Sotorasib and its Impurities
Sotorasib, sold under the brand names Lumakras and Lumykras, is an anti-cancer drug, it for the treatment of KRAS G12C mutant non small cell lung cancer, colorectal cancer, and appendix cancer. Reference standards of Sotorasib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
4-((R)-4-Acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one
4-((R)-4-Acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one
Catalogue No.:PA 19 2201000
CAS :
NA
Molecular Formula : C30H30F2N6O3
Molecular Weight : 560.61
4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one
4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one
Catalogue No.:PA 19 2201001
CAS :
2252403-56-6
Molecular Formula : C30H30F2N6O3
Molecular Weight : 560.61
