bosutinib

Bosutinib is used to treat chronic myeloid leukaemia that has an abnormal chromosome called the Philadelphia chromosome. It is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity.. Reference standards of Bosutinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below

stdClass Object
(
    [pname] => 4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-nitrosopiperazin-1-yl)propoxy)quinoline-3-carbonitrile
    [catalogue_number] => PA 02 0921030
    [category_ids] => ,70,71,78,80,81,82,162,
    [chemical_name] => 
    [weight] => 545.42
    [form] => C25H26Cl2N6O4
    [cas] => NA
    [pslug] => 4-2-4-dichloro-5-methoxyphenyl-amino-6-methoxy-7-3-4-nitrosopiperazin-1-yl-propoxy-quinoline-3-carbonitrile-pa020921030
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PA 02 0921030

4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-nitrosopiperazin-1-yl)propoxy)quinoline-3-carbonitrile

  • Catalogue No.:PA 02 0921030

  • CAS :

    NA

  • Molecular Formula : C25H26Cl2N6O4

  • Molecular Weight : 545.42

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Details 
stdClass Object
(
    [pname] => 1-(3-(2-Methoxy-5-nitrophenoxy)propyl)-4-nitrosopiperazine
    [catalogue_number] => PA 02 0921033
    [category_ids] => ,80,71,81,78,70,82,162,
    [chemical_name] => 
    [weight] => 324.34
    [form] => C14H20N4O5
    [cas] => NA
    [pslug] => 1-3-2-methoxy-5-nitrophenoxy-propyl-4-nitrosopiperazine-pa020921033
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PA 02 0921033

1-(3-(2-Methoxy-5-nitrophenoxy)propyl)-4-nitrosopiperazine

  • Catalogue No.:PA 02 0921033

  • CAS :

    NA

  • Molecular Formula : C14H20N4O5

  • Molecular Weight : 324.34

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Details 
stdClass Object
(
    [pname] => 2-Cyano-N-(2,4-dichloro-5-methoxyphenyl)-3-((4-methoxy-3-(3-(4-nitrosopiperazin-1-yl)propoxy)phenyl)amino)acrylamide
    [catalogue_number] => PA 02 0921034
    [category_ids] => ,80,71,81,78,70,82,162,
    [chemical_name] => 
    [weight] => 563.44
    [form] => C25H28Cl2N6O5
    [cas] => NA
    [pslug] => 2-cyano-n-2-4-dichloro-5-methoxyphenyl-3-4-methoxy-3-3-4-nitrosopiperazin-1-yl-propoxy-phenyl-amino-acrylamide-pa020921034
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PA 02 0921034

2-Cyano-N-(2,4-dichloro-5-methoxyphenyl)-3-((4-methoxy-3-(3-(4-nitrosopiperazin-1-yl)propoxy)phenyl)amino)acrylamide

  • Catalogue No.:PA 02 0921034

  • CAS :

    NA

  • Molecular Formula : C25H28Cl2N6O5

  • Molecular Weight : 563.44

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Details 
stdClass Object
(
    [pname] => N-(3-Cyano-6-methoxy-7-propoxyquinolin-4-yl)-N-(2,4-dichloro-5-methoxyphenyl)nitrous amide
    [catalogue_number] => PA 02 0921035
    [category_ids] => ,80,71,81,78,70,82,162,
    [chemical_name] => 
    [weight] => 461.3
    [form] => C21H18Cl2N4O4
    [cas] => NA
    [pslug] => n-3-cyano-6-methoxy-7-propoxyquinolin-4-yl-n-2-4-dichloro-5-methoxyphenyl-nitrous-amide-pa020921035
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PA 02 0921035

N-(3-Cyano-6-methoxy-7-propoxyquinolin-4-yl)-N-(2,4-dichloro-5-methoxyphenyl)nitrous amide

  • Catalogue No.:PA 02 0921035

  • CAS :

    NA

  • Molecular Formula : C21H18Cl2N4O4

  • Molecular Weight : 461.3

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Details 
stdClass Object
(
    [pname] => N,N'-((Propane-1,3-diylbis(oxy))bis(3-cyano-6-methoxyquinoline-7,4-diyl))bis(N-(2,4-dichloro-5-methoxyphenyl)nitrous amide)
    [catalogue_number] => PA 02 0921036
    [category_ids] => ,80,71,81,78,70,82,162,
    [chemical_name] => 
    [weight] => 878.5
    [form] => C39H28Cl4N8O8
    [cas] => NA
    [pslug] => n-n-propane-1-3-diylbis-oxy-bis-3-cyano-6-methoxyquinoline-7-4-diyl-bis-n-2-4-dichloro-5-methoxyphenyl-nitrous-amide-pa020921036
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PA 02 0921036

N,N'-((Propane-1,3-diylbis(oxy))bis(3-cyano-6-methoxyquinoline-7,4-diyl))bis(N-(2,4-dichloro-5-methoxyphenyl)nitrous amide)

  • Catalogue No.:PA 02 0921036

  • CAS :

    NA

  • Molecular Formula : C39H28Cl4N8O8

  • Molecular Weight : 878.5

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Details 
stdClass Object
(
    [pname] => N,N'-(((Piperazine-1,4-diylbis(propane-3,1-diyl))bis(oxy))bis(3-cyano-6-methoxyquinoline-7,4-diyl))bis(N-(2,4-dichloro-5-methoxyphenyl)nitrous amide)
    [catalogue_number] => PA 02 0921037
    [category_ids] => ,80,71,81,78,70,82,162,
    [chemical_name] => 
    [weight] => 1004.7
    [form] => C46H42Cl4N10O8
    [cas] => NA
    [pslug] => n-n-piperazine-1-4-diylbis-propane-3-1-diyl-bis-oxy-bis-3-cyano-6-methoxyquinoline-7-4-diyl-bis-n-2-4-dichloro-5-methoxyphenyl-nitrous-amide-pa020921037
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PA 02 0921037

N,N'-(((Piperazine-1,4-diylbis(propane-3,1-diyl))bis(oxy))bis(3-cyano-6-methoxyquinoline-7,4-diyl))bis(N-(2,4-dichloro-5-methoxyphenyl)nitrous amide)

  • Catalogue No.:PA 02 0921037

  • CAS :

    NA

  • Molecular Formula : C46H42Cl4N10O8

  • Molecular Weight : 1004.7

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Details 
stdClass Object
(
    [pname] => N-(3-Cyano-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinolin-4-yl)-N-(2,4-dichloro-5-methoxyphenyl)nitrous amide
    [catalogue_number] => PA 02 0921038
    [category_ids] => ,80,71,81,78,70,82,162,
    [chemical_name] => 
    [weight] => 559.45
    [form] => C26H28Cl2N6O4
    [cas] => NA
    [pslug] => n-3-cyano-6-methoxy-7-3-4-methylpiperazin-1-yl-propoxy-quinolin-4-yl-n-2-4-dichloro-5-methoxyphenyl-nitrous-amide-pa020921038
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PA 02 0921038

N-(3-Cyano-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinolin-4-yl)-N-(2,4-dichloro-5-methoxyphenyl)nitrous amide

  • Catalogue No.:PA 02 0921038

  • CAS :

    NA

  • Molecular Formula : C26H28Cl2N6O4

  • Molecular Weight : 559.45

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CPHI INDIA- 28, 30 November