tenofovir and its Impurities
Tenofovir disoproxil is used for HIV-1 infection and chronic hepatitis B treatment. It is available as a generic medication. It is sold under the trade name Viread.Reference standards of Tenofovir API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
(((((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(isopropoxy)phosphoryl)oxy)methyl Isopropyl Carbonate
(((((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(isopropoxy)phosphoryl)oxy)methyl Isopropyl Carbonate
Catalogue No.:PA 20 09850
CAS :
NA
Molecular Formula : C17H28N5O7P
Molecular Weight : 445.41
Isopropyl ((R)-((((S)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-D-alaninate
Isopropyl ((R)-((((S)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-D-alaninate
Catalogue No.:PA 20 09870
CAS :
NA
Molecular Formula : C21H29N6O5P
Molecular Weight : 476.47
N-[(R)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester
N-[(R)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester
Catalogue No.:PA 20 09880
CAS :
383365-04-6
Molecular Formula : C21H29N6O5P
Molecular Weight : 476.47
P-((((R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)-N-((S)-1-isopropoxy-1-oxopropan-2-yl)phosphonamidic Acid
P-((((R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)-N-((S)-1-isopropoxy-1-oxopropan-2-yl)phosphonamidic Acid
Catalogue No.:PA 20 09900
CAS :
851456-00-3
Molecular Formula : C15H25N6O5P
Molecular Weight : 400.37
((((((R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(ethoxy)phosphoryl)oxy)methyl Isopropyl Carbonate Fumarate
((((((R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(ethoxy)phosphoryl)oxy)methyl Isopropyl Carbonate Fumarate
Catalogue No.:PA 20 09515
CAS :
NA
Molecular Formula : C20H30N5O11P
Molecular Weight : 547.46
Isopropyl ((S)-((((S)-1-(6-((hydroxymethyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
Isopropyl ((S)-((((S)-1-(6-((hydroxymethyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
Catalogue No.:PA 20 09555
CAS :
NA
Molecular Formula : C22H31N6O6P
Molecular Weight : 506.5
((S)-((((R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alanine
((S)-((((R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alanine
Catalogue No.:PA 20 09565
CAS :
1234081-04-9
Molecular Formula : C18H23N6O5P
Molecular Weight : 434.39
Isopropyl (((((7-((S)-2-((bis(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)methoxy)propyl)-7H-purin-6-yl)amino)methyl)(9-((2R)-2-((hydroxy(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)methoxy)propyl)-9H-purin-6-yl)amino)methyl)(9-((2S)-2-((hydroxy(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)methoxy)propyl)-9H-purin-6-yl)carbamate
Isopropyl (((((7-((S)-2-((bis(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)methoxy)propyl)-7H-purin-6-yl)amino)methyl)(9-((2R)-2-((hydroxy(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)methoxy)propyl)-9H-purin-6-yl)amino)methyl)(9-((2S)-2-((hydroxy(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)methoxy)propyl)-9H-purin-6-yl)carbamate
Catalogue No.:PA 20 09960
CAS :
NA
Molecular Formula : C53H80N15O26P3
Molecular Weight : 1436.22
(((((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(((methoxycarbonyl)oxy)methoxy)phosphoryl)oxy)methyl Isopropyl Carbonate
(((((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(((methoxycarbonyl)oxy)methoxy)phosphoryl)oxy)methyl Isopropyl Carbonate
Catalogue No.:PA 20 09970
CAS :
2251049-93-9
Molecular Formula : C17H26N5O10P
Molecular Weight : 491.39
((Hydroxy((((2R)-1-(6-((hydroxymethyl)amino)-4,5-dihydro-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)oxy)methyl isopropyl Carbonate
((Hydroxy((((2R)-1-(6-((hydroxymethyl)amino)-4,5-dihydro-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)oxy)methyl isopropyl Carbonate
Catalogue No.:PA 20 09980
CAS :
NA
Molecular Formula : C15H26N5O8P
Molecular Weight : 435.37
((((((R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(((methoxycarbonyl)oxy)methoxy)phosphoryl)oxy)methyl Isopropyl Carbonate
((((((R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(((methoxycarbonyl)oxy)methoxy)phosphoryl)oxy)methyl Isopropyl Carbonate
Catalogue No.:PA 20 09575
CAS :
NA
Molecular Formula : C17H26N5O10P
Molecular Weight : 491.39
(((((1-(6-((((9-(2-((bis(((Isopropoxycarbonyl)oxy)methoxy)phosphoryl)methoxy)propyl)-9H-purin-6-yl)amino)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)(hydroxy)phosphoryl)oxy)methyl Isopropyl Carbonate
(((((1-(6-((((9-(2-((bis(((Isopropoxycarbonyl)oxy)methoxy)phosphoryl)methoxy)propyl)-9H-purin-6-yl)amino)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)(hydroxy)phosphoryl)oxy)methyl Isopropyl Carbonate
Catalogue No.:PA 20 09585
CAS :
NA
Molecular Formula : C34H52N10O17P2
Molecular Weight : 934.79
Tetraisopropyl ((((((((methylenebis(azanediyl))bis(9H-purine-6,9-diyl))bis(propane-1,2-diyl))bis(oxy))bis(methylene))bis(oxo-l5-phosphanetriyl))tetrakis(oxy))tetrakis(methylene)) Tetracarbonate
Tetraisopropyl ((((((((methylenebis(azanediyl))bis(9H-purine-6,9-diyl))bis(propane-1,2-diyl))bis(oxy))bis(methylene))bis(oxo-l5-phosphanetriyl))tetrakis(oxy))tetrakis(methylene)) Tetracarbonate
Catalogue No.:PA 20 09595
CAS :
NA
Molecular Formula : C39H60N10O20P2
Molecular Weight : 1050.91
Isopropyl ((S)-((((S)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-D-alaninate
Isopropyl ((S)-((((S)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-D-alaninate
Catalogue No.:PA 20 09625
CAS :
2488598-62-3
Molecular Formula : C21H29N6O5P
Molecular Weight : 476.47
(((((1-(6-((((9-(2-((bis(((Isopropoxycarbonyl)oxy)methoxy)phosphoryl)methoxy)propyl)-9H-purin-6-yl)amino)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)(hydroxy)phosphoryl)oxy)methyl Isopropyl Carbonate
(((((1-(6-((((9-(2-((bis(((Isopropoxycarbonyl)oxy)methoxy)phosphoryl)methoxy)propyl)-9H-purin-6-yl)amino)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)(hydroxy)phosphoryl)oxy)methyl Isopropyl Carbonate
Catalogue No.:PA 20 09635
CAS :
NA
Molecular Formula : C34H52N10O17P2
Molecular Weight : 934.79
(((((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)oxy)methyl Ethyl Carbonate Fumarate
(((((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)oxy)methyl Ethyl Carbonate Fumarate
Catalogue No.:PA 20 09645
CAS :
NA
Molecular Formula : C22H32N5O14P
Molecular Weight : 621.49
(((((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(((methoxycarbonyl)oxy)methoxy)phosphoryl)oxy)methyl Isopropyl Carbonate Fumarate
(((((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(((methoxycarbonyl)oxy)methoxy)phosphoryl)oxy)methyl Isopropyl Carbonate Fumarate
Catalogue No.:PA 20 09665
CAS :
2251049-94-0
Molecular Formula : C21H30N5O14P
Molecular Weight : 607.47
Isopropyl (9-(2-((bis(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)methoxy)propyl)-9H-purin-6-yl)carbamate
Isopropyl (9-(2-((bis(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)methoxy)propyl)-9H-purin-6-yl)carbamate
Catalogue No.:PA 20 09675
CAS :
2190481-17-3
Molecular Formula : C23H36N5O12P
Molecular Weight : 605.54
P-(((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)-N-(1-isopropoxy-1-oxopropan-2-yl)phosphonamidic Acid
P-(((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)-N-(1-isopropoxy-1-oxopropan-2-yl)phosphonamidic Acid
Catalogue No.:PA 20 09685
CAS :
NA
Molecular Formula : C15H25N6O5P
Molecular Weight : 400.38
(((((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(((propoxycarbonyl)oxy)methoxy)phosphoryl)oxy)methyl Isopropyl Carbonate Fumarate
(((((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(((propoxycarbonyl)oxy)methoxy)phosphoryl)oxy)methyl Isopropyl Carbonate Fumarate
Catalogue No.:PA 20 0091000
CAS :
NA
Molecular Formula : C23H34N5O14P
Molecular Weight : 635.52
((Hydroxy(((1-(6-((((9-((2R)-2-((hydroxy(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)methoxy)propyl)-9H-purin-6-yl)amino)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)oxy)methyl Isopropyl Carbonate
((Hydroxy(((1-(6-((((9-((2R)-2-((hydroxy(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)methoxy)propyl)-9H-purin-6-yl)amino)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)oxy)methyl Isopropyl Carbonate
Catalogue No.:PA 20 0091002
CAS :
NA
Molecular Formula : C29H44N10O14P2
Molecular Weight : 818.67
P-[[(1S)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]-phosphonic Acid Monoethyl Ester
P-[[(1S)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]-phosphonic Acid Monoethyl Ester
Catalogue No.:PA 20 0091003
CAS :
1255525-18-8
Molecular Formula : C11H18N5O4P
Molecular Weight : 315.27
Isopropyl ((S)-((((S)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
Isopropyl ((S)-((((S)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
Catalogue No.:PA 20 0091004
CAS :
NA
Molecular Formula : C21H29N6O5P
Molecular Weight : 476.47
Isopropyl ((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-D-alaninate
Isopropyl ((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-D-alaninate
Catalogue No.:PA 20 0091005
CAS :
2053424-82-9
Molecular Formula : C21H29N6O5P
Molecular Weight : 476.47
(((((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(methoxy)phosphoryl)oxy)methyl isopropyl Carbonate
(((((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(methoxy)phosphoryl)oxy)methyl isopropyl Carbonate
Catalogue No.:PA 20 0091007
CAS :
NA
Molecular Formula : C15H24N5O7P
Molecular Weight : 417.36
