sofosbuvir and its Impurities
A recently approved nucleotide analog used in the treatment of hepatitis. Sofosbuvir works by inhibiting the hepatitis C NS5B protein. It is a a prodrug of its active antiviral agent GS-461203 Reference standards of Sofosbuvir API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


[(2R,3R,4R,5R)-3-(Benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl]methyl Benzoate
[(2R,3R,4R,5R)-3-(Benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl]methyl Benzoate
Catalogue No.:PA 19 51580
CAS :
1199809-22-7
Molecular Formula : C20H19FO6
Molecular Weight : 374.36


[(2R,3R,4R,5S)-3-(Benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl]methyl Benzoate
[(2R,3R,4R,5S)-3-(Benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl]methyl Benzoate
Catalogue No.:PA 19 51590
CAS :
1639301-16-8
Molecular Formula : C20H19FO6
Molecular Weight : 374.36


[(2R,3R,4R,5R)-3-(Benzoyloxy)-5-chloro-4-fluoro-4-methyltetrahydrofuran-2-yl]methyl Benzoate
[(2R,3R,4R,5R)-3-(Benzoyloxy)-5-chloro-4-fluoro-4-methyltetrahydrofuran-2-yl]methyl Benzoate
Catalogue No.:PA 19 51600
CAS :
1199809-23-8
Molecular Formula : C20H18ClFO5
Molecular Weight : 392.81


[(2R,3R,4R,5S)-3-(Benzoyloxy)-5-chloro-4-fluoro-4-methyltetrahydrofuran-2-yl]methyl Benzoate
[(2R,3R,4R,5S)-3-(Benzoyloxy)-5-chloro-4-fluoro-4-methyltetrahydrofuran-2-yl]methyl Benzoate
Catalogue No.:PA 19 51610
CAS :
1500076-79-8
Molecular Formula : C20H18ClFO5
Molecular Weight : 392.81


(2R,3R,4R,5R)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl Benzoate
(2R,3R,4R,5R)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl Benzoate
Catalogue No.:PA 19 51620
CAS :
817204-32-3
Molecular Formula : C31H26FN3O7
Molecular Weight : 571.55


((2R,3R,4R,5R)-3-(Benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl Benzoate
((2R,3R,4R,5R)-3-(Benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl Benzoate
Catalogue No.:PA 19 51630
CAS :
863329-65-1
Molecular Formula : C24H21FN2O7
Molecular Weight : 468.43


1-((2S,3S,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
1-((2S,3S,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
Catalogue No.:PA 19 51640
CAS :
1946820-96-7
Molecular Formula : C10H13FN2O5
Molecular Weight : 260.22


1-((2S,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
1-((2S,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
Catalogue No.:PA 19 51650
CAS :
2041584-99-8
Molecular Formula : C10H13FN2O5
Molecular Weight : 260.22


1-((2R,3R,4R,5R)-3-Chloro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
1-((2R,3R,4R,5R)-3-Chloro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
Catalogue No.:PA 19 51660
CAS :
1496551-72-4
Molecular Formula : C10H13ClN2O5
Molecular Weight : 276.67


(1R,2S)-1-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-3-ethoxy-2-fluoro-2-methyl-3-oxopropyl Sulfate
(1R,2S)-1-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-3-ethoxy-2-fluoro-2-methyl-3-oxopropyl Sulfate
Catalogue No.:PA 19 51670
CAS :
2053891-28-2
Molecular Formula : C11H19FO8S
Molecular Weight : 330.33


(4S,5R)-Ethyl 5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-methyl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide
(4S,5R)-Ethyl 5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-methyl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide
Catalogue No.:PA 19 51680
CAS :
879551-01-6
Molecular Formula : C11H18O8S
Molecular Weight : 310.32


Mixture of (Pentafluorophenol, Sofosbuvir-14-ethyl impurity, Sofosbuvir-14, And n-Propyl Sofosbuvir-14)
Mixture of (Pentafluorophenol, Sofosbuvir-14-ethyl impurity, Sofosbuvir-14, And n-Propyl Sofosbuvir-14)
Catalogue No.:PA 19 51720
CAS :
NA
Molecular Formula : C59H50F20N3O16P3
Molecular Weight : 1529.93


Isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-Dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
Isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-Dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
Catalogue No.:PA 19 51790
CAS :
NA
Molecular Formula : C22H29FN3O9P
Molecular Weight : 529.45


(R)-Isopropyl 2-(((R)-(((2R,3R,4R,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
(R)-Isopropyl 2-(((R)-(((2R,3R,4R,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
Catalogue No.:PA 19 51800
CAS :
1496552-16-9
Molecular Formula : C22H29FN3O9P
Molecular Weight : 529.45


((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methyl Phenyl Hydrogen Phosphate
((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methyl Phenyl Hydrogen Phosphate
Catalogue No.:PA 19 51850
CAS :
1859162-80-3
Molecular Formula : C16H18FN2O8P
Molecular Weight : 416.29


(2R,3S,4S,5S)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
(2R,3S,4S,5S)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
Catalogue No.:PA 19 51870
CAS :
NA
Molecular Formula : C31H26FN3O7
Molecular Weight : 571.55


(S)-Isopropyl 2-(((S)-(((2S,3S,4S,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
(S)-Isopropyl 2-(((S)-(((2S,3S,4S,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
Catalogue No.:PA 19 51880
CAS :
NA
Molecular Formula : C22H29FN3O9P
Molecular Weight : 529.45


(R)-Isopropyl 2-(((R)-(((2S,3S,4S,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
(R)-Isopropyl 2-(((R)-(((2S,3S,4S,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
Catalogue No.:PA 19 51890
CAS :
NA
Molecular Formula : C22H29FN3O9P
Molecular Weight : 529.45


(S)-Ethyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate;
(S)-Ethyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate;
Catalogue No.:PA 19 51900
CAS :
2164516-85-0
Molecular Formula : C21H27FN3O9P
Molecular Weight : 515.43


1-((3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
1-((3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
Catalogue No.:PA 19 51910
CAS :
NA
Molecular Formula : C10H13FN2O5
Molecular Weight : 260.22


Isopropyl ((((2R,3R,4R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)-L-alaninate
Isopropyl ((((2R,3R,4R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)-L-alaninate
Catalogue No.:PA 19 51930
CAS :
NA
Molecular Formula : C34H45FN4O13P2
Molecular Weight : 798.69


Isopropyl ((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-D-alaninate
Isopropyl ((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-D-alaninate
Catalogue No.:PA 19 0511000
CAS :
NA
Molecular Formula : C22H29FN3O9P
Molecular Weight : 529.46


Methyl ((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
Methyl ((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
Catalogue No.:PA 19 0511002
CAS :
1394157-28-8
Molecular Formula : C20H25FN3O9P
Molecular Weight : 501.4


Isopropyl ((S)-(((2R,3R,4S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
Isopropyl ((S)-(((2R,3R,4S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
Catalogue No.:PA 19 0511009
CAS :
1987957-11-8
Molecular Formula : C22H30N3O10P
Molecular Weight : 527.47


((2R,3R,4R)-3-(Benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl)methyl benzoate
((2R,3R,4R)-3-(Benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl)methyl benzoate
Catalogue No.:PA 19 0511010
CAS :
1884385-12-9
Molecular Formula : C20H19FO6
Molecular Weight : 374.36


(2R,3R,4R,5R)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-chloro-4-methyltetrahydrofuran-3-yl benzoate
(2R,3R,4R,5R)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-chloro-4-methyltetrahydrofuran-3-yl benzoate
Catalogue No.:PA 19 0511011
CAS :
1496551-70-2
Molecular Formula : C31H26ClN3O7
Molecular Weight : 588.01


Isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-D-alaninate
Isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-D-alaninate
Catalogue No.:PA 19 0511008
CAS :
1496552-28-3
Molecular Formula : C22H29FN3O9P
Molecular Weight : 529.46


9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-1H-purine-2,6-dithione
9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-1H-purine-2,6-dithione
Catalogue No.:PA 19 0511014
CAS :
56496-81-2
Molecular Formula : C10H12N4O4S2
Molecular Weight : 316.35


Methyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
Methyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
Catalogue No.:PA 19 0511016
CAS :
1394157-34-6
Molecular Formula : C20H25FN3O9P
Molecular Weight : 501.4


((2R,3R,4R)-3-(Benzoyloxy)-5-chloro-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate
((2R,3R,4R)-3-(Benzoyloxy)-5-chloro-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate
Catalogue No.:PA 19 0511017
CAS :
1621160-31-3
Molecular Formula : C20H18ClFO5
Molecular Weight : 392.81