Roflumilast-impurities | Pharmaffiliates

roflumilast

Roflumilast is used in the prevention of lung attacks in severe COPD. It is a long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4).Reference standards of Roflumilast API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => Roflumilast N-Oxide
    [catalogue_number] => PA 18 15530
    [category_ids] => 82,81,78,76,75,71,70
    [chemical_name] => 
    [weight] => 419.21
    [form] => C17H14Cl2F2N2O4
    [cas] => 292135-78-5
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PA 18 15530

Roflumilast N-Oxide


  • Catalogue No.:PA 18 15530

  • CAS :

    292135-78-5

  • Molecular Formula : C17H14Cl2F2N2O4

  • Molecular Weight : 419.21

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stdClass Object
(
    [pname] => 5-Dechloro Roflumilast
    [catalogue_number] => PA 18 15510
    [category_ids] => ,71,75,81,78,70,82,
    [chemical_name] => 
    [weight] => 368.76
    [form] => C17H15ClF2N2O3
    [cas] => 1391053-75-0
    [pslug] => 1391053-75-0-5-dechloro-roflumilast-pa1815510
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PA 18 15510

5-Dechloro Roflumilast


  • Catalogue No.:PA 18 15510

  • CAS :

    1391053-75-0

  • Molecular Formula : C17H15ClF2N2O3

  • Molecular Weight : 368.76

stdClass Object
(
    [pname] => 3-O-Decyclopropyl Roflumilast
    [catalogue_number] => PA 18 15520
    [category_ids] => ,80,71,75,81,78,70,82,
    [chemical_name] => 
    [weight] => 349.12
    [form] => C13H8Cl2F2N2O3
    [cas] => 1391052-76-8
    [pslug] => 1391052-76-8-3-o-decyclopropyl-roflumilast-pa1815520
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PA 18 15520

3-O-Decyclopropyl Roflumilast


  • Catalogue No.:PA 18 15520

  • CAS :

    1391052-76-8

  • Molecular Formula : C13H8Cl2F2N2O3

  • Molecular Weight : 349.12

stdClass Object
(
    [pname] => Roflumilast Carboxylic Acid Impurity
    [catalogue_number] => PA 18 15540
    [category_ids] => ,80,75,70,
    [chemical_name] => 
    [weight] => 258.22
    [form] => C12H12F2O4
    [cas] => 162401-62-9
    [pslug] => 162401-62-9-roflumilast-carboxylic-acid-impurity-pa1815540
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PA 18 15540

Roflumilast Carboxylic Acid Impurity


  • Catalogue No.:PA 18 15540

  • CAS :

    162401-62-9

  • Molecular Formula : C12H12F2O4

  • Molecular Weight : 258.22

stdClass Object
(
    [pname] => 3,4-Di(cyclopropylmethoxy) Roflumilast
    [catalogue_number] => PA 18 15570
    [category_ids] => ,80,71,75,81,78,70,82,
    [chemical_name] => 
    [weight] => 407.29
    [form] => C20H20Cl2N2O3
    [cas] => 1391052-24-6
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PA 18 15570

3,4-Di(cyclopropylmethoxy) Roflumilast


  • Catalogue No.:PA 18 15570

  • CAS :

    1391052-24-6

  • Molecular Formula : C20H20Cl2N2O3

  • Molecular Weight : 407.29

stdClass Object
(
    [pname] => 4-(Cyclopropylmethoxy)-3-(difluoromethoxy) Roflumilast
    [catalogue_number] => PA 18 15580
    [category_ids] => ,80,71,75,81,78,70,82,
    [chemical_name] => 
    [weight] => 403.21
    [form] => C17H14Cl2F2N2O3
    [cas] => 162401-43-6
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PA 18 15580

4-(Cyclopropylmethoxy)-3-(difluoromethoxy) Roflumilast


  • Catalogue No.:PA 18 15580

  • CAS :

    162401-43-6

  • Molecular Formula : C17H14Cl2F2N2O3

  • Molecular Weight : 403.21

stdClass Object
(
    [pname] => 3,4-bis(Difluoromethoxy) Roflumilast
    [catalogue_number] => PA 18 15590
    [category_ids] => ,80,71,75,81,78,70,82,
    [chemical_name] => 
    [weight] => 399.12
    [form] => C14H8Cl2F4N2O3
    [cas] => 162401-30-1
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PA 18 15590

3,4-bis(Difluoromethoxy) Roflumilast


  • Catalogue No.:PA 18 15590

  • CAS :

    162401-30-1

  • Molecular Formula : C14H8Cl2F4N2O3

  • Molecular Weight : 399.12

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    [pname] => 3-Cyclobutyl-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
    [catalogue_number] => PA 18 15610
    [category_ids] => ,80,71,75,81,78,70,82,
    [chemical_name] => 
    [weight] => 387.21
    [form] => C17H14Cl2F2N2O2
    [cas] => NA
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PA 18 15610

3-Cyclobutyl-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide


  • Catalogue No.:PA 18 15610

  • CAS :

    NA

  • Molecular Formula : C17H14Cl2F2N2O2

  • Molecular Weight : 387.21

stdClass Object
(
    [pname] => 3-(But-3-en-1-yloxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
    [catalogue_number] => PA 18 15620
    [category_ids] => 80,71,75,70,78,82,81
    [chemical_name] => 
    [weight] => 403.21
    [form] => C17H14Cl2F2N2O3
    [cas] => 2368178-29-2
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PA 18 15620

3-(But-3-en-1-yloxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide


  • Catalogue No.:PA 18 15620

  • CAS :

    2368178-29-2

  • Molecular Formula : C17H14Cl2F2N2O3

  • Molecular Weight : 403.21

stdClass Object
(
    [pname] => 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic-d4 Acid
    [catalogue_number] => PA STI 023650
    [category_ids] => ,80,75,70,98,
    [chemical_name] => 
    [weight] => 262.24
    [form] => C12H8D4F2O4
    [cas] => 1794816-96-8
    [pslug] => 1794816-96-8-3-cyclopropylmethoxy-4-difluoromethoxybenzoic-d4-acid-pasti023650
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PA STI 023650

3-Cyclopropylmethoxy-4-difluoromethoxybenzoic-d4 Acid


  • Catalogue No.:PA STI 023650

  • CAS :

    1794816-96-8

  • Molecular Formula : C12H8D4F2O4

  • Molecular Weight : 262.24

stdClass Object
(
    [pname] => Roflumilast-d4 N-Oxide
    [catalogue_number] => PA STI 078310
    [category_ids] => ,71,98,76,75,81,78,70,82,
    [chemical_name] => 
    [weight] => 423.23
    [form] => C17H10D4Cl2F2N2O4
    [cas] => 1794760-31-8
    [pslug] => 1794760-31-8-roflumilast-d4-n-oxide-pasti078310
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PA STI 078310

Roflumilast-d4 N-Oxide


  • Catalogue No.:PA STI 078310

  • CAS :

    1794760-31-8

  • Molecular Formula : C17H10D4Cl2F2N2O4

  • Molecular Weight : 423.23

stdClass Object
(
    [pname] => 2,5-Dichloropyridin-4-amine
    [catalogue_number] => PA 18 15660
    [category_ids] => ,82,75,
    [chemical_name] => 
    [weight] => 163
    [form] => C5H4Cl2N2
    [cas] => 405230-82-2
    [pslug] => 405230-82-2-2-5-dichloropyridin-4-amine-pa1815660
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PA 18 15660

2,5-Dichloropyridin-4-amine


  • Catalogue No.:PA 18 15660

  • CAS :

    405230-82-2

  • Molecular Formula : C5H4Cl2N2

  • Molecular Weight : 163

stdClass Object
(
    [pname] => 2,3-Dichloropyridin-4-amine
    [catalogue_number] => PA 18 15670
    [category_ids] => ,82,75,78,70,82,
    [chemical_name] => 
    [weight] => 163
    [form] => C5H4Cl2N2
    [cas] => 184416-83-9
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PA 18 15670

2,3-Dichloropyridin-4-amine


  • Catalogue No.:PA 18 15670

  • CAS :

    184416-83-9

  • Molecular Formula : C5H4Cl2N2

  • Molecular Weight : 163

stdClass Object
(
    [pname] => 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-hydroxybenzamide
    [catalogue_number] => PA 18 0151000
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 353.2
    [form] => C16H14Cl2N2O3
    [cas] => 475271-62-6
    [pslug] => 475271-62-6-3-cyclopropylmethoxy-n-3-5-dichloropyridin-4-yl-4-hydroxybenzamide-pa180151000
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PA 18 0151000

3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-hydroxybenzamide


  • Catalogue No.:PA 18 0151000

  • CAS :

    475271-62-6

  • Molecular Formula : C16H14Cl2N2O3

  • Molecular Weight : 353.2

stdClass Object
(
    [pname] => N-(3-Bromo-5-chloropyridin-4-yl)-3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzamide
    [catalogue_number] => PA 18 0151001
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 447.66
    [form] => C17H14BrClF2N2O3
    [cas] => NA
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PA 18 0151001

N-(3-Bromo-5-chloropyridin-4-yl)-3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzamide


  • Catalogue No.:PA 18 0151001

  • CAS :

    NA

  • Molecular Formula : C17H14BrClF2N2O3

  • Molecular Weight : 447.66

stdClass Object
(
    [pname] => 5-((3,5-Dichloropyridin-4-yl)carbamoyl)-2-(difluoromethoxy)phenyl dimethylcarbamate
    [catalogue_number] => PA 18 0151002
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 420.19
    [form] => C16H13Cl2F2N3O4
    [cas] => 2048860-65-5
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PA 18 0151002

5-((3,5-Dichloropyridin-4-yl)carbamoyl)-2-(difluoromethoxy)phenyl dimethylcarbamate


  • Catalogue No.:PA 18 0151002

  • CAS :

    2048860-65-5

  • Molecular Formula : C16H13Cl2F2N3O4

  • Molecular Weight : 420.19

stdClass Object
(
    [pname] =>  4-(Difluoromethoxy)-3-Hydroxybenzoic Acid
    [catalogue_number] => PA 18 0151003
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 204.13
    [form] => C8H6F2O4
    [cas] => 913985-07-6
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PA 18 0151003

 4-(Difluoromethoxy)-3-Hydroxybenzoic Acid


  • Catalogue No.:PA 18 0151003

  • CAS :

    913985-07-6

  • Molecular Formula : C8H6F2O4

  • Molecular Weight : 204.13