travoprost and its Impurities
Travoprost is used to treat high pressure inside the eye including glaucoma, which is sold under the brand name Travatan. It is available as a generic medication in the United Kingdom.Reference standards of Travoprost API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


Propan -2-yl 7-[3,5-dihydroxy-2-[3- hydroxy-4-[3-(trifluoromethyl)phenoxy]-but-1-enyl]-cyclopentyl]hept-5-enoate
Propan -2-yl 7-[3,5-dihydroxy-2-[3- hydroxy-4-[3-(trifluoromethyl)phenoxy]-but-1-enyl]-cyclopentyl]hept-5-enoate
Catalogue No.:PA 47 05560
CAS :
1942815-92-0
Molecular Formula : C26H35F3O6
Molecular Weight : 500.55


(3aR,4R,5R,6aS)-4-((S,E)-3-((tert-Butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2,5-diol
(3aR,4R,5R,6aS)-4-((S,E)-3-((tert-Butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2,5-diol
Catalogue No.:PA 47 05580
CAS :
NA
Molecular Formula : C24H35F3O5Si
Molecular Weight : 488.62


Isopropyl (E)-7-((1S,2R,3S,5R)-3,5-dihydroxy-2-((S,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate
Isopropyl (E)-7-((1S,2R,3S,5R)-3,5-dihydroxy-2-((S,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate
Catalogue No.:PA 47 05590
CAS :
NA
Molecular Formula : C26H35F3O6
Molecular Weight : 500.56


(3aR,4S,5R,6aS)-5-((tert-Butyldimethylsilyl)oxy)-4-((R,E)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one
(3aR,4S,5R,6aS)-5-((tert-Butyldimethylsilyl)oxy)-4-((R,E)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one
Catalogue No.:PA 47 05600
CAS :
NA
Molecular Formula : C30H47F3O5Si2
Molecular Weight : 600.87


(3aR,4R,5S,6aS)-5-((tert-Butyldimethylsilyl)oxy)-4-((R,E)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one
(3aR,4R,5S,6aS)-5-((tert-Butyldimethylsilyl)oxy)-4-((R,E)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one
Catalogue No.:PA 47 05610
CAS :
NA
Molecular Formula : C30H47F3O5Si2
Molecular Weight : 600.87


(3aR,4S,5S,6aS)-5-((tert-Butyldimethylsilyl)oxy)-4-((R,E)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one
(3aR,4S,5S,6aS)-5-((tert-Butyldimethylsilyl)oxy)-4-((R,E)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one
Catalogue No.:PA 47 05620
CAS :
NA
Molecular Formula : C30H47F3O5Si2
Molecular Weight : 600.87


(3aR,4R,5R,6aS)-5-((tert-Butyldimethylsilyl)oxy)-4-((S,E)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one
(3aR,4R,5R,6aS)-5-((tert-Butyldimethylsilyl)oxy)-4-((S,E)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one
Catalogue No.:PA 47 05630
CAS :
NA
Molecular Formula : C30H47F3O5Si2
Molecular Weight : 600.87


(3aR,4R,5R,6aS)-5-((tert-Butyldimethylsilyl)oxy)-4-((R,Z)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one
(3aR,4R,5R,6aS)-5-((tert-Butyldimethylsilyl)oxy)-4-((R,Z)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one
Catalogue No.:PA 47 05640
CAS :
NA
Molecular Formula : C30H47F3O5Si2
Molecular Weight : 600.87


(3aR,4R,5R,6aS)-4-((R,E)-3-((tert-Butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate
(3aR,4R,5R,6aS)-4-((R,E)-3-((tert-Butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate
Catalogue No.:PA 47 05650
CAS :
NA
Molecular Formula : C37H41F3O6Si
Molecular Weight : 666.81


(3aS,4S,5S,6aR)-5-((tert-Butyldimethylsilyl)oxy)-4-((R,E)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one
(3aS,4S,5S,6aR)-5-((tert-Butyldimethylsilyl)oxy)-4-((R,E)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one
Catalogue No.:PA 47 05660
CAS :
NA
Molecular Formula : C30H47F3O5Si2
Molecular Weight : 600.87


(3aS,4S,5S,6aR)-5-((tert-Butyldimethylsilyl)oxy)-4-((S,E)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one
(3aS,4S,5S,6aR)-5-((tert-Butyldimethylsilyl)oxy)-4-((S,E)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one
Catalogue No.:PA 47 05670
CAS :
NA
Molecular Formula : C30H47F3O5Si2
Molecular Weight : 600.87


(3aR,4R,5R,6aS)-5-((tert-Butyldimethylsilyl)oxy)-4-((S,Z)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one
(3aR,4R,5R,6aS)-5-((tert-Butyldimethylsilyl)oxy)-4-((S,Z)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one
Catalogue No.:PA 47 05680
CAS :
NA
Molecular Formula : C30H47F3O5Si2
Molecular Weight : 600.87


(3aR,4R,5R,6aS)-5-((tert-Butyldimethylsilyl)oxy)-4-((R)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)butyl)hexahydro-2H-cyclopenta[b]furan-2-one
(3aR,4R,5R,6aS)-5-((tert-Butyldimethylsilyl)oxy)-4-((R)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)butyl)hexahydro-2H-cyclopenta[b]furan-2-one
Catalogue No.:PA 47 05690
CAS :
2323568-10-9
Molecular Formula : C30H49F3O5Si2
Molecular Weight : 602.88


(3aR,4R,5R,6aS)-2-Oxo-4-((E)-3-oxo-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate
(3aR,4R,5R,6aS)-2-Oxo-4-((E)-3-oxo-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate
Catalogue No.:PA 47 05700
CAS :
54142-64-2
Molecular Formula : C31H25F3O6
Molecular Weight : 550.53


(3aR,4R,5R,6aS)-4-((R,E)-3-Hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate
(3aR,4R,5R,6aS)-4-((R,E)-3-Hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate
Catalogue No.:PA 47 05710
CAS :
114488-91-4
Molecular Formula : C31H27F3O6
Molecular Weight : 552.55


(3aR,4R,5R,6aS)-4-((R,E)-3-Hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2,5-diol
(3aR,4R,5R,6aS)-4-((R,E)-3-Hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2,5-diol
Catalogue No.:PA 47 05720
CAS :
1204185-88-5
Molecular Formula : C18H21F3O5
Molecular Weight : 374.36


(3aR,​4R,​5R,​6aS)​-Hexahydro-​5-​hydroxy-​4-​[(1E,​3R)​-​3-​hydroxy-​4-​[3-​(trifluoromethyl)​phenoxy]​-​1-​buten-​1-​yl]​-​2H-​cyclopenta[b]​furan-​2-​one
(3aR,​4R,​5R,​6aS)​-Hexahydro-​5-​hydroxy-​4-​[(1E,​3R)​-​3-​hydroxy-​4-​[3-​(trifluoromethyl)​phenoxy]​-​1-​buten-​1-​yl]​-​2H-​cyclopenta[b]​furan-​2-​one
Catalogue No.:PA 47 05730
CAS :
53872-60-9
Molecular Formula : C18H19F3O5
Molecular Weight : 372.34


Isopropyl (Z)-7-((1R,2R,3R,5S)-5-hydroxy-3-((tetrahydro-2H-pyran-2-yl)oxy)-2-((3R,E)-3-((tetrahydro-2H-pyran-2-yl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate
Isopropyl (Z)-7-((1R,2R,3R,5S)-5-hydroxy-3-((tetrahydro-2H-pyran-2-yl)oxy)-2-((3R,E)-3-((tetrahydro-2H-pyran-2-yl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate
Catalogue No.:PA 47 0051006
CAS :
1373876-51-7
Molecular Formula : C36H51F3O8
Molecular Weight : 668.79


Isopropyl (Z)-7-((1R,2R,3R,5S)-5-hydroxy-2-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)hept-5-enoate
Isopropyl (Z)-7-((1R,2R,3R,5S)-5-hydroxy-2-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)hept-5-enoate
Catalogue No.:PA 47 0051007
CAS :
NA
Molecular Formula : C31H43F3O7
Molecular Weight : 584.67


Isopropyl (Z)-7-((1R,2R,3R,5S)-3-hydroxy-2-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)-5-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)hept-5-enoate
Isopropyl (Z)-7-((1R,2R,3R,5S)-3-hydroxy-2-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)-5-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)hept-5-enoate
Catalogue No.:PA 47 0051008
CAS :
NA
Molecular Formula : C31H43F3O7
Molecular Weight : 584.67


Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R,E)-3-((tetrahydro-2H-pyran-2-yl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate
Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R,E)-3-((tetrahydro-2H-pyran-2-yl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate
Catalogue No.:PA 47 0051009
CAS :
NA
Molecular Formula : C31H43F3O7
Molecular Weight : 584.67


Isopropyl (Z)-7-((1R,2R,3R,5S)-5-((diphenylphosphoryl)oxy)-3-hydroxy-2-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate
Isopropyl (Z)-7-((1R,2R,3R,5S)-5-((diphenylphosphoryl)oxy)-3-hydroxy-2-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate
Catalogue No.:PA 47 0051010
CAS :
NA
Molecular Formula : C38H44F3O7P
Molecular Weight : 700.73


(3aR,4R,5R,6aS)-4-((R,E)-3-Hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)-5-((triethylsilyl)oxy)hexahydro-2H-cyclopenta[b]furan-2-one
(3aR,4R,5R,6aS)-4-((R,E)-3-Hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)-5-((triethylsilyl)oxy)hexahydro-2H-cyclopenta[b]furan-2-one
Catalogue No.:PA 47 0051011
CAS :
1642863-99-7
Molecular Formula : C24H33F3O5Si
Molecular Weight : 486.6