regorafenib
A multikinase inhibitor, Regorafenib is used in the treatment of metastatic colorectal cancer and advanced gastrointestinal stromal tumors. Shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition.Reference standards of Regorafenib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
stdClass Object
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[pname] => Regorafenib
[catalogue_number] => PA 18 49000
[category_ids] => ,79,80,71,78,70,82,
[chemical_name] =>
[weight] => 482.82
[form] => C21H15ClF4N4O3
[cas] => 755037-03-7
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Catalogue No.:PA 18 49000
Molecular Formula : C21H15ClF4N4O3
Molecular Weight : 482.82
stdClass Object
(
[pname] => Regorafenib N-Oxide
[catalogue_number] => PA 18 49510
[category_ids] => ,79,80,71,76,75,78,70,82,
[chemical_name] =>
[weight] => 498.81
[form] => C21H15ClF4N4O4
[cas] => 835621-11-9
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Catalogue No.:PA 18 49510
Molecular Formula : C21H15ClF4N4O4
Molecular Weight : 498.81
stdClass Object
(
[pname] => 4-(4-Amino-3-fluorophenoxy)-N-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)picolinamide
[catalogue_number] => PA 18 49520
[category_ids] => ,79,80,71,76,75,78,70,82,89,
[chemical_name] =>
[weight] => 491.45
[form] => C25H19F2N5O4
[cas] => 2518234-85-8
[pslug] => 2518234-85-8-4-4-amino-3-fluorophenoxy-n-2-fluoro-4-2-methylcarbamoyl-pyridin-4-yl-oxy-phenyl-picolinamide-pa1849520
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4-(4-Amino-3-fluorophenoxy)-N-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)picolinamide
Catalogue No.:PA 18 49520
Molecular Formula : C25H19F2N5O4
Molecular Weight : 491.45
stdClass Object
(
[pname] => Hydroxyregorafenib
[catalogue_number] => PA 18 49530
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[chemical_name] =>
[weight] => 498.81
[form] => C21H15ClF4N4O4
[cas] => 1343498-71-4
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Catalogue No.:PA 18 49530
Molecular Formula : C21H15ClF4N4O4
Molecular Weight : 498.81
stdClass Object
(
[pname] => 4-Dechloro-2-chloro-Regorafenib
[catalogue_number] => PA 18 49540
[category_ids] => ,79,80,71,78,70,82,
[chemical_name] =>
[weight] => 482.82
[form] => C21H15ClF4N4O3
[cas] => NA
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4-Dechloro-2-chloro-Regorafenib
Catalogue No.:PA 18 49540
Molecular Formula : C21H15ClF4N4O3
Molecular Weight : 482.82
stdClass Object
(
[pname] => Regorafenib - Impurity C
[catalogue_number] => PA 18 49550
[category_ids] => 79,80,71,75
[chemical_name] =>
[weight] => 395.39
[form] => C20H18FN5O3
[cas] => 1855006-12-0
[pslug] => 1855006-12-0-regorafenib-impurity-c-pa1849550
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Catalogue No.:PA 18 49550
Molecular Formula : C20H18FN5O3
Molecular Weight : 395.39
stdClass Object
(
[pname] => Regorafenib - Impurity D
[catalogue_number] => PA 18 49560
[category_ids] => 89,79,71,75,80
[chemical_name] =>
[weight] => 548.5
[form] => C27H22F2N6O5
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stdClass Object
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[pname] => 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinic Acid
[catalogue_number] => PA 18 49570
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[chemical_name] =>
[weight] => 469.77
[form] => C20H12ClF4N3O4
[cas] => 1187945-05-6
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4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinic Acid
Catalogue No.:PA 18 49570
Molecular Formula : C20H12ClF4N3O4
Molecular Weight : 469.77
stdClass Object
(
[pname] => N-Desmethyl Regorafenib
[catalogue_number] => PA 18 49580
[category_ids] => 82,80,79,78,76,75,71,70
[chemical_name] =>
[weight] => 468.79
[form] => C20H13ClF4N4O3
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Catalogue No.:PA 18 49580
Molecular Formula : C20H13ClF4N4O3
Molecular Weight : 468.79
stdClass Object
(
[pname] => Regorafenib Tablets EP Impurity FP-A
[catalogue_number] => PA 18 49630
[category_ids] => ,80,71,76,75,78,70,82,
[chemical_name] =>
[weight] => 333.31
[form] => C16H16FN3O4
[cas] => 2514957-39-0
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Regorafenib Tablets EP Impurity FP-A
Catalogue No.:PA 18 49630
Molecular Formula : C16H16FN3O4
Molecular Weight : 333.31
stdClass Object
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[pname] => 4,4'-((2-Fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)azanediyl)bis(N-methylpicolinamide)
[catalogue_number] => PA 18 0491004
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[chemical_name] =>
[weight] => 529.53
[form] => C27H24FN7O4
[cas] => NA
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4,4'-((2-Fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)azanediyl)bis(N-methylpicolinamide)
Catalogue No.:PA 18 0491004
Molecular Formula : C27H24FN7O4
Molecular Weight : 529.53
stdClass Object
(
[pname] => 4-Chloro-N-methyl-6-(methylamino)picolinamide
[catalogue_number] => PA 18 0491005
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[chemical_name] =>
[weight] => 199.64
[form] => C8H10ClN3O
[cas] => 1446410-29-2
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4-Chloro-N-methyl-6-(methylamino)picolinamide
Catalogue No.:PA 18 0491005
Molecular Formula : C8H10ClN3O
Molecular Weight : 199.64
stdClass Object
(
[pname] => 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-ethylurea
[catalogue_number] => PA 18 0491006
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[chemical_name] =>
[weight] => 266.65
[form] => C10H10ClF3N2O
[cas] => 2711-21-9
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1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-ethylurea
Catalogue No.:PA 18 0491006
Molecular Formula : C10H10ClF3N2O
Molecular Weight : 266.65
stdClass Object
(
[pname] => 4-(4-Amino-3-(4-amino-3-fluorophenoxy)phenoxy)-N-methylpicolinamide
[catalogue_number] => PA 18 0491007
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[weight] => 368.37
[form] => C19H17FN4O3
[cas] => 2098799-12-1
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4-(4-Amino-3-(4-amino-3-fluorophenoxy)phenoxy)-N-methylpicolinamide
Catalogue No.:PA 18 0491007
Molecular Formula : C19H17FN4O3
Molecular Weight : 368.37
stdClass Object
(
[pname] => 4-(4-Amino-3-fluorophenoxy)picolinic Acid
[catalogue_number] => PA 18 0491008
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[chemical_name] =>
[weight] => 248.21
[form] => C12H9FN2O3
[cas] => 2817629-89-1
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4-(4-Amino-3-fluorophenoxy)picolinic Acid
Catalogue No.:PA 18 0491008
Molecular Formula : C12H9FN2O3
Molecular Weight : 248.21
stdClass Object
(
[pname] => Methyl 4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylate
[catalogue_number] => PA 18 0491009
[category_ids] => ,79,80,71,78,70,82,
[chemical_name] =>
[weight] => 262.24
[form] => C13H11FN2O3
[cas] => 864245-61-4
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Methyl 4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylate
Catalogue No.:PA 18 0491009
Molecular Formula : C13H11FN2O3
Molecular Weight : 262.24
stdClass Object
(
[pname] => Ethyl 4-(4-amino-3-fluorophenoxy)picolinate
[catalogue_number] => PA 18 0491010
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[chemical_name] =>
[weight] => 276.27
[form] => C14H13FN2O3
[cas] => 2817629-88-0
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Ethyl 4-(4-amino-3-fluorophenoxy)picolinate
Catalogue No.:PA 18 0491010
Molecular Formula : C14H13FN2O3
Molecular Weight : 276.27
stdClass Object
(
[pname] => 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea
[catalogue_number] => PA 18 0491011
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[chemical_name] =>
[weight] => 348.68
[form] => C14H9ClF4N2O2
[cas] => 1333390-56-9
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1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea
Catalogue No.:PA 18 0491011
Molecular Formula : C14H9ClF4N2O2
Molecular Weight : 348.68
stdClass Object
(
[pname] => 3-(4-Chloro-3-(trifluoromethyl)phenyl)-1-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)-1-(2-fluoro-4-hydroxyphenyl)urea
[catalogue_number] => PA 18 0491012
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[chemical_name] =>
[weight] => 570.24
[form] => C22H12Cl2F7N3O3
[cas] => NA
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3-(4-Chloro-3-(trifluoromethyl)phenyl)-1-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)-1-(2-fluoro-4-hydroxyphenyl)urea
Catalogue No.:PA 18 0491012
Molecular Formula : C22H12Cl2F7N3O3
Molecular Weight : 570.24
stdClass Object
(
[pname] => 4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate
[catalogue_number] => PA 18 0491013
[category_ids] => ,79,80,71,78,70,82,
[chemical_name] =>
[weight] => 570.24
[form] => C22H12Cl2F7N3O3
[cas] => 2518416-73-2
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4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate
Catalogue No.:PA 18 0491013
Molecular Formula : C22H12Cl2F7N3O3
Molecular Weight : 570.24
stdClass Object
(
[pname] => 1,3-Bis(4-chloro-3-(trifluoromethyl)phenyl)-1-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)urea
[catalogue_number] => PA 18 0491014
[category_ids] => ,79,80,71,78,70,82,
[chemical_name] =>
[weight] => 638.7
[form] => C23H11Cl3F9N3O2
[cas] => NA
[pslug] => 1-3-bis-4-chloro-3-trifluoromethyl-phenyl-1-4-chloro-3-trifluoromethyl-phenyl-carbamoyl-urea-pa180491014
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1,3-Bis(4-chloro-3-(trifluoromethyl)phenyl)-1-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)urea
stdClass Object
(
[pname] => 4,5,6-trichloro-N-methylpicolinamide
[catalogue_number] => PA 18 0491015
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[chemical_name] =>
[weight] => 239.48
[form] => C7H5Cl3N2O
[cas] => NA
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4,5,6-trichloro-N-methylpicolinamide
Catalogue No.:PA 18 0491015
Molecular Formula : C7H5Cl3N2O
Molecular Weight : 239.48
stdClass Object
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[catalogue_number] => PA 18 0491016
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[chemical_name] =>
[weight] => 348.68
[form] => C14H9ClF4N2O2
[cas] => NA
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1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-6-hydroxyphenyl)urea
Catalogue No.:PA 18 0491016
Molecular Formula : C14H9ClF4N2O2
Molecular Weight : 348.68
stdClass Object
(
[pname] => 4-Hydroxy-N-methylpicolinamide
[catalogue_number] => PA 18 0491017
[category_ids] => ,79,80,71,78,70,82,
[chemical_name] =>
[weight] => 152.15
[form] => C7H8N2O2
[cas] => 611226-36-9
[pslug] => 611226-36-9-4-hydroxy-n-methylpicolinamide-pa180491017
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4-Hydroxy-N-methylpicolinamide
Catalogue No.:PA 18 0491017
Molecular Formula : C7H8N2O2
Molecular Weight : 152.15
