sibutramine hydrochloride monohydrate and its Impurities

A hydrochloride salt of Sibutramine, which is an appetite suppressant used for the treatment of obesity and weight loss. Sibutramine is a monoamine reuptake inhibitor (MRI) which is now banned in many countries due to a high risk of cardiovascular diseases associated it. A phenethylamine derivative.Reference standards of Sibutramine Hydrochloride Monohydrate API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.