cabozantinib
Cabozantinib is used in two forms. A capsule form is used since 2012 to treat medullary thyroid cancer and a tablet form is used since 2016 as a second line treatment for renal cell carcinoma.. Reference standards of Cabozantinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
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[pname] => Cabozantinib
[catalogue_number] => PA 30 62000
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[chemical_name] =>
[weight] => 501.51
[form] => C28H24FN3O5
[cas] => 849217-68-1
[pslug] => 849217-68-1-cabozantinib-api-pa3062000
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Catalogue No.:PA 30 62000
Molecular Formula : C28H24FN3O5
Molecular Weight : 501.51
stdClass Object
(
[pname] => Cabozantinib Nitro Analog
[catalogue_number] => PA 30 62540
[category_ids] => ,80,71,78,70,82,
[chemical_name] =>
[weight] => 326.3
[form] => C17H14N2O5
[cas] => 190728-24-6
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Cabozantinib Nitro Analog
stdClass Object
(
[pname] => Cabozantinib Amine Analog
[catalogue_number] => PA 30 62550
[category_ids] => ,79,80,71,78,70,82,
[chemical_name] =>
[weight] => 296.32
[form] => C17H16N2O3
[cas] => 190728-25-7
[pslug] => 190728-25-7-cabozantinib-amine-analog-pa3062550
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Cabozantinib Amine Analog
Catalogue No.:PA 30 62550
Molecular Formula : C17H16N2O3
Molecular Weight : 296.32
stdClass Object
(
[pname] => Cabozantinib L-Malate
[catalogue_number] => PA 30 62590
[category_ids] => 70,71,78,80,82,121
[chemical_name] =>
[weight] => 635.59
[form] => C32H30FN3O10
[cas] => 1140909-48-3
[pslug] => 1140909-48-3-cabozantinib-l-malate-api-standards-pa3062590
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Catalogue No.:PA 30 62590
Molecular Formula : C32H30FN3O10
Molecular Weight : 635.59
stdClass Object
(
[pname] => 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic Acid
[catalogue_number] => PA 30 62600
[category_ids] => ,80,79,89,71,
[chemical_name] =>
[weight] => 223.2
[form] => C11H10FNO3
[cas] => 849217-48-7
[pslug] => 849217-48-7-1-4-fluorophenyl-carbamoyl-cyclopropanecarboxylic-acid-pa3062600
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1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic Acid
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[pname] => N-(4-Fluorophenyl)-n'-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide
[catalogue_number] => PA 30 62610
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[chemical_name] =>
[weight] => 314.31
[form] => C17H15FN2O3
[cas] => 849217-60-3
[pslug] => 849217-60-3-n-4-fluorophenyl-n-4-hydroxyphenyl-cyclopropane-1-1-dicarboxamide-pa3062610
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N-(4-Fluorophenyl)-n'-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide
Catalogue No.:PA 30 62610
Molecular Formula : C17H15FN2O3
Molecular Weight : 314.31
stdClass Object
(
[pname] => Cabozantinib Dimer Impurity
[catalogue_number] => PA 30 62620
[category_ids] => 82,80,79,78,71,70
[chemical_name] =>
[weight] => 646.65
[form] => C36H30N4O8
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Cabozantinib Dimer Impurity
Catalogue No.:PA 30 62620
Molecular Formula : C36H30N4O8
Molecular Weight : 646.65
stdClass Object
(
[pname] => Cabozantinib-d4
[catalogue_number] => PA STI 089396
[category_ids] => ,98,79,80,71,78,70,82,89,
[chemical_name] =>
[weight] => 505.54
[form] => C28H20D4FN3O5
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Catalogue No.:PA STI 089396
Molecular Formula : C28H20D4FN3O5
Molecular Weight : 505.54
stdClass Object
(
[pname] => N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-6,7-dimethoxyquinolin-4-amine
[catalogue_number] => PA 30 0621022
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[chemical_name] =>
[weight] => 483.52
[form] => C28H25N3O5
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N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-6,7-dimethoxyquinolin-4-amine
Catalogue No.:PA 30 0621022
Molecular Formula : C28H25N3O5
Molecular Weight : 483.52
stdClass Object
(
[pname] => (E)-N-(3-(4,5-Dimethoxy-2-nitrophenyl)-3-oxoprop-1-en-1-yl)-N-methylnitrous amide
[catalogue_number] => PA 30 0621032
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[weight] => 295.25
[form] => C12H13N3O6
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(E)-N-(3-(4,5-Dimethoxy-2-nitrophenyl)-3-oxoprop-1-en-1-yl)-N-methylnitrous amide
Catalogue No.:PA 30 0621032
Molecular Formula : C12H13N3O6
Molecular Weight : 295.25
stdClass Object
(
[pname] => 4-((4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)amino)-3-((4-fluorophenyl)carbamoyl)-4-oxobutyl (Z)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carbimidate
[catalogue_number] => PA 30 0621033
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[weight] => 1003.03
[form] => C56H48F2N6O10
[cas] => NA
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4-((4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)amino)-3-((4-fluorophenyl)carbamoyl)-4-oxobutyl (Z)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carbimidate
Catalogue No.:PA 30 0621033
Molecular Formula : C56H48F2N6O10
Molecular Weight : 1003.03
stdClass Object
(
[pname] => 5-(((3,4-Dimethoxyphenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
[catalogue_number] => PA 30 0621034
[category_ids] => ,79,80,71,78,70,82,
[chemical_name] =>
[weight] => 307.3
[form] => C15H17NO6
[cas] => 213699-53-7
[pslug] => 213699-53-7-5-3-4-dimethoxyphenyl-amino-methylene-2-2-dimethyl-1-3-dioxane-4-6-dione-pa300621034
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5-(((3,4-Dimethoxyphenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
stdClass Object
(
[pname] => Cabozantinib Methyl Ester Analog
[catalogue_number] => PA 30 0621035
[category_ids] => ,82,80,79,78,71,70,
[chemical_name] =>
[weight] => 422.43
[form] => C23H22N2O6
[cas] => 1584696-82-1
[pslug] => 1584696-82-1-cabozantinib-methyl-ester-analog-pa300621035
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Cabozantinib Methyl Ester Analog
Catalogue No.:PA 30 0621035
Molecular Formula : C23H22N2O6
Molecular Weight : 422.43
stdClass Object
(
[pname] => Cabozantinib Ethyl Ester Analog
[catalogue_number] => PA 30 0621036
[category_ids] => ,82,80,79,78,71,70,
[chemical_name] =>
[weight] => 436.46
[form] => C24H24N2O6
[cas] => 1584696-80-9
[pslug] => 1584696-80-9-cabozantinib-ethyl-ester-analog-pa300621036
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Cabozantinib Ethyl Ester Analog
Catalogue No.:PA 30 0621036
Molecular Formula : C24H24N2O6
Molecular Weight : 436.46
stdClass Object
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[pname] => N1-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N3-(4-fluorophenyl)-2-(2-hydroxyethyl)malonamide
[catalogue_number] => PA 30 0621037
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[chemical_name] =>
[weight] => 519.53
[form] => C28H26FN3O6
[cas] => NA
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N1-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N3-(4-fluorophenyl)-2-(2-hydroxyethyl)malonamide
Catalogue No.:PA 30 0621037
Molecular Formula : C28H26FN3O6
Molecular Weight : 519.53
stdClass Object
(
[pname] => (2S)-4-(4-((4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)amino)-3-((4-fluorophenyl)carbamoyl)-4-oxobutoxy)-2-hydroxy-4-oxobutanoic Acid
[catalogue_number] => PA 30 0621038
[category_ids] => ,79,80,71,78,70,82,89,
[chemical_name] =>
[weight] => 635.6
[form] => C32H30FN3O10
[cas] => NA
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(2S)-4-(4-((4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)amino)-3-((4-fluorophenyl)carbamoyl)-4-oxobutoxy)-2-hydroxy-4-oxobutanoic Acid
stdClass Object
(
[pname] => N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)-N-methylcyclopropane-1,1-dicarboxamide
[catalogue_number] => PA 30 0621039
[category_ids] => ,79,80,71,78,70,82,
[chemical_name] =>
[weight] => 515.54
[form] => C29H26FN3O5
[cas] => 2458244-61-4
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N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)-N-methylcyclopropane-1,1-dicarboxamide
Catalogue No.:PA 30 0621039
Molecular Formula : C29H26FN3O5
Molecular Weight : 515.54
stdClass Object
(
[pname] => N,N'-Bis(4-fluorophenyl)oxamide
[catalogue_number] => PA 30 0621040
[category_ids] => ,79,80,71,78,70,82,89,
[chemical_name] =>
[weight] => 276.24
[form] => C14H10F2N2O2
[cas] => 10197-51-0
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N,N'-Bis(4-fluorophenyl)oxamide
Catalogue No.:PA 30 0621040
Molecular Formula : C14H10F2N2O2
Molecular Weight : 276.24
stdClass Object
(
[pname] => N-Nitroso Cabozantinib
[catalogue_number] => PA 30 0621043
[category_ids] => ,71,78,70,82,162,
[chemical_name] =>
[weight] => 530.51
[form] => C28H23FN4O6
[cas] => NA
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Catalogue No.:PA 30 0621043
Molecular Formula : C28H23FN4O6
Molecular Weight : 530.51
stdClass Object
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[pname] => N-(6,7-dimethoxyquinolin-4-yl)-N-(4-hydroxyphenyl)nitrous amide
[catalogue_number] => PA 30 0621044
[category_ids] => ,71,78,70,82,162,
[chemical_name] =>
[weight] => 325.32
[form] => C17H15N3O4
[cas] => NA
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N-(6,7-dimethoxyquinolin-4-yl)-N-(4-hydroxyphenyl)nitrous amide
Catalogue No.:PA 30 0621044
Molecular Formula : C17H15N3O4
Molecular Weight : 325.32
stdClass Object
(
[pname] => N-(3,4-dimethoxyphenyl)-N-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)nitrous amide
[catalogue_number] => PA 30 0621045
[category_ids] => ,71,78,70,82,162,
[chemical_name] =>
[weight] => 336.30
[form] => C15H16N2O7
[cas] => NA
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N-(3,4-dimethoxyphenyl)-N-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)nitrous amide
Catalogue No.:PA 30 0621045
Molecular Formula : C15H16N2O7
Molecular Weight : 336.30
