Tucatinib and its Impurities
Tucatinib, sold under the brand name Tukysa, is a small molecule inhibitor of HER2 for the treatment of HER2-positive breast cancer. Reference standards of Tucatinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
1-(4-((4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)-3-(1-hydroxy-2-methylpropan-2-yl)thiourea
1-(4-((4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)-3-(1-hydroxy-2-methylpropan-2-yl)thiourea
Catalogue No.:PA 20 3361001
CAS :
1429755-58-7
Molecular Formula : C26H26N8O2S
Molecular Weight : 514.61
1-(4-((4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)-4,4-dimethylimidazolidine-2-thione
1-(4-((4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)-4,4-dimethylimidazolidine-2-thione
Catalogue No.:PA 20 3361002
CAS :
2954734-92-8
Molecular Formula : C26H24N8OS
Molecular Weight : 496.59
N4-(4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrothiazol-2-yl)quinazoline-4,6-diamine
N4-(4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrothiazol-2-yl)quinazoline-4,6-diamine
Catalogue No.:PA 20 3361003
CAS :
937266-01-8
Molecular Formula : C26H24N8OS
Molecular Weight : 496.59
2-Amino-2-methylpropyl (4-((4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)carbamate
2-Amino-2-methylpropyl (4-((4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)carbamate
Catalogue No.:PA 20 3361006
CAS :
NA
Molecular Formula : C26H26N8O3
Molecular Weight : 498.55
