Vonoprazan and its Impurities
Vonoprazan is used in form of the fumarate for the treatment of gastroduodenal ulcer and reflux esophagitis. It is a first-in-class potassium-competitive acid blocker.Reference standards of Vonoprazan API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


5-((2-(2-Fluorophenyl)-4-((methylamino)methyl)-1H-pyrrol-1-yl)sulfonyl)-1,2,3,4-tetrahydropyridin-2-ol
5-((2-(2-Fluorophenyl)-4-((methylamino)methyl)-1H-pyrrol-1-yl)sulfonyl)-1,2,3,4-tetrahydropyridin-2-ol
Catalogue No.:PA 22 0471002
CAS :
2416241-96-6
Molecular Formula : C17H20FN3O3S
Molecular Weight : 365.42


1-(5-(2-Fluorophenyl)-1-((1,4,5,6-tetrahydropyridin-3-yl)sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine
1-(5-(2-Fluorophenyl)-1-((1,4,5,6-tetrahydropyridin-3-yl)sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine
Catalogue No.:PA 22 0471003
CAS :
2416241-97-7
Molecular Formula : C17H20FN3O2S
Molecular Weight : 349.42


N-((5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methyl)-N-methylaspartic Acid
N-((5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methyl)-N-methylaspartic Acid
Catalogue No.:PA 22 0471007
CAS :
2170020-79-6
Molecular Formula : C21H20FN3O6S
Molecular Weight : 461.46


1-(1-((1,6-Dihydropyridin-3-yl)sulfonyl)-5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine
1-(1-((1,6-Dihydropyridin-3-yl)sulfonyl)-5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine
Catalogue No.:PA 22 0471025
CAS :
2416241-95-5
Molecular Formula : C17H18FN3O2S
Molecular Weight : 347.41


1,2-bis((5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methyl)-1,2-dimethylhydrazine
1,2-bis((5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methyl)-1,2-dimethylhydrazine
Catalogue No.:PA 22 0471027
CAS :
NA
Molecular Formula : C34H30F2N6O4S2
Molecular Weight : 688.77


1-(5-(2-Fluorophenyl)-1H-pyrrol-3-yl)-N-((5-(2-fluorophenyl)-1H-pyrrol-3-yl)methyl)-N-methylmethanamine
1-(5-(2-Fluorophenyl)-1H-pyrrol-3-yl)-N-((5-(2-fluorophenyl)-1H-pyrrol-3-yl)methyl)-N-methylmethanamine
Catalogue No.:PA 22 0471029
CAS :
3058423-29-0
Molecular Formula : C23H21F2N3
Molecular Weight : 377.44


N-((5-(2-Fluorophenyl)-1-((6-hydroxy-1,4,5,6-tetrahydropyridin-3-yl)sulfonyl)-1H-pyrrol-3-yl)methyl)-N-methylnitrous Amide
N-((5-(2-Fluorophenyl)-1-((6-hydroxy-1,4,5,6-tetrahydropyridin-3-yl)sulfonyl)-1H-pyrrol-3-yl)methyl)-N-methylnitrous Amide
Catalogue No.:PA 22 0471035
CAS :
NA
Molecular Formula : C17H19FN4O4S
Molecular Weight : 394.42


5-((2-(2-Fluorophenyl)-4-((methylamino)methyl)-1H-pyrrol-1-yl)sulfonyl)-1-nitroso-1,2,3,4-tetrahydropyridin-2-ol
5-((2-(2-Fluorophenyl)-4-((methylamino)methyl)-1H-pyrrol-1-yl)sulfonyl)-1-nitroso-1,2,3,4-tetrahydropyridin-2-ol
Catalogue No.:PA 22 0471036
CAS :
NA
Molecular Formula : C17H19FN4O4S
Molecular Weight : 394.42


N-((5-(2-Fluorophenyl)-1-((6-hydroxy-1-nitroso-1,4,5,6-tetrahydropyridin-3-yl)sulfonyl)-1H-pyrrol-3-yl)methyl)-N-methylnitrous Amide
N-((5-(2-Fluorophenyl)-1-((6-hydroxy-1-nitroso-1,4,5,6-tetrahydropyridin-3-yl)sulfonyl)-1H-pyrrol-3-yl)methyl)-N-methylnitrous Amide
Catalogue No.:PA 22 0471037
CAS :
NA
Molecular Formula : C17H18FN5O5S
Molecular Weight : 423.42


N-((5-(2-Fluorophenyl)-1-((1,4,5,6-tetrahydropyridin-3-yl)sulfonyl)-1H-pyrrol-3-yl)methyl)-N-methylnitrous Amide
N-((5-(2-Fluorophenyl)-1-((1,4,5,6-tetrahydropyridin-3-yl)sulfonyl)-1H-pyrrol-3-yl)methyl)-N-methylnitrous Amide
Catalogue No.:PA 22 0471038
CAS :
NA
Molecular Formula : C17H19FN4O3S
Molecular Weight : 378.42


1-(5-(2-Fluorophenyl)-1-((1-nitroso-1,4,5,6-tetrahydropyridin-3-yl)sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine
1-(5-(2-Fluorophenyl)-1-((1-nitroso-1,4,5,6-tetrahydropyridin-3-yl)sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine
Catalogue No.:PA 22 0471039
CAS :
NA
Molecular Formula : C17H19FN4O3S
Molecular Weight : 378.42


N-((5-(2-Fluorophenyl)-1-((1-nitroso-1,4,5,6-tetrahydropyridin-3-yl)sulfonyl)-1H-pyrrol-3-yl)methyl)-N-methylnitrous Amide
N-((5-(2-Fluorophenyl)-1-((1-nitroso-1,4,5,6-tetrahydropyridin-3-yl)sulfonyl)-1H-pyrrol-3-yl)methyl)-N-methylnitrous Amide
Catalogue No.:PA 22 0471040
CAS :
NA
Molecular Formula : C17H18FN5O4S
Molecular Weight : 407.42


((5-(2-Fluoro-4-hydroxyphenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methyl)(methyl)sulfamic Acid
((5-(2-Fluoro-4-hydroxyphenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methyl)(methyl)sulfamic Acid
Catalogue No.:PA 22 0471048
CAS :
1883595-40-1
Molecular Formula : C17H16FN3O6S2
Molecular Weight : 441.45


1-(5-(3-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine Hydrochloride
1-(5-(3-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine Hydrochloride
Catalogue No.:PA 22 0831001
CAS :
881681-79-4
Molecular Formula : C17H17ClFN3O2S
Molecular Weight : 381.85


1-(5-(4-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine Hydrochloride
1-(5-(4-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine Hydrochloride
Catalogue No.:PA 22 0471053
CAS :
2650821-03-5
Molecular Formula : C17H17ClFN3O2S
Molecular Weight : 381.85


1-(1-((5-Chloropyridin-3-yl)sulfonyl)-5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine Fumarate
1-(1-((5-Chloropyridin-3-yl)sulfonyl)-5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine Fumarate
Catalogue No.:PA 22 0471059
CAS :
NA
Molecular Formula : C21H19ClFN3O6S
Molecular Weight : 495.91


N-((5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methyl)ethanamine Hydrochloride
N-((5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methyl)ethanamine Hydrochloride
Catalogue No.:PA 22 0471062
CAS :
NA
Molecular Formula : C18H19ClFN3O2S
Molecular Weight : 395.88


3-(4-Fluorophenyl)-1-methyl-N-((5-(2-oxopyrrolidin-1-yl)pyridin-3-yl)methyl)-1H-pyrazole-5-carboxamide
3-(4-Fluorophenyl)-1-methyl-N-((5-(2-oxopyrrolidin-1-yl)pyridin-3-yl)methyl)-1H-pyrazole-5-carboxamide
Catalogue No.:PA 22 0471063
CAS :
2034535-57-2
Molecular Formula : C21H20FN5O2
Molecular Weight : 393.42