nilotinib

Nilotinib is used to treat Philadelphia chromosome positive chronic myelogenous leukaemia. It is sold under the brand name Tasigna. It is not safe for use during pregnancy. Reference standards of Nilotinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => 4-Methyl-1-[3-nitro-5-(trifluoromethyl)phenyl]-1H-imidazole
    [catalogue_number] => PA 14 64540
    [category_ids] => ,80,71,70,78,82,75,79,89,
    [chemical_name] => 
    [weight] => 271.2
    [form] => C11H8F3N3O2
    [cas] => 916975-92-3
    [pslug] => 916975-92-3-4-methyl-1-3-nitro-5-trifluoromethyl-phenyl-1h-imidazole-pa1464540
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PA 14 64540

4-Methyl-1-[3-nitro-5-(trifluoromethyl)phenyl]-1H-imidazole

  • Catalogue No.:PA 14 64540

  • CAS :

    916975-92-3

  • Molecular Formula : C11H8F3N3O2

  • Molecular Weight : 271.2

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stdClass Object
(
    [pname] => Nilotinib - Impurity H (Hydrochloride Salt)
    [catalogue_number] => PA 14 64550
    [category_ids] => ,80,71,70,78,82,75,79,89,
    [chemical_name] => 
    [weight] => 565.98
    [form] => C28H23ClF3N7O
    [cas] => NA
    [pslug] => -nilotinib-impurity-h-hydrochloride-salt-pa1464550
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PA 14 64550

Nilotinib - Impurity H (Hydrochloride Salt)

  • Catalogue No.:PA 14 64550

  • CAS :

    NA

  • Molecular Formula : C28H23ClF3N7O

  • Molecular Weight : 565.98

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stdClass Object
(
    [pname] => 3-((4-Chloro-6-(pyridin-3-yl)pyrimidin-2-yl)amino)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide
    [catalogue_number] => PA 14 64560
    [category_ids] => ,80,71,70,78,82,75,79,89,
    [chemical_name] => 
    [weight] => 563.96
    [form] => C28H21ClF3N7O
    [cas] => NA
    [pslug] => 3-4-chloro-6-pyridin-3-yl-pyrimidin-2-yl-amino-4-methyl-n-3-4-methyl-1h-imidazol-1-yl-5-trifluoromethyl-phenyl-benzamide-pa1464560
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PA 14 64560

3-((4-Chloro-6-(pyridin-3-yl)pyrimidin-2-yl)amino)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

  • Catalogue No.:PA 14 64560

  • CAS :

    NA

  • Molecular Formula : C28H21ClF3N7O

  • Molecular Weight : 563.96

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Details 
stdClass Object
(
    [pname] => Nilotinib - Impurity H (Freebase)
    [catalogue_number] => PA 14 64570
    [category_ids] => ,80,71,70,78,82,75,79,89,
    [chemical_name] => 
    [weight] => 529.52
    [form] => C28H22F3N7O
    [cas] => 641571-15-5
    [pslug] => 641571-15-5-nilotinib-impurity-h-freebase-pa1464570
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PA 14 64570

Nilotinib - Impurity H (Freebase)

  • Catalogue No.:PA 14 64570

  • CAS :

    641571-15-5

  • Molecular Formula : C28H22F3N7O

  • Molecular Weight : 529.52

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stdClass Object
(
    [pname] => 3-(4-Ethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Hydrochloride
    [catalogue_number] => PA 14 64580
    [category_ids] => ,80,71,70,78,82,75,79,89,
    [chemical_name] => 
    [weight] => 291.7
    [form] => C12H13ClF3N3
    [cas] => NA
    [pslug] => 3-4-ethyl-1h-imidazol-1-yl-5-trifluoromethyl-aniline-hydrochloride-pa1464580
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PA 14 64580

3-(4-Ethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Hydrochloride

  • Catalogue No.:PA 14 64580

  • CAS :

    NA

  • Molecular Formula : C12H13ClF3N3

  • Molecular Weight : 291.7

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stdClass Object
(
    [pname] => 3-(1H-Imidazol-1-yl)-5-(trifluoromethyl)aniline
    [catalogue_number] => PA 14 64590
    [category_ids] => ,80,71,70,78,82,75,79,89,
    [chemical_name] => 
    [weight] => 227.19
    [form] => C10H8F3N3
    [cas] => 943320-48-7
    [pslug] => 943320-48-7-3-1h-imidazol-1-yl-5-trifluoromethyl-aniline-pa1464590
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PA 14 64590

3-(1H-Imidazol-1-yl)-5-(trifluoromethyl)aniline

  • Catalogue No.:PA 14 64590

  • CAS :

    943320-48-7

  • Molecular Formula : C10H8F3N3

  • Molecular Weight : 227.19

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stdClass Object
(
    [pname] => 3-(4-Methyl-1H-imidazol-1-yl)-5-trifluoromethylaniline-d3
    [catalogue_number] => PA STI 062190
    [category_ids] => ,79,80,71,98,78,70,82,
    [chemical_name] => 
    [weight] => 244.23
    [form] => C11H7D3F3N3
    [cas] => 1246815-34-8
    [pslug] => 1246815-34-8-3-4-methyl-1h-imidazol-1-yl-5-trifluoromethylaniline-d3-pasti062190
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PA STI 062190

3-(4-Methyl-1H-imidazol-1-yl)-5-trifluoromethylaniline-d3

  • Catalogue No.:PA STI 062190

  • CAS :

    1246815-34-8

  • Molecular Formula : C11H7D3F3N3

  • Molecular Weight : 244.23

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Details 
stdClass Object
(
    [pname] => 3-Iodo-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide-d3
    [catalogue_number] => PA STI 053340
    [category_ids] => ,71,98,78,70,82,
    [chemical_name] => 
    [weight] => 488.26
    [form] => C19H12D3F3IN3O
    [cas] => 1246818-65-4
    [pslug] => 1246818-65-4-3-iodo-4-methyl-n-3-4-methyl-1h-imidazol-1-yl-5-trifluoromethyl-phenyl-benzamide-d3-pasti053340
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PA STI 053340

3-Iodo-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide-d3

  • Catalogue No.:PA STI 053340

  • CAS :

    1246818-65-4

  • Molecular Formula : C19H12D3F3IN3O

  • Molecular Weight : 488.26

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stdClass Object
(
    [pname] => Nilotinib N-Oxide
    [catalogue_number] => PA 14 64600
    [category_ids] => 85,83,75,76,78,82,71,70,80
    [chemical_name] => 
    [weight] => 545.53
    [form] => C28H22F3N7O2
    [cas] => 1246817-85-5
    [pslug] => 1246817-85-5-nilotinib-n-oxide-pa1464600
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PA 14 64600

Nilotinib N-Oxide

  • Catalogue No.:PA 14 64600

  • CAS :

    1246817-85-5

  • Molecular Formula : C28H22F3N7O2

  • Molecular Weight : 545.53

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Details 
stdClass Object
(
    [pname] => Nilotinib System Suitability Mixture
    [catalogue_number] => PA 14 0641001
    [category_ids] => ,80,71,76,75,93,78,70,82,
    [chemical_name] => 
    [weight] => NA
    [form] => NA
    [cas] => NA
    [pslug] => nilotinib-system-suitability-mixture-pa140641001
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PA 14 0641001

Nilotinib System Suitability Mixture

  • Catalogue No.:PA 14 0641001

  • CAS :

    NA

  • Molecular Formula : NA

  • Molecular Weight : NA

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stdClass Object
(
    [pname] => Nilotinib N-Oxide (Pyrimidine N3-Oxide)
    [catalogue_number] => PA 14 0641034
    [category_ids] => ,75,76,78,82,71,70,
    [chemical_name] => 
    [weight] => 545.53
    [form] => C28H22F3N7O2
    [cas] => NA
    [pslug] => nilotinib-n-oxide-pyrimidine-n3-oxide-pa140641034
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PA 14 0641034

Nilotinib N-Oxide (Pyrimidine N3-Oxide)

  • Catalogue No.:PA 14 0641034

  • CAS :

    NA

  • Molecular Formula : C28H22F3N7O2

  • Molecular Weight : 545.53

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stdClass Object
(
    [pname] => Nilotinib N-Oxide (Pyrimidine N1-Oxide)
    [catalogue_number] => PA 14 0641035
    [category_ids] => ,75,76,78,82,71,70,
    [chemical_name] => 
    [weight] => 545.53
    [form] => C28H22F3N7O2
    [cas] => NA
    [pslug] => nilotinib-n-oxide-pyrimidine-n1-oxide-pa140641035
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PA 14 0641035

Nilotinib N-Oxide (Pyrimidine N1-Oxide)

  • Catalogue No.:PA 14 0641035

  • CAS :

    NA

  • Molecular Formula : C28H22F3N7O2

  • Molecular Weight : 545.53

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stdClass Object
(
    [pname] => 5-Amino-2-methylbenzoic Acid
    [catalogue_number] => PA 14 0641036
    [category_ids] => ,75,76,78,82,71,70,
    [chemical_name] => 
    [weight] => 151.17
    [form] => C8H9NO2
    [cas] => 2840-04-2
    [pslug] => 2840-04-2-5-amino-2-methylbenzoic-acid-pa140641036
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PA 14 0641036

5-Amino-2-methylbenzoic Acid

  • Catalogue No.:PA 14 0641036

  • CAS :

    2840-04-2

  • Molecular Formula : C8H9NO2

  • Molecular Weight : 151.17

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Details 
stdClass Object
(
    [pname] => 3-Amino-2-methylbenzoic Acid
    [catalogue_number] => PA 14 0641037
    [category_ids] => ,75,76,78,82,71,70,
    [chemical_name] => 
    [weight] => 151.17
    [form] => C8H9NO2
    [cas] => 52130-17-3
    [pslug] => 52130-17-3-3-amino-2-methylbenzoic-acid-pa140641037
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PA 14 0641037

3-Amino-2-methylbenzoic Acid

  • Catalogue No.:PA 14 0641037

  • CAS :

    52130-17-3

  • Molecular Formula : C8H9NO2

  • Molecular Weight : 151.17

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Details 
stdClass Object
(
    [pname] => 3-Amino-5-methylbenzoic Acid
    [catalogue_number] => PA 14 0641038
    [category_ids] => ,75,76,78,82,71,70,
    [chemical_name] => 
    [weight] => 151.17
    [form] => C8H9NO2
    [cas] => 2305-37-5
    [pslug] => 2305-37-5-3-amino-5-methylbenzoic-acid-pa140641038
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PA 14 0641038

3-Amino-5-methylbenzoic Acid

  • Catalogue No.:PA 14 0641038

  • CAS :

    2305-37-5

  • Molecular Formula : C8H9NO2

  • Molecular Weight : 151.17

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Details 
stdClass Object
(
    [pname] => 3-(2-Ethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
    [catalogue_number] => PA 14 0641039
    [category_ids] => ,75,76,78,82,71,70,
    [chemical_name] => 
    [weight] => 255.24
    [form] => C12H12F3N3
    [cas] => 1260802-16-1
    [pslug] => 1260802-16-1-3-2-ethyl-1h-imidazol-1-yl-5-trifluoromethyl-aniline-pa140641039
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PA 14 0641039

3-(2-Ethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

  • Catalogue No.:PA 14 0641039

  • CAS :

    1260802-16-1

  • Molecular Formula : C12H12F3N3

  • Molecular Weight : 255.24

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Details 
stdClass Object
(
    [pname] => Ethyl 3-(3-(diaminomethylene)guanidino)-4-methylbenzoate
    [catalogue_number] => PA 14 0641040
    [category_ids] => ,75,76,78,82,71,70,
    [chemical_name] => 
    [weight] => 263.3
    [form] => C12H17N5O2
    [cas] => NA
    [pslug] => ethyl-3-3-diaminomethylene-guanidino-4-methylbenzoate-pa140641040
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PA 14 0641040

Ethyl 3-(3-(diaminomethylene)guanidino)-4-methylbenzoate

  • Catalogue No.:PA 14 0641040

  • CAS :

    NA

  • Molecular Formula : C12H17N5O2

  • Molecular Weight : 263.3

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CPHI INDIA- 28, 30 November