voclosporin and its Impurities
Voclosporin is more potent and less toxic than currently available treatments within the drug class of calcineurin inhibitors. Voclosporin is a novel cyclosporine analog and immunosuppressive compound currently being investigated for the treatment of psoriasis and for the prevention of organ rejection in kidney transplant patients. Reference standards of Voclosporin API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Cyclosporin A, 6-[(2S,3R,4R,6E)-3-(acetyloxy)-4-methyl-2-(methylamino)-6,8-nonadienoic Acid]
Cyclosporin A, 6-[(2S,3R,4R,6E)-3-(acetyloxy)-4-methyl-2-(methylamino)-6,8-nonadienoic Acid]
Catalogue No.:PA 22 0901001
CAS :
515814-02-5
Molecular Formula : C65H113N11O13
Molecular Weight : 1256.68
(3S,6S,9S,12S,15S,18R,21S,24S,27S,30S)-3-Ethyl-6-((1R,2R,E)-1-hydroxy-2-methylhepta-4,6-dien-1-yl)-12,15,24,30-tetraisobutyl-9,27-diisopropyl-1,7,10,13,16,18,21,25,31-nonamethyl-4-nitroso-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
(3S,6S,9S,12S,15S,18R,21S,24S,27S,30S)-3-Ethyl-6-((1R,2R,E)-1-hydroxy-2-methylhepta-4,6-dien-1-yl)-12,15,24,30-tetraisobutyl-9,27-diisopropyl-1,7,10,13,16,18,21,25,31-nonamethyl-4-nitroso-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
Catalogue No.:PA PEP 001187
CAS :
NA
Molecular Formula : C63H110N12O13
Molecular Weight : 1243.64
(3R,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhepta-4,6-dien-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
(3R,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhepta-4,6-dien-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
Catalogue No.:PA PEP 003544
CAS :
NA
Molecular Formula : C63H111N11O12
Molecular Weight : 1214.65
(3S,6S,9S,12R,15S,21S,24S,30S,33S)-30-Ethyl-33-((2R,E)-1-hydroxy-2-methylhepta-4,6-dien-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
(3S,6S,9S,12R,15S,21S,24S,30S,33S)-30-Ethyl-33-((2R,E)-1-hydroxy-2-methylhepta-4,6-dien-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
Catalogue No.:PA PEP 003920
CAS :
NA
Molecular Formula : C63H111N11O12
Molecular Weight : 1214.65
(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,4E,6Z)-1-hydroxy-2-methylocta-4,6-dien-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,4E,6Z)-1-hydroxy-2-methylocta-4,6-dien-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
Catalogue No.:PA PEP 003921
CAS :
NA
Molecular Formula : C64H113N11O12
Molecular Weight : 1228.67
(1R,2R,4E,6E,10E)-1-((2S,5S,11S,14S,17S,20S,23R,26S,29S)-5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopropyl-1,7,10,16,20,23,25,28,31-nonamethyl-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl)-2-methyltrideca-4,6,10,12-tetraen-1-yl acetate
(1R,2R,4E,6E,10E)-1-((2S,5S,11S,14S,17S,20S,23R,26S,29S)-5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopropyl-1,7,10,16,20,23,25,28,31-nonamethyl-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl)-2-methyltrideca-4,6,10,12-tetraen-1-yl acetate
Catalogue No.:PA PEP 003922
CAS :
NA
Molecular Formula : C71H121N11O13
Molecular Weight : 1336.81
(3S,6S,9S,12R,15S,18S,21S,24S,30S)-30-Ethyl-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-33-((R,E)-2-methylhepta-4,6-dien-1-ylidene)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
(3S,6S,9S,12R,15S,18S,21S,24S,30S)-30-Ethyl-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-33-((R,E)-2-methylhepta-4,6-dien-1-ylidene)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
Catalogue No.:PA PEP 003923
CAS :
NA
Molecular Formula : C63H109N11O11
Molecular Weight : 1196.63
