Baricitinib was approved in February of 2017 as a second-line orally administered treatment for moderate to severe active rheumatoid arthritis in adults, either as a monotherapy or when combined with methotrexate.Baricitinib is a selective and reversible Janus kinase 1 (JAK1) and 2 (JAK2) inhibitor. Janus kinases belong to the tyrosine protein kinase family and play an important role in the proinflammatory pathway signalling that is frequently over-activated in autoimmune disorders such as rheumatoid arthritis. Reference standards of Baricitinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
stdClass Object ( [pname] => 2-(1-(Ethylsulfonyl)-3-(4-(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile [catalogue_number] => PA 29 0411009 [category_ids] => ,70,75,76,78,82,162, [chemical_name] => [weight] => 400.42 [form] => C16H16N8O3S [cas] => NA [pslug] => 2-1-ethylsulfonyl-3-4-7-nitroso-7h-pyrrolo-2-3-d-pyrimidin-4-yl-1h-pyrazol-1-yl-azetidin-3-yl-acetonitrile-pa290411009 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 29 0411009
CAS :
Molecular Formula : C16H16N8O3S
Molecular Weight : 400.42
stdClass Object ( [pname] => 4-Chloro-7-nitroso-7H-pyrrolo[2,3-d]pyrimidine [catalogue_number] => PA 29 0411015 [category_ids] => ,70,78,82,162, [chemical_name] => [weight] => 182.57 [form] => C6H3ClN4O [cas] => NA [pslug] => 4-chloro-7-nitroso-7h-pyrrolo-2-3-d-pyrimidine-pa290411015 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 29 0411015
Molecular Formula : C6H3ClN4O
Molecular Weight : 182.57
stdClass Object ( [pname] => 4-Bromo-1-nitroso-1H-pyrazole [catalogue_number] => PA 29 0411016 [category_ids] => ,70,78,82,162, [chemical_name] => [weight] => 175.97 [form] => C3H2BrN3O [cas] => NA [pslug] => 4-bromo-1-nitroso-1h-pyrazole-pa290411016 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 29 0411016
Molecular Formula : C3H2BrN3O
Molecular Weight : 175.97
stdClass Object ( [pname] => 2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-nitrosoazetidin-3-yl)acetonitrile [catalogue_number] => PA 29 0411025 [category_ids] => ,78,70,82,162, [chemical_name] => [weight] => 308.31 [form] => C14H12N8O [cas] => NA [pslug] => 2-3-4-7h-pyrrolo-2-3-d-pyrimidin-4-yl-1h-pyrazol-1-yl-1-nitrosoazetidin-3-yl-acetonitrile-pa290411025 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 29 0411025
Molecular Formula : C14H12N8O
Molecular Weight : 308.31
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