Zanubrutinib and its Impurities

Zanubrutinib, sold under the brand name Brukinsa, is for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Reference standards of Zanubrutinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

Displaying 31 results for Zanubrutinib Impurities
Drug Reference Standards & Impurity Synthesis in India
PA 26 0391000

(S)-7-(1-Acryloylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-7-(1-Acryloylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391000

  • CAS :

    NA

  • Molecular Formula : C27H28N6O4

  • Molecular Weight : 500.56

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0390000

Zanubrutinib

Zanubrutinib

  • Catalogue No.:PA 26 0390000

  • CAS :

    1691249-45-2

  • Molecular Formula : C27H29N5O3

  • Molecular Weight : 471.56

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391001

Zanubrutinib R-Isomer

Zanubrutinib R-Isomer

  • Catalogue No.:PA 26 0391001

  • CAS :

    1691249-44-1

  • Molecular Formula : C27H29N5O3

  • Molecular Weight : 471.56

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391002

(S)-7-(1-(3-Chloropropanoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-7-(1-(3-Chloropropanoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391002

  • CAS :

    1633351-79-7

  • Molecular Formula : C27H30ClN5O3

  • Molecular Weight : 508.02

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391003

(S)-7-(1-Acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carbonitrile

(S)-7-(1-Acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carbonitrile

  • Catalogue No.:PA 26 0391003

  • CAS :

    2432022-47-2

  • Molecular Formula : C27H27N5O2

  • Molecular Weight : 453.55

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391004

5-Amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

5-Amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

  • Catalogue No.:PA 26 0391004

  • CAS :

    NA

  • Molecular Formula : C16H12N4O

  • Molecular Weight : 276.3

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391005

3-(4-(3-Carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoic Acid

3-(4-(3-Carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoic Acid

  • Catalogue No.:PA 26 0391005

  • CAS :

    NA

  • Molecular Formula : C27H31N5O4

  • Molecular Weight : 489.58

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391006

2-(4-Phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine

2-(4-Phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine

  • Catalogue No.:PA 26 0391006

  • CAS :

    NA

  • Molecular Formula : C23H26N4O

  • Molecular Weight : 374.49

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391007

4-Acryloyl-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

4-Acryloyl-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391007

  • CAS :

    NA

  • Molecular Formula : C30H31N5O4

  • Molecular Weight : 525.61

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391008

(S)-4-Nitroso-2-(4-phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-4-Nitroso-2-(4-phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391008

  • CAS :

    NA

  • Molecular Formula : C24H26N6O3

  • Molecular Weight : 446.51

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391009

(S)-7-(1-Nitrosopiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-7-(1-Nitrosopiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391009

  • CAS :

    NA

  • Molecular Formula : C24H26N6O3

  • Molecular Weight : 446.51

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391010

7-(1-(3-hydroxypropanoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

7-(1-(3-Hydroxypropanoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391010

  • CAS :

    NA

  • Molecular Formula : C27H31N5O4

  • Molecular Weight : 489.58

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391011

7-(1-(3-hydroxypropanoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-3-(4-(3-Carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoic Acid

  • Catalogue No.:PA 26 0391011

  • CAS :

    NA

  • Molecular Formula : C27H31N5O4

  • Molecular Weight : 489.58

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391012

(S)-4-Acryloyl-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-4-Acryloyl-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391012

  • CAS :

    NA

  • Molecular Formula : C30H31N5O4

  • Molecular Weight : 525.61

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391013

(S)-4-(3-(4-((R)-3-Carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoyl)-2-(4-phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-4-(3-(4-((R)-3-Carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoyl)-2-(4-phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391013

  • CAS :

    NA

  • Molecular Formula : C51H56N10O5

  • Molecular Weight : 889.07

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391014

(R)-7-(1-Acryloylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(R)-7-(1-Acryloylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391014

  • CAS :

    NA

  • Molecular Formula : C27H28N6O4

  • Molecular Weight : 500.56

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391015

(S)-7-(1-(3-Chloropropanoyl)piperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-7-(1-(3-Chloropropanoyl)piperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391015

  • CAS :

    NA

  • Molecular Formula : C27H29ClN6O4

  • Molecular Weight : 537.02

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391016

(S)-4-Nitroso-2-(4-phenoxyphenyl)-7-(1-propionylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-4-Nitroso-2-(4-phenoxyphenyl)-7-(1-propionylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391016

  • CAS :

    NA

  • Molecular Formula : C27H30N6O4

  • Molecular Weight : 502.58

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391017

(S)-7-(1-Benzoylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-7-(1-Benzoylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391017

  • CAS :

    NA

  • Molecular Formula : C31H30N6O4

  • Molecular Weight : 550.62

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391018

(S)-3-(4-(3-Carbamoyl-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoic Acid

(S)-3-(4-(3-Carbamoyl-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoic Acid

  • Catalogue No.:PA 26 0391018

  • CAS :

    NA

  • Molecular Formula : C27H30N6O5

  • Molecular Weight : 518.57

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391019

(S)-7-(1-Acetylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-7-(1-Acetylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391019

  • CAS :

    NA

  • Molecular Formula : C26H28N6O4

  • Molecular Weight : 488.55

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391020

(R)-4-Nitroso-2-(4-phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(R)-4-Nitroso-2-(4-phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391020

  • CAS :

    NA

  • Molecular Formula : C24H26N6O3

  • Molecular Weight : 446.51

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391021

tert-Butyl 4-(3-carbamoyl-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate

tert-Butyl 4-(3-carbamoyl-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate

  • Catalogue No.:PA 26 0391021

  • CAS :

    NA

  • Molecular Formula : C29H34N6O5

  • Molecular Weight : 546.63

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391022

2-(4-Phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic Acid

2-(4-Phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic Acid

  • Catalogue No.:PA 26 0391022

  • CAS :

    NA

  • Molecular Formula : C24H26N4O3

  • Molecular Weight : 418.5

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391023

tert-Butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate

tert-Butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate

  • Catalogue No.:PA 26 0391023

  • CAS :

    2190506-55-7

  • Molecular Formula : C29H29N5O3

  • Molecular Weight : 495.58

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391024

(S)-5-(1-Acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-5-(1-Acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391024

  • CAS :

    NA

  • Molecular Formula : C27H29N5O3

  • Molecular Weight : 471.56

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391025

(7S,7'S)-7,7'-((1-Oxopropane-1,3-diyl)bis(piperidine-1,4-diyl))bis(2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide)

(7S,7'S)-7,7'-((1-Oxopropane-1,3-diyl)bis(piperidine-1,4-diyl))bis(2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide)

  • Catalogue No.:PA 26 0391025

  • CAS :

    NA

  • Molecular Formula : C51H56N10O5

  • Molecular Weight : 889.07

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391026

7-(1-Benzoylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

7-(1-Benzoylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391026

  • CAS :

    NA

  • Molecular Formula : C31H31N5O3

  • Molecular Weight : 521.62

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391027

2-(Hydroxy(4-phenoxyphenyl)methylene)malononitrile

2-(Hydroxy(4-phenoxyphenyl)methylene)malononitrile

  • Catalogue No.:PA 26 0391027

  • CAS :

    330792-68-2

  • Molecular Formula : C16H10N2O2

  • Molecular Weight : 262.27

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391028

(S)-7-(1-Acryloylpiperidin-4-yl)-3-carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine 1-oxide

(S)-7-(1-Acryloylpiperidin-4-yl)-3-carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine 1-oxide

  • Catalogue No.:PA 26 0391028

  • CAS :

    NA

  • Molecular Formula : C27H29N5O4

  • Molecular Weight : 487.56

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Drug Reference Standards & Impurity Synthesis in India
PA 26 0391029

(S)-2-(4-Phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-2-(4-Phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391029

  • CAS :

    1633352-71-2

  • Molecular Formula : C24H27N5O2

  • Molecular Weight : 417.51

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