Zanubrutinib

Zanubrutinib, sold under the brand name Brukinsa, is for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Reference standards of Zanubrutinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
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    [pname] => (S)-7-(1-Acryloylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391000
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 500.56
    [form] => C27H28N6O4
    [cas] => NA
    [pslug] => s-7-1-acryloylpiperidin-4-yl-4-nitroso-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidine-3-carboxamide-pa260391000
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PA 26 0391000

(S)-7-(1-Acryloylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391000

  • CAS :

    NA

  • Molecular Formula : C27H28N6O4

  • Molecular Weight : 500.56

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Details 
stdClass Object
(
    [pname] => (R)-7-(1-Acryloylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391014
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 500.56
    [form] => C27H28N6O4
    [cas] => NA
    [pslug] => r-7-1-acryloylpiperidin-4-yl-4-nitroso-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidine-3-carboxamide-pa260391014
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PA 26 0391014

(R)-7-(1-Acryloylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391014

  • CAS :

    NA

  • Molecular Formula : C27H28N6O4

  • Molecular Weight : 500.56

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Details 
stdClass Object
(
    [pname] => (S)-7-(1-(3-Chloropropanoyl)piperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391015
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 537.02
    [form] => C27H29ClN6O4
    [cas] => NA
    [pslug] => s-7-1-3-chloropropanoyl-piperidin-4-yl-4-nitroso-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidine-3-carboxamide-pa260391015
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PA 26 0391015

(S)-7-(1-(3-Chloropropanoyl)piperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391015

  • CAS :

    NA

  • Molecular Formula : C27H29ClN6O4

  • Molecular Weight : 537.02

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Details 
stdClass Object
(
    [pname] => (S)-4-Nitroso-2-(4-phenoxyphenyl)-7-(1-propionylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391016
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 502.58
    [form] => C27H30N6O4
    [cas] => NA
    [pslug] => s-4-nitroso-2-4-phenoxyphenyl-7-1-propionylpiperidin-4-yl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidine-3-carboxamide-pa260391016
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PA 26 0391016

(S)-4-Nitroso-2-(4-phenoxyphenyl)-7-(1-propionylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391016

  • CAS :

    NA

  • Molecular Formula : C27H30N6O4

  • Molecular Weight : 502.58

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Details 
stdClass Object
(
    [pname] => (S)-7-(1-Benzoylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391017
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 550.62
    [form] => C31H30N6O4
    [cas] => NA
    [pslug] => s-7-1-benzoylpiperidin-4-yl-4-nitroso-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidine-3-carboxamide-pa260391017
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PA 26 0391017

(S)-7-(1-Benzoylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391017

  • CAS :

    NA

  • Molecular Formula : C31H30N6O4

  • Molecular Weight : 550.62

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Details 
stdClass Object
(
    [pname] => (S)-3-(4-(3-Carbamoyl-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoic Acid
    [catalogue_number] => PA 26 0391018
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 518.57
    [form] => C27H30N6O5
    [cas] => NA
    [pslug] => s-3-4-3-carbamoyl-4-nitroso-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidin-7-yl-piperidin-1-yl-propanoic-acid-pa260391018
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PA 26 0391018

(S)-3-(4-(3-Carbamoyl-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoic Acid

  • Catalogue No.:PA 26 0391018

  • CAS :

    NA

  • Molecular Formula : C27H30N6O5

  • Molecular Weight : 518.57

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Details 
stdClass Object
(
    [pname] => (S)-7-(1-Acetylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391019
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 488.55
    [form] => C26H28N6O4
    [cas] => NA
    [pslug] => s-7-1-acetylpiperidin-4-yl-4-nitroso-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidine-3-carboxamide-pa260391019
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PA 26 0391019

(S)-7-(1-Acetylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391019

  • CAS :

    NA

  • Molecular Formula : C26H28N6O4

  • Molecular Weight : 488.55

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Details 
stdClass Object
(
    [pname] => (R)-4-Nitroso-2-(4-phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
    [catalogue_number] => PA 26 0391020
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 446.51
    [form] => C24H26N6O3
    [cas] => NA
    [pslug] => r-4-nitroso-2-4-phenoxyphenyl-7-piperidin-4-yl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidine-3-carboxamide-pa260391020
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PA 26 0391020

(R)-4-Nitroso-2-(4-phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391020

  • CAS :

    NA

  • Molecular Formula : C24H26N6O3

  • Molecular Weight : 446.51

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Details 
stdClass Object
(
    [pname] => tert-Butyl 4-(3-carbamoyl-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate
    [catalogue_number] => PA 26 0391021
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 546.63
    [form] => C29H34N6O5
    [cas] => NA
    [pslug] => tert-butyl-4-3-carbamoyl-4-nitroso-2-4-phenoxyphenyl-4-5-6-7-tetrahydropyrazolo-1-5-a-pyrimidin-7-yl-piperidine-1-carboxylate-pa260391021
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PA 26 0391021

tert-Butyl 4-(3-carbamoyl-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate

  • Catalogue No.:PA 26 0391021

  • CAS :

    NA

  • Molecular Formula : C29H34N6O5

  • Molecular Weight : 546.63

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