Ibrutinib-impurities | Pharmaffiliates

ibrutinib

Ibrutinib is used to treat chronic lymphocytic leukemia Waldenström's macroglobulinemia, and as a second-line treatment for mantle cell lymphoma, marginal zone lymphoma, and chronic graft vs host disease. It is a small molecule drug. Reference standards of Ibrutinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

PA 09 27510

1,3-bis((R)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one


  • Catalogue No.:PA 09 27510

  • CAS :

    NA

  • Molecular Formula : C47H46N12O3

  • Molecular Weight : 826.95

PA 09 27520

(R)-3-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-oxopropyl Acrylate


  • Catalogue No.:PA 09 27520

  • CAS :

    NA

  • Molecular Formula : C28H28N6O4

  • Molecular Weight : 512.56

PA 09 27530

1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidyl]-3-[[(1R)-3-(4-phenoxyphenyl)-1-(1-prop-2-enoyl-3-piperidyl)pyrazolo[3,4-d]pyrimidin-4-yl]amino]propan-1-one


  • Catalogue No.:PA 09 27530

  • CAS :

    2031255-23-7

  • Molecular Formula : C50H48N12O4

  • Molecular Weight : 880.99

PAI 09 007080

4-Aminopyrazolo[3,4-d]pyrimidine


  • Catalogue No.:PAI 09 007080

  • CAS :

    2380-63-4

  • Molecular Formula : C5H5N5

  • Molecular Weight : 135.13

PA 09 0271001

Ibrutinib-biotin


  • Catalogue No.:PA 09 0271001

  • CAS :

    1599432-18-4

  • Molecular Formula : C56H80N12O9S

  • Molecular Weight : 1097.39

PA 09 0271002

(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethan-1-one


  • Catalogue No.:PA 09 0271002

  • CAS :

    NA

  • Molecular Formula : C24H24N6O2

  • Molecular Weight : 428.5

PA 09 0271003

(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-chloropropan-1-one


  • Catalogue No.:PA 09 0271003

  • CAS :

    1288338-96-4

  • Molecular Formula : C25H25ClN6O2

  • Molecular Weight : 476.97

PA 09 0271004

(R)-N-(3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-1,1,1-triphenyl-l5-phosphanimine


  • Catalogue No.:PA 09 0271004

  • CAS :

    NA

  • Molecular Formula : C40H35N6OP

  • Molecular Weight : 646.73

PA 09 0271005

(R)-1-(3-(3-(4-Phenoxyphenyl)-4-((triphenyl-l5-phosphanylidene)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one


  • Catalogue No.:PA 09 0271005

  • CAS :

    NA

  • Molecular Formula : C43H37N6O2P

  • Molecular Weight : 700.78

PA 09 0271006

1-((S)-3-(2-(3-((R)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-oxopropyl)-4-imino-3-(4-phenoxyphenyl)-2,4-dihydro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one


  • Catalogue No.:PA 09 0271006

  • CAS :

    NA

  • Molecular Formula : C50H48N12O4

  • Molecular Weight : 881.01

PA 09 0271007

(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Dihydrochloride


  • Catalogue No.:PA 09 0271007

  • CAS :

    1701403-10-2

  • Molecular Formula : C22H24Cl2N6O

  • Molecular Weight : 459.38

PA 09 0271008

Ibrutinib N-Oxide impurity


  • Catalogue No.:PA 09 0271008

  • CAS :

    NA

  • Molecular Formula : C25H24N6O3

  • Molecular Weight : 456.5

PA 09 0271009

(R)-N-Desacryloyl N-Propionyl Ibrutinib


  • Catalogue No.:PA 09 0271009

  • CAS :

    1839099-22-7

  • Molecular Formula : C25H26N6O2

  • Molecular Weight : 442.52

PA 09 0271012

1-((R)-3-(5-(3-((R)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-oxopropyl)-4-imino-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one


  • Catalogue No.:PA 09 0271012

  • CAS :

    2417548-76-4

  • Molecular Formula : C50H48N12O4

  • Molecular Weight : 881.01

PA STI 088988

1-((R)-3-(4-Amino-3-(4-(phenoxy-d5)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2,3-dihydroxypropan-1-one


  • Catalogue No.:PA STI 088988

  • CAS :

    2068022-09-1

  • Molecular Formula : C25H21D5N6O4

  • Molecular Weight : 479.55

PA 09 0271010

1-Methyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine


  • Catalogue No.:PA 09 0271010

  • CAS :

    2213398-75-3

  • Molecular Formula : C18H15N5O

  • Molecular Weight : 317.35

PA 09 0271011

1,1'-(((Oxybis(4,1-phenylene))bis(4-amino-1H-pyrazolo[3,4-d]pyrimidine-3,1-diyl))bis(piperidine-3,1-diyl))bis(prop-2-en-1-one)


  • Catalogue No.:PA 09 0271011

  • CAS :

    NA

  • Molecular Formula : C38H38N12O3

  • Molecular Weight : 710.8