sacubitril
An antihypertensive drug, Sacubitril is used in combination with valsartan for the treatment of heart ailments. A prodrug of sacubitrilat which is an inhibitor of enzyme neprilysin, which aids the degradation of blood pressure-lowering peptides, atrial and brain natriuretic peptide.Reference standards of Sacubitril API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
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Sacubitril - API Standards
Catalogue No.:PA 19 66000
Molecular Formula : C24H29NO5
Molecular Weight : 411.49
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[pname] => (2R,4S)-2-Methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-(4-phenylphenyl)pentanoic Acid
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(2R,4S)-2-Methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-(4-phenylphenyl)pentanoic Acid
Catalogue No.:PA 19 66520
Molecular Formula : C23H29NO4
Molecular Weight : 383.48
stdClass Object
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[pname] => Sacubitrilat
[catalogue_number] => PA 19 66580
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[chemical_name] =>
[weight] => 383.44
[form] => C22H25NO5
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Catalogue No.:PA 19 66580
Molecular Formula : C22H25NO5
Molecular Weight : 383.44
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[weight] => 430.52
[form] => C24H28NO5 ·0.5Ca
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Sacubitril Calcium - API Standards
Catalogue No.:PA 19 66610
Molecular Formula : C24H28NO5 ·0.5Ca
Molecular Weight : 430.52
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[catalogue_number] => PA 19 66620
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[weight] => 265.35
[form] => C18H19NO
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Sacubitril (3R,5S)-Pyrrolidinone Impurity
Catalogue No.:PA 19 66620
Molecular Formula : C18H19NO
Molecular Weight : 265.35
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[weight] => 347.88
[form] => C20H26ClNO2
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(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride
Catalogue No.:PA 19 66660
Molecular Formula : C20H26ClNO2
Molecular Weight : 347.88
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Catalogue No.:PA 19 66510
Molecular Formula : C24H29NO5
Molecular Weight : 411.49
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(2S,4R)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic Acid
Catalogue No.:PA 19 66530
Molecular Formula : C23H29NO4
Molecular Weight : 383.48
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(2S,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic Acid
Catalogue No.:PA 19 66540
Molecular Formula : C23H29NO4
Molecular Weight : 383.48
stdClass Object
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(αR,γR)-γ-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic Acid
Catalogue No.:PA 19 66550
Molecular Formula : C23H29NO4
Molecular Weight : 383.48
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[pname] => (2S,4S)-Sacubitril
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Catalogue No.:PA 19 66560
Molecular Formula : C24H29NO5
Molecular Weight : 411.49
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Catalogue No.:PA 19 66570
Molecular Formula : C24H29NO5
Molecular Weight : 411.49
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(R,E)-5-([1,1'-Biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpent-2-enoic Acid
Catalogue No.:PA 19 66590
Molecular Formula : C22H23NO5
Molecular Weight : 381.42
stdClass Object
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(R,E)-5-([1,1-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic Acid
stdClass Object
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[weight] => 333.86
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Methyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate Hydrochloride
Catalogue No.:PA 19 66650
Molecular Formula : C19H24ClNO2
Molecular Weight : 333.86
stdClass Object
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[form] => C25H33NO4
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Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoate
Catalogue No.:PA 19 66670
Molecular Formula : C25H33NO4
Molecular Weight : 411.54
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(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-amino-2-methylpentanoic Acid Hydrochloride
Catalogue No.:PA 19 66680
Molecular Formula : C18H22ClNO2
Molecular Weight : 319.83
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[weight] => 353.46
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Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-acetamido-2-methylpentanoate
Catalogue No.:PA 19 66690
Molecular Formula : C22H27NO3
Molecular Weight : 353.46
stdClass Object
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[weight] => 393.48
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2,5-Dioxopyrrolidine Sacubitril
Catalogue No.:PA 19 66700
Molecular Formula : C24H27NO4
Molecular Weight : 393.48
stdClass Object
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((R)-2-Biphenyl-4-yl-1-formylethyl)carbamic Acid t-butyl Ester
Catalogue No.:PA 19 66710
Molecular Formula : C20H23NO3
Molecular Weight : 325.41
stdClass Object
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[weight] => 327.42
[form] => C20H25NO3
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(R)-tert-Butyl (1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
Catalogue No.:PA 19 66720
Molecular Formula : C20H25NO3
Molecular Weight : 327.42
stdClass Object
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4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-methoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic Acid
Catalogue No.:PA 19 66730
Molecular Formula : C23H27NO5
Molecular Weight : 397.47
stdClass Object
(
[pname] => 4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-4-methyl-5-oxo-5-propoxypentan-2-yl)amino)-4-oxobutanoic Acid
[catalogue_number] => PA 19 66740
[category_ids] => 75,70,78,80,82
[chemical_name] =>
[weight] => 425.53
[form] => C25H31NO5
[cas] => 2751722-76-4
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4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-4-methyl-5-oxo-5-propoxypentan-2-yl)amino)-4-oxobutanoic Acid
Catalogue No.:PA 19 66740
Molecular Formula : C25H31NO5
Molecular Weight : 425.53
stdClass Object
(
[pname] => rel.4-(((2R,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic Acid
[catalogue_number] => PA 19 0661034
[category_ids] => ,82,80,78,75,70,
[chemical_name] =>
[weight] => 411.5
[form] => C24H29NO5
[cas] => 766480-48-2
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rel.4-(((2R,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic Acid
stdClass Object
(
[pname] => Sacubitril Lactam
[catalogue_number] => PA 19 0661035
[category_ids] => ,80,75,70,82,78,
[chemical_name] =>
[weight] => 265.36
[form] => C18H19NO
[cas] => 1038925-22-2
[pslug] => 1038925-22-2-sacubitril-lactam-pa190661035
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Catalogue No.:PA 19 0661035
Molecular Formula : C18H19NO
Molecular Weight : 265.36
stdClass Object
(
[pname] => N-Nitroso Sacubitril
[catalogue_number] => PA 19 0661036
[category_ids] => ,70,75,78,80,82,162,
[chemical_name] =>
[weight] => 440.5
[form] => C24H28N2O6
[cas] => NA
[pslug] => n-nitroso-sacubitril-pa190661036
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stdClass Object
(
[pname] => (2Z,4R)-5-[1,1′-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic Acid
[catalogue_number] => PA 19 0661045
[category_ids] => ,80,75,70,82,78,
[chemical_name] =>
[weight] => 381.47
[form] => C23H27NO4
[cas] => 1361408-16-3
[pslug] => 1361408-16-3-2z-4r-5-1-1-biphenyl-4-yl-4-1-1-dimethylethoxy-carbonyl-amino-2-methyl-2-pentenoic-acid-pa190661045
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(2Z,4R)-5-[1,1′-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic Acid
Catalogue No.:PA 19 0661045
Molecular Formula : C23H27NO4
Molecular Weight : 381.47
stdClass Object
(
[pname] => Ethyl (R)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate
[catalogue_number] => PA 19 0661046
[category_ids] => ,80,79,70,82,78,75,
[chemical_name] =>
[weight] => 409.53
[form] => C25H31NO4
[cas] => 149709-59-1
[pslug] => 149709-59-1-ethyl-r-5-1-1-biphenyl-4-yl-4-tert-butoxycarbonyl-amino-2-methylpent-2-enoate-pa190661046
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Ethyl (R)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate
Catalogue No.:PA 19 0661046
Molecular Formula : C25H31NO4
Molecular Weight : 409.53
stdClass Object
(
[pname] => Methyl (R)-3-([1,1'-biphenyl]-4-yl)-2-acetamidopropanoate
[catalogue_number] => PA 19 0661047
[category_ids] => ,80,75,70,82,78,
[chemical_name] =>
[weight] => 297.35
[form] => C18H19NO3
[cas] => 164460-67-7
[pslug] => 164460-67-7-methyl-r-3-1-1-biphenyl-4-yl-2-acetamidopropanoate-pa190661047
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Methyl (R)-3-([1,1'-biphenyl]-4-yl)-2-acetamidopropanoate
Catalogue No.:PA 19 0661047
Molecular Formula : C18H19NO3
Molecular Weight : 297.35
stdClass Object
(
[pname] => Methyl (R)-3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoate
[catalogue_number] => PA 19 0661048
[category_ids] => ,80,75,70,82,78,
[chemical_name] =>
[weight] => 355.43
[form] => C21H25NO4
[cas] => 149818-98-4
[pslug] => 149818-98-4-methyl-r-3-1-1-biphenyl-4-yl-2-tert-butoxycarbonyl-amino-propanoate-pa190661048
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Methyl (R)-3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoate
Catalogue No.:PA 19 0661048
Molecular Formula : C21H25NO4
Molecular Weight : 355.43
stdClass Object
(
[pname] => tert-Butyl (R)-(3-([1,1'-biphenyl]-4-yl)-1-hydrazinyl-1-oxopropan-2-yl)carbamate
[catalogue_number] => PA 19 0661049
[category_ids] => ,80,75,70,82,78,
[chemical_name] =>
[weight] => 355.44
[form] => C20H25N3O3
[cas] => 919528-68-0
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tert-Butyl (R)-(3-([1,1'-biphenyl]-4-yl)-1-hydrazinyl-1-oxopropan-2-yl)carbamate
Catalogue No.:PA 19 0661049
Molecular Formula : C20H25N3O3
Molecular Weight : 355.44
stdClass Object
(
[pname] => Boc-D-4,4'-biphenylalanine
[catalogue_number] => PA 19 0661050
[category_ids] => ,80,75,70,82,78,
[chemical_name] =>
[weight] => 341.41
[form] => C20H23NO4
[cas] => 128779-47-5
[pslug] => 128779-47-5-boc-d-4-4-biphenylalanine-pa190661050
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Boc-D-4,4'-biphenylalanine
Catalogue No.:PA 19 0661050
Molecular Formula : C20H23NO4
Molecular Weight : 341.41
stdClass Object
(
[pname] => (1-Ethoxy-1-oxopropan-2-yl)triphenylphosphonium Bromide
[catalogue_number] => PA 19 0661051
[category_ids] => ,80,75,70,82,78,
[chemical_name] =>
[weight] => 443.32
[form] => C23H24BrO2P
[cas] => 30018-16-7
[pslug] => 30018-16-7-1-ethoxy-1-oxopropan-2-yl-triphenylphosphonium-bromide-pa190661051
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(1-Ethoxy-1-oxopropan-2-yl)triphenylphosphonium Bromide
Catalogue No.:PA 19 0661051
Molecular Formula : C23H24BrO2P
Molecular Weight : 443.32
stdClass Object
(
[pname] => rel-Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-acetamido-2-methylpentanoate
[catalogue_number] => PA 19 0661052
[category_ids] => ,80,75,70,82,78,
[chemical_name] =>
[weight] => 353.46
[form] => C22H27NO3
[cas] => 2806120-13-6
[pslug] => 2806120-13-6-rel-ethyl-2r-4s-5-1-1-biphenyl-4-yl-4-acetamido-2-methylpentanoate-pa190661052
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rel-Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-acetamido-2-methylpentanoate
Catalogue No.:PA 19 0661052
Molecular Formula : C22H27NO3
Molecular Weight : 353.46
stdClass Object
(
[pname] => 5-([1,1'-Biphenyl]-4-ylmethyl)-3-methyl-1-nitrosopyrrolidin-2-one
[catalogue_number] => PA 19 0661055
[category_ids] => ,70,75,78,80,82,162,
[chemical_name] =>
[weight] => 294.35
[form] => C18H18N2O2
[cas] => NA
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5-([1,1'-Biphenyl]-4-ylmethyl)-3-methyl-1-nitrosopyrrolidin-2-one
Catalogue No.:PA 19 0661055
Molecular Formula : C18H18N2O2
Molecular Weight : 294.35
stdClass Object
(
[pname] => 5-([1,1'-Biphenyl]-4-ylmethyl)-3-methylpyrrolidin-2-one
[catalogue_number] => PA 19 0661053
[category_ids] => ,80,71,78,82,
[chemical_name] =>
[weight] => 265.36
[form] => C18H19NO
[cas] => 2101222-42-6
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5-([1,1'-Biphenyl]-4-ylmethyl)-3-methylpyrrolidin-2-one
Catalogue No.:PA 19 0661053
Molecular Formula : C18H19NO
Molecular Weight : 265.36
stdClass Object
(
[pname] => Methyl (Z)-3-([1,1'-biphenyl]-4-yl)-2-acetamidoacrylate
[catalogue_number] => PA 19 0661054
[category_ids] => ,80,75,70,82,78,
[chemical_name] =>
[weight] => 295.34
[form] => C18H17NO3
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Methyl (Z)-3-([1,1'-biphenyl]-4-yl)-2-acetamidoacrylate
Catalogue No.:PA 19 0661054
Molecular Formula : C18H17NO3
Molecular Weight : 295.34
stdClass Object
(
[pname] => Ethyl (S,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate
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[category_ids] => ,80,79,70,82,78,75,
[chemical_name] =>
[weight] => 409.53
[form] => C25H31NO4
[cas] => 2131788-25-3
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Ethyl (S,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate
Catalogue No.:PA 19 0661056
Molecular Formula : C25H31NO4
Molecular Weight : 409.53
stdClass Object
(
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[catalogue_number] => PA 19 0661057
[category_ids] => ,80,75,70,82,78,
[chemical_name] =>
[weight] => 227.31
[form] => C15H17NO
[cas] => 1426129-52-3
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(R)-3-([1,1'-Biphenyl]-4-yl)-2-aminopropan-1-ol
Catalogue No.:PA 19 0661057
Molecular Formula : C15H17NO
Molecular Weight : 227.31
stdClass Object
(
[pname] => Calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-methoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
[catalogue_number] => PA 19 0661058
[category_ids] => ,82,80,78,75,70,
[chemical_name] =>
[weight] => 835.02
[form] => C46H54CaN2O10
[cas] => 2751722-74-2
[pslug] => 2751722-74-2-calcium-4-2s-4r-1-1-1-biphenyl-4-yl-5-methoxy-4-methyl-5-oxopentan-2-yl-amino-4-oxobutanoate-pa190661058
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Calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-methoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
Catalogue No.:PA 19 0661058
Molecular Formula : C46H54CaN2O10
Molecular Weight : 835.02
stdClass Object
(
[pname] => Methyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoate
[catalogue_number] => PA 19 0661059
[category_ids] => ,80,75,70,82,78,
[chemical_name] =>
[weight] => 379.46
[form] => C23H25NO4
[cas] => NA
[pslug] => methyl-2r-4s-5-1-1-biphenyl-4-yl-4-2-5-dioxopyrrolidin-1-yl-2-methylpentanoate-pa190661059
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Methyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoate
Catalogue No.:PA 19 0661059
Molecular Formula : C23H25NO4
Molecular Weight : 379.46
stdClass Object
(
[pname] => Propyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoate
[catalogue_number] => PA 19 0661060
[category_ids] => ,80,75,70,82,78,
[chemical_name] =>
[weight] => 407.51
[form] => C25H29NO4
[cas] => NA
[pslug] => propyl-2r-4s-5-1-1-biphenyl-4-yl-4-2-5-dioxopyrrolidin-1-yl-2-methylpentanoate-pa190661060
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Propyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoate
Catalogue No.:PA 19 0661060
Molecular Formula : C25H29NO4
Molecular Weight : 407.51
stdClass Object
(
[pname] => 2-Methylpropan-2-aminium 4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
[catalogue_number] => PA 19 0661061
[category_ids] => ,70,75,78,80,82,
[chemical_name] =>
[weight] => 484.64
[form] => C28H40N2O5
[cas] => NA
[pslug] => 2-methylpropan-2-aminium-4-2r-4s-1-1-1-biphenyl-4-yl-5-ethoxy-4-methyl-5-oxopentan-2-yl-amino-4-oxobutanoate-pa190661061
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2-Methylpropan-2-aminium 4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
Catalogue No.:PA 19 0661061
Molecular Formula : C28H40N2O5
Molecular Weight : 484.64