everolimus
Everolimus is currently used as an immunosuppressant to prevent rejection of organ transplants. It is a derivative of Rapamycin, and works similarly to Rapamycin as an mTOR inhibitor. Reference standards of Everolimus API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
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[pname] => Everolimus
[catalogue_number] => PA 05 73000
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[weight] => 958.22
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Catalogue No.:PA 05 73000
Molecular Formula : C53H83NO14
Molecular Weight : 958.22
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[pname] => Desmethyl Everolimus
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[pname] => (2S)-1-[[(2R,3R,6S)-6-[(2S,3E,5E,7E,9S,11R)-2,13-Dimethoxy-3,9,11-trimethyl-12-oxo-3,5,7-tridecatrienyl]tetrahydro-2-hydroxy-3-methyl-2H-pyran-2-yl]oxoacetyl]-2-piperidinecarboxylic Acid
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(2S)-1-[[(2R,3R,6S)-6-[(2S,3E,5E,7E,9S,11R)-2,13-Dimethoxy-3,9,11-trimethyl-12-oxo-3,5,7-tridecatrienyl]tetrahydro-2-hydroxy-3-methyl-2H-pyran-2-yl]oxoacetyl]-2-piperidinecarboxylic Acid
Catalogue No.:PA 05 73550
Molecular Formula : C32H49NO9
Molecular Weight : 591.73
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(S)-(2R,3S,6R,E)-1-((1S,3R,4R)-4-(2-Hydroxyethoxy)-3-methoxycyclohexyl)-2,6,8-trimethyl-5,9-dioxonon-7-en-3-yl 1-(2-((2R,3R,6S)-6-((2S,3E,5E,7E,9S,11R)-2,13-dimethoxy-3,9,11-trimethyl-12-oxotrideca-3,5,7-trien-1-yl)-2-hydroxy-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylate
Catalogue No.:PA 05 73580
Molecular Formula : C53H83NO14
Molecular Weight : 958.22
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1-(2-((2R,6S)-2-Hydroxy-6-((2R,3E,5E,7E,9R,11S,14R,15E,17S,19E,22R)-14-hydroxy-22-((1S,3R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxotricosa-3,5,7,15,19-pentaen-1-yl)tetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylic Acid
Catalogue No.:PA 05 73590
Molecular Formula : C53H83NO14
Molecular Weight : 958.22
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Everolimus 28-Ethylhydroxy Impurity
Catalogue No.:PA 05 73600
Molecular Formula : C53H83NO14
Molecular Weight : 958.22
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(1R,9S,12S,15S,16E,18R,19R,21R,23S,24Z,26E,28E,30S,35R)-1-18-Dihydroxy-12{(1R)-2-[1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04.9]-hexatriaconta-16,24,26,28,-tetraene-2,3,10,14,20-pentanone
Catalogue No.:PA 05 73630
Molecular Formula : C53H83NO14
Molecular Weight : 958.22
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[weight] => 956.21
[form] => C53H81NO14
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(1R,9S,12S,15S,16E,18R,19R,21R,23S,24E,26E,28E,30S,35R)-1-Hydroxy-12{(1R)-2-[1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04.9]-hexatriaconta-16,24,26,28,-tetraene-2,3,10,14,18,20-Hexanone
Catalogue No.:PA 05 73640
Molecular Formula : C53H81NO14
Molecular Weight : 956.21
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[pname] => Everolimus O-Ethyl Impurity
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Everolimus O-Ethyl Impurity
Catalogue No.:PA 05 73650
Molecular Formula : C54H85NO14
Molecular Weight : 972.25
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[pname] => Everolimus 27-O-Desmethyl
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Everolimus 27-O-Desmethyl
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[pname] => Rapamycin, 7-O-demethyl-42-O-(2-hydroxyethyl)-, (7ξ)-
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Rapamycin, 7-O-demethyl-42-O-(2-hydroxyethyl)-, (7ξ)-
Catalogue No.:PA 05 0731004
Molecular Formula : C52H81NO14
Molecular Weight : 944.21
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[pname] => 16-Demethoxy-16(R)-ethoxyeverolimus
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16-Demethoxy-16(R)-ethoxyeverolimus
Catalogue No.:PA 05 0731005
Molecular Formula : C54H85NO14
Molecular Weight : 972.27
stdClass Object
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(3S,6R,7E,9R,10R,12R,14R,16E,18E,20E,23S,26R,27R,34aS)-15-Ethoxy-9,27-dihydroxy-3-((R)-1-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)propan-2-yl)-10-methoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,15,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1]oxa[4]azacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentaone
Catalogue No.:PA 05 0731006
Molecular Formula : C54H85NO14
Molecular Weight : 972.27
stdClass Object
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[pname] => Everolimus Impurity 1
[catalogue_number] => PA 05 0731007
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[weight] => 974.24
[form] => C53H83NO15
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Catalogue No.:PA 05 0731007
Molecular Formula : C53H83NO15
Molecular Weight : 974.24
stdClass Object
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[pname] => (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,21,27-Trihydroxy-3-((R)-1-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)propan-2-yl)-10-methoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1]oxa[4]azacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentaone
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(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,21,27-Trihydroxy-3-((R)-1-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)propan-2-yl)-10-methoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1]oxa[4]azacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentaone
Catalogue No.:PA 05 0731008
Molecular Formula : C52H81NO14
Molecular Weight : 944.21
stdClass Object
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[pname] => (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-21-Ethoxy-9,27-dihydroxy-3-((R)-1-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)propan-2-yl)-10-methoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1]oxa[4]azacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentaone
[catalogue_number] => PA 05 0731009
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[chemical_name] =>
[weight] => 972.27
[form] => C54H85NO14
[cas] => NA
[pslug] => 3s-6r-7e-9r-10r-12r-14s-15e-17e-19e-21s-23s-26r-27r-34as-21-ethoxy-9-27-dihydroxy-3-r-1-1s-3r-4r-4-2-hydroxyethoxy-3-methoxycyclohexyl-propan-2-yl-10-methoxy-6-8-12-14-20-26-hexamethyl-9-10-12-13-14-21-22-23-24-25-26-27-32-33-34-34a-hexadecahydro-3h-23-27-epoxypyrido-2-1-c-1-oxa-4-azacyclohentriacontine-1-5-11-28-29-4h-6h-31h-pentaone-pa050731009
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(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-21-Ethoxy-9,27-dihydroxy-3-((R)-1-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)propan-2-yl)-10-methoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1]oxa[4]azacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentaone
Catalogue No.:PA 05 0731009
Molecular Formula : C54H85NO14
Molecular Weight : 972.27
stdClass Object
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[pname] => (2R,3S,E)-1-((1S,3R,4R)-4-(2-Hydroxyethoxy)-3-methoxycyclohexyl)-2,6,8-trimethyl-5,9-dioxonon-7-en-3-yl (2S)-1-(2-((2R,3R)-6-((2S,3E,5E,7E,9S,11R)-2,13-dimethoxy-3,9,11-trimethyl-12-oxotrideca-3,5,7-trien-1-yl)-2-hydroxy-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylate
[catalogue_number] => PA 05 0731010
[category_ids] => ,81,78,70,82,
[chemical_name] =>
[weight] => 958.24
[form] => C53H83NO14
[cas] => NA
[pslug] => 2r-3s-e-1-1s-3r-4r-4-2-hydroxyethoxy-3-methoxycyclohexyl-2-6-8-trimethyl-5-9-dioxonon-7-en-3-yl-2s-1-2-2r-3r-6-2s-3e-5e-7e-9s-11r-2-13-dimethoxy-3-9-11-trimethyl-12-oxotrideca-3-5-7-trien-1-yl-2-hydroxy-3-methyltetrahydro-2h-pyran-2-yl-2-oxoacetyl-piperidine-2-carboxylate-pa050731010
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(2R,3S,E)-1-((1S,3R,4R)-4-(2-Hydroxyethoxy)-3-methoxycyclohexyl)-2,6,8-trimethyl-5,9-dioxonon-7-en-3-yl (2S)-1-(2-((2R,3R)-6-((2S,3E,5E,7E,9S,11R)-2,13-dimethoxy-3,9,11-trimethyl-12-oxotrideca-3,5,7-trien-1-yl)-2-hydroxy-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylate
Catalogue No.:PA 05 0731010
Molecular Formula : C53H83NO14
Molecular Weight : 958.24
stdClass Object
(
[pname] => (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,23S,26R,27R,34aS)-15-Ethoxy-9,27-dihydroxy-3-((R)-1-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)propan-2-yl)-10-methoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1]oxa[4]azacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentaone
[catalogue_number] => PA 05 0731011
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[weight] => 972.27
[form] => C54H85NO14
[cas] => NA
[pslug] => 3s-6r-7e-9r-10r-12r-14s-15e-17e-19e-23s-26r-27r-34as-15-ethoxy-9-27-dihydroxy-3-r-1-1s-3r-4r-4-2-hydroxyethoxy-3-methoxycyclohexyl-propan-2-yl-10-methoxy-6-8-12-14-20-26-hexamethyl-9-10-12-13-14-21-22-23-24-25-26-27-32-33-34-34a-hexadecahydro-3h-23-27-epoxypyrido-2-1-c-1-oxa-4-azacyclohentriacontine-1-5-11-28-29-4h-6h-31h-pentaone-pa050731011
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(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,23S,26R,27R,34aS)-15-Ethoxy-9,27-dihydroxy-3-((R)-1-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)propan-2-yl)-10-methoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1]oxa[4]azacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentaone
Catalogue No.:PA 05 0731011
Molecular Formula : C54H85NO14
Molecular Weight : 972.27
