baricitinib
Baricitinib was approved in February of 2017 as a second-line orally administered treatment for moderate to severe active rheumatoid arthritis in adults, either as a monotherapy or when combined with methotrexate.Baricitinib is a selective and reversible Janus kinase 1 (JAK1) and 2 (JAK2) inhibitor. Janus kinases belong to the tyrosine protein kinase family and play an important role in the proinflammatory pathway signalling that is frequently over-activated in autoimmune disorders such as rheumatoid arthritis. Reference standards of Baricitinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
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2-(1-(Ethylsulfonyl)-3-(4-(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile
Catalogue No.:PA 29 0411009
Molecular Formula : C16H16N8O3S
Molecular Weight : 400.42
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4-Chloro-7-nitroso-7H-pyrrolo[2,3-d]pyrimidine
Catalogue No.:PA 29 0411015
Molecular Formula : C6H3ClN4O
Molecular Weight : 182.57
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4-Bromo-1-nitroso-1H-pyrazole
Catalogue No.:PA 29 0411016
Molecular Formula : C3H2BrN3O
Molecular Weight : 175.97
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[form] => C14H12N8O
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2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-nitrosoazetidin-3-yl)acetonitrile
Catalogue No.:PA 29 0411025
Molecular Formula : C14H12N8O
Molecular Weight : 308.31
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2-(3-(4-(7-Nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(propylsulfonyl)azetidin-3-yl)acetonitrile
Catalogue No.:PA 29 0411030
Molecular Formula : C17H18N8O3S
Molecular Weight : 414.44
