Siponimod and its Impurities
Siponimod, sold under the brand name Mayzent, is a selective sphingosine-1-phosphate receptor modulator for oral use that is used for multiple sclerosis. Reference standards of Siponimod API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


(E)-1-(4-(1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)-2-hydroxyazetidine-3-carboxylic Acid
(E)-1-(4-(1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)-2-hydroxyazetidine-3-carboxylic Acid
Catalogue No.:PA 19 1831002
CAS :
NA
Molecular Formula : C29H35F3N2O4
Molecular Weight : 532.6


(Z)-1-(4-(1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine-3-carboxylic Acid
(Z)-1-(4-(1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine-3-carboxylic Acid
Catalogue No.:PA 19 1831003
CAS :
2768181-14-0
Molecular Formula : C29H35F3N2O3
Molecular Weight : 516.61


3-((4-((E)-1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)(nitroso)amino)-2-(((1-(4-((E)-1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine-3-carbonyl)oxy)methyl)propanoic Acid
3-((4-((E)-1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)(nitroso)amino)-2-(((1-(4-((E)-1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine-3-carbonyl)oxy)methyl)propanoic Acid
Catalogue No.:PA 19 1831005
CAS :
NA
Molecular Formula : C58H69F6N5O7
Molecular Weight : 1062.21


(E)-2-(((4-(1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)(nitroso)amino)methyl)acrylic Acid
(E)-2-(((4-(1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)(nitroso)amino)methyl)acrylic Acid
Catalogue No.:PA 19 1831006
CAS :
NA
Molecular Formula : C29H34F3N3O4
Molecular Weight : 545.6


Dimethyl 1,1'-(((1-oxobut-2-ene-1,3-diyl)bis(2-ethyl-4,1-phenylene))bis(methylene))(E)-bis(azetidine-3-carboxylate)
Dimethyl 1,1'-(((1-oxobut-2-ene-1,3-diyl)bis(2-ethyl-4,1-phenylene))bis(methylene))(E)-bis(azetidine-3-carboxylate)
Catalogue No.:PA 19 1831007
CAS :
NA
Molecular Formula : C32H40N2O5
Molecular Weight : 532.68


Dimethyl 1,1'-(((1-oxobut-2-ene-1,3-diyl)bis(2-ethyl-4,1-phenylene))bis(methylene))(Z)-bis(azetidine-3-carboxylate)
Dimethyl 1,1'-(((1-oxobut-2-ene-1,3-diyl)bis(2-ethyl-4,1-phenylene))bis(methylene))(Z)-bis(azetidine-3-carboxylate)
Catalogue No.:PA 19 1831008
CAS :
NA
Molecular Formula : C32H40N2O5
Molecular Weight : 532.68


1-(4-(1-(((4-Cyclohexyl-3-methylbenzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine-3-carboxylic Acid
1-(4-(1-(((4-Cyclohexyl-3-methylbenzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine-3-carboxylic Acid
Catalogue No.:PA 19 1831009
CAS :
800380-45-4
Molecular Formula : C29H38N2O3
Molecular Weight : 462.63


(E)-2-(((4-(1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)amino)methyl)acrylic Acid
(E)-2-(((4-(1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)amino)methyl)acrylic Acid
Catalogue No.:PA 19 1831010
CAS :
NA
Molecular Formula : C29H35F3N2O3
Molecular Weight : 516.61


(E)-3-((4-(1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)amino)-2-(hydroxymethyl)propanoic Acid
(E)-3-((4-(1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)amino)-2-(hydroxymethyl)propanoic Acid
Catalogue No.:PA 19 1831011
CAS :
NA
Molecular Formula : C29H37F3N2O4
Molecular Weight : 534.62


3-((4-((E)-1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)amino)-2-(((1-(4-((E)-1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine-3-carbonyl)oxy)methyl)propanoic Acid
3-((4-((E)-1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)amino)-2-(((1-(4-((E)-1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine-3-carbonyl)oxy)methyl)propanoic Acid
Catalogue No.:PA 19 1831012
CAS :
NA
Molecular Formula : C58H70F6N4O6
Molecular Weight : 1032.52


(E)-N-((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)-1-(4-(1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine-3-carboxamide
(E)-N-((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)-1-(4-(1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine-3-carboxamide
Catalogue No.:PA 19 1831015
CAS :
NA
Molecular Formula : C43H51F6N3O3
Molecular Weight : 771.8


(E)-3-Carboxy-1-(4-(1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine 1-oxide
(E)-3-Carboxy-1-(4-(1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine 1-oxide
Catalogue No.:PA 19 1831017
CAS :
NA
Molecular Formula : C29H35F3N2O4
Molecular Weight : 532.6


(Z)-3-((4-(1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)amino)-2-(hydroxymethyl)propanoic Acid
(Z)-3-((4-(1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)amino)-2-(hydroxymethyl)propanoic Acid
Catalogue No.:PA 19 1831018
CAS :
NA
Molecular Formula : C29H37F3N2O4
Molecular Weight : 534.62


(E)-1-(2-Ethyl-4-(1-(((2-(trifluoromethyl)-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-4-yl)methoxy)imino)ethyl)benzyl)azetidine-3-carboxylic Acid
(E)-1-(2-Ethyl-4-(1-(((2-(trifluoromethyl)-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-4-yl)methoxy)imino)ethyl)benzyl)azetidine-3-carboxylic Acid
Catalogue No.:PA 19 1831021
CAS :
2768181-12-8
Molecular Formula : C29H33F3N2O3
Molecular Weight : 514.59


(E)-1-(4-(1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-vinylbenzyl)azetidine-3-carboxylic Acid
(E)-1-(4-(1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-vinylbenzyl)azetidine-3-carboxylic Acid
Catalogue No.:PA 19 1831022
CAS :
2768181-13-9
Molecular Formula : C29H33F3N2O3
Molecular Weight : 514.59


Methyl (E)-1-(4-(1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine-3-carboxylate
Methyl (E)-1-(4-(1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine-3-carboxylate
Catalogue No.:PA 19 1831023
CAS :
2746387-08-4
Molecular Formula : C30H37F3N2O3
Molecular Weight : 530.63


(E)-1-(4-(1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)benzyl)azetidine-3-carboxylic Acid
(E)-1-(4-(1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)benzyl)azetidine-3-carboxylic Acid
Catalogue No.:PA 19 1831025
CAS :
2768181-18-4
Molecular Formula : C27H31F3N2O3
Molecular Weight : 488.55


(E)-1-((1-(4-(1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidin-3-yl)methyl)azetidine-3-carboxylic Acid
(E)-1-((1-(4-(1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidin-3-yl)methyl)azetidine-3-carboxylic Acid
Catalogue No.:PA 19 1831026
CAS :
NA
Molecular Formula : C33H42F3N3O3
Molecular Weight : 585.71


(Z)-2-(((4-(1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)amino)methyl)acrylic Acid
(Z)-2-(((4-(1-(((4-Cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)amino)methyl)acrylic Acid
Catalogue No.:PA 19 1831029
CAS :
NA
Molecular Formula : C29H35F3N2O3
Molecular Weight : 516.61