imatinib
Impurities
- Imatinib is a small molecule kinase inhibitor used to treat certain types of cancer. It is occasionally referred to as CGP57148B or STI571. It is used in treating chronic myelogenous leukemia, gastrointestinal stromal tumors and a number of other malignancies. Reference standards of Imatinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
stdClass Object
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[pname] => Imatinib (Pyridine)-N-oxide
[catalogue_number] => PA 09 05010
[category_ids] => ,80,71,75,78,70,82,
[chemical_name] =>
[weight] => 509.6
[form] => C29H31N7O2
[cas] => 571186-92-0
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Imatinib (Pyridine)-N-oxide
stdClass Object
(
[pname] => Imatinib (Piperidine)-N,N-DiOxide
[catalogue_number] => PA 09 05020
[category_ids] => ,80,71,75,78,70,82,
[chemical_name] =>
[weight] => 525.6
[form] => C29H31N7O3
[cas] => 571186-93-1
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Imatinib (Piperidine)-N,N-DiOxide
stdClass Object
(
[pname] => Imatinib (Piperidine)-N,N-DiOxide Methanesulfonate
[catalogue_number] => PA 09 05021
[category_ids] => ,80,71,75,78,70,82,88,
[chemical_name] =>
[weight] => 621.71
[form] => C30H35N7O6S
[cas] => NA
[pslug] => imatinib-piperidine-n-n-dioxide-methanesulfonate-pa0905021
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Imatinib (Piperidine)-N,N-DiOxide Methanesulfonate
Catalogue No.:PA 09 05021
Molecular Formula : C30H35N7O6S
Molecular Weight : 621.71
stdClass Object
(
[pname] => Imatinib - Impurity D
[catalogue_number] => PA 09 05040
[category_ids] => ,82,80,78,75,71,70,
[chemical_name] =>
[weight] => 923.50
[form] => C53H51ClN12O2
[cas] => NA
[pslug] => imatinib-impurity-d-pa0905040
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Catalogue No.:PA 09 05040
Molecular Formula : C53H51ClN12O2
Molecular Weight : 923.50
stdClass Object
(
[pname] => 4-(4-Methylpiperazin-1-ylmethyl)benzoyl chloride Dichydrochloride
[catalogue_number] => PA 09 05510
[category_ids] => ,71,75,80,78,70,82,
[chemical_name] =>
[weight] => 325.66
[form] => C13H19Cl3N2O
[cas] => 106261-64-7
[pslug] => 106261-64-7-4-4-methylpiperazin-1-ylmethyl-benzoyl-chloride-dichydrochloride-pa0905510
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4-(4-Methylpiperazin-1-ylmethyl)benzoyl chloride Dichydrochloride
Catalogue No.:PA 09 05510
Molecular Formula : C13H19Cl3N2O
Molecular Weight : 325.66
stdClass Object
(
[pname] => Imatinib - Impurity F
[catalogue_number] => PA 09 05520
[category_ids] => ,80,71,75,78,70,82,
[chemical_name] =>
[weight] => 277.32
[form] => C16H15N5
[cas] => 152460-10-1
[pslug] => 152460-10-1-imatinib-impurity-f-pa0905520
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Catalogue No.:PA 09 05520
Molecular Formula : C16H15N5
Molecular Weight : 277.32
stdClass Object
(
[pname] => Imatinib Meta-methyl-piperazine Impurity
[catalogue_number] => PA 09 05530
[category_ids] => ,80,71,75,78,70,82,
[chemical_name] =>
[weight] => 493.6
[form] => C29H31N7O
[cas] => 1246819-59-9
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Imatinib Meta-methyl-piperazine Impurity
stdClass Object
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[pname] => Imatinib (Piperidine)-N4-Oxide
[catalogue_number] => PA 09 05540
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[chemical_name] =>
[weight] => 509.6
[form] => C29H31N7O2
[cas] => 938082-57-6
[pslug] => 938082-57-6-imatinib-piperidine-n4-oxide-pa0905540
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Imatinib (Piperidine)-N4-Oxide
stdClass Object
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[pname] => 1-(Chloromethyl)-1-methyl-4-(4-((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)benzyl)piperazin-1-ium chloride
[catalogue_number] => PA 09 05550
[category_ids] => ,80,71,75,78,70,82,
[chemical_name] =>
[weight] => 578.54
[form] => C30H33Cl2N7O
[cas] => NA
[pslug] => 1-chloromethyl-1-methyl-4-4-4-methyl-3-4-pyridin-3-yl-pyrimidin-2-yl-amino-phenyl-carbamoyl-benzyl-piperazin-1-ium-chloride-pa0905550
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1-(Chloromethyl)-1-methyl-4-(4-((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)benzyl)piperazin-1-ium chloride
Catalogue No.:PA 09 05550
Molecular Formula : C30H33Cl2N7O
Molecular Weight : 578.54
stdClass Object
(
[pname] => Imatinib Carboxylic Impurity
[catalogue_number] => PA 09 05560
[category_ids] => ,80,71,75,78,70,82,
[chemical_name] =>
[weight] => 307.22
[form] => C13H20Cl2N2O2
[cas] => 106261-49-8
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Imatinib Carboxylic Impurity
Catalogue No.:PA 09 05560
Molecular Formula : C13H20Cl2N2O2
Molecular Weight : 307.22
stdClass Object
(
[pname] => 4-Methyl-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide methanesulfonate
[catalogue_number] => PA 09 28510
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[chemical_name] =>
[weight] => 491.56
[form] => C25H25N5O4S
[cas] => NA
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4-Methyl-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide methanesulfonate
Catalogue No.:PA 09 28510
Molecular Formula : C25H25N5O4S
Molecular Weight : 491.56
stdClass Object
(
[pname] => Imatinib Meta-methyl-piperazine Impurity-d3
[catalogue_number] => PA STI 052680
[category_ids] => ,80,71,75,98,78,70,82,
[chemical_name] =>
[weight] => 496.62
[form] => C29H28D3N7O
[cas] => 1246819-35-9
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Imatinib Meta-methyl-piperazine Impurity-d3
Catalogue No.:PA STI 052680
Molecular Formula : C29H28D3N7O
Molecular Weight : 496.62
stdClass Object
(
[pname] => Imatinib Para-diaminomethylbenzene Impurity-d3
[catalogue_number] => PA STI 052690
[category_ids] => ,80,71,75,98,78,70,82,
[chemical_name] =>
[weight] => 496.62
[form] => C29H28D3N7O
[cas] => 1246819-27-1
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Imatinib Para-diaminomethylbenzene Impurity-d3
Catalogue No.:PA STI 052690
Molecular Formula : C29H28D3N7O
Molecular Weight : 496.62
stdClass Object
(
[pname] => N-(4-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
[catalogue_number] => PA 09 05610
[category_ids] => ,80,71,76,75,78,70,82,
[chemical_name] =>
[weight] => 277.32
[form] => C16H15N5
[cas] => 112696-91-0
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N-(4-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
Catalogue No.:PA 09 05610
Molecular Formula : C16H15N5
Molecular Weight : 277.32
stdClass Object
(
[pname] => Imatinib para-Diaminomethylbenzene
[catalogue_number] => PA 09 0051000
[category_ids] => ,75,76,78,82,
[chemical_name] =>
[weight] => 493.60
[form] => C29H31N7O
[cas] => 1026753-54-7
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Imatinib para-Diaminomethylbenzene
Catalogue No.:PA 09 0051000
Molecular Formula : C29H31N7O
Molecular Weight : 493.60
stdClass Object
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[pname] => Imatinib D4
[catalogue_number] => PA STI 088698
[category_ids] => ,78,75,70,76,82,
[chemical_name] =>
[weight] => 497.64
[form] => C29H27D4N7O
[cas] => 1134803-16-9
[pslug] => 1134803-16-9-imatinib-d4-pasti088698
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Catalogue No.:PA STI 088698
Molecular Formula : C29H27D4N7O
Molecular Weight : 497.64
stdClass Object
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[pname] => N-Boc-N-Desmethyl Imatinib
[catalogue_number] => PA 09 0051001
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 579.71
[form] => C33H37N7O3
[cas] => 1076199-23-9
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N-Boc-N-Desmethyl Imatinib
Catalogue No.:PA 09 0051001
Molecular Formula : C33H37N7O3
Molecular Weight : 579.71
stdClass Object
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[pname] => 6-Methyl-N1-(4-methyl-6-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
[catalogue_number] => PA 09 0051002
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 291.36
[form] => C17H17N5
[cas] => 1032314-73-0
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6-Methyl-N1-(4-methyl-6-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
Catalogue No.:PA 09 0051002
Molecular Formula : C17H17N5
Molecular Weight : 291.36
stdClass Object
(
[pname] => 4-methyl-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
[catalogue_number] => PA 09 0051003
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 395.47
[form] => C24H21N5O
[cas] => 152459-96-6
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4-methyl-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
Catalogue No.:PA 09 0051003
Molecular Formula : C24H21N5O
Molecular Weight : 395.47
stdClass Object
(
[pname] => 4-(chloromethyl)benzoic acid
[catalogue_number] => PA 09 0051004
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 170.59
[form] => C8H7ClO2
[cas] => 1642-81-5
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4-(chloromethyl)benzoic acid
Catalogue No.:PA 09 0051004
Molecular Formula : C8H7ClO2
Molecular Weight : 170.59
stdClass Object
(
[pname] => N-(2-methyl-5-nitrophenyl)-[3,4'-bipyridin]-2'-amine
[catalogue_number] => PA 09 0051005
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 306.33
[form] => C17H14N4O2
[cas] => 641615-50-1
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N-(2-methyl-5-nitrophenyl)-[3,4'-bipyridin]-2'-amine
Catalogue No.:PA 09 0051005
Molecular Formula : C17H14N4O2
Molecular Weight : 306.33
stdClass Object
(
[pname] => Desmethyl Imatinib D4
[catalogue_number] => PA STI 089122
[category_ids] => ,98,75,76,78,70,82,
[chemical_name] =>
[weight] => 483.61
[form] => C28H25D4N7O
[cas] => NA
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Catalogue No.:PA STI 089122
Molecular Formula : C28H25D4N7O
Molecular Weight : 483.61
stdClass Object
(
[pname] => sec-Butyl 4-((4-methylpiperazin-1-yl)methyl)benzoate
[catalogue_number] => PA 09 0051006
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 290.41
[form] => C17H26N2O2
[cas] => NA
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sec-Butyl 4-((4-methylpiperazin-1-yl)methyl)benzoate
Catalogue No.:PA 09 0051006
Molecular Formula : C17H26N2O2
Molecular Weight : 290.41
stdClass Object
(
[pname] => N-(4-Methyl-3-(nitroso(4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
[catalogue_number] => PA 09 0051007
[category_ids] => ,70,75,76,78,82,162,
[chemical_name] =>
[weight] => 522.61
[form] => C29H30N8O2
[cas] => NA
[pslug] => n-4-methyl-3-nitroso-4-pyridin-3-yl-pyrimidin-2-yl-amino-phenyl-4-4-methylpiperazin-1-yl-methyl-benzamide-pa090051007
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N-(4-Methyl-3-(nitroso(4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
Catalogue No.:PA 09 0051007
Molecular Formula : C29H30N8O2
Molecular Weight : 522.61
stdClass Object
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[pname] => N-(4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-nitrosopiperazin-1-yl)methyl)benzamide
[catalogue_number] => PA 09 0051008
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[chemical_name] =>
[weight] => 508.59
[form] => C28H28N8O2
[cas] => 2816369-80-7
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N-(4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-nitrosopiperazin-1-yl)methyl)benzamide
Catalogue No.:PA 09 0051008
Molecular Formula : C28H28N8O2
Molecular Weight : 508.59
stdClass Object
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N-(4-Methyl-3-(nitroso(4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperazin-1-ylmethyl)benzamide
Catalogue No.:PA 09 0051012
Molecular Formula : C28H28N8O2
Molecular Weight : 508.59
stdClass Object
(
[pname] => N-(4-Methyl-3-(nitroso(4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide Acetate
[catalogue_number] => PA 09 0051013
[category_ids] => ,70,75,76,78,82,162,
[chemical_name] =>
[weight] => 582.67
[form] => C31H34N8O4
[cas] => NA
[pslug] => n-4-methyl-3-nitroso-4-pyridin-3-yl-pyrimidin-2-yl-amino-phenyl-4-4-methylpiperazin-1-yl-methyl-benzamide-acetate-pa090051013
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N-(4-Methyl-3-(nitroso(4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide Acetate
Catalogue No.:PA 09 0051013
Molecular Formula : C31H34N8O4
Molecular Weight : 582.67
