dabrafenib

Dabrafenib is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It is used alone or in combination with another medication to treat a type of skin cancer.. Reference standards of Dabrafenib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below

stdClass Object
(
    [pname] => Dabrafenib
    [catalogue_number] => PA 31 06000
    [category_ids] => ,79,80,71,78,70,82,89,88,
    [chemical_name] => 
    [weight] => 519.56
    [form] => C23H20F3N5O2S2
    [cas] => 1195765-45-7
    [pslug] => 1195765-45-7-dabrafenib-api-pa3106000
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PA 31 06000

Dabrafenib

  • Catalogue No.:PA 31 06000

  • CAS :

    1195765-45-7

  • Molecular Formula : C23H20F3N5O2S2

  • Molecular Weight : 519.56

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Details 
stdClass Object
(
    [pname] => M30-Dabrafenib
    [catalogue_number] => PA 31 0061017
    [category_ids] => ,79,80,71,78,70,82,89,88,
    [chemical_name] => 
    [weight] => 551.52
    [form] => C22H16F3N5O5S2
    [cas] => 1613724-38-1
    [pslug] => 1613724-38-1-m30-dabrafenib-pa310061017
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PA 31 0061017

M30-Dabrafenib

  • Catalogue No.:PA 31 0061017

  • CAS :

    1613724-38-1

  • Molecular Formula : C22H16F3N5O5S2

  • Molecular Weight : 551.52

Enquire
Details 
stdClass Object
(
    [pname] => M31-Dabrafenib
    [catalogue_number] => PA 31 0061018
    [category_ids] => ,79,80,71,78,70,82,89,88,
    [chemical_name] => 
    [weight] => 503.52
    [form] => C22H16F3N5O2S2
    [cas] => 1613724-51-8
    [pslug] => 1613724-51-8-m31-dabrafenib-pa310061018
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PA 31 0061018

M31-Dabrafenib

  • Catalogue No.:PA 31 0061018

  • CAS :

    1613724-51-8

  • Molecular Formula : C22H16F3N5O2S2

  • Molecular Weight : 503.52

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Details 
stdClass Object
(
    [pname] => Dabrafenib Glucuronide
    [catalogue_number] => PA 31 0061019
    [category_ids] => ,79,80,71,78,70,82,89,88,95,
    [chemical_name] => 
    [weight] => 695.64
    [form] => C28H24F3N5O9S2
    [cas] => 2147682-66-2
    [pslug] => 2147682-66-2-dabrafenib-glucuronide-pa310061019
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PA 31 0061019

Dabrafenib Glucuronide

  • Catalogue No.:PA 31 0061019

  • CAS :

    2147682-66-2

  • Molecular Formula : C28H24F3N5O9S2

  • Molecular Weight : 695.64

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Details 
stdClass Object
(
    [pname] => Methyl 3-((2,6-difluorophenyl)sulfonamido)-2-fluorobenzoate
    [catalogue_number] => PA 31 0061021
    [category_ids] => ,71,78,70,82,
    [chemical_name] => 
    [weight] => 345.29
    [form] => C14H10F3NO4S
    [cas] => 1195768-19-4
    [pslug] => 1195768-19-4-methyl-3-2-6-difluorophenyl-sulfonamido-2-fluorobenzoate-pa310061021
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PA 31 0061021

Methyl 3-((2,6-difluorophenyl)sulfonamido)-2-fluorobenzoate

  • Catalogue No.:PA 31 0061021

  • CAS :

    1195768-19-4

  • Molecular Formula : C14H10F3NO4S

  • Molecular Weight : 345.29

Enquire
Details 
stdClass Object
(
    [pname] => N-(3-(2-(tert-Butyl)-5-(2-hydroxypyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
    [catalogue_number] => PA 31 0061022
    [category_ids] => ,71,78,70,82,
    [chemical_name] => 
    [weight] => 520.55
    [form] => C23H19F3N4O3S2
    [cas] => NA
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PA 31 0061022

N-(3-(2-(tert-Butyl)-5-(2-hydroxypyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

  • Catalogue No.:PA 31 0061022

  • CAS :

    NA

  • Molecular Formula : C23H19F3N4O3S2

  • Molecular Weight : 520.55

Enquire
Details 
stdClass Object
(
    [pname] => 2,6-Difluoro-N-(2-fluoro-3-(2-(2-hydroxypyrimidin-4-yl)acetyl)phenyl)benzenesulfonamide
    [catalogue_number] => PA 31 0061023
    [category_ids] => ,71,78,70,82,
    [chemical_name] => 
    [weight] => 423.37
    [form] => C18H12F3N3O4S
    [cas] => NA
    [pslug] => 2-6-difluoro-n-2-fluoro-3-2-2-hydroxypyrimidin-4-yl-acetyl-phenyl-benzenesulfonamide-pa310061023
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PA 31 0061023

2,6-Difluoro-N-(2-fluoro-3-(2-(2-hydroxypyrimidin-4-yl)acetyl)phenyl)benzenesulfonamide

  • Catalogue No.:PA 31 0061023

  • CAS :

    NA

  • Molecular Formula : C18H12F3N3O4S

  • Molecular Weight : 423.37

Enquire
Details 
stdClass Object
(
    [pname] => 2,6-Difluorobenzenesulfonyl Fluoride
    [catalogue_number] => PA 31 0061024
    [category_ids] => ,71,78,70,82,
    [chemical_name] => 
    [weight] => 196.14
    [form] => C6H3F3O2S
    [cas] => 447460-43-7
    [pslug] => 447460-43-7-2-6-difluorobenzenesulfonyl-fluoride-pa310061024
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PA 31 0061024

2,6-Difluorobenzenesulfonyl Fluoride

  • Catalogue No.:PA 31 0061024

  • CAS :

    447460-43-7

  • Molecular Formula : C6H3F3O2S

  • Molecular Weight : 196.14

Enquire
Details 
stdClass Object
(
    [pname] => N-(3-(2-(tert-Butyl)-4-hydroxy-5-(2-hydroxypyrimidin-4-yl)-4,5-dihydrothiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
    [catalogue_number] => PA 31 0061025
    [category_ids] => ,71,78,70,82,
    [chemical_name] => 
    [weight] => 538.56
    [form] => C23H21F3N4O4S2
    [cas] => NA
    [pslug] => n-3-2-tert-butyl-4-hydroxy-5-2-hydroxypyrimidin-4-yl-4-5-dihydrothiazol-4-yl-2-fluorophenyl-2-6-difluorobenzenesulfonamide-pa310061025
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PA 31 0061025

N-(3-(2-(tert-Butyl)-4-hydroxy-5-(2-hydroxypyrimidin-4-yl)-4,5-dihydrothiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

  • Catalogue No.:PA 31 0061025

  • CAS :

    NA

  • Molecular Formula : C23H21F3N4O4S2

  • Molecular Weight : 538.56

Enquire
Details 
stdClass Object
(
    [pname] => N-(3-(2-(Tert-butyl)-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
    [catalogue_number] => PA 31 0061026
    [category_ids] => 89,88,80,79,71,82,78,70
    [chemical_name] => 
    [weight] => 538.99
    [form] => C23H18ClF3N4O2S2
    [cas] => 1195768-23-0
    [pslug] => 1195768-23-0-n-3-2-tert-butyl-5-2-chloropyrimidin-4-yl-thiazol-4-yl-2-fluorophenyl-2-6-difluorobenzenesulfonamide-pa310061026
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PA 31 0061026

N-(3-(2-(Tert-butyl)-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

  • Catalogue No.:PA 31 0061026

  • CAS :

    1195768-23-0

  • Molecular Formula : C23H18ClF3N4O2S2

  • Molecular Weight : 538.99

Enquire
Details 
stdClass Object
(
    [pname] => Methyl 2-fluoro-3-((2-fluoro-6-hydroxyphenyl)sulfonamido)benzoate
    [catalogue_number] => PA 31 0061027
    [category_ids] => ,71,78,70,82,
    [chemical_name] => 
    [weight] => 343.3
    [form] => C14H11F2NO5S
    [cas] => NA
    [pslug] => methyl-2-fluoro-3-2-fluoro-6-hydroxyphenyl-sulfonamido-benzoate-pa310061027
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PA 31 0061027

Methyl 2-fluoro-3-((2-fluoro-6-hydroxyphenyl)sulfonamido)benzoate

  • Catalogue No.:PA 31 0061027

  • CAS :

    NA

  • Molecular Formula : C14H11F2NO5S

  • Molecular Weight : 343.3

Enquire
Details 
stdClass Object
(
    [pname] => Dabrafenib Amine Impurity
    [catalogue_number] => PA 31 0061028
    [category_ids] => ,79,80,71,78,70,82,
    [chemical_name] => 
    [weight] => 343.42
    [form] => C17H18FN5S
    [cas] => 1195769-01-7
    [pslug] => 1195769-01-7-dabrafenib-amine-impurity-pa310061028
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PA 31 0061028

Dabrafenib Amine Impurity

  • Catalogue No.:PA 31 0061028

  • CAS :

    1195769-01-7

  • Molecular Formula : C17H18FN5S

  • Molecular Weight : 343.42

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Details 
stdClass Object
(
    [pname] => N-(3-(2-(2-Aminopyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
    [catalogue_number] => PA 31 0061029
    [category_ids] => ,79,80,71,78,70,82,
    [chemical_name] => 
    [weight] => 422.38
    [form] => C18H13F3N4O3S
    [cas] => NA
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PA 31 0061029

N-(3-(2-(2-Aminopyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

  • Catalogue No.:PA 31 0061029

  • CAS :

    NA

  • Molecular Formula : C18H13F3N4O3S

  • Molecular Weight : 422.38

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Details 
stdClass Object
(
    [pname] => 2-Amino-4-(2-(tert-butyl)-4-(3-((2,6-difluorophenyl)sulfonamido)-2-fluorophenyl)thiazol-5-yl)pyrimidine 1-oxide
    [catalogue_number] => PA 31 0061032
    [category_ids] => ,71,78,70,82,
    [chemical_name] => 
    [weight] => 535.56
    [form] => C23H20F3N5O3S2
    [cas] => NA
    [pslug] => 2-amino-4-2-tert-butyl-4-3-2-6-difluorophenyl-sulfonamido-2-fluorophenyl-thiazol-5-yl-pyrimidine-1-oxide-pa310061032
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PA 31 0061032

2-Amino-4-(2-(tert-butyl)-4-(3-((2,6-difluorophenyl)sulfonamido)-2-fluorophenyl)thiazol-5-yl)pyrimidine 1-oxide

  • Catalogue No.:PA 31 0061032

  • CAS :

    NA

  • Molecular Formula : C23H20F3N5O3S2

  • Molecular Weight : 535.56

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Details 
stdClass Object
(
    [pname] => Dabrafenib Methoxy Impurity
    [catalogue_number] => PA 31 0061033
    [category_ids] => ,71,78,70,82,
    [chemical_name] => 
    [weight] => 534.57
    [form] => C24H21F3N4O3S2
    [cas] => 1907654-22-1
    [pslug] => 1907654-22-1-dabrafenib-methoxy-impurity-pa310061033
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PA 31 0061033

Dabrafenib Methoxy Impurity

  • Catalogue No.:PA 31 0061033

  • CAS :

    1907654-22-1

  • Molecular Formula : C24H21F3N4O3S2

  • Molecular Weight : 534.57

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Details 
stdClass Object
(
    [pname] => 1-(3-Amino-2-fluorophenyl)-2-(2-chloropyrimidin-4-yl)ethan-1-one
    [catalogue_number] => PA 31 0061035
    [category_ids] => ,79,80,71,78,70,82,
    [chemical_name] => 
    [weight] => 265.67
    [form] => C12H9ClFN3O
    [cas] => NA
    [pslug] => 1-3-amino-2-fluorophenyl-2-2-chloropyrimidin-4-yl-ethan-1-one-pa310061035
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PA 31 0061035

1-(3-Amino-2-fluorophenyl)-2-(2-chloropyrimidin-4-yl)ethan-1-one

  • Catalogue No.:PA 31 0061035

  • CAS :

    NA

  • Molecular Formula : C12H9ClFN3O

  • Molecular Weight : 265.67

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Details 
stdClass Object
(
    [pname] => N-(3-(2-(2-Chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-N-((2,6-difluorophenyl)sulfonyl)-2,6-difluorobenzenesulfonamide
    [catalogue_number] => PA 31 0061036
    [category_ids] => ,79,80,71,78,70,82,
    [chemical_name] => 
    [weight] => 617.95
    [form] => C24H13ClF5N3O5S2
    [cas] => NA
    [pslug] => n-3-2-2-chloropyrimidin-4-yl-acetyl-2-fluorophenyl-n-2-6-difluorophenyl-sulfonyl-2-6-difluorobenzenesulfonamide-pa310061036
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PA 31 0061036

N-(3-(2-(2-Chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-N-((2,6-difluorophenyl)sulfonyl)-2,6-difluorobenzenesulfonamide

  • Catalogue No.:PA 31 0061036

  • CAS :

    NA

  • Molecular Formula : C24H13ClF5N3O5S2

  • Molecular Weight : 617.95

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CPHI INDIA- 28, 30 November