Nintedanib-impurities | Pharmaffiliates

nintedanib

A Nintedanib is used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer. It is a small molecule kinase inhibitor. Reference standards of Nintedanib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

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    [pname] => Nintedanib - API Standards 
    [catalogue_number] => PA 14 54000
    [category_ids] => ,79,71,78,70,82,
    [chemical_name] => 
    [weight] => 539.62
    [form] => C31H33N5O4
    [cas] => 656247-17-5
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PA 14 54000

Nintedanib - API Standards


  • Catalogue No.:PA 14 54000

  • CAS :

    656247-17-5

  • Molecular Formula : C31H33N5O4

  • Molecular Weight : 539.62

stdClass Object
(
    [pname] => Nintedanib Esylate - API Standards 
    [catalogue_number] => PA 14 54620
    [category_ids] => ,77,71,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 649.76
    [form] => C33H39N5O7S
    [cas] => 656247-18-6
    [pslug] => 656247-18-6-nintedanib-esylate-pa1454620
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PA 14 54620

Nintedanib Esylate - API Standards


  • Catalogue No.:PA 14 54620

  • CAS :

    656247-18-6

  • Molecular Formula : C33H39N5O7S

  • Molecular Weight : 649.76

stdClass Object
(
    [pname] => Intedanib E-isomer
    [catalogue_number] => PA 14 54510
    [category_ids] => ,79,71,78,70,82,
    [chemical_name] => 
    [weight] => 539.62
    [form] => C31H33N5O4
    [cas] => NA
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PA 14 54510

Intedanib E-isomer


  • Catalogue No.:PA 14 54510

  • CAS :

    NA

  • Molecular Formula : C31H33N5O4

  • Molecular Weight : 539.62

stdClass Object
(
    [pname] => (Z)-3-(((4-(N-Methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylic Acid
    [catalogue_number] => PA 14 54520
    [category_ids] => ,79,71,78,70,82,
    [chemical_name] => 
    [weight] => 525.6
    [form] => C30H31N5O4
    [cas] => 894783-71-2
    [pslug] => 894783-71-2-z-3-4-n-methyl-2-4-methylpiperazin-1-yl-acetamido-phenyl-amino-phenyl-methylene-2-oxoindoline-6-carboxylic-acid-pa1454520
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PA 14 54520

(Z)-3-(((4-(N-Methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylic Acid


  • Catalogue No.:PA 14 54520

  • CAS :

    894783-71-2

  • Molecular Formula : C30H31N5O4

  • Molecular Weight : 525.6

stdClass Object
(
    [pname] => (Z)-1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1,4-dioxide
    [catalogue_number] => PA 14 54530
    [category_ids] => ,79,71,78,70,82,
    [chemical_name] => 
    [weight] => 571.62
    [form] => C31H33N5O6
    [cas] => NA
    [pslug] => z-1-2-4-6-methoxycarbonyl-2-oxoindolin-3-ylidene-phenyl-methyl-amino-phenyl-methyl-amino-2-oxoethyl-4-methylpiperazine-1-4-dioxide-pa1454530
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PA 14 54530

(Z)-1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1,4-dioxide


  • Catalogue No.:PA 14 54530

  • CAS :

    NA

  • Molecular Formula : C31H33N5O6

  • Molecular Weight : 571.62

stdClass Object
(
    [pname] => (Z)-Methyl 3-((methyl(4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
    [catalogue_number] => PA 14 54540
    [category_ids] => ,79,71,78,70,82,
    [chemical_name] => 
    [weight] => 553.65
    [form] => C32H35N5O4
    [cas] => NA
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PA 14 54540

(Z)-Methyl 3-((methyl(4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate


  • Catalogue No.:PA 14 54540

  • CAS :

    NA

  • Molecular Formula : C32H35N5O4

  • Molecular Weight : 553.65

stdClass Object
(
    [pname] => (Z)-Methyl 1-acetyl-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
    [catalogue_number] => PA 14 54560
    [category_ids] => 82,79,78,71,70
    [chemical_name] => 
    [weight] => 581.66
    [form] => C33H35N5O5
    [cas] => 2380229-45-6
    [pslug] => 2380229-45-6-z-methyl-1-acetyl-3-4-n-methyl-2-4-methylpiperazin-1-yl-acetamido-phenyl-amino-phenyl-methylene-2-oxoindoline-6-carboxylate-pa1454560
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PA 14 54560

(Z)-Methyl 1-acetyl-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate


  • Catalogue No.:PA 14 54560

  • CAS :

    2380229-45-6

  • Molecular Formula : C33H35N5O5

  • Molecular Weight : 581.66

stdClass Object
(
    [pname] => (Z)-Methyl 3-(((4-(N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
    [catalogue_number] => PA 14 54570
    [category_ids] => 79,71,70,78,82
    [chemical_name] => 
    [weight] => 441.48
    [form] => C26H23N3O4
    [cas] => 1139458-48-2
    [pslug] => 1139458-48-2-z-methyl-3-4-n-methylacetamido-phenyl-amino-phenyl-methylene-2-oxoindoline-6-carboxylate-pa1454570
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PA 14 54570

(Z)-Methyl 3-(((4-(N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate


  • Catalogue No.:PA 14 54570

  • CAS :

    1139458-48-2

  • Molecular Formula : C26H23N3O4

  • Molecular Weight : 441.48

stdClass Object
(
    [pname] => (3Z,3'Z)-Dimethyl 3,3'-(((((2,2'-(piperazine-1,4-diyl)bis(acetyl))bis(methylazanediyl))bis(4,1-phenylene))bis(azanediyl))bis(phenylmethanylylidene))bis(2-oxoindoline-6-carboxylate)
    [catalogue_number] => PA 14 54580
    [category_ids] => 82,80,79,78,75,71,70
    [chemical_name] => 
    [weight] => 965.06
    [form] => C56H52N8O8
    [cas] => 2410284-90-9
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PA 14 54580

(3Z,3'Z)-Dimethyl 3,3'-(((((2,2'-(piperazine-1,4-diyl)bis(acetyl))bis(methylazanediyl))bis(4,1-phenylene))bis(azanediyl))bis(phenylmethanylylidene))bis(2-oxoindoline-6-carboxylate)


  • Catalogue No.:PA 14 54580

  • CAS :

    2410284-90-9

  • Molecular Formula : C56H52N8O8

  • Molecular Weight : 965.06

stdClass Object
(
    [pname] => Methyl (3Z)-3-[({4-[2-(4-ethylpiperazin-1-yl)-N-methylacetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
    [catalogue_number] => PA 14 54590
    [category_ids] => ,77,71,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 553.65
    [form] => C32H35N5O4
    [cas] => NA
    [pslug] => methyl-3z-3-4-2-4-ethylpiperazin-1-yl-n-methylacetamido-phenyl-amino-phenyl-methylidene-2-oxo-2-3-dihydro-1h-indole-6-carboxylate-pa1454590
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PA 14 54590

Methyl (3Z)-3-[({4-[2-(4-ethylpiperazin-1-yl)-N-methylacetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate


  • Catalogue No.:PA 14 54590

  • CAS :

    NA

  • Molecular Formula : C32H35N5O4

  • Molecular Weight : 553.65

stdClass Object
(
    [pname] => (Z)-1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1-oxide
    [catalogue_number] => PA 14 54600
    [category_ids] => ,77,71,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 555.62
    [form] => C31H33N5O5
    [cas] => NA
    [pslug] => z-1-2-4-6-methoxycarbonyl-2-oxoindolin-3-ylidene-phenyl-methyl-amino-phenyl-methyl-amino-2-oxoethyl-4-methylpiperazine-1-oxide-pa1454600
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PA 14 54600

(Z)-1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1-oxide


  • Catalogue No.:PA 14 54600

  • CAS :

    NA

  • Molecular Formula : C31H33N5O5

  • Molecular Weight : 555.62

stdClass Object
(
    [pname] => Ethyl (3Z)-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
    [catalogue_number] => PA 14 54610
    [category_ids] => 85,83,77,71,70,78,82
    [chemical_name] => 
    [weight] => 553.65
    [form] => C32H35N5O4
    [cas] => 1139455-52-9
    [pslug] => 1139455-52-9-ethyl-3z-3-4-n-methyl-2-4-methylpiperazin-1-yl-acetamido-phenyl-amino-phenyl-methylidene-2-oxo-2-3-dihydro-1h-indole-6-carboxylate-pa1454610
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PA 14 54610

Ethyl (3Z)-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate


  • Catalogue No.:PA 14 54610

  • CAS :

    1139455-52-9

  • Molecular Formula : C32H35N5O4

  • Molecular Weight : 553.65

stdClass Object
(
    [pname] => Intedanib-d3
    [catalogue_number] => PA STI 053200
    [category_ids] => 98,82,79,78,71,70
    [chemical_name] => 
    [weight] => 542.64
    [form] => C31H30D3N5O4
    [cas] => 1624587-84-3
    [pslug] => 1624587-84-3-intedanib-d3-pasti053200
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PA STI 053200

Intedanib-d3


  • Catalogue No.:PA STI 053200

  • CAS :

    1624587-84-3

  • Molecular Formula : C31H30D3N5O4

  • Molecular Weight : 542.64

stdClass Object
(
    [pname] => Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxo-1-propionylindoline-6-carboxylate
    [catalogue_number] => PA 14 0541035
    [category_ids] => ,71,78,70,82,
    [chemical_name] => 
    [weight] => 595.7
    [form] => C34H37N5O5
    [cas] => 2097505-01-4
    [pslug] => 2097505-01-4-methyl-z-3-4-n-methyl-2-4-methylpiperazin-1-yl-acetamido-phenyl-amino-phenyl-methylene-2-oxo-1-propionylindoline-6-carboxylate-pa140541035
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PA 14 0541035

Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxo-1-propionylindoline-6-carboxylate


  • Catalogue No.:PA 14 0541035

  • CAS :

    2097505-01-4

  • Molecular Formula : C34H37N5O5

  • Molecular Weight : 595.7

stdClass Object
(
    [pname] => N-nitroso-N-desmethylnintedanib
    [catalogue_number] => PA 14 0541039
    [category_ids] => ,70,71,78,79,82,162,
    [chemical_name] => 
    [weight] => 554.61
    [form] => C30H30N6O5
    [cas] => NA
    [pslug] => n-nitroso-n-desmethylnintedanib-pa140541039
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PA 14 0541039

N-nitroso-N-desmethylnintedanib


  • Catalogue No.:PA 14 0541039

  • CAS :

    NA

  • Molecular Formula : C30H30N6O5

  • Molecular Weight : 554.61

stdClass Object
(
    [pname] => Nintedanib Acetamide Impurity
    [catalogue_number] => PA 14 0541040
    [category_ids] => ,79,71,78,70,82,
    [chemical_name] => 
    [weight] => 248.33
    [form] => C13H20N4O
    [cas] => 262368-25-2
    [pslug] => 262368-25-2-nintedanib-acetamide-impurity-pa140541040
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PA 14 0541040

Nintedanib Acetamide Impurity


  • Catalogue No.:PA 14 0541040

  • CAS :

    262368-25-2

  • Molecular Formula : C13H20N4O

  • Molecular Weight : 248.33

stdClass Object
(
    [pname] => Nintedanib 4-Nitrophenyl 2-(4-Nitroso)
    [catalogue_number] => PA 14 0541042
    [category_ids] => ,70,71,78,79,82,162,
    [chemical_name] => 
    [weight] => 307.31
    [form] => C13H17N5O4
    [cas] => 2490403-92-2
    [pslug] => 2490403-92-2-nintedanib-4-nitrophenyl-2-4-nitroso-pa140541042
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PA 14 0541042

Nintedanib 4-Nitrophenyl 2-(4-Nitroso)


  • Catalogue No.:PA 14 0541042

  • CAS :

    2490403-92-2

  • Molecular Formula : C13H17N5O4

  • Molecular Weight : 307.31

stdClass Object
(
    [pname] => Methyl 1-acetyl-2-oxoindoline-6-carboxylate
    [catalogue_number] => PA 14 0541043
    [category_ids] => ,79,71,78,70,82,
    [chemical_name] => 
    [weight] => 233.22
    [form] => C12H11NO4
    [cas] => 676326-36-6
    [pslug] => 676326-36-6-methyl-1-acetyl-2-oxoindoline-6-carboxylate-pa140541043
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PA 14 0541043

Methyl 1-acetyl-2-oxoindoline-6-carboxylate


  • Catalogue No.:PA 14 0541043

  • CAS :

    676326-36-6

  • Molecular Formula : C12H11NO4

  • Molecular Weight : 233.22

stdClass Object
(
    [pname] => Dimethyl 3,3'-(((((2,2'-(piperazine-1,4-diyl)bis(acetyl))bis(methylazanediyl))bis(4,1-phenylene))bis(azanediyl))bis(phenylmethanylylidene))bis(1-acetyl-2-oxoindoline-6-carboxylate)
    [catalogue_number] => PA 14 0541044
    [category_ids] => ,79,71,78,82,
    [chemical_name] => 
    [weight] => 1049.15
    [form] => C60H56N8O10
    [cas] => 2410649-55-5
    [pslug] => 2410649-55-5-dimethyl-3-3-2-2-piperazine-1-4-diyl-bis-acetyl-bis-methylazanediyl-bis-4-1-phenylene-bis-azanediyl-bis-phenylmethanylylidene-bis-1-acetyl-2-oxoindoline-6-carboxylate-pa140541044
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PA 14 0541044

Dimethyl 3,3'-(((((2,2'-(piperazine-1,4-diyl)bis(acetyl))bis(methylazanediyl))bis(4,1-phenylene))bis(azanediyl))bis(phenylmethanylylidene))bis(1-acetyl-2-oxoindoline-6-carboxylate)


  • Catalogue No.:PA 14 0541044

  • CAS :

    2410649-55-5

  • Molecular Formula : C60H56N8O10

  • Molecular Weight : 1049.15

stdClass Object
(
    [pname] => 1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1,4-dioxide
    [catalogue_number] => PA 14 0541045
    [category_ids] => ,79,71,78,70,82,
    [chemical_name] => 
    [weight] => 571.63
    [form] => C31H33N5O6
    [cas] => 2734676-68-5
    [pslug] => 2734676-68-5-1-2-4-6-methoxycarbonyl-2-oxoindolin-3-ylidene-phenyl-methyl-amino-phenyl-methyl-amino-2-oxoethyl-4-methylpiperazine-1-4-dioxide-pa140541045
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PA 14 0541045

1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1,4-dioxide


  • Catalogue No.:PA 14 0541045

  • CAS :

    2734676-68-5

  • Molecular Formula : C31H33N5O6

  • Molecular Weight : 571.63

stdClass Object
(
    [pname] => N-(4-Aminophenyl)-2-chloro-N-methylacetamide
    [catalogue_number] => PA 14 0541046
    [category_ids] => ,79,71,78,70,82,
    [chemical_name] => 
    [weight] => 198.65
    [form] => C9H11ClN2O
    [cas] => 855860-75-2
    [pslug] => 855860-75-2-n-4-aminophenyl-2-chloro-n-methylacetamide-pa140541046
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PA 14 0541046

N-(4-Aminophenyl)-2-chloro-N-methylacetamide


  • Catalogue No.:PA 14 0541046

  • CAS :

    855860-75-2

  • Molecular Formula : C9H11ClN2O

  • Molecular Weight : 198.65

stdClass Object
(
    [pname] => Methyl 4-chloro-3-nitrobenzoate
    [catalogue_number] => PA 14 0541047
    [category_ids] => ,82,78,76,79,71,78,70,82,75,70,
    [chemical_name] => 
    [weight] => 215.59
    [form] => C8H6ClNO4
    [cas] => 14719-83-6
    [pslug] => 14719-83-6-methyl-4-chloro-3-nitrobenzoate-pa140541047
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PA 14 0541047

Methyl 4-chloro-3-nitrobenzoate


  • Catalogue No.:PA 14 0541047

  • CAS :

    14719-83-6

  • Molecular Formula : C8H6ClNO4

  • Molecular Weight : 215.59

stdClass Object
(
    [pname] => N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
    [catalogue_number] => PA 14 0541048
    [category_ids] => ,82,78,76,79,71,78,70,82,75,70,
    [chemical_name] => 
    [weight] => 292.34
    [form] => C14H20N4O3
    [cas] => 1139453-98-7
    [pslug] => 1139453-98-7-n-methyl-2-4-methylpiperazin-1-yl-n-4-nitrophenyl-acetamide-pa140541048
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PA 14 0541048

N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide


  • Catalogue No.:PA 14 0541048

  • CAS :

    1139453-98-7

  • Molecular Formula : C14H20N4O3

  • Molecular Weight : 292.34

stdClass Object
(
    [pname] => Methyl 3-(((4-hydroxyphenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
    [catalogue_number] => PA 14 0541049
    [category_ids] => ,79,71,78,70,82,
    [chemical_name] => 
    [weight] => 386.41
    [form] => C23H18N2O4
    [cas] => 2519501-85-8
    [pslug] => 2519501-85-8-methyl-3-4-hydroxyphenyl-amino-phenyl-methylene-2-oxoindoline-6-carboxylate-pa140541049
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PA 14 0541049

Methyl 3-(((4-hydroxyphenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate


  • Catalogue No.:PA 14 0541049

  • CAS :

    2519501-85-8

  • Molecular Formula : C23H18N2O4

  • Molecular Weight : 386.41