sunitinib and its Impurities
An oral anti cancer drug. Works by inhibiting cellular signals by targeting multiple receptor tyrosine kinases (RTKs). Sunitinib is approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) Reference standards of Sunitinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


(Z)-N-Ethyl-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]- 2,4-dimethyl-1H-pyrrole-3-carboxamide
(Z)-N-Ethyl-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]- 2,4-dimethyl-1H-pyrrole-3-carboxamide
Catalogue No.:PA 19 75520
CAS :
NA
Molecular Formula : C18H18FN3O2
Molecular Weight : 327.35


(E)-N-(2-(Diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
(E)-N-(2-(Diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
Catalogue No.:PA 19 75570
CAS :
1691223-83-2
Molecular Formula : C22H27FN4O2
Molecular Weight : 398.47


(Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-N-(2-hydroxyethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
(Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-N-(2-hydroxyethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
Catalogue No.:PA 19 75660
CAS :
2170562-55-5
Molecular Formula : C18H18FN3O3
Molecular Weight : 343.36


(Z)-3-((3,5-Dimethyl-4-(pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)-5-fluoroindolin-2-one
(Z)-3-((3,5-Dimethyl-4-(pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)-5-fluoroindolin-2-one
Catalogue No.:PA 19 75680
CAS :
2135339-43-2
Molecular Formula : C20H20FN3O2
Molecular Weight : 353.4


(Z)-N-(2-(Ethylamino)ethyl)-5-((6-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
(Z)-N-(2-(Ethylamino)ethyl)-5-((6-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
Catalogue No.:PA 19 75690
CAS :
NA
Molecular Formula : C20H23FN4O2
Molecular Weight : 370.43


(E)-N-(2-(Diethylamino)ethyl)-5-((4-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
(E)-N-(2-(Diethylamino)ethyl)-5-((4-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
Catalogue No.:PA 19 75700
CAS :
NA
Molecular Formula : C22H27FN4O2
Molecular Weight : 398.48


(Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-N,N,2,4-tetramethyl-1H-pyrrole-3-carboxamide
(Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-N,N,2,4-tetramethyl-1H-pyrrole-3-carboxamide
Catalogue No.:PA 19 75720
CAS :
1348032-93-8
Molecular Formula : C18H18FN3O2
Molecular Weight : 327.36


(Z)-N-(2-(diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2-formyl-4-methyl-1H-pyrrole-3-carboxamide
(Z)-N-(2-(diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2-formyl-4-methyl-1H-pyrrole-3-carboxamide
Catalogue No.:PA 19 0751004
CAS :
2377533-92-9
Molecular Formula : C22H25FN4O3
Molecular Weight : 412.47


(Z)-N-(3-(Dimethylamino)propyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
(Z)-N-(3-(Dimethylamino)propyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
Catalogue No.:PA 19 0751017
CAS :
2417674-06-5
Molecular Formula : C21H25FN4O2
Molecular Weight : 384.46


N-Ethyl-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
N-Ethyl-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
Catalogue No.:PA 19 0751018
CAS :
1467015-10-6
Molecular Formula : C18H18FN3O2
Molecular Weight : 327.36


(Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carbonyl Chloride
(Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carbonyl Chloride
Catalogue No.:PAI 19 011011
CAS :
1158560-66-7
Molecular Formula : C16H12ClFN2O2
Molecular Weight : 318.73


(Z)-N-(2-(Diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1-nitroso-1H-pyrrole-3-carboxamide
(Z)-N-(2-(Diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1-nitroso-1H-pyrrole-3-carboxamide
Catalogue No.:PA 19 0751020
CAS :
NA
Molecular Formula : C22H26FN5O3
Molecular Weight : 427.48


5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1h-pyrrole-3-carboxylic acid (BSC)
5-(5-Fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
Catalogue No.:PA BSC 07519410
CAS :
356068-93-4
Molecular Formula : C16H13FN2O3
Molecular Weight : 300.29