solifenacin

Impurities - A muscarinic receptor antagonist drug used for treating contraction of overactive bladder such as incontinence, urinary frequency, and urgency. Solifenacin is a competitive cholinergic receptor antagonist, selective for the M3 receptor subtype. It was manufactured and marketed by Astellas, GlaxoSmithKline and Teva Pharmaceutical Industries. Reference standards of Solifenacin API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => (R)-Quinuclidinyl Benzoyl Solifenacin
    [catalogue_number] => PA 19 50610
    [category_ids] => ,80,79,75,71,
    [chemical_name] => 
    [weight] => 378.46
    [form] => C23H26N2O3
    [cas] => 1956436-64-8
    [pslug] => 1956436-64-8-r-quinuclidinyl-benzoyl-solifenacin-pa1950610
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PA 19 50610
PA 19 50610

(R)-Quinuclidinyl Benzoyl Solifenacin


  • Catalogue No.:PA 19 50610

  • CAS :

    1956436-64-8

  • Molecular Formula : C23H26N2O3

  • Molecular Weight : 378.46

stdClass Object
(
    [pname] => (S)-(1S,2R,3R,4S)-2-Ethylquinuclidin-3-yl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
    [catalogue_number] => PA 19 50620
    [category_ids] => ,79,80,71,75,78,
    [chemical_name] => 
    [weight] => 390.52
    [form] => C25H30N2O2
    [cas] => 605696-10-4
    [pslug] => 605696-10-4-s-1s-2r-3r-4s-2-ethylquinuclidin-3-yl-1-phenyl-3-4-dihydroisoquinoline-2-1h-carboxylate-pa1950620
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PA 19 50620
PA 19 50620

(S)-(1S,2R,3R,4S)-2-Ethylquinuclidin-3-yl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate


  • Catalogue No.:PA 19 50620

  • CAS :

    605696-10-4

  • Molecular Formula : C25H30N2O2

  • Molecular Weight : 390.52

stdClass Object
(
    [pname] => (S)-(1S,2R,3R,4S)-2-Methylquinuclidin-3-yl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
    [catalogue_number] => PA 19 50630
    [category_ids] => ,79,80,71,75,78,
    [chemical_name] => 
    [weight] => 376.49
    [form] => C24H28N2O2
    [cas] => NA
    [pslug] => s-1s-2r-3r-4s-2-methylquinuclidin-3-yl-1-phenyl-3-4-dihydroisoquinoline-2-1h-carboxylate-pa1950630
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PA 19 50630
PA 19 50630

(S)-(1S,2R,3R,4S)-2-Methylquinuclidin-3-yl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate


  • Catalogue No.:PA 19 50630

  • CAS :

    NA

  • Molecular Formula : C24H28N2O2

  • Molecular Weight : 376.49

stdClass Object
(
    [pname] => cis-Hydroxy Solifenacin-d5 N-Oxide
(Mixture of Diastereomers)
    [catalogue_number] => PA STI 051630
    [category_ids] => ,69,98,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 399.49
    [form] => C23H21D5N2O4
    [cas] => NA
    [pslug] => cis-hydroxy-solifenacin-d5-n-oxide
-mixture-of-diastereomers-pasti051630
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PA STI 051630
PA STI 051630

cis-Hydroxy Solifenacin-d5 N-Oxide (Mixture of Diastereomers)


  • Catalogue No.:PA STI 051630

  • CAS :

    NA

  • Molecular Formula : C23H21D5N2O4

  • Molecular Weight : 399.49

stdClass Object
(
    [pname] => (1S)-1-Phenyl-2-((((R)-quinuclidin-3-yl)oxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline 2-oxide
    [catalogue_number] => PA 19 50740
    [category_ids] => ,80,79,75,78,70,82,
    [chemical_name] => 
    [weight] => 378.47
    [form] => C23H26N2O3
    [cas] => NA
    [pslug] => 1s-1-phenyl-2-r-quinuclidin-3-yl-oxy-carbonyl-1-2-3-4-tetrahydroisoquinoline-2-oxide-pa1950740
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PA 19 50740
PA 19 50740

(1S)-1-Phenyl-2-((((R)-quinuclidin-3-yl)oxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline 2-oxide


  • Catalogue No.:PA 19 50740

  • CAS :

    NA

  • Molecular Formula : C23H26N2O3

  • Molecular Weight : 378.47

stdClass Object
(
    [pname] => (R)-Quinuclidin-3-yl (1S)-4-hydroxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
    [catalogue_number] => PA 19 50750
    [category_ids] => ,80,79,75,78,70,82,
    [chemical_name] => 
    [weight] => 378.47
    [form] => C23H26N2O3
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PA 19 50750
PA 19 50750

(R)-Quinuclidin-3-yl (1S)-4-hydroxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate


  • Catalogue No.:PA 19 50750

  • CAS :

    NA

  • Molecular Formula : C23H26N2O3

  • Molecular Weight : 378.47

stdClass Object
(
    [pname] => (1S,3R,4S)-Quinuclidin-3-yl Benzylcarbamate
    [catalogue_number] => PA 19 50760
    [category_ids] => ,80,79,75,78,70,82,
    [chemical_name] => 
    [weight] => 260.34
    [form] => C15H20N2O2
    [cas] => 1427376-05-3
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PA 19 50760
PA 19 50760

(1S,3R,4S)-Quinuclidin-3-yl Benzylcarbamate


  • Catalogue No.:PA 19 50760

  • CAS :

    1427376-05-3

  • Molecular Formula : C15H20N2O2

  • Molecular Weight : 260.34

stdClass Object
(
    [pname] => (R)-3-(((S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)oxy)quinuclidine 1-oxide Fumarate
    [catalogue_number] => PA 19 50770
    [category_ids] => ,80,79,75,78,70,82,
    [chemical_name] => 
    [weight] => 494.54
    [form] => C27H30N2O7
    [cas] => NA
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PA 19 50770
PA 19 50770

(R)-3-(((S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)oxy)quinuclidine 1-oxide Fumarate


  • Catalogue No.:PA 19 50770

  • CAS :

    NA

  • Molecular Formula : C27H30N2O7

  • Molecular Weight : 494.54

stdClass Object
(
    [pname] => 4R-Hydroxy Solifenacin
    [catalogue_number] => PA 19 0501000
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 378.47
    [form] => C23H26N2O3
    [cas] => 861998-77-8
    [pslug] => 861998-77-8-4r-hydroxy-solifenacin-pa190501000
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PA 19 0501000
PA 19 0501000

4R-Hydroxy Solifenacin


  • Catalogue No.:PA 19 0501000

  • CAS :

    861998-77-8

  • Molecular Formula : C23H26N2O3

  • Molecular Weight : 378.47

stdClass Object
(
    [pname] => (1S,3R,4S)-Quinuclidin-3-yl (1S,4R)-4-hydroxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
    [catalogue_number] => PA 19 0501001
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 378.47
    [form] => C23H26N2O3
    [cas] => NA
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PA 19 0501001
PA 19 0501001

(1S,3R,4S)-Quinuclidin-3-yl (1S,4R)-4-hydroxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate


  • Catalogue No.:PA 19 0501001

  • CAS :

    NA

  • Molecular Formula : C23H26N2O3

  • Molecular Weight : 378.47

stdClass Object
(
    [pname] => Solifenacin Identification Mixture A
    [catalogue_number] => PA 19 0501004
    [category_ids] => ,80,71,76,75,93,78,70,82,
    [chemical_name] => 
    [weight] => NA
    [form] => NA
    [cas] => NA
    [pslug] => solifenacin-identification-mixture-a-pa190501004
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PA 19 0501004
PA 19 0501004

Solifenacin Identification Mixture A


  • Catalogue No.:PA 19 0501004

  • CAS :

    NA

  • Molecular Formula : NA

  • Molecular Weight : NA

stdClass Object
(
    [pname] => Solifenacin Identification Mixture B
    [catalogue_number] => PA 19 0501003
    [category_ids] => ,80,71,76,75,93,78,70,82,
    [chemical_name] => 
    [weight] => NA
    [form] => NA
    [cas] => NA
    [pslug] => solifenacin-identification-mixture-b-pa190501003
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PA 19 0501003
PA 19 0501003

Solifenacin Identification Mixture B


  • Catalogue No.:PA 19 0501003

  • CAS :

    NA

  • Molecular Formula : NA

  • Molecular Weight : NA

stdClass Object
(
    [pname] => (1S)-3,4-Dihydro-1-phenyl-2(1H)-isoquinolinecarbonyl chloride
    [catalogue_number] => PA 19 0501005
    [category_ids] => ,82,78,76,75,70,
    [chemical_name] => 
    [weight] => 271.74
    [form] => C16H14ClNO
    [cas] => 1195949-26-8
    [pslug] => 1195949-26-8-1s-3-4-dihydro-1-phenyl-2-1h-isoquinolinecarbonyl-chloride-pa190501005
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PA 19 0501005
PA 19 0501005

(1S)-3,4-Dihydro-1-phenyl-2(1H)-isoquinolinecarbonyl chloride


  • Catalogue No.:PA 19 0501005

  • CAS :

    1195949-26-8

  • Molecular Formula : C16H14ClNO

  • Molecular Weight : 271.74

stdClass Object
(
    [pname] => Methyl (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
    [catalogue_number] => PA 19 0501006
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 267.33
    [form] => C17H17NO2
    [cas] => 1251905-45-9
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PA 19 0501006
PA 19 0501006

Methyl (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate


  • Catalogue No.:PA 19 0501006

  • CAS :

    1251905-45-9

  • Molecular Formula : C17H17NO2

  • Molecular Weight : 267.33

stdClass Object
(
    [pname] => Ethyl (R)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
    [catalogue_number] => PA 19 0501007
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 281.36
    [form] => C18H19NO2
    [cas] => 180468-41-1
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PA 19 0501007
PA 19 0501007

Ethyl (R)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate


  • Catalogue No.:PA 19 0501007

  • CAS :

    180468-41-1

  • Molecular Formula : C18H19NO2

  • Molecular Weight : 281.36

stdClass Object
(
    [pname] => (R)-Quinuclidin-3-yl (S)-1-hydroxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
    [catalogue_number] => PA 19 0501008
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 378.47
    [form] => C23H26N2O3
    [cas] => NA
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PA 19 0501008
PA 19 0501008

(R)-Quinuclidin-3-yl (S)-1-hydroxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate


  • Catalogue No.:PA 19 0501008

  • CAS :

    NA

  • Molecular Formula : C23H26N2O3

  • Molecular Weight : 378.47

stdClass Object
(
    [pname] => Solifenacin Succinate (IPRS/82/19) - from IPC
    [catalogue_number] => PA IPRS 82 19
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => NA
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PA IPRS 82 19
PA IPRS 82 19

Solifenacin Succinate (IPRS/82/19) - from IPC


  • Catalogue No.:PA IPRS 82 19

  • CAS :

    NA

  • Molecular Formula : NA

  • Molecular Weight : NA

stdClass Object
(
    [pname] => Quinuclidin-3-one
    [catalogue_number] => PA 19 0501009
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 125.17
    [form] => C7H11NO
    [cas] => 3731-38-2
    [pslug] => 3731-38-2-quinuclidin-3-one-pa190501009
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PA 19 0501009
PA 19 0501009

Quinuclidin-3-one


  • Catalogue No.:PA 19 0501009

  • CAS :

    3731-38-2

  • Molecular Formula : C7H11NO

  • Molecular Weight : 125.17

stdClass Object
(
    [pname] => Quinuclidin-3-yl 1-phenyl-3,4-Dihydroisoquinoline-2(1H)-Carboxylate Succinate
    [catalogue_number] => PA 19 0501010
    [category_ids] => ,82,78,76,75,70,
    [chemical_name] => 
    [weight] => 480.56
    [form] => C27H32N2O6
    [cas] => 2518398-14-4
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PA 19 0501010
PA 19 0501010

Quinuclidin-3-yl 1-phenyl-3,4-Dihydroisoquinoline-2(1H)-Carboxylate Succinate


  • Catalogue No.:PA 19 0501010

  • CAS :

    2518398-14-4

  • Molecular Formula : C27H32N2O6

  • Molecular Weight : 480.56

stdClass Object
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    [catalogue_number] => PA 19 0501011
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    [chemical_name] => 
    [weight] => 374.4
    [form] => C22H18N2O4
    [cas] => 1229227-22-8
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PA 19 0501011
PA 19 0501011

Solifenacin Nitrophenyl Ester Impurity


  • Catalogue No.:PA 19 0501011

  • CAS :

    1229227-22-8

  • Molecular Formula : C22H18N2O4

  • Molecular Weight : 374.4

stdClass Object
(
    [pname] => Solifenacin
    [catalogue_number] => PA 19 2090000
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 362.47
    [form] => C23H26N2O2
    [cas] => 242478-37-1
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PA 19 2090000
PA 19 2090000

Solifenacin


  • Catalogue No.:PA 19 2090000

  • CAS :

    242478-37-1

  • Molecular Formula : C23H26N2O2

  • Molecular Weight : 362.47

stdClass Object
(
    [pname] => (2R,3R)-2-Ethylquinuclidin-3-yl (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
    [catalogue_number] => PA 19 2091000
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 390.53
    [form] => C25H30N2O2
    [cas] => 2407763-27-1
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PA 19 2091000
PA 19 2091000

(2R,3R)-2-Ethylquinuclidin-3-yl (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate


  • Catalogue No.:PA 19 2091000

  • CAS :

    2407763-27-1

  • Molecular Formula : C25H30N2O2

  • Molecular Weight : 390.53

stdClass Object
(
    [pname] => 2-Nitroso-1-phenyl-1,2,3,4-tetrahydroisoquinoline
    [catalogue_number] => PA 19 2091001
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 238.29
    [form] => C15H14N2O
    [cas] => 2659259-64-8
    [pslug] => 2659259-64-8-2-nitroso-1-phenyl-1-2-3-4-tetrahydroisoquinoline-pa192091001
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PA 19 2091001
PA 19 2091001

2-Nitroso-1-phenyl-1,2,3,4-tetrahydroisoquinoline


  • Catalogue No.:PA 19 2091001

  • CAS :

    2659259-64-8

  • Molecular Formula : C15H14N2O

  • Molecular Weight : 238.29

stdClass Object
(
    [pname] => (S)-Quinuclidinyl Benzoyl Solifenacin
    [catalogue_number] => PA 19 2091002
    [category_ids] => ,80,79,75,71,
    [chemical_name] => 
    [weight] => 378.47
    [form] => C23H26N2O3
    [cas] => 2407763-28-2
    [pslug] => 2407763-28-2-s-quinuclidinyl-benzoyl-solifenacin-pa192091002
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PA 19 2091002
PA 19 2091002

(S)-Quinuclidinyl Benzoyl Solifenacin


  • Catalogue No.:PA 19 2091002

  • CAS :

    2407763-28-2

  • Molecular Formula : C23H26N2O3

  • Molecular Weight : 378.47

stdClass Object
(
    [pname] => (R)-Quinuclidin-3-yl acetate (2R,3R)-2,3-dihydroxysuccinate
    [catalogue_number] => PA 19 2091004
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 319.31
    [form] => C13H21NO8
    [cas] => 139729-83-2
    [pslug] => 139729-83-2-r-quinuclidin-3-yl-acetate-2r-3r-2-3-dihydroxysuccinate-pa192091004
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PA 19 2091004
PA 19 2091004

(R)-Quinuclidin-3-yl acetate (2R,3R)-2,3-dihydroxysuccinate


  • Catalogue No.:PA 19 2091004

  • CAS :

    139729-83-2

  • Molecular Formula : C13H21NO8

  • Molecular Weight : 319.31

stdClass Object
(
    [pname] => (R)-4-Nitrophenyl quinuclidin-3-yl carbonate
    [catalogue_number] => PA 19 2091005
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 292.29
    [form] => C14H16N2O5
    [cas] => 1243274-81-8
    [pslug] => 1243274-81-8-r-4-nitrophenyl-quinuclidin-3-yl-carbonate-pa192091005
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PA 19 2091005
PA 19 2091005

(R)-4-Nitrophenyl quinuclidin-3-yl carbonate


  • Catalogue No.:PA 19 2091005

  • CAS :

    1243274-81-8

  • Molecular Formula : C14H16N2O5

  • Molecular Weight : 292.29

stdClass Object
(
    [pname] => Di-((3R)-1-Azabicyclo[2.2.2]oct-3-yl)carbonate
    [catalogue_number] => PA 19 2091007
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 280.37
    [form] => C15H24N2O3
    [cas] => NA
    [pslug] => di-3r-1-azabicyclo-2-2-2-oct-3-yl-carbonate-pa192091007
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PA 19 2091007
PA 19 2091007

Di-((3R)-1-Azabicyclo[2.2.2]oct-3-yl)carbonate


  • Catalogue No.:PA 19 2091007

  • CAS :

    NA

  • Molecular Formula : C15H24N2O3

  • Molecular Weight : 280.37

stdClass Object
(
    [pname] => (2-Bromophenethyl)carbamic Chloride
    [catalogue_number] => PA 19 2091008
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 262.53
    [form] => C9H9BrClNO
    [cas] => 1896361-64-0
    [pslug] => 1896361-64-0-2-bromophenethyl-carbamic-chloride-pa192091008
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PA 19 2091008
PA 19 2091008

(2-Bromophenethyl)carbamic Chloride


  • Catalogue No.:PA 19 2091008

  • CAS :

    1896361-64-0

  • Molecular Formula : C9H9BrClNO

  • Molecular Weight : 262.53

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