Tezacaftor
Tezacaftor is used to treat cystic fibrosis in certain people. It is a drug that is sold as a fixed-dose combination with ivacaftor as Symdeko.Reference standards of Tezacaftor API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
stdClass Object
(
[pname] => Tezacaftor
[catalogue_number] => PA 47 98000
[category_ids] => ,80,79,78,70,82,89,
[chemical_name] =>
[weight] => 520.51
[form] => C26H27F3N2O6
[cas] => 1152311-62-0
[pslug] => 1152311-62-0-tezacaftor-api-pa4798000
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
Catalogue No.:PA 47 98000
Molecular Formula : C26H27F3N2O6
Molecular Weight : 520.51
stdClass Object
(
[pname] => 1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(8-fluoro-2-hydroxy-4-(hydroxymethyl)-1,1-dimethyl-1,2,4,5-tetrahydro-[1,4]oxazepino[4,5-a]indol-9-yl)cyclopropane-1-carboxamide
[catalogue_number] => PA 47 0981000
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 518.49
[form] => C26H25F3N2O6
[cas] => 1432657-04-9
[pslug] => 1432657-04-9-1-2-2-difluorobenzo-d-1-3-dioxol-5-yl-n-8-fluoro-2-hydroxy-4-hydroxymethyl-1-1-dimethyl-1-2-4-5-tetrahydro-1-4-oxazepino-4-5-a-indol-9-yl-cyclopropane-1-carboxamide-pa470981000
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(8-fluoro-2-hydroxy-4-(hydroxymethyl)-1,1-dimethyl-1,2,4,5-tetrahydro-[1,4]oxazepino[4,5-a]indol-9-yl)cyclopropane-1-carboxamide
Catalogue No.:PA 47 0981000
Molecular Formula : C26H25F3N2O6
Molecular Weight : 518.49
stdClass Object
(
[pname] => (R)-1-(5-Amino-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-1-yl)-3-(benzyloxy)propan-2-ol
[catalogue_number] => PA 47 0981001
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 476.59
[form] => C29H33FN2O3
[cas] => 1294504-67-8
[pslug] => 1294504-67-8-r-1-5-amino-2-1-benzyloxy-2-methylpropan-2-yl-6-fluoro-1h-indol-1-yl-3-benzyloxy-propan-2-ol-pa470981001
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
(R)-1-(5-Amino-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-1-yl)-3-(benzyloxy)propan-2-ol
Catalogue No.:PA 47 0981001
Molecular Formula : C29H33FN2O3
Molecular Weight : 476.59
stdClass Object
(
[pname] => (R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane-1-carboxamide
[catalogue_number] => PA 47 0981002
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 560.57
[form] => C29H31F3N2O6
[cas] => 1152311-90-4
[pslug] => 1152311-90-4-r-1-2-2-difluorobenzo-d-1-3-dioxol-5-yl-n-1-2-2-dimethyl-1-3-dioxolan-4-yl-methyl-6-fluoro-2-1-hydroxy-2-methylpropan-2-yl-1h-indol-5-yl-cyclopropane-1-carboxamide-pa470981002
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
(R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane-1-carboxamide
Catalogue No.:PA 47 0981002
Molecular Formula : C29H31F3N2O6
Molecular Weight : 560.57
stdClass Object
(
[pname] => Tezacaftor Metabolite
[catalogue_number] => PA 47 0981003
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 518.49
[form] => C26H25F3N2O6
[cas] => 1432656-97-7
[pslug] => 1432656-97-7-tezacaftor-metabolite-pa470981003
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
Catalogue No.:PA 47 0981003
Molecular Formula : C26H25F3N2O6
Molecular Weight : 518.49
stdClass Object
(
[pname] => Tezacaftor Enantiomer
[catalogue_number] => PA 47 0981004
[category_ids] => ,80,79,78,70,82,89,
[chemical_name] =>
[weight] => 520.51
[form] => C26H27F3N2O6
[cas] => 1152311-99-3
[pslug] => 1152311-99-3-tezacaftor-enantiomer-pa470981004
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
Catalogue No.:PA 47 0981004
Molecular Formula : C26H27F3N2O6
Molecular Weight : 520.51
stdClass Object
(
[pname] => R,R Dihydro Tezacaftor
[catalogue_number] => PA 47 0981005
[category_ids] => ,78,82,70,
[chemical_name] =>
[weight] => 522.52
[form] => C26H29F3N2O6
[cas] => NA
[pslug] => r-r-dihydro-tezacaftor-pa470981005
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
Catalogue No.:PA 47 0981005
Molecular Formula : C26H29F3N2O6
Molecular Weight : 522.52
stdClass Object
(
[pname] => R,S Dihydro Tezacaftor
[catalogue_number] => PA 47 0981006
[category_ids] => ,78,82,70,
[chemical_name] =>
[weight] => 522.52
[form] => C26H29F3N2O6
[cas] => NA
[pslug] => r-s-dihydro-tezacaftor-pa470981006
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
Catalogue No.:PA 47 0981006
Molecular Formula : C26H29F3N2O6
Molecular Weight : 522.52
stdClass Object
(
[pname] => Acetonide O-Benzyl Tezacaftor
[catalogue_number] => PA 47 0981007
[category_ids] => ,80,79,78,70,82,
[chemical_name] =>
[weight] => 650.7
[form] => C36H37F3N2O6
[cas] => NA
[pslug] => acetonide-o-benzyl-tezacaftor-pa470981007
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
Acetonide O-Benzyl Tezacaftor
stdClass Object
(
[pname] => O-Benzyl Tezacaftor
[catalogue_number] => PA 47 0981008
[category_ids] => ,78,70,82,
[chemical_name] =>
[weight] => 610.63
[form] => C33H33F3N2O6
[cas] => NA
[pslug] => o-benzyl-tezacaftor-pa470981008
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
Catalogue No.:PA 47 0981008
Molecular Formula : C33H33F3N2O6
Molecular Weight : 610.63
stdClass Object
(
[pname] => 1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane-1-carboxamide
[catalogue_number] => PA 47 0981009
[category_ids] => ,78,70,82,
[chemical_name] =>
[weight] => 446.43
[form] => C23H21F3N2O4
[cas] => 1152311-65-3
[pslug] => 1152311-65-3-1-2-2-difluorobenzo-d-1-3-dioxol-5-yl-n-6-fluoro-2-1-hydroxy-2-methylpropan-2-yl-1h-indol-5-yl-cyclopropane-1-carboxamide-pa470981009
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane-1-carboxamide
Catalogue No.:PA 47 0981009
Molecular Formula : C23H21F3N2O4
Molecular Weight : 446.43
stdClass Object
(
[pname] => (S)-1-(5-amino-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-1-yl)-3-(benzyloxy)propan-2-ol
[catalogue_number] => PA 47 0981011
[category_ids] => ,80,79,78,70,82,89,
[chemical_name] =>
[weight] => 476.59
[form] => C29H33FN2O3
[cas] => NA
[pslug] => s-1-5-amino-2-1-benzyloxy-2-methylpropan-2-yl-6-fluoro-1h-indol-1-yl-3-benzyloxy-propan-2-ol-pa470981011
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
(S)-1-(5-amino-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-1-yl)-3-(benzyloxy)propan-2-ol
Catalogue No.:PA 47 0981011
Molecular Formula : C29H33FN2O3
Molecular Weight : 476.59
stdClass Object
(
[pname] => (R)-N-(1-(3-(Benzyloxy)-2-hydroxypropyl)-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-5-yl)acetamide
[catalogue_number] => PA 47 0981010
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 518.63
[form] => C31H35FN2O4
[cas] => NA
[pslug] => r-n-1-3-benzyloxy-2-hydroxypropyl-2-1-benzyloxy-2-methylpropan-2-yl-6-fluoro-1h-indol-5-yl-acetamide-pa470981010
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
(R)-N-(1-(3-(Benzyloxy)-2-hydroxypropyl)-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-5-yl)acetamide
Catalogue No.:PA 47 0981010
Molecular Formula : C31H35FN2O4
Molecular Weight : 518.63
