avanafil

Impurities - Chemically, it is a derivative of pyrimidine and is only available as the S-enantiomer.  Avanafil is a new phosphodiesterase-5 inhibitor that is faster acting and more selective than other drugs belonging to the same class. . Reference standards of Avanafil API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => Avanafil Keto Analog
    [catalogue_number] => PA 28 44590
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 400.82
    [form] => C18H17ClN6O3
    [cas] => 1452128-53-8
    [pslug] => 1452128-53-8-avanafil-keto-analog-pa2844590
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PA 28 44590
PA 28 44590

Avanafil Keto Analog

  • Catalogue No.:PA 28 44590

  • CAS :

    1452128-53-8

  • Molecular Formula : C18H17ClN6O3

  • Molecular Weight : 400.82

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Details 
stdClass Object
(
    [pname] => Avanafi Dichloro Analog
    [catalogue_number] => PA 28 44620
    [category_ids] => ,80,71,78,70,82,79,75,
    [chemical_name] => 
    [weight] => 518.4
    [form] => C23H25Cl2N7O3
    [cas] => 2520113-66-8
    [pslug] => 2520113-66-8-avanafi-dichloro-analog-pa2844620
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PA 28 44620
PA 28 44620

Avanafi Dichloro Analog

  • Catalogue No.:PA 28 44620

  • CAS :

    2520113-66-8

  • Molecular Formula : C23H25Cl2N7O3

  • Molecular Weight : 518.4

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Details 
stdClass Object
(
    [pname] => (1,4,5,6-Tetrahydropyrimidin-2-yl)methanamine
    [catalogue_number] => PA 28 44630
    [category_ids] => ,80,79,84,75,
    [chemical_name] => 
    [weight] => 113.16
    [form] => C5H11N3
    [cas] => 759408-08-7
    [pslug] => 759408-08-7-1-4-5-6-tetrahydropyrimidin-2-yl-methanamine-pa2844630
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PA 28 44630
PA 28 44630

(1,4,5,6-Tetrahydropyrimidin-2-yl)methanamine

  • Catalogue No.:PA 28 44630

  • CAS :

    759408-08-7

  • Molecular Formula : C5H11N3

  • Molecular Weight : 113.16

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Details 
stdClass Object
(
    [pname] => 4-((4-((3-Chloro-4-methoxybenzyl)amino)-5-((pyrimidin-2-ylmethyl)carbamoyl)pyrimidin-2-yl)amino)-5-hydroxypentanoic Acid
    [catalogue_number] => PA 28 44640
    [category_ids] => ,80,71,78,70,82,79,75,
    [chemical_name] => 
    [weight] => 515.95
    [form] => C23H26ClN7O5
    [cas] => 2748151-94-0
    [pslug] => 2748151-94-0-4-4-3-chloro-4-methoxybenzyl-amino-5-pyrimidin-2-ylmethyl-carbamoyl-pyrimidin-2-yl-amino-5-hydroxypentanoic-acid-pa2844640
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PA 28 44640
PA 28 44640

4-((4-((3-Chloro-4-methoxybenzyl)amino)-5-((pyrimidin-2-ylmethyl)carbamoyl)pyrimidin-2-yl)amino)-5-hydroxypentanoic Acid

  • Catalogue No.:PA 28 44640

  • CAS :

    2748151-94-0

  • Molecular Formula : C23H26ClN7O5

  • Molecular Weight : 515.95

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Details 
stdClass Object
(
    [pname] => 4-((3-Chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylic Acid
    [catalogue_number] => PA 28 44650
    [category_ids] => ,80,71,78,70,82,79,75,88,
    [chemical_name] => 
    [weight] => 339.8
    [form] => C14H14ClN3O3S
    [cas] => 330786-34-0
    [pslug] => 330786-34-0-4-3-chloro-4-methoxybenzyl-amino-2-methylthio-pyrimidine-5-carboxylic-acid-pa2844650
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PA 28 44650
PA 28 44650

4-((3-Chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylic Acid

  • Catalogue No.:PA 28 44650

  • CAS :

    330786-34-0

  • Molecular Formula : C14H14ClN3O3S

  • Molecular Weight : 339.8

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Details 
stdClass Object
(
    [pname] => Avanafil Isopropyl Amide Analog
    [catalogue_number] => PA 28 44660
    [category_ids] => ,80,71,78,70,82,79,75,
    [chemical_name] => 
    [weight] => 433.93
    [form] => C21H28ClN5O3
    [cas] => 2520114-11-6
    [pslug] => 2520114-11-6-avanafil-isopropyl-amide-analog-pa2844660
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PA 28 44660
PA 28 44660

Avanafil Isopropyl Amide Analog

  • Catalogue No.:PA 28 44660

  • CAS :

    2520114-11-6

  • Molecular Formula : C21H28ClN5O3

  • Molecular Weight : 433.93

Enquire
Details 
stdClass Object
(
    [pname] => Ethyl 4-((2-chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
    [catalogue_number] => PA 28 0441000
    [category_ids] => ,75,76,70,78,82,
    [chemical_name] => 
    [weight] => 367.85
    [form] => C16H18ClN3O3S
    [cas] => 2520114-23-0
    [pslug] => 2520114-23-0-ethyl-4-2-chloro-4-methoxybenzyl-amino-2-methylthio-pyrimidine-5-carboxylate-pa280441000
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PA 28 0441000
PA 28 0441000

Ethyl 4-((2-chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate

  • Catalogue No.:PA 28 0441000

  • CAS :

    2520114-23-0

  • Molecular Formula : C16H18ClN3O3S

  • Molecular Weight : 367.85

Enquire
Details 
stdClass Object
(
    [pname] => Ethyl 4-((3,5-dichloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
    [catalogue_number] => PA 28 0441001
    [category_ids] => ,75,76,70,78,82,
    [chemical_name] => 
    [weight] => 402.29
    [form] => C16H17Cl2N3O3S
    [cas] => 2250242-48-7
    [pslug] => 2250242-48-7-ethyl-4-3-5-dichloro-4-methoxybenzyl-amino-2-methylthio-pyrimidine-5-carboxylate-pa280441001
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PA 28 0441001
PA 28 0441001

Ethyl 4-((3,5-dichloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate

  • Catalogue No.:PA 28 0441001

  • CAS :

    2250242-48-7

  • Molecular Formula : C16H17Cl2N3O3S

  • Molecular Weight : 402.29

Enquire
Details 
stdClass Object
(
    [pname] => Ethyl 4-((3-chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
    [catalogue_number] => PA 28 0441002
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 337.76
    [form] => C15H16ClN3O4
    [cas] => 330785-99-4
    [pslug] => 330785-99-4-ethyl-4-3-chloro-4-methoxybenzyl-amino-2-methylthio-pyrimidine-5-carboxylate-pa280441002
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PA 28 0441002
PA 28 0441002

Ethyl 4-((3-chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate

  • Catalogue No.:PA 28 0441002

  • CAS :

    330785-99-4

  • Molecular Formula : C15H16ClN3O4

  • Molecular Weight : 337.76

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Details 
stdClass Object
(
    [pname] => (S)-Ethyl 4-(3-chloro-4-methoxybenzylamino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate
    [catalogue_number] => PA 28 0441004
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 420.89
    [form] => C20H25ClN4O4
    [cas] => 330785-83-6
    [pslug] => 330785-83-6-s-ethyl-4-3-chloro-4-methoxybenzylamino-2-2-hydroxymethyl-pyrrolidin-1-yl-pyrimidine-5-carboxylate-pa280441004
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PA 28 0441004
PA 28 0441004

(S)-Ethyl 4-(3-chloro-4-methoxybenzylamino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate

  • Catalogue No.:PA 28 0441004

  • CAS :

    330785-83-6

  • Molecular Formula : C20H25ClN4O4

  • Molecular Weight : 420.89

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Details 
stdClass Object
(
    [pname] => (S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-((1,4,5,6-tetrahydropyrimidin-2-yl)methyl)pyrimidine-5-carboxamide
    [catalogue_number] => PA 28 0441005
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 487.99
    [form] => C23H30ClN7O3
    [cas] => 2520113-69-1
    [pslug] => 2520113-69-1-s-4-3-chloro-4-methoxybenzyl-amino-2-2-hydroxymethyl-pyrrolidin-1-yl-n-1-4-5-6-tetrahydropyrimidin-2-yl-methyl-pyrimidine-5-carboxamide-pa280441005
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PA 28 0441005
PA 28 0441005

(S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-((1,4,5,6-tetrahydropyrimidin-2-yl)methyl)pyrimidine-5-carboxamide

  • Catalogue No.:PA 28 0441005

  • CAS :

    2520113-69-1

  • Molecular Formula : C23H30ClN7O3

  • Molecular Weight : 487.99

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Details 
stdClass Object
(
    [pname] => (S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N,N-bis(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide
    [catalogue_number] => PA 28 0441006
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 576.06
    [form] => C28H30ClN9O3
    [cas] => NA
    [pslug] => s-4-3-chloro-4-methoxybenzyl-amino-2-2-hydroxymethyl-pyrrolidin-1-yl-n-n-bis-pyrimidin-2-ylmethyl-pyrimidine-5-carboxamide-pa280441006
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PA 28 0441006
PA 28 0441006

(S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N,N-bis(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide

  • Catalogue No.:PA 28 0441006

  • CAS :

    NA

  • Molecular Formula : C28H30ClN9O3

  • Molecular Weight : 576.06

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Details 
stdClass Object
(
    [pname] => (R)-2-(2-(Hydroxymethyl)pyrrolidin-1-yl)-4-((4-methoxybenzyl)amino)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide
    [catalogue_number] => PA 28 0441007
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 449.52
    [form] => C23H27N7O3
    [cas] => 2250242-21-6
    [pslug] => 2250242-21-6-r-2-2-hydroxymethyl-pyrrolidin-1-yl-4-4-methoxybenzyl-amino-n-pyrimidin-2-ylmethyl-pyrimidine-5-carboxamide-pa280441007
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PA 28 0441007
PA 28 0441007

(R)-2-(2-(Hydroxymethyl)pyrrolidin-1-yl)-4-((4-methoxybenzyl)amino)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide

  • Catalogue No.:PA 28 0441007

  • CAS :

    2250242-21-6

  • Molecular Formula : C23H27N7O3

  • Molecular Weight : 449.52

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Details 
stdClass Object
(
    [pname] => 1H-Benzo[d][1,2,3]triazol-1-yl (S)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate
    [catalogue_number] => PA 28 0441008
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 509.95
    [form] => C24H24ClN7O4
    [cas] => 2520113-98-6
    [pslug] => 2520113-98-6-1h-benzo-d-1-2-3-triazol-1-yl-s-4-3-chloro-4-methoxybenzyl-amino-2-2-hydroxymethyl-pyrrolidin-1-yl-pyrimidine-5-carboxylate-pa280441008
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PA 28 0441008
PA 28 0441008

1H-Benzo[d][1,2,3]triazol-1-yl (S)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate

  • Catalogue No.:PA 28 0441008

  • CAS :

    2520113-98-6

  • Molecular Formula : C24H24ClN7O4

  • Molecular Weight : 509.95

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Details 
stdClass Object
(
    [pname] => 4-((3-Chloro-4-methoxybenzyl)amino)-2-((S)-2-(((4-((3-chloro-4-methoxybenzyl)amino)-2-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carbonyl)oxy)methyl)pyrrolidin-1-yl)pyrimidine-5-carboxylic acid
    [catalogue_number] => PA 28 0441009
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 767.67
    [form] => C36H40Cl2N8O7
    [cas] => 2520114-03-6
    [pslug] => 2520114-03-6-4-3-chloro-4-methoxybenzyl-amino-2-s-2-4-3-chloro-4-methoxybenzyl-amino-2-s-2-hydroxymethyl-pyrrolidin-1-yl-pyrimidine-5-carbonyl-oxy-methyl-pyrrolidin-1-yl-pyrimidine-5-carboxylic-acid-pa280441009
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PA 28 0441009
PA 28 0441009

4-((3-Chloro-4-methoxybenzyl)amino)-2-((S)-2-(((4-((3-chloro-4-methoxybenzyl)amino)-2-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carbonyl)oxy)methyl)pyrrolidin-1-yl)pyrimidine-5-carboxylic acid

  • Catalogue No.:PA 28 0441009

  • CAS :

    2520114-03-6

  • Molecular Formula : C36H40Cl2N8O7

  • Molecular Weight : 767.67

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Details 
stdClass Object
(
    [pname] => (S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-isopropyl-N-(isopropylcarbamoyl)pyrimidine-5-carboxamide
    [catalogue_number] => PA 28 0441010
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 519.04
    [form] => C25H35ClN6O4
    [cas] => 2520114-17-2
    [pslug] => 2520114-17-2-s-4-3-chloro-4-methoxybenzyl-amino-2-2-hydroxymethyl-pyrrolidin-1-yl-n-isopropyl-n-isopropylcarbamoyl-pyrimidine-5-carboxamide-pa280441010
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PA 28 0441010
PA 28 0441010

(S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-isopropyl-N-(isopropylcarbamoyl)pyrimidine-5-carboxamide

  • Catalogue No.:PA 28 0441010

  • CAS :

    2520114-17-2

  • Molecular Formula : C25H35ClN6O4

  • Molecular Weight : 519.04

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Details 
stdClass Object
(
    [pname] => Ethyl (S)-4-((3,5-dichloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate
    [catalogue_number] => PA 28 0441011
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 455.34
    [form] => C20H24Cl2N4O4
    [cas] => 2520114-19-4
    [pslug] => 2520114-19-4-ethyl-s-4-3-5-dichloro-4-methoxybenzyl-amino-2-2-hydroxymethyl-pyrrolidin-1-yl-pyrimidine-5-carboxylate-pa280441011
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PA 28 0441011
PA 28 0441011

Ethyl (S)-4-((3,5-dichloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate

  • Catalogue No.:PA 28 0441011

  • CAS :

    2520114-19-4

  • Molecular Formula : C20H24Cl2N4O4

  • Molecular Weight : 455.34

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Details 
stdClass Object
(
    [pname] =>  (S)-4-((3,5-Dichloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylic acid
    [catalogue_number] => PA 28 0441012
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 427.28
    [form] =>  C18H20Cl2N4O4
    [cas] => 1643811-26-0
    [pslug] => 1643811-26-0s-4-3-5-dichloro-4-methoxybenzyl-amino-2-2-hydroxymethyl-pyrrolidin-1-yl-pyrimidine-5-carboxylic-acid-pa280441012
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PA 28 0441012
PA 28 0441012

 (S)-4-((3,5-Dichloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylic acid

  • Catalogue No.:PA 28 0441012

  • CAS :

    1643811-26-0

  • Molecular Formula : C18H20Cl2N4O4

  • Molecular Weight : 427.28

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Details 
stdClass Object
(
    [pname] =>  Ethyl (S)-4-((2-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate
    [catalogue_number] => PA 28 0441013
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 420.89
    [form] => C20H25ClN4O4
    [cas] => 2520114-28-5
    [pslug] => 2520114-28-5-ethyl-s-4-2-chloro-4-methoxybenzyl-amino-2-2-hydroxymethyl-pyrrolidin-1-yl-pyrimidine-5-carboxylate-pa280441013
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PA 28 0441013
PA 28 0441013

 Ethyl (S)-4-((2-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate

  • Catalogue No.:PA 28 0441013

  • CAS :

    2520114-28-5

  • Molecular Formula : C20H25ClN4O4

  • Molecular Weight : 420.89

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Details 
stdClass Object
(
    [pname] => 4-((3-Chloro-4-methoxybenzyl)amino)-2-(methylsulfinyl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide
    [catalogue_number] => PA 28 0441014
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 446.91
    [form] => C19H19ClN6O3S
    [cas] => 1364671-52-2
    [pslug] => 1364671-52-2-4-3-chloro-4-methoxybenzyl-amino-2-methylsulfinyl-n-pyrimidin-2-ylmethyl-pyrimidine-5-carboxamide-pa280441014
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PA 28 0441014
PA 28 0441014

4-((3-Chloro-4-methoxybenzyl)amino)-2-(methylsulfinyl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide

  • Catalogue No.:PA 28 0441014

  • CAS :

    1364671-52-2

  • Molecular Formula : C19H19ClN6O3S

  • Molecular Weight : 446.91

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Details 
stdClass Object
(
    [pname] => Avanafil D4
    [catalogue_number] => PA STI 089027
    [category_ids] => ,98,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 487.98
    [form] =>  C23H22D4ClN7O3
    [cas] => 2012598-68-2
    [pslug] => 2012598-68-2-avanafil-d4-pasti089027
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PA STI 089027
PA STI 089027

Avanafil D4

  • Catalogue No.:PA STI 089027

  • CAS :

    2012598-68-2

  • Molecular Formula : C23H22D4ClN7O3

  • Molecular Weight : 487.98

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Details 
stdClass Object
(
    [pname] => Avanafil Diamine Impurity
    [catalogue_number] => PA 28 0441015
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 554.43
    [form] => C26H25Cl2N7O3
    [cas] => 1643811-29-3
    [pslug] => 1643811-29-3-avanafil-diamine-impurity-pa280441015
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PA 28 0441015
PA 28 0441015

Avanafil Diamine Impurity

  • Catalogue No.:PA 28 0441015

  • CAS :

    1643811-29-3

  • Molecular Formula : C26H25Cl2N7O3

  • Molecular Weight : 554.43

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