Sofosbuvir-impurities | Pharmaffiliates

sofosbuvir

A recently approved nucleotide analog used in the treatment of hepatitis. Sofosbuvir works by inhibiting the hepatitis C NS5B protein. It is a a prodrug of its active antiviral agent GS-461203 Reference standards of Sofosbuvir API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

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(
    [pname] => Sofosbuvir - API Standards 
    [catalogue_number] => PA 19 51000
    [category_ids] => ,80,77,79,71,98,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 529.45
    [form] => C22H29FN3O9P
    [cas] => 1190307-88-0
    [pslug] => 1190307-88-0-sofosbuvir-api-pa1951000
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PA 19 51000

Sofosbuvir - API Standards


  • Catalogue No.:PA 19 51000

  • CAS :

    1190307-88-0

  • Molecular Formula : C22H29FN3O9P

  • Molecular Weight : 529.45

stdClass Object
(
    [pname] => Sofosbuvir Nucleoside Derivative
    [catalogue_number] => PA 19 51510
    [category_ids] => ,69,70,75,76,78,79,82,
    [chemical_name] => 
    [weight] => 260.22
    [form] => C10H13FN2O5
    [cas] => 863329-66-2
    [pslug] => 863329-66-2-sofosbuvir-nucleoside-derivative-pa1951510
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PA 19 51510

Sofosbuvir Nucleoside Derivative


  • Catalogue No.:PA 19 51510

  • CAS :

    863329-66-2

  • Molecular Formula : C10H13FN2O5

  • Molecular Weight : 260.22

stdClass Object
(
    [pname] => Sofosbuvir Metabolite GS-566500
    [catalogue_number] => PA 19 51520
    [category_ids] => ,80,77,79,71,98,76,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 411.28
    [form] => C13H19FN3O9P
    [cas] => 1233335-78-8
    [pslug] => 1233335-78-8-sofosbuvir-metabolite-gs-566500-pa1951520
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PA 19 51520

Sofosbuvir Metabolite GS-566500


  • Catalogue No.:PA 19 51520

  • CAS :

    1233335-78-8

  • Molecular Formula : C13H19FN3O9P

  • Molecular Weight : 411.28

stdClass Object
(
    [pname] => ((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methyl dihydrogen Phosphate
    [catalogue_number] => PA 19 51530
    [category_ids] => 85,83,82,80,79,78,77,76,71,70
    [chemical_name] => 
    [weight] => 340.2
    [form] => C10H14FN2O8P
    [cas] => 1015073-43-4
    [pslug] => 1015073-43-4-2r-3r-4r-5r-5-2-4-dioxo-3-4-dihydropyrimidin-1-2h-yl-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl-methyl-dihydrogen-phosphate-pa1951530
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PA 19 51530

((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methyl dihydrogen Phosphate


  • Catalogue No.:PA 19 51530

  • CAS :

    1015073-43-4

  • Molecular Formula : C10H14FN2O8P

  • Molecular Weight : 340.2

stdClass Object
(
    [pname] => N-(2-((Trimethylsilyl)oxy)pyrimidin-4-yl)benzamide
    [catalogue_number] => PA 19 51550
    [category_ids] => ,80,79,71,76,78,70,82,
    [chemical_name] => 
    [weight] => 287.39
    [form] => C14H17N3O2Si
    [cas] => 85743-99-3
    [pslug] => 85743-99-3-n-2-trimethylsilyl-oxy-pyrimidin-4-yl-benzamide-pa1951550
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PA 19 51550

N-(2-((Trimethylsilyl)oxy)pyrimidin-4-yl)benzamide


  • Catalogue No.:PA 19 51550

  • CAS :

    85743-99-3

  • Molecular Formula : C14H17N3O2Si

  • Molecular Weight : 287.39

stdClass Object
(
    [pname] => 1-((2R,3R,4R,5R)-3-Chloro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
    [catalogue_number] => PA 19 51660
    [category_ids] => ,77,79,71,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 276.67
    [form] => C10H13ClN2O5
    [cas] => 1496551-72-4
    [pslug] => 1496551-72-4-1-2r-3r-4r-5r-3-chloro-4-hydroxy-5-hydroxymethyl-3-methyltetrahydrofuran-2-yl-pyrimidine-2-4-1h-3h-dione-pa1951660
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PA 19 51660

1-((2R,3R,4R,5R)-3-Chloro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione


  • Catalogue No.:PA 19 51660

  • CAS :

    1496551-72-4

  • Molecular Formula : C10H13ClN2O5

  • Molecular Weight : 276.67

stdClass Object
(
    [pname] => (1R,2S)-1-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-3-ethoxy-2-fluoro-2-methyl-3-oxopropyl Sulfate
    [catalogue_number] => PA 19 51670
    [category_ids] => ,77,79,71,85,78,70,82,88,
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    [weight] => 330.33
    [form] => C11H19FO8S
    [cas] => 2053891-28-2
    [pslug] => 2053891-28-2-1r-2s-1-r-2-2-dimethyl-1-3-dioxolan-4-yl-3-ethoxy-2-fluoro-2-methyl-3-oxopropyl-sulfate-pa1951670
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PA 19 51670

(1R,2S)-1-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-3-ethoxy-2-fluoro-2-methyl-3-oxopropyl Sulfate


  • Catalogue No.:PA 19 51670

  • CAS :

    2053891-28-2

  • Molecular Formula : C11H19FO8S

  • Molecular Weight : 330.33

stdClass Object
(
    [pname] => (4S,5R)-Ethyl 5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-methyl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide
    [catalogue_number] => PA 19 51680
    [category_ids] => ,77,79,71,85,78,70,82,88,
    [chemical_name] => 
    [weight] => 310.32
    [form] => C11H18O8S
    [cas] => 879551-01-6
    [pslug] => 879551-01-6-4s-5r-ethyl-5-r-2-2-dimethyl-1-3-dioxolan-4-yl-4-methyl-1-3-2-dioxathiolane-4-carboxylate-2-2-dioxide-pa1951680
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PA 19 51680

(4S,5R)-Ethyl 5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-methyl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide


  • Catalogue No.:PA 19 51680

  • CAS :

    879551-01-6

  • Molecular Formula : C11H18O8S

  • Molecular Weight : 310.32

stdClass Object
(
    [pname] => (2S,3R)-Ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,3-dihydroxy-2-methylpropanoate
    [catalogue_number] => PA 19 51690
    [category_ids] => ,77,79,71,85,78,70,82,
    [chemical_name] => 
    [weight] => 248.27
    [form] => C11H20O6
    [cas] => 93635-76-8
    [pslug] => 93635-76-8-2s-3r-ethyl-3-r-2-2-dimethyl-1-3-dioxolan-4-yl-2-3-dihydroxy-2-methylpropanoate-pa1951690
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PA 19 51690

(2S,3R)-Ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,3-dihydroxy-2-methylpropanoate


  • Catalogue No.:PA 19 51690

  • CAS :

    93635-76-8

  • Molecular Formula : C11H20O6

  • Molecular Weight : 248.27

stdClass Object
(
    [pname] => (S,E)-Ethyl 3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylacrylate
    [catalogue_number] => PA 19 51700
    [category_ids] => ,77,79,71,85,78,70,82,
    [chemical_name] => 
    [weight] => 214.26
    [form] => C11H18O4
    [cas] => 81997-76-4
    [pslug] => 81997-76-4-s-e-ethyl-3-2-2-dimethyl-1-3-dioxolan-4-yl-2-methylacrylate-pa1951700
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PA 19 51700

(S,E)-Ethyl 3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylacrylate


  • Catalogue No.:PA 19 51700

  • CAS :

    81997-76-4

  • Molecular Formula : C11H18O4

  • Molecular Weight : 214.26

stdClass Object
(
    [pname] => (R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde
    [catalogue_number] => PA 19 51710
    [category_ids] => ,77,79,71,85,78,70,82,
    [chemical_name] => 
    [weight] => 130.14
    [form] => C6H10O3
    [cas] => 15186-48-8
    [pslug] => 15186-48-8-r-2-2-dimethyl-1-3-dioxolane-4-carbaldehyde-pa1951710
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PA 19 51710

(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde


  • Catalogue No.:PA 19 51710

  • CAS :

    15186-48-8

  • Molecular Formula : C6H10O3

  • Molecular Weight : 130.14

stdClass Object
(
    [pname] => Chloro Sofosbuvir
    [catalogue_number] => PA 19 51820
    [category_ids] => ,79,80,71,76,75,85,83,78,70,82,72,
    [chemical_name] => 
    [weight] => 545.91
    [form] => C22H29ClN3O9P
    [cas] => 1496552-51-2
    [pslug] => 1496552-51-2-chloro-sofosbuvir-pa1951820
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PA 19 51820

Chloro Sofosbuvir


  • Catalogue No.:PA 19 51820

  • CAS :

    1496552-51-2

  • Molecular Formula : C22H29ClN3O9P

  • Molecular Weight : 545.91

stdClass Object
(
    [pname] => (S)-Ethyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate;
    [catalogue_number] => PA 19 51900
    [category_ids] => ,80,79,75,78,70,82,
    [chemical_name] => 
    [weight] => 515.43
    [form] => C21H27FN3O9P
    [cas] => 2164516-85-0
    [pslug] => 2164516-85-0-s-ethyl-2-s-2r-3r-4r-5r-5-2-4-dioxo-3-4-dihydropyrimidin-1-2h-yl-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl-methoxy-phenoxy-phosphoryl-amino-propanoate-pa1951900
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PA 19 51900

(S)-Ethyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate;


  • Catalogue No.:PA 19 51900

  • CAS :

    2164516-85-0

  • Molecular Formula : C21H27FN3O9P

  • Molecular Weight : 515.43

stdClass Object
(
    [pname] => Methyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
    [catalogue_number] => PA 19 0511016
    [category_ids] => ,79,71,78,70,82,
    [chemical_name] => 
    [weight] => 501.4
    [form] => C20H25FN3O9P
    [cas] => 1394157-34-6
    [pslug] => 1394157-34-6-methyl-s-2r-3r-4r-5r-5-2-4-dioxo-3-4-dihydropyrimidin-1-2h-yl-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl-methoxy-phenoxy-phosphoryl-l-alaninate-pa190511016
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PA 19 0511016

Methyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate


  • Catalogue No.:PA 19 0511016

  • CAS :

    1394157-34-6

  • Molecular Formula : C20H25FN3O9P

  • Molecular Weight : 501.4

stdClass Object
(
    [pname] => Isopropyl ((((3S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-D-alaninate
    [catalogue_number] => PA 19 0511018
    [category_ids] => ,80,77,79,71,98,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 529.46
    [form] => C22H29FN3O9P
    [cas] => 2766447-19-0
    [pslug] => 2766447-19-0-isopropyl-3s-5-2-4-dioxo-3-4-dihydropyrimidin-1-2h-yl-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl-methoxy-phenoxy-phosphoryl-d-alaninate-pa190511018
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PA 19 0511018

Isopropyl ((((3S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-D-alaninate


  • Catalogue No.:PA 19 0511018

  • CAS :

    2766447-19-0

  • Molecular Formula : C22H29FN3O9P

  • Molecular Weight : 529.46

stdClass Object
(
    [pname] => Isopropyl ((S)-(((2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
    [catalogue_number] => PA 19 0511019
    [category_ids] => ,80,77,79,71,98,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 528.47
    [form] => C22H30FN4O8P
    [cas] => 1334513-10-8
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PA 19 0511019

Isopropyl ((S)-(((2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate


  • Catalogue No.:PA 19 0511019

  • CAS :

    1334513-10-8

  • Molecular Formula : C22H30FN4O8P

  • Molecular Weight : 528.47

stdClass Object
(
    [pname] => Isopropyl ((S)-((S)-1-((2S,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)ethoxy)(phenoxy)phosphoryl)-L-alaninate
    [catalogue_number] => PA 19 0511020
    [category_ids] => ,80,77,79,71,98,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 541.49
    [form] => C23H32N3O10P
    [cas] => 2500766-09-4
    [pslug] => 2500766-09-4-isopropyl-s-s-1-2s-3r-4r-5r-5-2-4-dioxo-3-4-dihydropyrimidin-1-2h-yl-3-4-dihydroxy-4-methyltetrahydrofuran-2-yl-ethoxy-phenoxy-phosphoryl-l-alaninate-pa190511020
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)
PA 19 0511020

Isopropyl ((S)-((S)-1-((2S,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)ethoxy)(phenoxy)phosphoryl)-L-alaninate


  • Catalogue No.:PA 19 0511020

  • CAS :

    2500766-09-4

  • Molecular Formula : C23H32N3O10P

  • Molecular Weight : 541.49