osimertinib
Osimertinib is used to treat locally advanced or metastatic non-small-cell lung cancer. It is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor.Reference standards of Osimertinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
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[pname] => Osimertinib
[catalogue_number] => PA 15 51000
[category_ids] => ,79,80,78,70,82,
[chemical_name] =>
[weight] => 499.61
[form] => C28H33N7O2
[cas] => 1421373-65-0
[pslug] => 1421373-65-0-osimertinib-api-pa1551000
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Catalogue No.:PA 15 51000
Molecular Formula : C28H33N7O2
Molecular Weight : 499.61
stdClass Object
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[pname] => 2-Dimethylaminoethanol
[catalogue_number] => PA 15 51550
[category_ids] => ,79,75,92,
[chemical_name] =>
[weight] => 89.14
[form] => C4H11NO
[cas] => 108-01-0
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stdClass Object
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[pname] => 2-(tert-Butoxy)-4-fluoro-5-nitroaniline
[catalogue_number] => PA 15 51560
[category_ids] => ,79,75,80,89,
[chemical_name] =>
[weight] => 228.22
[form] => C10H13FN2O3
[cas] => NA
[pslug] => 2-tert-butoxy-4-fluoro-5-nitroaniline-pa1551560
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2-(tert-Butoxy)-4-fluoro-5-nitroaniline
Catalogue No.:PA 15 51560
Molecular Formula : C10H13FN2O3
Molecular Weight : 228.22
stdClass Object
(
[pname] => 4-Fluoro-6-methoxy-2,3-dinitroaniline
[catalogue_number] => PA 15 51570
[category_ids] => ,79,75,80,89,
[chemical_name] =>
[weight] => 231.14
[form] => C7H6FN3O5
[cas] => NA
[pslug] => 4-fluoro-6-methoxy-2-3-dinitroaniline-pa1551570
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4-Fluoro-6-methoxy-2,3-dinitroaniline
Catalogue No.:PA 15 51570
Molecular Formula : C7H6FN3O5
Molecular Weight : 231.14
stdClass Object
(
[pname] => Osimertinib N-Methylacrylamide Impurity
[catalogue_number] => PA 15 0511027
[category_ids] => ,79,80,78,70,82,
[chemical_name] =>
[weight] => 539.64
[form] => C30H33N7O3
[cas] => 2850389-35-2
[pslug] => 2850389-35-2-osimertinib-n-methylacrylamide-impurity-pa150511027
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Osimertinib N-Methylacrylamide Impurity
Catalogue No.:PA 15 0511027
Molecular Formula : C30H33N7O3
Molecular Weight : 539.64
stdClass Object
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[pname] => 1-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)azetidin-2-one
[catalogue_number] => PA 15 0511028
[category_ids] => ,79,80,78,70,82,
[chemical_name] =>
[weight] => 499.62
[form] => C28H33N7O2
[cas] => NA
[pslug] => 1-2-2-dimethylamino-ethyl-methyl-amino-4-methoxy-5-4-1-methyl-1h-indol-3-yl-pyrimidin-2-yl-amino-phenyl-azetidin-2-one-pa150511028
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1-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)azetidin-2-one
Catalogue No.:PA 15 0511028
Molecular Formula : C28H33N7O2
Molecular Weight : 499.62
stdClass Object
(
[pname] => N-(4-Fluoro-2-methoxyphenyl)acetamide
[catalogue_number] => PA 15 0511029
[category_ids] => ,79,80,78,70,82,
[chemical_name] =>
[weight] => 183.18
[form] => C9H10FNO2
[cas] => 582-11-6
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N-(4-Fluoro-2-methoxyphenyl)acetamide
Catalogue No.:PA 15 0511029
Molecular Formula : C9H10FNO2
Molecular Weight : 183.18
stdClass Object
(
[pname] => 1-Fluoro-5-methoxy-2,4-dinitrobenzene
[catalogue_number] => PA 15 0511030
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[weight] => 216.12
[form] => C7H5FN2O5
[cas] => 394-18-3
[pslug] => 394-18-3-1-fluoro-5-methoxy-2-4-dinitrobenzene-pa150511030
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1-Fluoro-5-methoxy-2,4-dinitrobenzene
Catalogue No.:PA 15 0511030
Molecular Formula : C7H5FN2O5
Molecular Weight : 216.12
stdClass Object
(
[pname] => N-(4-Fluoro-2-methoxy-5-nitrophenyl)acetamide
[catalogue_number] => PA 15 0511031
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[weight] => 228.18
[form] => C9H9FN2O4
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N-(4-Fluoro-2-methoxy-5-nitrophenyl)acetamide
Catalogue No.:PA 15 0511031
Molecular Formula : C9H9FN2O4
Molecular Weight : 228.18
stdClass Object
(
[pname] => 2,2,2-Trifluoro-N-(4-fluoro-2-methoxy-5-nitrophenyl)acetamide
[catalogue_number] => PA 15 0511037
[category_ids] => ,79,80,78,70,82,
[chemical_name] =>
[weight] => 282.15
[form] => C9H6F4N2O4
[cas] => 3025819-85-3
[pslug] => 3025819-85-3-2-2-2-trifluoro-n-4-fluoro-2-methoxy-5-nitrophenyl-acetamide-pa150511037
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2,2,2-Trifluoro-N-(4-fluoro-2-methoxy-5-nitrophenyl)acetamide
Catalogue No.:PA 15 0511037
Molecular Formula : C9H6F4N2O4
Molecular Weight : 282.15
stdClass Object
(
[pname] => O-Desmethyl Osimertinib Impurity
[catalogue_number] => PA 15 0511038
[category_ids] => ,79,80,78,70,82,
[chemical_name] =>
[weight] => 485.59
[form] => C27H31N7O2
[cas] => 2226039-64-9
[pslug] => 2226039-64-9-o-desmethyl-osimertinib-impurity-pa150511038
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O-Desmethyl Osimertinib Impurity
Catalogue No.:PA 15 0511038
Molecular Formula : C27H31N7O2
Molecular Weight : 485.59
stdClass Object
(
[pname] => N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-N-(3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-3-oxopropyl)acrylamide
[catalogue_number] => PA 15 0511039
[category_ids] => ,79,80,78,70,82,
[chemical_name] =>
[weight] => 999.24
[form] => C56H66N14O4
[cas] => 2919324-18-6
[pslug] => 2919324-18-6-n-2-2-dimethylamino-ethyl-methyl-amino-4-methoxy-5-4-1-methyl-1h-indol-3-yl-pyrimidin-2-yl-amino-phenyl-n-3-2-2-dimethylamino-ethyl-methyl-amino-4-methoxy-5-4-1-methyl-1h-indol-3-yl-pyrimidin-2-yl-amino-phenyl-amino-3-oxopropyl-acrylamide-pa150511039
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N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-N-(3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-3-oxopropyl)acrylamide
Catalogue No.:PA 15 0511039
Molecular Formula : C56H66N14O4
Molecular Weight : 999.24
stdClass Object
(
[pname] => N-(2,4-Dimethoxyphenyl)acrylamide
[catalogue_number] => PA 15 0511040
[category_ids] => ,79,80,78,70,82,
[chemical_name] =>
[weight] => 207.23
[form] => C11H13NO3
[cas] => 187932-63-4
[pslug] => 187932-63-4-n-2-4-dimethoxyphenyl-acrylamide-pa150511040
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N-(2,4-Dimethoxyphenyl)acrylamide
Catalogue No.:PA 15 0511040
Molecular Formula : C11H13NO3
Molecular Weight : 207.23
stdClass Object
(
[pname] => N-(2-Methoxyphenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine
[catalogue_number] => PA 15 0511041
[category_ids] => ,79,80,78,70,82,
[chemical_name] =>
[weight] => 330.39
[form] => C20H18N4O
[cas] => 2734281-31-1
[pslug] => 2734281-31-1-n-2-methoxyphenyl-4-1-methyl-1h-indol-3-yl-pyrimidin-2-amine-pa150511041
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N-(2-Methoxyphenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine
Catalogue No.:PA 15 0511041
Molecular Formula : C20H18N4O
Molecular Weight : 330.39
