Baricitinib was approved in February of 2017 as a second-line orally administered treatment for moderate to severe active rheumatoid arthritis in adults, either as a monotherapy or when combined with methotrexate.Baricitinib is a selective and reversible Janus kinase 1 (JAK1) and 2 (JAK2) inhibitor. Janus kinases belong to the tyrosine protein kinase family and play an important role in the proinflammatory pathway signalling that is frequently over-activated in autoimmune disorders such as rheumatoid arthritis. Reference standards of Baricitinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
stdClass Object ( [pname] => Baricitinib - API Standards [catalogue_number] => PA 29 41000 [category_ids] => ,71,81,78,70,82,88, [chemical_name] => [weight] => 371.42 [form] => C16H17N7O2S [cas] => 1187594-09-7 [pslug] => 1187594-09-7-baricitinib-api-pa2941000 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 29 41000
CAS :
Molecular Formula : C16H17N7O2S
Molecular Weight : 371.42
stdClass Object ( [pname] => 1-(1-Ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole [catalogue_number] => PA 29 0411017 [category_ids] => ,71,81,78,70,82,88, [chemical_name] => [weight] => 266.15 [form] => C13H23BN2O3 [cas] => 1029716-44-6 [pslug] => 1029716-44-6-1-1-ethoxyethyl-4-4-4-5-5-tetramethyl-1-3-2-dioxaborolan-2-yl-1h-pyrazole-pa290411017 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 29 0411017
Molecular Formula : C13H23BN2O3
Molecular Weight : 266.15
stdClass Object ( [pname] => tert-Butyl 3-(cyanomethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate [catalogue_number] => PA 29 0411018 [category_ids] => ,71,78,70,82,88, [chemical_name] => [weight] => 388.28 [form] => C19H29BN4O4 [cas] => 1153949-15-5 [pslug] => 1153949-15-5-tert-butyl-3-cyanomethyl-3-4-4-4-5-5-tetramethyl-1-3-2-dioxaborolan-2-yl-1h-pyrazol-1-yl-azetidine-1-carboxylate-pa290411018 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 29 0411018
Molecular Formula : C19H29BN4O4
Molecular Weight : 388.28
stdClass Object ( [pname] => (4-(1-(3-(Cyanomethyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl Pivalate [catalogue_number] => PA 29 0411019 [category_ids] => ,71,78,70,82,88, [chemical_name] => [weight] => 393.45 [form] => C20H23N7O2 [cas] => 2102104-38-9 [pslug] => 2102104-38-9-4-1-3-cyanomethyl-azetidin-3-yl-1h-pyrazol-4-yl-7h-pyrrolo-2-3-d-pyrimidin-7-yl-methyl-pivalate-pa290411019 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 29 0411019
Molecular Formula : C20H23N7O2
Molecular Weight : 393.45
stdClass Object ( [pname] => (4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl Pivalate [catalogue_number] => PA 29 0411020 [category_ids] => ,71,78,70,82,88, [chemical_name] => [weight] => 485.56 [form] => C22H27N7O4S [cas] => 1187595-90-9 [pslug] => 1187595-90-9-4-1-3-cyanomethyl-1-ethylsulfonyl-azetidin-3-yl-1h-pyrazol-4-yl-7h-pyrrolo-2-3-d-pyrimidin-7-yl-methyl-pivalate-pa290411020 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 29 0411020
Molecular Formula : C22H27N7O4S
Molecular Weight : 485.56
stdClass Object ( [pname] => tert-Butyl 3-(cyanomethyl)-3-(4-(7-((pivaloyloxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate [catalogue_number] => PA 29 0411023 [category_ids] => ,71,81,78,70,82, [chemical_name] => [weight] => 493.57 [form] => C25H31N7O4 [cas] => 2102104-37-8 [pslug] => 2102104-37-8-tert-butyl-3-cyanomethyl-3-4-7-pivaloyloxy-methyl-7h-pyrrolo-2-3-d-pyrimidin-4-yl-1h-pyrazol-1-yl-azetidine-1-carboxylate-pa290411023 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 29 0411023
Molecular Formula : C25H31N7O4
Molecular Weight : 493.57
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