51-heptaoxa-9,18,27,32-tetraazatripentacontanoic Acid
Catalogue No.:PA 19 1851023
CAS :
NA
Molecular Formula : C49H90N4O16
Molecular Weight : 991.27


(S)-(2-(2-(((Benzyloxy)carbonyl)amino)-2-methylpropanamido)-5-(tert-butoxy)-5-oxopentanoyl)glycine
(S)-(2-(2-(((Benzyloxy)carbonyl)amino)-2-methylpropanamido)-5-(tert-butoxy)-5-oxopentanoyl)glycine
Catalogue No.:PA 19 1851025
CAS :
NA
Molecular Formula : C23H33N3O8
Molecular Weight : 479.53


Methyl (6S,12S)-12-(3-(tert-butoxy)-3-oxopropyl)-2,2,9,9-tetramethyl-4,7,10,13-tetraoxo-6-((1-trityl-1H-imidazol-4-yl)methyl)-3-oxa-5,8,11,14-tetraazahexadecan-16-oate
Methyl (6S,12S)-12-(3-(tert-butoxy)-3-oxopropyl)-2,2,9,9-tetramethyl-4,7,10,13-tetraoxo-6-((1-trityl-1H-imidazol-4-yl)methyl)-3-oxa-5,8,11,14-tetraazahexadecan-16-oate
Catalogue No.:PA 19 1851027
CAS :
NA
Molecular Formula : C46H58N6O9
Molecular Weight : 839


(6S,12S)-12-(2-Carboxyethyl)-2,2,9,9-tetramethyl-4,7,10,13-tetraoxo-6-((1-trityl-1H-imidazol-4-yl)methyl)-3-oxa-5,8,11,14-tetraazahexadecan-16-oic Acid
(6S,12S)-12-(2-Carboxyethyl)-2,2,9,9-tetramethyl-4,7,10,13-tetraoxo-6-((1-trityl-1H-imidazol-4-yl)methyl)-3-oxa-5,8,11,14-tetraazahexadecan-16-oic Acid
Catalogue No.:PA 19 1851028
CAS :
NA
Molecular Formula : C41H48N6O9
Molecular Weight : 768.87


((S)-5-(tert-Butoxy)-2-(2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-5-oxopentanoyl)glycine
((S)-5-(tert-Butoxy)-2-(2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-5-oxopentanoyl)glycine
Catalogue No.:PA 19 1851029
CAS :
2377584-78-4
Molecular Formula : C26H42N6O9
Molecular Weight : 582.66


((R)-5-(tert-Butoxy)-2-(2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-5-oxopentanoyl)glycine
((R)-5-(tert-Butoxy)-2-(2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-5-oxopentanoyl)glycine
Catalogue No.:PA 19 1851030
CAS :
NA
Molecular Formula : C45H56N6O9
Molecular Weight : 824.98


((S)-5-(tert-Butoxy)-2-(2-(2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-2-methylpropanamido)-5-oxopentanoyl)glycine
((S)-5-(tert-Butoxy)-2-(2-(2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-2-methylpropanamido)-5-oxopentanoyl)glycine
Catalogue No.:PA 19 1851031
CAS :
NA
Molecular Formula : C49H63N7O10
Molecular Weight : 910.08


tert-Butyl (S)-4-(((benzyloxy)carbonyl)amino)-5-((2-methoxy-2-oxoethyl)amino)-5-oxopentanoate
tert-Butyl (S)-4-(((benzyloxy)carbonyl)amino)-5-((2-methoxy-2-oxoethyl)amino)-5-oxopentanoate
Catalogue No.:PAI 19 185001
CAS :
63276-51-7
Molecular Formula : C20H28N2O7
Molecular Weight : 408.45


Methyl (S)-8-(3-(tert-butoxy)-3-oxopropyl)-5,5-dimethyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oate
Methyl (S)-8-(3-(tert-butoxy)-3-oxopropyl)-5,5-dimethyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oate
Catalogue No.:PAI 19 185002
CAS :
2377584-75-1
Molecular Formula : C24H35N3O8
Molecular Weight : 493.56