Binimetinib
Binimetinib, also known as Mektovi and ARRY-162. It is used to treat a type of skin cancer.Reference standards of Binimetinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
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(
[pname] => Binimetinib
[catalogue_number] => PA 02 1850000
[category_ids] => ,123,81,78,75,76,82,
[chemical_name] =>
[weight] => 441.23
[form] => C17H15BrF2N4O3
[cas] => 606143-89-9
[pslug] => 606143-89-9-binimetinib-pa021850000
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Catalogue No.:PA 02 1850000
Molecular Formula : C17H15BrF2N4O3
Molecular Weight : 441.23
stdClass Object
(
[pname] => Methyl 4-amino-2,3-difluoro-5-nitrobenzoate
[catalogue_number] => PA 02 1851002
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 232.14
[form] => C8H6F2N2O4
[cas] => 284030-58-6
[pslug] => 284030-58-6-methyl-4-amino-2-3-difluoro-5-nitrobenzoate-pa021851002
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Methyl 4-amino-2,3-difluoro-5-nitrobenzoate
Catalogue No.:PA 02 1851002
Molecular Formula : C8H6F2N2O4
Molecular Weight : 232.14
stdClass Object
(
[pname] => Binimetinib Glucuronide
[catalogue_number] => PA 02 1851003
[category_ids] => ,70,75,76,78,82,95,
[chemical_name] =>
[weight] => 617.36
[form] => C23H23BrF2N4O9
[cas] => NA
[pslug] => binimetinib-glucuronide-pa021851003
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Catalogue No.:PA 02 1851003
Molecular Formula : C23H23BrF2N4O9
Molecular Weight : 617.36
stdClass Object
(
[pname] => Binimetinib Dimer Impurity
[catalogue_number] => PA 02 1851004
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 614.22
[form] => C23H17Br2F3N4O3
[cas] => NA
[pslug] => binimetinib-dimer-impurity-pa021851004
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Binimetinib Dimer Impurity
Catalogue No.:PA 02 1851004
Molecular Formula : C23H17Br2F3N4O3
Molecular Weight : 614.22
stdClass Object
(
[pname] => Binimetinib Amide Impurity
[catalogue_number] => PA 02 1851005
[category_ids] => ,123,81,78,75,76,82,
[chemical_name] =>
[weight] => 497.34
[form] => C21H23BrF2N4O3
[cas] => 1604812-70-5
[pslug] => 1604812-70-5-binimetinib-amide-impurity-pa021851005
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Binimetinib Amide Impurity
Catalogue No.:PA 02 1851005
Molecular Formula : C21H23BrF2N4O3
Molecular Weight : 497.34
stdClass Object
(
[pname] => Binimetinib Methyl Ester Impurity
[catalogue_number] => PA 02 1851006
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 396.19
[form] => C16H12BrF2N3O2
[cas] => 1415559-93-1
[pslug] => 1415559-93-1-binimetinib-methyl-ester-impurity-pa021851006
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Binimetinib Methyl Ester Impurity
Catalogue No.:PA 02 1851006
Molecular Formula : C16H12BrF2N3O2
Molecular Weight : 396.19
stdClass Object
(
[pname] => 5-((4-Bromo-2-fluorophenyl)amino)-N'-(5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carbonyl)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carbohydrazide
[catalogue_number] => PA 02 1851007
[category_ids] => ,78,75,76,82,
[chemical_name] =>
[weight] => 760.35
[form] => C30H20Br2F4N8O2
[cas] => NA
[pslug] => 5-4-bromo-2-fluorophenyl-amino-n-5-4-bromo-2-fluorophenyl-amino-4-fluoro-1-methyl-1h-benzo-d-imidazole-6-carbonyl-4-fluoro-1-methyl-1h-benzo-d-imidazole-6-carbohydrazide-pa021851007
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5-((4-Bromo-2-fluorophenyl)amino)-N'-(5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carbonyl)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carbohydrazide
Catalogue No.:PA 02 1851007
Molecular Formula : C30H20Br2F4N8O2
Molecular Weight : 760.35
stdClass Object
(
[pname] => N-(2-(Aminooxy)ethoxy)-5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxamide
[catalogue_number] => PA 02 1851008
[category_ids] => ,78,75,76,82,
[chemical_name] =>
[weight] => 456.25
[form] => C17H16BrF2N5O3
[cas] => NA
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N-(2-(Aminooxy)ethoxy)-5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxamide
Catalogue No.:PA 02 1851008
Molecular Formula : C17H16BrF2N5O3
Molecular Weight : 456.25
stdClass Object
(
[pname] => N,N'-(Ethane-1,2-diylbis(oxy))bis(5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxamide)
[catalogue_number] => PA 02 1851009
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[chemical_name] =>
[weight] => 820.4
[form] => C32H24Br2F4N8O4
[cas] => NA
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N,N'-(Ethane-1,2-diylbis(oxy))bis(5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxamide)
stdClass Object
(
[pname] => 1,3-Dioxoisoindolin-2-yl 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate
[catalogue_number] => PA 02 1851010
[category_ids] => ,78,75,76,82,
[chemical_name] =>
[weight] => 527.28
[form] => C23H13BrF2N4O4
[cas] => NA
[pslug] => 1-3-dioxoisoindolin-2-yl-5-4-bromo-2-fluorophenyl-amino-4-fluoro-1-methyl-1h-benzo-d-imidazole-6-carboxylate-pa021851010
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1,3-Dioxoisoindolin-2-yl 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate
Catalogue No.:PA 02 1851010
Molecular Formula : C23H13BrF2N4O4
Molecular Weight : 527.28
stdClass Object
(
[pname] => 1-(4-Bromo-2-fluorophenyl)-8-fluoro-5-methyl-1,5-dihydro-3H-imidazo[4',5':4,5]benzo[1,2-c]isoxazol-3-one
[catalogue_number] => PA 02 1851011
[category_ids] => ,78,75,76,82,
[chemical_name] =>
[weight] => 380.15
[form] => C15H8BrF2N3O2
[cas] => NA
[pslug] => 1-4-bromo-2-fluorophenyl-8-fluoro-5-methyl-1-5-dihydro-3h-imidazo-4-5-4-5-benzo-1-2-c-isoxazol-3-one-pa021851011
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1-(4-Bromo-2-fluorophenyl)-8-fluoro-5-methyl-1,5-dihydro-3H-imidazo[4',5':4,5]benzo[1,2-c]isoxazol-3-one
Catalogue No.:PA 02 1851011
Molecular Formula : C15H8BrF2N3O2
Molecular Weight : 380.15
stdClass Object
(
[pname] => Ethyl 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate
[catalogue_number] => PA 02 1851012
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[chemical_name] =>
[weight] => 410.22
[form] => C17H14BrF2N3O2
[cas] => 2509103-99-3
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Ethyl 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate
Catalogue No.:PA 02 1851012
Molecular Formula : C17H14BrF2N3O2
Molecular Weight : 410.22
stdClass Object
(
[pname] => N-Desmethyl Binimetinib
[catalogue_number] => PA 02 1851013
[category_ids] => ,78,75,76,82,
[chemical_name] =>
[weight] => 427.21
[form] => C16H13BrF2N4O3
[cas] => NA
[pslug] => n-desmethyl-binimetinib-pa021851013
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Catalogue No.:PA 02 1851013
Molecular Formula : C16H13BrF2N4O3
Molecular Weight : 427.21
stdClass Object
(
[pname] => Binimetinib-D3
[catalogue_number] => PA STI 089454
[category_ids] => ,98,123,81,78,75,76,82,
[chemical_name] =>
[weight] => 444.25
[form] => C17H12D3BrF2N4O3
[cas] => NA
[pslug] => binimetinib-d3-pasti089454
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Catalogue No.:PA STI 089454
Molecular Formula : C17H12D3BrF2N4O3
Molecular Weight : 444.25
stdClass Object
(
[pname] => Binimetinib Acid Nitroso Impurity
[catalogue_number] => PA 02 1851014
[category_ids] => ,123,81,78,75,76,82,162,
[chemical_name] =>
[weight] => 411.16
[form] => C15H9BrF2N4O3
[cas] => NA
[pslug] => binimetinib-acid-nitroso-impurity-pa021851014
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Binimetinib Acid Nitroso Impurity
Catalogue No.:PA 02 1851014
Molecular Formula : C15H9BrF2N4O3
Molecular Weight : 411.16
stdClass Object
(
[pname] => Binimetinib Methyl Ester Nitroso Impurity
[catalogue_number] => PA 02 1851015
[category_ids] => ,123,81,78,75,76,82,162,
[chemical_name] =>
[weight] => 425.19
[form] => C16H11BrF2N4O3
[cas] => NA
[pslug] => binimetinib-methyl-ester-nitroso-impurity-pa021851015
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Binimetinib Methyl Ester Nitroso Impurity
Catalogue No.:PA 02 1851015
Molecular Formula : C16H11BrF2N4O3
Molecular Weight : 425.19
stdClass Object
(
[pname] => Binimetinib Nitroso Amide Impurity
[catalogue_number] => PA 02 1851016
[category_ids] => ,123,81,78,75,76,82,162,
[chemical_name] =>
[weight] => 526.34
[form] => C21H22BrF2N5O4
[cas] => NA
[pslug] => binimetinib-nitroso-amide-impurity-pa021851016
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Binimetinib Nitroso Amide Impurity
Catalogue No.:PA 02 1851016
Molecular Formula : C21H22BrF2N5O4
Molecular Weight : 526.34
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(
[pname] => 5-((4-Bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-N-(2-(vinyloxy)ethoxy)-1H-benzo[d]imidazole-6-carboxamide
[catalogue_number] => PA 02 1851017
[category_ids] => ,78,75,76,82,
[chemical_name] =>
[weight] => 467.27
[form] => C19H17BrF2N4O3
[cas] => 1415559-75-9
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5-((4-Bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-N-(2-(vinyloxy)ethoxy)-1H-benzo[d]imidazole-6-carboxamide
Catalogue No.:PA 02 1851017
Molecular Formula : C19H17BrF2N4O3
Molecular Weight : 467.27
stdClass Object
(
[pname] => Binimetinib Des Ethanediol Impurity
[catalogue_number] => PA 02 1851018
[category_ids] => ,123,81,78,75,76,82,
[chemical_name] =>
[weight] => 381.18
[form] => C15H11BrF2N4O
[cas] => 2851526-50-4
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Binimetinib Des Ethanediol Impurity
Catalogue No.:PA 02 1851018
Molecular Formula : C15H11BrF2N4O
Molecular Weight : 381.18
stdClass Object
(
[pname] => Binimetinib Des Bromo Impurity
[catalogue_number] => PA 02 1851019
[category_ids] => ,123,81,78,75,76,82,
[chemical_name] =>
[weight] => 362.34
[form] => C17H16F2N4O3
[cas] => NA
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Binimetinib Des Bromo Impurity
Catalogue No.:PA 02 1851019
Molecular Formula : C17H16F2N4O3
Molecular Weight : 362.34
stdClass Object
(
[pname] => 4-Fluoro-5-((2-fluorophenyl)amino)-1-methyl-1H-benzo[d]imidazole-6-carboxylic Acid
[catalogue_number] => PA 02 1851020
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[chemical_name] =>
[weight] => 303.27
[form] => C15H11F2N3O2
[cas] => 2649854-87-3
[pslug] => 2649854-87-3-4-fluoro-5-2-fluorophenyl-amino-1-methyl-1h-benzo-d-imidazole-6-carboxylic-acid-pa021851020
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4-Fluoro-5-((2-fluorophenyl)amino)-1-methyl-1H-benzo[d]imidazole-6-carboxylic Acid
Catalogue No.:PA 02 1851020
Molecular Formula : C15H11F2N3O2
Molecular Weight : 303.27
stdClass Object
(
[pname] => 4-Fluoro-5-((2-fluorophenyl)amino)-1-methyl-N-(2-(vinyloxy)ethoxy)-1H-benzo[d]imidazole-6-carboxamide
[catalogue_number] => PA 02 1851021
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[chemical_name] =>
[weight] => 388.37
[form] => C19H18F2N4O3
[cas] => 2649854-88-4
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4-Fluoro-5-((2-fluorophenyl)amino)-1-methyl-N-(2-(vinyloxy)ethoxy)-1H-benzo[d]imidazole-6-carboxamide
Catalogue No.:PA 02 1851021
Molecular Formula : C19H18F2N4O3
Molecular Weight : 388.37
stdClass Object
(
[pname] => 5-((4-Bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylic Acid
[catalogue_number] => PA 02 1851022
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[chemical_name] =>
[weight] => 382.16
[form] => C15H10BrF2N3O2
[cas] => NA
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5-((4-Bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylic Acid
Catalogue No.:PA 02 1851022
Molecular Formula : C15H10BrF2N3O2
Molecular Weight : 382.16
stdClass Object
(
[pname] => 5-((4-Bromo-2-fluorophenyl)amino)-N-(2-ethoxyethoxy)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxamide
[catalogue_number] => PA 02 1851023
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[weight] => 469.29
[form] => C19H19BrF2N4O3
[cas] => NA
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5-((4-Bromo-2-fluorophenyl)amino)-N-(2-ethoxyethoxy)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxamide
Catalogue No.:PA 02 1851023
Molecular Formula : C19H19BrF2N4O3
Molecular Weight : 469.29
stdClass Object
(
[pname] => Binimetinib Acid Impurity
[catalogue_number] => PA 02 1851025
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[weight] => 382.16
[form] => C15H10BrF2N3O2
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Binimetinib Acid Impurity
Catalogue No.:PA 02 1851025
Molecular Formula : C15H10BrF2N3O2
Molecular Weight : 382.16
stdClass Object
(
[pname] => 5-(4-Bromo-2-fluorophenyl)-4-fluoro-7-(2-hydroxyethoxy)-1,6-dimethyl-1,5,6,7-tetrahydro-8H-imidazo[4,5-g]quinazolin-8-one
[catalogue_number] => PA 02 1851026
[category_ids] => ,78,75,76,82,
[chemical_name] =>
[weight] => 467.27
[form] => C19H17BrF2N4O3
[cas] => NA
[pslug] => 5-4-bromo-2-fluorophenyl-4-fluoro-7-2-hydroxyethoxy-1-6-dimethyl-1-5-6-7-tetrahydro-8h-imidazo-4-5-g-quinazolin-8-one-pa021851026
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5-(4-Bromo-2-fluorophenyl)-4-fluoro-7-(2-hydroxyethoxy)-1,6-dimethyl-1,5,6,7-tetrahydro-8H-imidazo[4,5-g]quinazolin-8-one
Catalogue No.:PA 02 1851026
Molecular Formula : C19H17BrF2N4O3
Molecular Weight : 467.27
stdClass Object
(
[pname] => 2-((5-((4-Bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxamido)oxy)ethyl acetate
[catalogue_number] => PA 02 1851027
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[chemical_name] =>
[weight] => 483.27
[form] => C19H17BrF2N4O4
[cas] => NA
[pslug] => 2-5-4-bromo-2-fluorophenyl-amino-4-fluoro-1-methyl-1h-benzo-d-imidazole-6-carboxamido-oxy-ethyl-acetate-pa021851027
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2-((5-((4-Bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxamido)oxy)ethyl acetate
Catalogue No.:PA 02 1851027
Molecular Formula : C19H17BrF2N4O4
Molecular Weight : 483.27
stdClass Object
(
[pname] => 2,4-Diamino-3-fluoro-5-nitrobenzoic Acid
[catalogue_number] => PA 02 1851028
[category_ids] => ,78,75,76,82,
[chemical_name] =>
[weight] => 215.14
[form] => C7H6FN3O4
[cas] => 918321-31-0
[pslug] => 918321-31-0-2-4-diamino-3-fluoro-5-nitrobenzoic-acid-pa021851028
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2,4-Diamino-3-fluoro-5-nitrobenzoic Acid
Catalogue No.:PA 02 1851028
Molecular Formula : C7H6FN3O4
Molecular Weight : 215.14
stdClass Object
(
[pname] => Binimetinib 13C2,D4 Â Â Â
[catalogue_number] => PA STI 089870
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[chemical_name] =>
[weight] => 447.24
[form] => C1513C2H11D4BrF2N4O3
[cas] => NA
[pslug] => binimetinib-13c2-d4-pasti089870
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Binimetinib 13C2,D4 Â Â Â
Catalogue No.:PA STI 089870
Molecular Formula : C1513C2H11D4BrF2N4O3
Molecular Weight : 447.24
stdClass Object
(
[pname] => 5-((4-Bromo-2-fluorophenyl)amino)-4-fluoro-N-hydroxy-1-methyl-1H-benzo[d]imidazole-6-carboxamide
[catalogue_number] => PA 02 1851029
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[chemical_name] =>
[weight] => 397.18
[form] => C15H11BrF2N4O2
[cas] => NA
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5-((4-Bromo-2-fluorophenyl)amino)-4-fluoro-N-hydroxy-1-methyl-1H-benzo[d]imidazole-6-carboxamide
Catalogue No.:PA 02 1851029
Molecular Formula : C15H11BrF2N4O2
Molecular Weight : 397.18
stdClass Object
(
[pname] => N-Nitroso N-Desmethyl Binimetinib
[catalogue_number] => PA 02 1851030
[category_ids] => ,78,75,76,82,162,
[chemical_name] =>
[weight] => 456.2
[form] => C16H12BrF2N5O4
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N-Nitroso N-Desmethyl Binimetinib