Tezacaftor and its Impurities

Tezacaftor is used to treat cystic fibrosis in certain people. It is a drug that is sold as a fixed-dose combination with ivacaftor as Symdeko.Reference standards of Tezacaftor API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

Displaying 21 results for Tezacaftor Impurities
Drug Reference Standards & Impurity Synthesis in India
PA 47 98000

Tezacaftor

Tezacaftor

  • Catalogue No.:PA 47 98000

  • CAS :

    1152311-62-0

  • Molecular Formula : C26H27F3N2O6

  • Molecular Weight : 520.51

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Drug Reference Standards & Impurity Synthesis in India
PA 47 0981000

1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(8-fluoro-2-hydroxy-4-(hydroxymethyl)-1,1-dimethyl-1,2,4,5-tetrahydro-[1,4]oxazepino[4,5-a]indol-9-yl)cyclopropane-1-carboxamide

1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(8-fluoro-2-hydroxy-4-(hydroxymethyl)-1,1-dimethyl-1,2,4,5-tetrahydro-[1,4]oxazepino[4,5-a]indol-9-yl)cyclopropane-1-carboxamide

  • Catalogue No.:PA 47 0981000

  • CAS :

    1432657-04-9

  • Molecular Formula : C26H25F3N2O6

  • Molecular Weight : 518.49

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Drug Reference Standards & Impurity Synthesis in India
PA 47 0981001

(R)-1-(5-Amino-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-1-yl)-3-(benzyloxy)propan-2-ol

(R)-1-(5-Amino-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-1-yl)-3-(benzyloxy)propan-2-ol

  • Catalogue No.:PA 47 0981001

  • CAS :

    1294504-67-8

  • Molecular Formula : C29H33FN2O3

  • Molecular Weight : 476.59

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Drug Reference Standards & Impurity Synthesis in India
PA 47 0981002

(R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane-1-carboxamide

(R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane-1-carboxamide

  • Catalogue No.:PA 47 0981002

  • CAS :

    1152311-90-4

  • Molecular Formula : C29H31F3N2O6

  • Molecular Weight : 560.57

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Drug Reference Standards & Impurity Synthesis in India
PA 47 0981003

Tezacaftor Metabolite

Tezacaftor Metabolite

  • Catalogue No.:PA 47 0981003

  • CAS :

    1432656-97-7

  • Molecular Formula : C26H25F3N2O6

  • Molecular Weight : 518.49

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Drug Reference Standards & Impurity Synthesis in India
PAI 47 098001

(R)-1-(Benzyloxy)-3-((2-bromo-5-fluoro-4-nitrophenyl)amino)propan-2-ol

(R)-1-(Benzyloxy)-3-((2-bromo-5-fluoro-4-nitrophenyl)amino)propan-2-ol

  • Catalogue No.:PAI 47 098001

  • CAS :

    1342896-73-4

  • Molecular Formula : C16H16BrFN2O4

  • Molecular Weight : 399.22

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Drug Reference Standards & Impurity Synthesis in India
PAI 47 098002

(R)-1-((4-Amino-2-bromo-5-fluorophenyl)amino)-3-(benzyloxy)propan-2-ol

(R)-1-((4-Amino-2-bromo-5-fluorophenyl)amino)-3-(benzyloxy)propan-2-ol

  • Catalogue No.:PAI 47 098002

  • CAS :

    1294504-63-4

  • Molecular Formula : C16H18BrFN2O2

  • Molecular Weight : 369.23

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Drug Reference Standards & Impurity Synthesis in India
PAI 47 098003

(R)-1-((4-Amino-2-(4-(benzyloxy)-3,3-dimethylbut-1-yn-1-yl)-5-fluorophenyl)amino)-3-(benzyloxy)propan-2-ol

(R)-1-((4-Amino-2-(4-(benzyloxy)-3,3-dimethylbut-1-yn-1-yl)-5-fluorophenyl)amino)-3-(benzyloxy)propan-2-ol

  • Catalogue No.:PAI 47 098003

  • CAS :

    1294504-66-7

  • Molecular Formula : C29H33FN2O3

  • Molecular Weight : 476.59

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Drug Reference Standards & Impurity Synthesis in India
PAI 47 098004

(R)-N-(1-(3-(Benzyloxy)-2-hydroxypropyl)-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-5-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamide

(R)-N-(1-(3-(Benzyloxy)-2-hydroxypropyl)-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-5-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamide

  • Catalogue No.:PAI 47 098004

  • CAS :

    1294504-68-9

  • Molecular Formula : C40H39F3N2O6

  • Molecular Weight : 700.76

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Drug Reference Standards & Impurity Synthesis in India
PA STI 089673

Tezacaftor D4

Tezacaftor D4

  • Catalogue No.:PA STI 089673

  • CAS :

    1961280-24-9

  • Molecular Formula : C26H23D4F3N2O6

  • Molecular Weight : 524.53

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Drug Reference Standards & Impurity Synthesis in India
PA 47 0981004

Tezacaftor Enantiomer

Tezacaftor Enantiomer

  • Catalogue No.:PA 47 0981004

  • CAS :

    1152311-99-3

  • Molecular Formula : C26H27F3N2O6

  • Molecular Weight : 520.51

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Drug Reference Standards & Impurity Synthesis in India
PA 47 0981005

R,R Dihydro Tezacaftor

R,R Dihydro Tezacaftor

  • Catalogue No.:PA 47 0981005

  • CAS :

    NA

  • Molecular Formula : C26H29F3N2O6

  • Molecular Weight : 522.52

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Drug Reference Standards & Impurity Synthesis in India
PA 47 0981006

R,S Dihydro Tezacaftor

R,S Dihydro Tezacaftor

  • Catalogue No.:PA 47 0981006

  • CAS :

    NA

  • Molecular Formula : C26H29F3N2O6

  • Molecular Weight : 522.52

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Drug Reference Standards & Impurity Synthesis in India
PA 47 0981007

Acetonide O-Benzyl Tezacaftor

Acetonide O-Benzyl Tezacaftor

  • Catalogue No.:PA 47 0981007

  • CAS :

    NA

  • Molecular Formula : C36H37F3N2O6

  • Molecular Weight : 650.7

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Drug Reference Standards & Impurity Synthesis in India
PA 47 0981008

O-Benzyl Tezacaftor

O-Benzyl Tezacaftor

  • Catalogue No.:PA 47 0981008

  • CAS :

    NA

  • Molecular Formula : C33H33F3N2O6

  • Molecular Weight : 610.63

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Drug Reference Standards & Impurity Synthesis in India
PA 47 0981009

1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane-1-carboxamide

1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane-1-carboxamide

  • Catalogue No.:PA 47 0981009

  • CAS :

    1152311-65-3

  • Molecular Formula : C23H21F3N2O4

  • Molecular Weight : 446.43

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Drug Reference Standards & Impurity Synthesis in India
PA 47 0981011

(S)-1-(5-amino-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-1-yl)-3-(benzyloxy)propan-2-ol

(S)-1-(5-amino-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-1-yl)-3-(benzyloxy)propan-2-ol

  • Catalogue No.:PA 47 0981011

  • CAS :

    NA

  • Molecular Formula : C29H33FN2O3

  • Molecular Weight : 476.59

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Drug Reference Standards & Impurity Synthesis in India
PA 47 0981010

(R)-N-(1-(3-(Benzyloxy)-2-hydroxypropyl)-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-5-yl)acetamide

(R)-N-(1-(3-(Benzyloxy)-2-hydroxypropyl)-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-5-yl)acetamide

  • Catalogue No.:PA 47 0981010

  • CAS :

    NA

  • Molecular Formula : C31H35FN2O4

  • Molecular Weight : 518.63

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Drug Reference Standards & Impurity Synthesis in India
PA 47 0981012

(R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-4-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane-1-carboxamide

(R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-4-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane-1-carboxamide

  • Catalogue No.:PA 47 0981012

  • CAS :

    NA

  • Molecular Formula : C26H27F3N2O6

  • Molecular Weight : 520.51

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Drug Reference Standards & Impurity Synthesis in India
PA 47 0981013

1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(6-(2,3-dihydroxypropoxy)-1-(2,3-dihydroxypropyl)-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane-1-carboxamide

1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(6-(2,3-dihydroxypropoxy)-1-(2,3-dihydroxypropyl)-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane-1-carboxamide

  • Catalogue No.:PA 47 0981013

  • CAS :

    NA

  • Molecular Formula : C29H34F2N2O9

  • Molecular Weight : 592.59

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Drug Reference Standards & Impurity Synthesis in India
PA 47 0981014

3-(5-(1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-1-yl)-2-hydroxypropyl acetate

3-(5-(1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-1-yl)-2-hydroxypropyl acetate

  • Catalogue No.:PA 47 0981014

  • CAS :

    NA

  • Molecular Formula : C28H29F3N2O7

  • Molecular Weight : 562.54

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