sacubitril
An antihypertensive drug, Sacubitril is used in combination with valsartan for the treatment of heart ailments. A prodrug of sacubitrilat which is an inhibitor of enzyme neprilysin, which aids the degradation of blood pressure-lowering peptides, atrial and brain natriuretic peptide.Reference standards of Sacubitril API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
stdClass Object
(
[pname] => Sacubitrilat
[catalogue_number] => PA 19 66580
[category_ids] => 82,80,79,78,75,70
[chemical_name] =>
[weight] => 383.44
[form] => C22H25NO5
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Catalogue No.:PA 19 66580
Molecular Formula : C22H25NO5
Molecular Weight : 383.44
stdClass Object
(
[pname] => Sacubitril mixture with Valsartan
[catalogue_number] => PA 19 66600
[category_ids] => 82,80,79,78,75,71,70
[chemical_name] =>
[weight] => 847.01
[form] => C48H58N6O8
[cas] => 1360873-85-3
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Sacubitril mixture with Valsartan
Catalogue No.:PA 19 66600
Molecular Formula : C48H58N6O8
Molecular Weight : 847.01
stdClass Object
(
[pname] => Sacubitril Calcium
[catalogue_number] => PA 19 66610
[category_ids] => ,80,75,70,82,78,79,71,
[chemical_name] =>
[weight] => 430.52
[form] => C24H28NO5 ·0.5Ca
[cas] => 1369773-39-6
[pslug] => 1369773-39-6-sacubitril-calcium-pa1966610
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Catalogue No.:PA 19 66610
Molecular Formula : C24H28NO5 ·0.5Ca
Molecular Weight : 430.52
stdClass Object
(
[pname] => Sacubitril (3R,5S)-Pyrrolidinone Impurity
[catalogue_number] => PA 19 66620
[category_ids] => 82,80,79,78,75,70
[chemical_name] =>
[weight] => 265.35
[form] => C18H19NO
[cas] => 1038924-70-7
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Sacubitril (3R,5S)-Pyrrolidinone Impurity
Catalogue No.:PA 19 66620
Molecular Formula : C18H19NO
Molecular Weight : 265.35
stdClass Object
(
[pname] => (R,E)-5-([1,1-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic Acid
[catalogue_number] => PA 19 66630
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[chemical_name] =>
[weight] => 379.5
[form] => C24H29NO3
[cas] => 1012341-48-8
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(R,E)-5-([1,1-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic Acid
stdClass Object
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[chemical_name] =>
[weight] => 409.53
[form] => C25H31NO4
[cas] => 1817838-91-7
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(R,E)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate
Catalogue No.:PA 19 66640
Molecular Formula : C25H31NO4
Molecular Weight : 409.53
stdClass Object
(
[pname] => Methyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate Hydrochloride
[catalogue_number] => PA 19 66650
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[weight] => 333.86
[form] => C19H24ClNO2
[cas] => 1933501-50-8
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Methyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate Hydrochloride
Catalogue No.:PA 19 66650
Molecular Formula : C19H24ClNO2
Molecular Weight : 333.86
stdClass Object
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[form] => C20H26ClNO2
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(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride
Catalogue No.:PA 19 66660
Molecular Formula : C20H26ClNO2
Molecular Weight : 347.88
stdClass Object
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Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoate
Catalogue No.:PA 19 66670
Molecular Formula : C25H33NO4
Molecular Weight : 411.54
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[weight] => 319.83
[form] => C18H22ClNO2
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(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-amino-2-methylpentanoic Acid Hydrochloride
Catalogue No.:PA 19 66680
Molecular Formula : C18H22ClNO2
Molecular Weight : 319.83
stdClass Object
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[catalogue_number] => PA 19 66690
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[chemical_name] =>
[weight] => 353.46
[form] => C22H27NO3
[cas] => NA
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Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-acetamido-2-methylpentanoate
Catalogue No.:PA 19 66690
Molecular Formula : C22H27NO3
Molecular Weight : 353.46
stdClass Object
(
[pname] => 2,5-Dioxopyrrolidine Sacubitril
[catalogue_number] => PA 19 66700
[category_ids] => ,80,75,70,82,78,79,
[chemical_name] =>
[weight] => 393.48
[form] => C24H27NO4
[cas] => 1038924-97-8
[pslug] => 1038924-97-8-2-5-dioxopyrrolidine-sacubitril-pa1966700
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2,5-Dioxopyrrolidine Sacubitril
Catalogue No.:PA 19 66700
Molecular Formula : C24H27NO4
Molecular Weight : 393.48
stdClass Object
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[pname] => ((R)-2-Biphenyl-4-yl-1-formylethyl)carbamic Acid t-butyl Ester
[catalogue_number] => PA 19 66710
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[weight] => 325.41
[form] => C20H23NO3
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((R)-2-Biphenyl-4-yl-1-formylethyl)carbamic Acid t-butyl Ester
Catalogue No.:PA 19 66710
Molecular Formula : C20H23NO3
Molecular Weight : 325.41
stdClass Object
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[catalogue_number] => PA 19 66720
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[weight] => 327.42
[form] => C20H25NO3
[cas] => 1426129-50-1
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(R)-tert-Butyl (1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
Catalogue No.:PA 19 66720
Molecular Formula : C20H25NO3
Molecular Weight : 327.42
stdClass Object
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[pname] => Ethyl (R)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate
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[weight] => 409.53
[form] => C25H31NO4
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Ethyl (R)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate
Catalogue No.:PA 19 0661046
Molecular Formula : C25H31NO4
Molecular Weight : 409.53
stdClass Object
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[weight] => 409.53
[form] => C25H31NO4
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Ethyl (S,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate
Catalogue No.:PA 19 0661056
Molecular Formula : C25H31NO4
Molecular Weight : 409.53
stdClass Object
(
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[catalogue_number] => PA 19 0661062
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[chemical_name] =>
[weight] => 412.44
[form] => C22H24N2O6
[cas] => NA
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(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-(3-carboxy-N-nitrosopropanamido)-2-methylpentanoic Acid
Catalogue No.:PA 19 0661062
Molecular Formula : C22H24N2O6
Molecular Weight : 412.44
stdClass Object
(
[pname] => (2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)(nitroso)amino)-2-methylpentanoic Acid
[catalogue_number] => PA 19 0661063
[category_ids] => ,70,75,78,79,80,82,162,
[chemical_name] =>
[weight] => 412.49
[form] => C23H28N2O5
[cas] => NA
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(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)(nitroso)amino)-2-methylpentanoic Acid
Catalogue No.:PA 19 0661063
Molecular Formula : C23H28N2O5
Molecular Weight : 412.49
stdClass Object
(
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[catalogue_number] => PA 19 0661067
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[weight] => 327.42
[form] => C20H25NO3
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tert-Butyl (1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
Catalogue No.:PA 19 0661067
Molecular Formula : C20H25NO3
Molecular Weight : 327.42
stdClass Object
(
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[catalogue_number] => PA 19 0661068
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[weight] => 411.54
[form] => C25H33NO4
[cas] => NA
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Ethyl (2S,4R)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoate
Catalogue No.:PA 19 0661068
Molecular Formula : C25H33NO4
Molecular Weight : 411.54
stdClass Object
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Ethyl (2R,4R)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoate
Catalogue No.:PA 19 0661069
Molecular Formula : C25H33NO4
Molecular Weight : 411.54
stdClass Object
(
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[catalogue_number] => PA 19 0661070
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[weight] => 325.41
[form] => C20H23NO3
[cas] => 182192-86-5
[pslug] => 182192-86-5-tert-butyl-s-1-1-1-biphenyl-4-yl-3-oxopropan-2-yl-carbamate-pa190661070
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)
tert-Butyl (S)-(1-([1,1'-biphenyl]-4-yl)-3-oxopropan-2-yl)carbamate
Catalogue No.:PA 19 0661070
Molecular Formula : C20H23NO3
Molecular Weight : 325.41
