spironolactone and its Impurities
Spironolactone is used for the treatment of heart failures and kidney diseases. It is metabolised in liver and major metabolites of spironolactone are 7α-TMS,6β-OH-7α-TMS and canrenone,. Reference standards of Spironolactone API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
(2'R,8R,9S,10R,13S,14S)-3-Methoxy-10,13-dimethyl-1,2,7,8,9,10,11,12,13,14,15,16-dodecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-5'(4'H)-one
(2'R,8R,9S,10R,13S,14S)-3-Methoxy-10,13-dimethyl-1,2,7,8,9,10,11,12,13,14,15,16-dodecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-5'(4'H)-one
Catalogue No.:PA 19 18510
CAS :
NA
Molecular Formula : C23H32O3
Molecular Weight : 356.5
(2'S,8R,9S,10R,13S,14S)-10,13-Dimethyl-1,8,9,10,11,12,13,14,15,16-decahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione
(2'S,8R,9S,10R,13S,14S)-10,13-Dimethyl-1,8,9,10,11,12,13,14,15,16-decahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione
Catalogue No.:PA 19 18520
CAS :
NA
Molecular Formula : C22H28O3
Molecular Weight : 340.46
Spironolactone Related Compound A (Canrenone (3-Oxo-17-alpha-pregna-4,6-diene-21, 17-carbolactone)) (1619017)
Spironolactone Related Compound A (Canrenone (3-Oxo-17-alpha-pregna-4,6-diene-21, 17-carbolactone)) (1619017)
Catalogue No.:PA USP1619017
CAS :
976-71-6
Molecular Formula : NA
Molecular Weight : NA
Spironolactone Related Compound B ((2'R)-7alpha-(Acetylthio)-5'H-spiro[androst-4-ene-17,2'-furan]-3 (1619028)
Spironolactone Related Compound B ((2'R)-7alpha-(Acetylthio)-5'H-spiro[androst-4-ene-17,2'-furan]-3 (1619028)
Catalogue No.:PA USP1619028
CAS :
132458-33-4
Molecular Formula : NA
Molecular Weight : NA
Spironolactone Related Compound C ((2'R)-3',4'-Dihydro-5'H-spiro[androst-4-ene-17,2'-furan]-3,5'-di (1619039)
Spironolactone Related Compound C ((2'R)-3',4'-Dihydro-5'H-spiro[androst-4-ene-17,2'-furan]-3,5'-di (1619039)
Catalogue No.:PA USP1619039
CAS :
976-70-5
Molecular Formula : NA
Molecular Weight : NA
Spironolactone Related Compound D ((2'R)-7alpha-(Acetyldisulfanyl)-3',4'-dihydro-5'H-spiro[androst- (1619040)
Spironolactone Related Compound D ((2'R)-7alpha-(Acetyldisulfanyl)-3',4'-dihydro-5'H-spiro[androst- (1619040)
Catalogue No.:PA USP1619040
CAS :
NA
Molecular Formula : NA
Molecular Weight : NA
Spironolactone Epimer Mixture (7-Epispironolactone approximately 56% and Spironolactone approximate (1619051)
Spironolactone Epimer Mixture (7-Epispironolactone approximately 56% and Spironolactone approximate (1619051)
Catalogue No.:PA USP1619051
CAS :
NA
Molecular Formula : NA
Molecular Weight : NA
Spironolactone Related Compound I (S-[17alpha-(Ethoxymethyl)-17-hydroxy-3-oxoandrost-4-en-7alpha-yl (1619094)
Spironolactone Related Compound I (S-[17alpha-(Ethoxymethyl)-17-hydroxy-3-oxoandrost-4-en-7alpha-yl (1619094)
Catalogue No.:PA USP1619094
CAS :
NA
Molecular Formula : NA
Molecular Weight : NA
(8R,9S,10R,13S,14S,17S)-17-Hydroxy-17-(3-hydroxyprop-1-yn-1-yl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
(8R,9S,10R,13S,14S,17S)-17-Hydroxy-17-(3-hydroxyprop-1-yn-1-yl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
Catalogue No.:PAI 19 018001
CAS :
NA
Molecular Formula : C22H30O3
Molecular Weight : 342.48
(8R,9S,10R,13S,14S,17R)-17-Hydroxy-17-(3-hydroxyprop-1-en-1-yl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
(8R,9S,10R,13S,14S,17R)-17-Hydroxy-17-(3-hydroxyprop-1-en-1-yl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
Catalogue No.:PAI 19 018002
CAS :
NA
Molecular Formula : C22H32O3
Molecular Weight : 344.5
(8R,9S,10R,13S,14S,17R)-10,13-Dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione
(8R,9S,10R,13S,14S,17R)-10,13-Dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione
Catalogue No.:PAI 19 018003
CAS :
52845-59-7
Molecular Formula : C22H28O3
Molecular Weight : 340.46
(8R,9S,10R,13S,14S,17R)-10,13-Dimethyl-1,8,9,10,11,12,13,14,15,16-decahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione
(8R,9S,10R,13S,14S,17R)-10,13-Dimethyl-1,8,9,10,11,12,13,14,15,16-decahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione
Catalogue No.:PAI 19 018004
CAS :
NA
Molecular Formula : C22H26O3
Molecular Weight : 338.45
Ethyl 3-((3S,8R,9S,10R,13S,14S,17S)-3,17-dihydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)propiolate
Ethyl 3-((3S,8R,9S,10R,13S,14S,17S)-3,17-dihydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)propiolate
Catalogue No.:PAI 19 018005
CAS :
NA
Molecular Formula : C24H34O4
Molecular Weight : 386.53
Ethyl (E)-3-((3S,8R,9S,10R,13S,14S,17R)-3,17-dihydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)acrylate
Ethyl (E)-3-((3S,8R,9S,10R,13S,14S,17R)-3,17-dihydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)acrylate
Catalogue No.:PAI 19 018006
CAS :
NA
Molecular Formula : C24H36O4
Molecular Weight : 388.55
(3S,8R,9S,10R,13S,14S,17R)-3-Hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-5'-one
(3S,8R,9S,10R,13S,14S,17R)-3-Hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-5'-one
Catalogue No.:PAI 19 018007
CAS :
NA
Molecular Formula : C22H30O3
Molecular Weight : 342.48
Ethyl 3-((3S,8R,9S,10R,13S,14S,17S)-3-((tert-butyldimethylsilyl)oxy)-17-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)propiolate
Ethyl 3-((3S,8R,9S,10R,13S,14S,17S)-3-((tert-butyldimethylsilyl)oxy)-17-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)propiolate
Catalogue No.:PAI 19 018009
CAS :
NA
Molecular Formula : C30H48O4Si
Molecular Weight : 500.8
Ethyl (E)-3-((3S,8R,9S,10R,13S,14S,17R)-3-((tert-butyldimethylsilyl)oxy)-17-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)acrylate
Ethyl (E)-3-((3S,8R,9S,10R,13S,14S,17R)-3-((tert-butyldimethylsilyl)oxy)-17-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)acrylate
Catalogue No.:PAI 19 018010
CAS :
NA
Molecular Formula : C30H50O4Si
Molecular Weight : 502.81
(3S,8R,9S,10R,13S,14S,17R)-3-((tert-Butyldimethylsilyl)oxy)-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-5'-one
(3S,8R,9S,10R,13S,14S,17R)-3-((tert-Butyldimethylsilyl)oxy)-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-5'-one
Catalogue No.:PAI 19 018011
CAS :
NA
Molecular Formula : C28H44O3Si
Molecular Weight : 456.74