tofacitinib and its Impurities
Tofacitinib is used to treat psoriatic arthritis and moderate-to-severe forms of rheumatoid arthritis. It is sold under the brand Xeljanz. Reference standards of Tofacitinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
 
	
			                                   
																				3-((3R,4R)-3-((6-Aminopyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile
3-((3R,4R)-3-((6-Aminopyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile
- Catalogue No.:PA 73 0061001 
- CAS : - 1640971-60-3
- Molecular Formula : C14H20N6O 
- Molecular Weight : 288.36 
 
	
			                                  ![N-Methyl-N-[(3R,4R)-4-methyl-3-piperidinyl]-7H-Pyr PA 73 0061002](https://www.pharmaffiliates.com/pimages/PA730061002.jpg) 
																				N-Methyl-N-[(3R,4R)-4-methyl-3-piperidinyl]-7H-Pyrrolo[2,3-d]pyrimidin-4-amine Hydrochloride
N-Methyl-N-[(3R,4R)-4-methyl-3-piperidinyl]-7H-Pyrrolo[2,3-d]pyrimidin-4-amine Hydrochloride
- Catalogue No.:PA 73 0061002 
- CAS : - 1260590-51-9
- Molecular Formula : C13H20ClN5 
- Molecular Weight : 281.79 
 
	
			                                  ![(3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimi PA 73 0061004](https://www.pharmaffiliates.com/pimages/PA730061004.jpg) 
																				(3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carbaldehyde
(3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carbaldehyde
- Catalogue No.:PA 73 0061004 
- CAS : - 2227199-28-0
- Molecular Formula : C14H19N5O 
- Molecular Weight : 273.34 
 
	
			                                  ![3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4 PA 73 0061005](https://www.pharmaffiliates.com/pimages/PA730061005.jpg) 
																				3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-3,6-dihydropyridin-1(2H)-yl)-3-oxopropanenitrile
3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-3,6-dihydropyridin-1(2H)-yl)-3-oxopropanenitrile
- Catalogue No.:PA 73 0061005 
- CAS : - 2504210-31-3
- Molecular Formula : C16H18N6O 
- Molecular Weight : 310.36 
 
	
			                                   
																				N1-methyl-N1-((3R,4R)-4-methyl-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)malonamide
N1-methyl-N1-((3R,4R)-4-methyl-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)malonamide
- Catalogue No.:PA 73 0061009 
- CAS : - 2504210-30-2
- Molecular Formula : C16H22N6O2 
- Molecular Weight : 330.39 
 
	
			                                   
																				2-cyano-N-methyl-N-((3R,4R)-4-methyl-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)acetamide
2-cyano-N-methyl-N-((3R,4R)-4-methyl-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)acetamide
- Catalogue No.:PA 73 0061010 
- CAS : - 1092578-43-2
- Molecular Formula : C16H20N6O 
- Molecular Weight : 312.38 
 
	
			                                   
																				1,3-bis((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)propane-1,3-dione
1,3-bis((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)propane-1,3-dione
- Catalogue No.:PA 73 0061012 
- CAS : - 2504210-41-5
- Molecular Formula : C29H38N10O2 
- Molecular Weight : 558.69 
 
	
			                                   
																				N2,N4-bis((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N2,N4-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
N2,N4-bis((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N2,N4-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
- Catalogue No.:PA 73 0061013 
- CAS : - 2459302-78-2
- Molecular Formula : C34H45N7 
- Molecular Weight : 551.78 
 
	
			                                   
																				N-((3S,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
N-((3S,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- Catalogue No.:PA 73 0061018 
- CAS : - 2056104-91-5
- Molecular Formula : C27H31N5O2S 
- Molecular Weight : 489.64 
 
	
			                                   
																				N-((3R,4S)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
N-((3R,4S)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- Catalogue No.:PA 73 0061019 
- CAS : - 1092578-44-3
- Molecular Formula : C27H31N5O2S 
- Molecular Weight : 489.22 
 
	
			                                   
																				3-((3R,4R)-4-methyl-3-(methyl(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
3-((3R,4R)-4-methyl-3-(methyl(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
- Catalogue No.:PA 73 0061020 
- CAS : - 2259288-22-5
- Molecular Formula : C23H26N6O3S 
- Molecular Weight : 466.56 
 
	
			                                   
																				3-(4-(((3R,4R)-1-(2-cyanoacetyl)-4-methylpiperidin-3-yl)(methyl)amino)-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-oxopropanenitrile
3-(4-(((3R,4R)-1-(2-cyanoacetyl)-4-methylpiperidin-3-yl)(methyl)amino)-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-oxopropanenitrile
- Catalogue No.:PA 73 0061021 
- CAS : - 2459302-82-8
- Molecular Formula : C19H23N7O2 
- Molecular Weight : 381.44 
 
	
			                                   
																				N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7-(p-tolylsulfinyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7-(p-tolylsulfinyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- Catalogue No.:PA 73 0061022 
- CAS : - 2504210-33-5
- Molecular Formula : C27H31N5OS 
- Molecular Weight : 473.64 
 
	
			                                   
																				3-((3R,4R)-4-methyl-3-(methyl(6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
3-((3R,4R)-4-methyl-3-(methyl(6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
- Catalogue No.:PA 73 0061025 
- CAS : - 1640971-51-2
- Molecular Formula : C16H20N6O2 
- Molecular Weight : 328.38 
 
	
			                                  ![3-((3R,4R)-3-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)ami PA 73 0061016](https://www.pharmaffiliates.com/pimages/PA730061016.jpg) 
																				3-((3R,4R)-3-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile
3-((3R,4R)-3-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile
- Catalogue No.:PA 73 0061016 
- CAS : - 1527525-58-1
- Molecular Formula : C15H18N6O 
- Molecular Weight : 298.35 
 
	
			                                   
																				(Z)-2-((3R,4R)-3-((1H-indol-4-yl)(methyl)amino)-4-methylpiperidine-1-carbonyl)-3-amino-5-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-5-oxopent-2-enenitrile
(Z)-2-((3R,4R)-3-((1H-indol-4-yl)(methyl)amino)-4-methylpiperidine-1-carbonyl)-3-amino-5-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-5-oxopent-2-enenitrile
- Catalogue No.:PA 73 0061015 
- CAS : - 2382711-65-9
- Molecular Formula : C34H42N10O2 
- Molecular Weight : 622.78 
 
	
			                                   
																				3-Imino-5-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-2-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carbonyl)-5-oxopentanenitrile
3-Imino-5-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-2-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carbonyl)-5-oxopentanenitrile
- Catalogue No.:PA 73 0061028 
- CAS : - 2102040-00-4
- Molecular Formula : C32H40N12O2 
- Molecular Weight : 624.75 
 
	
			                                  ![3-((3R,4S)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr PA 73 0061030](https://www.pharmaffiliates.com/pimages/PA730061030.jpg) 
																				3-((3R,4S)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylate
3-((3R,4S)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylate
- Catalogue No.:PA 73 0061030 
- CAS : - 2174011-53-9
- Molecular Formula : C22H28N6O8 
- Molecular Weight : 504.5 
 
	
			                                   
																				3-((3R,4R)-4-Methyl-3-(methyl(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
3-((3R,4R)-4-Methyl-3-(methyl(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
- Catalogue No.:PA 73 0061032 
- CAS : - NA
- Molecular Formula : C16H19N7O2 
- Molecular Weight : 341.38 
 
	
			                                   
																				1-((4R)-4-Methyl-3-(methyl(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)propan-1-one
1-((4R)-4-Methyl-3-(methyl(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)propan-1-one
- Catalogue No.:PA 73 0061037 
- CAS : - NA
- Molecular Formula : C16H22N6O2 
- Molecular Weight : 330.39 
 
	
			                                   
																				N-((3R,4R)-1-(2-Cyanoacetyl)-4-methylpiperidin-3-yl)-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)nitrous Amide
N-((3R,4R)-1-(2-Cyanoacetyl)-4-methylpiperidin-3-yl)-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)nitrous Amide
- Catalogue No.:PA 73 0061039 
- CAS : - NA
- Molecular Formula : C15H17N7O2 
- Molecular Weight : 327.35 
 
	
			                                  ![3-((3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr PA STI 089598](https://www.pharmaffiliates.com/pimages/PASTI089598.jpg) 
																				3-((3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile-1,2,3-13C3-15N
3-((3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile-1,2,3-13C3-15N
- Catalogue No.:PA STI 089598 
- CAS : - 2256762-71-5
- Molecular Formula : C1313C3H20N515NO 
- Molecular Weight : 316.35 
 
	
			                                   
																				3-(4-Methyl-3-(methyl(6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
3-(4-Methyl-3-(methyl(6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
- Catalogue No.:PA 73 0061042 
- CAS : - 1269823-96-2
- Molecular Formula : C16H20N6O2 
- Molecular Weight : 328.38 
 
	
			                                   
																				3-((3R,4R)-4-Methyl-3-(methyl(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
3-((3R,4R)-4-Methyl-3-(methyl(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
- Catalogue No.:PA 73 0061043 
- CAS : - NA
- Molecular Formula : C17H22N6O 
- Molecular Weight : 326.40 
 
	
			                                   
																				Ethyl (E)-3-amino-2-cyano-5-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-5-oxopent-2-enoate
Ethyl (E)-3-amino-2-cyano-5-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-5-oxopent-2-enoate
- Catalogue No.:PA 73 0061044 
- CAS : - 2459302-85-1
- Molecular Formula : C21H27N7O3 
- Molecular Weight : 425.49 
 
	
			                                   
																				Butyl 3-amino-2-cyano-5-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-5-oxopent-2-enoate
Butyl 3-amino-2-cyano-5-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-5-oxopent-2-enoate
- Catalogue No.:PA 73 0061048 
- CAS : - 2716897-36-6
- Molecular Formula : C23H31N7O3 
- Molecular Weight : 453.55 
 
	
			                                   
																				N-Methyl-N-((3R,4R)-4-methyl-1-nitrosopiperidin-3-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-amine
N-Methyl-N-((3R,4R)-4-methyl-1-nitrosopiperidin-3-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-amine
- Catalogue No.:PA 73 0061058 
- CAS : - NA
- Molecular Formula : C13H20N6O 
- Molecular Weight : 276.34 
 
	
			                                   
																				N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7-nitroso-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-amine
N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7-nitroso-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-amine
- Catalogue No.:PA 73 0061059 
- CAS : - NA
- Molecular Formula : C13H20N6O 
- Molecular Weight : 276.34 
 
	
			                                   
																				N-Methyl-N-((3R,4R)-4-methyl-1-nitrosopiperidin-3-yl)-7-nitroso-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-amine
N-Methyl-N-((3R,4R)-4-methyl-1-nitrosopiperidin-3-yl)-7-nitroso-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-amine
- Catalogue No.:PA 73 0061060 
- CAS : - NA
- Molecular Formula : C13H19N7O2 
- Molecular Weight : 305.34 
 
	
			                                  ![3-((3S,4S)-3-((2-Chloro-7H-pyrrolo[2,3-d]pyrimidin PA 73 0061057](https://www.pharmaffiliates.com/pimages/PA730061057.jpg) 
																				3-((3S,4S)-3-((2-Chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile
3-((3S,4S)-3-((2-Chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile
- Catalogue No.:PA 73 0061057 
- CAS : - NA
- Molecular Formula : C16H19ClN6O 
- Molecular Weight : 346.82 
 
	
			                                   
																				N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-amine Dihydrochloride
N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-amine Dihydrochloride
- Catalogue No.:PA 73 0061062 
- CAS : - 2640342-78-3
- Molecular Formula : C13H23Cl2N5 
- Molecular Weight : 320.26 

 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				![(3R,4R)-1-(2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-y PA 73 0061007](https://www.pharmaffiliates.com/pimages/PA730061007.jpg) 
																				![(3R,4R)-N,4-dimethyl-1-(7H-pyrrolo[2,3-d]pyrimidin PA 73 0061008](https://www.pharmaffiliates.com/pimages/PA730061008.jpg) 
																				 
																				 
																				 
																				 
																				 
																				![1-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4 PA 73 0061026](https://www.pharmaffiliates.com/pimages/PA730061026.jpg) 
																				![4-chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine PA 73 0061027](https://www.pharmaffiliates.com/pimages/PA730061027.jpg) 
																				 
																				 
																				 
																				![5H,6H,7H-Pyrrolo[2,3-d]pyrimidin-6-one PA 73 0061035](https://www.pharmaffiliates.com/pimages/PA730061035.jpg) 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
 
 
 
