Zanubrutinib

Nitrosamine Standards - Zanubrutinib, sold under the brand name Brukinsa, is for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Reference standards of Zanubrutinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => (S)-7-(1-Acryloylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391000
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 500.56
    [form] => C27H28N6O4
    [cas] => NA
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PA 26 0391000
PA 26 0391000

(S)-7-(1-Acryloylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391000

  • CAS :

    NA

  • Molecular Formula : C27H28N6O4

  • Molecular Weight : 500.56

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Details 
stdClass Object
(
    [pname] => (R)-7-(1-Acryloylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391014
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 500.56
    [form] => C27H28N6O4
    [cas] => NA
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PA 26 0391014
PA 26 0391014

(R)-7-(1-Acryloylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391014

  • CAS :

    NA

  • Molecular Formula : C27H28N6O4

  • Molecular Weight : 500.56

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Details 
stdClass Object
(
    [pname] => (S)-7-(1-(3-Chloropropanoyl)piperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391015
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 537.02
    [form] => C27H29ClN6O4
    [cas] => NA
    [pslug] => s-7-1-3-chloropropanoyl-piperidin-4-yl-4-nitroso-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidine-3-carboxamide-pa260391015
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PA 26 0391015
PA 26 0391015

(S)-7-(1-(3-Chloropropanoyl)piperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391015

  • CAS :

    NA

  • Molecular Formula : C27H29ClN6O4

  • Molecular Weight : 537.02

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Details 
stdClass Object
(
    [pname] => (S)-4-Nitroso-2-(4-phenoxyphenyl)-7-(1-propionylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391016
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 502.58
    [form] => C27H30N6O4
    [cas] => NA
    [pslug] => s-4-nitroso-2-4-phenoxyphenyl-7-1-propionylpiperidin-4-yl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidine-3-carboxamide-pa260391016
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PA 26 0391016
PA 26 0391016

(S)-4-Nitroso-2-(4-phenoxyphenyl)-7-(1-propionylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391016

  • CAS :

    NA

  • Molecular Formula : C27H30N6O4

  • Molecular Weight : 502.58

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Details 
stdClass Object
(
    [pname] => (S)-7-(1-Benzoylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391017
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 550.62
    [form] => C31H30N6O4
    [cas] => NA
    [pslug] => s-7-1-benzoylpiperidin-4-yl-4-nitroso-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidine-3-carboxamide-pa260391017
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PA 26 0391017
PA 26 0391017

(S)-7-(1-Benzoylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391017

  • CAS :

    NA

  • Molecular Formula : C31H30N6O4

  • Molecular Weight : 550.62

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Details 
stdClass Object
(
    [pname] => (S)-3-(4-(3-Carbamoyl-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoic Acid
    [catalogue_number] => PA 26 0391018
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 518.57
    [form] => C27H30N6O5
    [cas] => NA
    [pslug] => s-3-4-3-carbamoyl-4-nitroso-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidin-7-yl-piperidin-1-yl-propanoic-acid-pa260391018
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PA 26 0391018
PA 26 0391018

(S)-3-(4-(3-Carbamoyl-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoic Acid

  • Catalogue No.:PA 26 0391018

  • CAS :

    NA

  • Molecular Formula : C27H30N6O5

  • Molecular Weight : 518.57

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Details 
stdClass Object
(
    [pname] => (S)-7-(1-Acetylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391019
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 488.55
    [form] => C26H28N6O4
    [cas] => NA
    [pslug] => s-7-1-acetylpiperidin-4-yl-4-nitroso-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidine-3-carboxamide-pa260391019
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PA 26 0391019
PA 26 0391019

(S)-7-(1-Acetylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391019

  • CAS :

    NA

  • Molecular Formula : C26H28N6O4

  • Molecular Weight : 488.55

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Details 
stdClass Object
(
    [pname] => (R)-4-Nitroso-2-(4-phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391020
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 446.51
    [form] => C24H26N6O3
    [cas] => NA
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PA 26 0391020
PA 26 0391020

(R)-4-Nitroso-2-(4-phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391020

  • CAS :

    NA

  • Molecular Formula : C24H26N6O3

  • Molecular Weight : 446.51

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Details 
stdClass Object
(
    [pname] => tert-Butyl 4-(3-carbamoyl-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate
    [catalogue_number] => PA 26 0391021
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 546.63
    [form] => C29H34N6O5
    [cas] => NA
    [pslug] => tert-butyl-4-3-carbamoyl-4-nitroso-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidin-7-yl-piperidine-1-carboxylate-pa260391021
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PA 26 0391021
PA 26 0391021

tert-Butyl 4-(3-carbamoyl-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate

  • Catalogue No.:PA 26 0391021

  • CAS :

    NA

  • Molecular Formula : C29H34N6O5

  • Molecular Weight : 546.63

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Details 
stdClass Object
(
    [pname] => 4-Nitroso-7-(1-nitrosopiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391030
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 475.51
    [form] => C24H25N7O4
    [cas] => NA
    [pslug] => 4-nitroso-7-1-nitrosopiperidin-4-yl-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidine-3-carboxamide-pa260391030
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PA 26 0391030
PA 26 0391030

4-Nitroso-7-(1-nitrosopiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391030

  • CAS :

    NA

  • Molecular Formula : C24H25N7O4

  • Molecular Weight : 475.51

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Details 
stdClass Object
(
    [pname] => 5-(1-Acryloylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391031
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 500.56
    [form] => C27H28N6O4
    [cas] => NA
    [pslug] => 5-1-acryloylpiperidin-4-yl-4-nitroso-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidine-3-carboxamide-pa260391031
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PA 26 0391031
PA 26 0391031

5-(1-Acryloylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391031

  • CAS :

    NA

  • Molecular Formula : C27H28N6O4

  • Molecular Weight : 500.56

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Details 
stdClass Object
(
    [pname] => 7-(1-(3-(4-(3-Carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)-3-oxopropyl)piperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391032
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 918.07
    [form] => C51H55N11O6
    [cas] => NA
    [pslug] => 7-1-3-4-3-carbamoyl-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidin-7-yl-piperidin-1-yl-3-oxopropyl-piperidin-4-yl-4-nitroso-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidine-3-carboxamide-pa260391032
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PA 26 0391032
PA 26 0391032

7-(1-(3-(4-(3-Carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)-3-oxopropyl)piperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391032

  • CAS :

    NA

  • Molecular Formula : C51H55N11O6

  • Molecular Weight : 918.07

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Details 
stdClass Object
(
    [pname] => 7-(1-(3-(4-(3-Carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoyl)piperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391033
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 918.07
    [form] => C51H55N11O6
    [cas] => NA
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PA 26 0391033
PA 26 0391033

7-(1-(3-(4-(3-Carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoyl)piperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391033

  • CAS :

    NA

  • Molecular Formula : C51H55N11O6

  • Molecular Weight : 918.07

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Details 
stdClass Object
(
    [pname] => 7,7'-((1-Oxopropane-1,3-diyl)bis(piperidine-1,4-diyl))bis(4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide)
    [catalogue_number] => PA 26 0391034
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 947.07
    [form] => C51H54N12O7
    [cas] => NA
    [pslug] => 7-7-1-oxopropane-1-3-diyl-bis-piperidine-1-4-diyl-bis-4-nitroso-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidine-3-carboxamide-pa260391034
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PA 26 0391034
PA 26 0391034

7,7'-((1-Oxopropane-1,3-diyl)bis(piperidine-1,4-diyl))bis(4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide)

  • Catalogue No.:PA 26 0391034

  • CAS :

    NA

  • Molecular Formula : C51H54N12O7

  • Molecular Weight : 947.07

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Details 
stdClass Object
(
    [pname] => 7-(1-(3-Chloropropanoyl)piperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391035
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 537.02
    [form] => C27H29ClN6O4
    [cas] => NA
    [pslug] => 7-1-3-chloropropanoyl-piperidin-4-yl-4-nitroso-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidine-3-carboxamide-pa260391035
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PA 26 0391035
PA 26 0391035

7-(1-(3-Chloropropanoyl)piperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391035

  • CAS :

    NA

  • Molecular Formula : C27H29ClN6O4

  • Molecular Weight : 537.02

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stdClass Object
(
    [pname] => 7-(1-Benzoylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391036
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 550.62
    [form] => C31H30N6O4
    [cas] => NA
    [pslug] => 7-1-benzoylpiperidin-4-yl-4-nitroso-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidine-3-carboxamide-pa260391036
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PA 26 0391036
PA 26 0391036

7-(1-Benzoylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391036

  • CAS :

    NA

  • Molecular Formula : C31H30N6O4

  • Molecular Weight : 550.62

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