simvastatin and its Impurities
Simvastatin is used along with exercise, diet, and weight loss to decrease elevated lipid levels. Simvastatin, marketed under the trade name Zocor. It is available as a generic medication.Reference standards of Simvastatin API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
(1S,3R,7S,8S,8aR)-8-(2-((R)-4,6-Dioxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
(1S,3R,7S,8S,8aR)-8-(2-((R)-4,6-Dioxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
Catalogue No.:PA 19 11590
CAS :
1426939-44-7
Molecular Formula : C25H36O5
Molecular Weight : 416.55
6(R)-[2-(8(S)-(2,2-Dimethyl-d6-butyryl)oxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-(t-butyl-dimethylsilyl)oxy-3,4,5,6-tetrahydro-2H-pyran-2-one
6(R)-[2-(8(S)-(2,2-Dimethyl-d6-butyryl)oxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-(t-butyl-dimethylsilyl)oxy-3,4,5,6-tetrahydro-2H-pyran-2-one
Catalogue No.:PA STI 034180
CAS :
1335460-29-1
Molecular Formula : C31H46D6O5Si
Molecular Weight : 538.86
(3R,5R)-Methyl 7-((1S,2S,6R,8S,8aR)-8-((2,2-dimethylbutanoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-3,5-dihydroxyheptanoate
(3R,5R)-Methyl 7-((1S,2S,6R,8S,8aR)-8-((2,2-dimethylbutanoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-3,5-dihydroxyheptanoate
Catalogue No.:PAI 19 001510
CAS :
145576-26-7
Molecular Formula : C26H42O6
Molecular Weight : 450.61
(3R,5R)-Methyl 3,5-bis((tert-butyldimethylsilyl)oxy)-7-((1S,2S,6R,8S,8aR)-8-((2,2-dimethylbutanoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoate
(3R,5R)-Methyl 3,5-bis((tert-butyldimethylsilyl)oxy)-7-((1S,2S,6R,8S,8aR)-8-((2,2-dimethylbutanoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoate
Catalogue No.:PAI 19 001520
CAS :
NA
Molecular Formula : C38H70O6Si2
Molecular Weight : 678.13
(3R,5R)-(2R,4R)-2-(2-((1S,2S,6R,8S,8aR)-8-((2,2-Dimethylbutanoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)-6-oxotetrahydro-2H-pyran-4-yl 3,5-bis((tert-butyldimethylsilyl)oxy)-7-((1S,6R,8S,8aR)-8-((2,2-dimethylbutanoyl)oxy)-6-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoate
(3R,5R)-(2R,4R)-2-(2-((1S,2S,6R,8S,8aR)-8-((2,2-Dimethylbutanoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)-6-oxotetrahydro-2H-pyran-4-yl 3,5-bis((tert-butyldimethylsilyl)oxy)-7-((1S,6R,8S,8aR)-8-((2,2-dimethylbutanoyl)oxy)-6-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoate
Catalogue No.:PAI 19 001530
CAS :
NA
Molecular Formula : C61H102O10Si2
Molecular Weight : 1051.63
(3R,5R)-(2R,4R)-2-(2-((1S,2S,6R,8S,8aR)-8-((2,2-Dimethylbutanoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)-6-oxotetrahydro-2H-pyran-4-yl 7-((1S,6R,8S,8aR)-8-((2,2-dimethylbutanoyl)oxy)-6-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-3,5-dihydroxyheptanoate
(3R,5R)-(2R,4R)-2-(2-((1S,2S,6R,8S,8aR)-8-((2,2-Dimethylbutanoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)-6-oxotetrahydro-2H-pyran-4-yl 7-((1S,6R,8S,8aR)-8-((2,2-dimethylbutanoyl)oxy)-6-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-3,5-dihydroxyheptanoate
Catalogue No.:PAI 19 001540
CAS :
NA
Molecular Formula : C49H74O10
Molecular Weight : 823.11
(3R,5R)-(2R,4R)-2-(2-((1S,2S,6R,8S,8aR)-8-((2,2-dimethylbutanoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)-6-oxotetrahydro-2H-pyran-4-yl 3,5-bis((tert-butyldimethylsilyl)oxy)-7-((1S,2S,6R,8S,8aR)-8-((2,2-dimethylbutanoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoate
(3R,5R)-(2R,4R)-2-(2-((1S,2S,6R,8S,8aR)-8-((2,2-dimethylbutanoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)-6-oxotetrahydro-2H-pyran-4-yl 3,5-bis((tert-butyldimethylsilyl)oxy)-7-((1S,2S,6R,8S,8aR)-8-((2,2-dimethylbutanoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoate
Catalogue No.:PAI 19 001550
CAS :
NA
Molecular Formula : C62H104O10Si2
Molecular Weight : 1065.65
(S)-(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-((tert-Butyldimethylsilyl)oxy)-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate
(S)-(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-((tert-Butyldimethylsilyl)oxy)-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate
Catalogue No.:PAI 19 001560
CAS :
NA
Molecular Formula : C30H50O5Si
Molecular Weight : 518.80
(3R,5R)-3-((tert-Butyldimethylsilyl)oxy)-5-hydroxy-7-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoic acid
(3R,5R)-3-((tert-Butyldimethylsilyl)oxy)-5-hydroxy-7-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoic acid
Catalogue No.:PAI 19 001570
CAS :
NA
Molecular Formula : C25H44O5Si
Molecular Weight : 452.70
(4R,6R)-4-((tert-Butyldimethylsilyl)oxy)-6-(2-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)tetrahydro-2H-pyran-2-one
(4R,6R)-4-((tert-Butyldimethylsilyl)oxy)-6-(2-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)tetrahydro-2H-pyran-2-one
Catalogue No.:PAI 19 001580
CAS :
NA
Molecular Formula : C25H42O4Si
Molecular Weight : 434.68
(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-((tert-Butyldimethylsilyl)oxy)-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbut-3-enoate
(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-((tert-Butyldimethylsilyl)oxy)-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbut-3-enoate
Catalogue No.:PAI 19 001590
CAS :
NA
Molecular Formula : C31H50O5Si
Molecular Weight : 530.81
(1S,3R,7S,8S,8aR)-8-(2-((4S)-6-(2-Methoxy-2-oxoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
(1S,3R,7S,8S,8aR)-8-(2-((4S)-6-(2-Methoxy-2-oxoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
Catalogue No.:PAI 19 001600
CAS :
NA
Molecular Formula : C29H46O6
Molecular Weight : 490.68
2-((6S)-6-(2-((1S,2S,6R,8S,8aR)-8-((2,2-dimethylbutanoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid
2-((6S)-6-(2-((1S,2S,6R,8S,8aR)-8-((2,2-dimethylbutanoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid
Catalogue No.:PAI 19 001610
CAS :
NA
Molecular Formula : C28H44O6
Molecular Weight : 476.65
(3R,5R)-3,5-Dihydroxy-7-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoic Acid
(3R,5R)-3,5-Dihydroxy-7-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoic Acid
Catalogue No.:PAI 19 001630
CAS :
NA
Molecular Formula : C19H30O5
Molecular Weight : 338.44
Acetyl Simvastatin ((1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-(acetoxy)-6-oxotetrahydro-2H-pyran-2-yl]ethyl (1010208)
Acetyl Simvastatin ((1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-(acetoxy)-6-oxotetrahydro-2H-pyran-2-yl]ethyl (1010208)
Catalogue No.:PA USP1010208
CAS :
145576-25-6
Molecular Formula : NA
Molecular Weight : NA
Anhydro Simvastatin ((1S,3R,7S,8S,8aR)-3,7-Dimethyl-8-[2-[(2R)-6-oxo-3,6-dihydro-2H-pyran-2-yl]ethy (1035402)
Anhydro Simvastatin ((1S,3R,7S,8S,8aR)-3,7-Dimethyl-8-[2-[(2R)-6-oxo-3,6-dihydro-2H-pyran-2-yl]ethy (1035402)
Catalogue No.:PA USP1035402
CAS :
210980-68-0
Molecular Formula : NA
Molecular Weight : NA
Methylene Simvastatin ((1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethy (1428229)
Methylene Simvastatin ((1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethy (1428229)
Catalogue No.:PA USP1428229
CAS :
1449248-72-9
Molecular Formula : NA
Molecular Weight : NA
(4R,6R)-4-((tert-Butyldimethylsilyl)oxy)-6-(2-((1S,2S,6S,8S,8aS)-8-hydroxy-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)ethyl)tetrahydro-2H-pyran-2-one
(4R,6R)-4-((tert-Butyldimethylsilyl)oxy)-6-(2-((1S,2S,6S,8S,8aS)-8-hydroxy-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)ethyl)tetrahydro-2H-pyran-2-one
Catalogue No.:PAI 19 001660
CAS :
NA
Molecular Formula : C25H44O4Si
Molecular Weight : 436.71
(1S,3S,7S,8S,8aS)-8-(2-((2R,4R)-4-((tert-Butyldimethylsilyl)oxy)-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl 2,2-dimethylbutanoate
(1S,3S,7S,8S,8aS)-8-(2-((2R,4R)-4-((tert-Butyldimethylsilyl)oxy)-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl 2,2-dimethylbutanoate
Catalogue No.:PAI 19 001670
CAS :
NA
Molecular Formula : C31H54O5Si
Molecular Weight : 534.85
(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-((tert-Butyldimethylsilyl)oxy)-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl isobutyrate
(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-((tert-Butyldimethylsilyl)oxy)-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl isobutyrate
Catalogue No.:PAI 19 001691
CAS :
NA
Molecular Formula : C29H48O5Si
Molecular Weight : 504.78
(1aS,2R,3S,3aR,4S,6R,7bR)-3-(2-((2S,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-2,6-dimethyl-1a,2,3,3a,4,5,6,7b-octahydronaphtho[1,2-b]oxiren-4-yl 2,2-dimethylbutanoate compound with (1aS,2R,5S,6S,8aR)-5-(2-((2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-2,6-dimethyl-1a,2,4,4a,5,6-hexahydro-3H-naphtho[1,8a-b]oxiren-4-yl 2,2-dimethylbutanoate (1:1)
(1aS,2R,3S,3aR,4S,6R,7bR)-3-(2-((2S,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-2,6-dimethyl-1a,2,3,3a,4,5,6,7b-octahydronaphtho[1,2-b]oxiren-4-yl 2,2-dimethylbutanoate compound with (1aS,2R,5S,6S,8aR)-5-(2-((2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-2,6-dimethyl-1a,2,4,4a,5,6-hexahydro-3H-naphtho[1,8a-b]oxiren-4-yl 2,2-dimethylbutanoate (1:1)
Catalogue No.:PAI 19 001690
CAS :
NA
Molecular Formula : C50H76O12
Molecular Weight : 869.15
(1S,3R,7S,8S,8aR)-3,7-Dimethyl-8-(2-((R)-6-oxo-3,6-dihydro-2H-pyran-2-yl)ethyl)-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (R)-2-methylbutanoate
(1S,3R,7S,8S,8aR)-3,7-Dimethyl-8-(2-((R)-6-oxo-3,6-dihydro-2H-pyran-2-yl)ethyl)-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (R)-2-methylbutanoate
Catalogue No.:PAI 19 001692
CAS :
NA
Molecular Formula : C24H34O4
Molecular Weight : 386.53
(1S,3S,7S,8S,8aS)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyldecahydronaphthalen-1-yl 2,2-dimethylbutanoate
(1S,3S,7S,8S,8aS)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyldecahydronaphthalen-1-yl 2,2-dimethylbutanoate
Catalogue No.:PA 19 11620
CAS :
87770-13-6
Molecular Formula : C25H42O5
Molecular Weight : 422.61
(1S,3S,7S,8S,8aS)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyldecahydronaphthalen-1-yl 2,2-dimethylbut-3-enoate
(1S,3S,7S,8S,8aS)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyldecahydronaphthalen-1-yl 2,2-dimethylbut-3-enoate
Catalogue No.:PA 19 11630
CAS :
NA
Molecular Formula : C25H40O5
Molecular Weight : 420.59