voclosporin and its Impurities
Voclosporin is more potent and less toxic than currently available treatments within the drug class of calcineurin inhibitors. Voclosporin is a novel cyclosporine analog and immunosuppressive compound currently being investigated for the treatment of psoriasis and for the prevention of organ rejection in kidney transplant patients. Reference standards of Voclosporin API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
 
	
			                                   
																				Cyclosporin A, 6-[(2S,3R,4R,6E)-3-(acetyloxy)-4-methyl-2-(methylamino)-6,8-nonadienoic Acid]
Cyclosporin A, 6-[(2S,3R,4R,6E)-3-(acetyloxy)-4-methyl-2-(methylamino)-6,8-nonadienoic Acid]
- Catalogue No.:PA 22 0901001 
- CAS : - 515814-02-5
- Molecular Formula : C65H113N11O13 
- Molecular Weight : 1256.68 
 
	
			                                   
																				(3S,6S,9S,12S,15S,18R,21S,24S,27S,30S)-3-Ethyl-6-((1R,2R,E)-1-hydroxy-2-methylhepta-4,6-dien-1-yl)-12,15,24,30-tetraisobutyl-9,27-diisopropyl-1,7,10,13,16,18,21,25,31-nonamethyl-4-nitroso-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
(3S,6S,9S,12S,15S,18R,21S,24S,27S,30S)-3-Ethyl-6-((1R,2R,E)-1-hydroxy-2-methylhepta-4,6-dien-1-yl)-12,15,24,30-tetraisobutyl-9,27-diisopropyl-1,7,10,13,16,18,21,25,31-nonamethyl-4-nitroso-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
- Catalogue No.:PA PEP 001187 
- CAS : - NA
- Molecular Formula : C63H110N12O13 
- Molecular Weight : 1243.64 
 
	
			                                   
																				(3R,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhepta-4,6-dien-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
(3R,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhepta-4,6-dien-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
- Catalogue No.:PA PEP 003544 
- CAS : - NA
- Molecular Formula : C63H111N11O12 
- Molecular Weight : 1214.65 
 
	
			                                   
																				(3S,6S,9S,12R,15S,21S,24S,30S,33S)-30-Ethyl-33-((2R,E)-1-hydroxy-2-methylhepta-4,6-dien-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
(3S,6S,9S,12R,15S,21S,24S,30S,33S)-30-Ethyl-33-((2R,E)-1-hydroxy-2-methylhepta-4,6-dien-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
- Catalogue No.:PA PEP 003920 
- CAS : - NA
- Molecular Formula : C63H111N11O12 
- Molecular Weight : 1214.65 
 
	
			                                   
																				(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,4E,6Z)-1-hydroxy-2-methylocta-4,6-dien-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,4E,6Z)-1-hydroxy-2-methylocta-4,6-dien-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
- Catalogue No.:PA PEP 003921 
- CAS : - NA
- Molecular Formula : C64H113N11O12 
- Molecular Weight : 1228.67 
 
	
			                                   
																				(1R,2R,4E,6E,10E)-1-((2S,5S,11S,14S,17S,20S,23R,26S,29S)-5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopropyl-1,7,10,16,20,23,25,28,31-nonamethyl-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl)-2-methyltrideca-4,6,10,12-tetraen-1-yl acetate
(1R,2R,4E,6E,10E)-1-((2S,5S,11S,14S,17S,20S,23R,26S,29S)-5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopropyl-1,7,10,16,20,23,25,28,31-nonamethyl-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl)-2-methyltrideca-4,6,10,12-tetraen-1-yl acetate
- Catalogue No.:PA PEP 003922 
- CAS : - NA
- Molecular Formula : C71H121N11O13 
- Molecular Weight : 1336.81 
 
	
			                                   
																				(3S,6S,9S,12R,15S,18S,21S,24S,30S)-30-Ethyl-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-33-((R,E)-2-methylhepta-4,6-dien-1-ylidene)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
(3S,6S,9S,12R,15S,18S,21S,24S,30S)-30-Ethyl-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-33-((R,E)-2-methylhepta-4,6-dien-1-ylidene)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
- Catalogue No.:PA PEP 003923 
- CAS : - NA
- Molecular Formula : C63H109N11O11 
- Molecular Weight : 1196.63 

 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
 
 
 
