ivacaftor
Impurities
- Ivacaftor is used for the treatment of cystic fibrosis in people having one of several specific mutations in the cystic fibrosis transmembrane conductance regulator protein. It is one of the most expensive drugs. Reference standards of Ivacaftor API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
stdClass Object
(
[pname] => N-(3,5-Di-tert-butyl-2-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
[catalogue_number] => PA 09 40540
[category_ids] => ,80,79,75,71,
[chemical_name] =>
[weight] => 392.49
[form] => C24H28N2O3
[cas] => 873051-52-6
[pslug] => 873051-52-6-n-3-5-di-tert-butyl-2-hydroxyphenyl-4-oxo-1-4-dihydroquinoline-3-carboxamide-pa0940540
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N-(3,5-Di-tert-butyl-2-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
Catalogue No.:PA 09 40540
Molecular Formula : C24H28N2O3
Molecular Weight : 392.49
stdClass Object
(
[pname] => Ivacaftor N-glucuronide
[catalogue_number] => PA 09 40550
[category_ids] => ,71,75,79,80,95,
[chemical_name] =>
[weight] => 568.61
[form] => C30H36N2O9
[cas] => NA
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Catalogue No.:PA 09 40550
Molecular Formula : C30H36N2O9
Molecular Weight : 568.61
stdClass Object
(
[pname] => Ivacaftor Carboxylic Acid
[catalogue_number] => PA 09 40560
[category_ids] => ,80,79,71,75,
[chemical_name] =>
[weight] => 422.47
[form] => C24H26N2O5
[cas] => 1246213-24-0
[pslug] => 1246213-24-0-ivacaftor-carboxylic-acid-pa0940560
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Ivacaftor Carboxylic Acid
Catalogue No.:PA 09 40560
Molecular Formula : C24H26N2O5
Molecular Weight : 422.47
stdClass Object
(
[pname] => Hydroxymethyl Ivacaftor
[catalogue_number] => PA 09 40570
[category_ids] => ,80,79,71,75,
[chemical_name] =>
[weight] => 408.49
[form] => C24H28N2O4
[cas] => 1246213-23-9
[pslug] => 1246213-23-9-hydroxymethyl-ivacaftor-pa0940570
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Catalogue No.:PA 09 40570
Molecular Formula : C24H28N2O4
Molecular Weight : 408.49
stdClass Object
(
[pname] => diethyl 2-((phenylamino)methylene)malonate
[catalogue_number] => PA 09 0401000
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 263.29
[form] => C14H17NO4
[cas] => 54535-22-7
[pslug] => 54535-22-7-diethyl-2-phenylamino-methylene-malonate-pa090401000
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diethyl 2-((phenylamino)methylene)malonate
Catalogue No.:PA 09 0401000
Molecular Formula : C14H17NO4
Molecular Weight : 263.29
stdClass Object
(
[pname] => De-Alkylated Ivacaftor
[catalogue_number] => PA 09 0401001
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 336.39
[form] => C20H20N2O3
[cas] => 873054-39-8
[pslug] => 873054-39-8-de-alkylated-ivacaftor-pa090401001
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Catalogue No.:PA 09 0401001
Molecular Formula : C20H20N2O3
Molecular Weight : 336.39
stdClass Object
(
[pname] => Ivacaftor D4
[catalogue_number] => PA STI 089107
[category_ids] => ,98,75,76,78,70,82,
[chemical_name] =>
[weight] => 396.52
[form] => C24H24D4N2O3
[cas] => NA
[pslug] => ivacaftor-d4-pasti089107
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Catalogue No.:PA STI 089107
Molecular Formula : C24H24D4N2O3
Molecular Weight : 396.52
stdClass Object
(
[pname] => 4-Hydroxyquinoline-3-carboxylic Acid
[catalogue_number] => PA 09 0401002
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 189.17
[form] => C10H7NO3
[cas] => 34785-11-0
[pslug] => 34785-11-0-4-hydroxyquinoline-3-carboxylic-acid-pa090401002
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4-Hydroxyquinoline-3-carboxylic Acid
Catalogue No.:PA 09 0401002
Molecular Formula : C10H7NO3
Molecular Weight : 189.17
stdClass Object
(
[pname] => Ivacaftor D18
[catalogue_number] => PA STI 089190
[category_ids] => ,98,75,76,78,70,82,
[chemical_name] =>
[weight] => 410.61
[form] => C24H10D18N2O3
[cas] => 1413431-05-6
[pslug] => 1413431-05-6-ivacaftor-d18-pasti089190
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Catalogue No.:PA STI 089190
Molecular Formula : C24H10D18N2O3
Molecular Weight : 410.61
