Tucatinib

Tucatinib, sold under the brand name Tukysa, is a small molecule inhibitor of HER2 for the treatment of HER2-positive breast cancer. Reference standards of Tucatinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => Tucatinib
    [catalogue_number] => PA 20 3360000
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 480.53
    [form] => C26H24N8O2
    [cas] => 937263-43-9
    [pslug] => 937263-43-9-tucatinib-api-pa203360000
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PA 20 3360000

Tucatinib

  • Catalogue No.:PA 20 3360000

  • CAS :

    937263-43-9

  • Molecular Formula : C26H24N8O2

  • Molecular Weight : 480.53

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Details 
stdClass Object
(
    [pname] => 4,6-Quinazolinediamine, N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]
    [catalogue_number] => PA 20 3361000
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 383.42
    [form] => C21H17N7O
    [cas] => 2307628-67-5
    [pslug] => 2307628-67-5-4-6-quinazolinediamine-n4-3-methyl-4-1-2-4-triazolo-1-5-a-pyridin-7-yloxy-phenyl-pa203361000
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PA 20 3361000

4,6-Quinazolinediamine, N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]

  • Catalogue No.:PA 20 3361000

  • CAS :

    2307628-67-5

  • Molecular Formula : C21H17N7O

  • Molecular Weight : 383.42

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Details 
stdClass Object
(
    [pname] => 1-(4-((4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)-3-(1-hydroxy-2-methylpropan-2-yl)thiourea
    [catalogue_number] => PA 20 3361001
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 514.61
    [form] => C26H26N8O2S
    [cas] => 1429755-58-7
    [pslug] => 1429755-58-7-1-4-4-1-2-4-triazolo-1-5-a-pyridin-7-yloxy-3-methylphenyl-amino-quinazolin-6-yl-3-1-hydroxy-2-methylpropan-2-yl-thiourea-pa203361001
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PA 20 3361001

1-(4-((4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)-3-(1-hydroxy-2-methylpropan-2-yl)thiourea

  • Catalogue No.:PA 20 3361001

  • CAS :

    1429755-58-7

  • Molecular Formula : C26H26N8O2S

  • Molecular Weight : 514.61

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Details 
stdClass Object
(
    [pname] => 1-(4-((4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)-4,4-dimethylimidazolidine-2-thione
    [catalogue_number] => PA 20 3361002
    [category_ids] => 70,82,78,75,76
    [chemical_name] => 
    [weight] => 496.59
    [form] => C26H24N8OS
    [cas] => 2954734-92-8
    [pslug] => 2954734-92-8-1-4-4-1-2-4-triazolo-1-5-a-pyridin-7-yloxy-3-methylphenyl-amino-quinazolin-6-yl-4-4-dimethylimidazolidine-2-thione-pa203361002
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PA 20 3361002

1-(4-((4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)-4,4-dimethylimidazolidine-2-thione

  • Catalogue No.:PA 20 3361002

  • CAS :

    2954734-92-8

  • Molecular Formula : C26H24N8OS

  • Molecular Weight : 496.59

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Details 
stdClass Object
(
    [pname] => N4-(4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrothiazol-2-yl)quinazoline-4,6-diamine
    [catalogue_number] => PA 20 3361003
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 496.59
    [form] => C26H24N8OS
    [cas] => 937266-01-8
    [pslug] => 937266-01-8-n4-4-1-2-4-triazolo-1-5-a-pyridin-7-yloxy-3-methylphenyl-n6-4-4-dimethyl-4-5-dihydrothiazol-2-yl-quinazoline-4-6-diamine-pa203361003
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PA 20 3361003

N4-(4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrothiazol-2-yl)quinazoline-4,6-diamine

  • Catalogue No.:PA 20 3361003

  • CAS :

    937266-01-8

  • Molecular Formula : C26H24N8OS

  • Molecular Weight : 496.59

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Details 
stdClass Object
(
    [pname] => 4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylaniline
    [catalogue_number] => PA 20 3361004
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 240.27
    [form] => C13H12N4O
    [cas] => 937263-71-3
    [pslug] => 937263-71-3-4-1-2-4-triazolo-1-5-a-pyridin-7-yloxy-3-methylaniline-pa203361004
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PA 20 3361004

4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylaniline

  • Catalogue No.:PA 20 3361004

  • CAS :

    937263-71-3

  • Molecular Formula : C13H12N4O

  • Molecular Weight : 240.27

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Details 
stdClass Object
(
    [pname] => Tucatinib Hemiethanolate
    [catalogue_number] => PA 20 3361005
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 1007.13
    [form] => C54H54N16O5
    [cas] => 1429755-56-5
    [pslug] => 1429755-56-5-tucatinib-hemiethanolate-pa203361005
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PA 20 3361005

Tucatinib Hemiethanolate

  • Catalogue No.:PA 20 3361005

  • CAS :

    1429755-56-5

  • Molecular Formula : C54H54N16O5

  • Molecular Weight : 1007.13

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Details 
stdClass Object
(
    [pname] => 2-Amino-2-methylpropyl (4-((4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)carbamate
    [catalogue_number] => PA 20 3361006
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 498.55
    [form] => C26H26N8O3
    [cas] => NA
    [pslug] => 2-amino-2-methylpropyl-4-4-1-2-4-triazolo-1-5-a-pyridin-7-yloxy-3-methylphenyl-amino-quinazolin-6-yl-carbamate-pa203361006
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PA 20 3361006

2-Amino-2-methylpropyl (4-((4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)carbamate

  • Catalogue No.:PA 20 3361006

  • CAS :

    NA

  • Molecular Formula : C26H26N8O3

  • Molecular Weight : 498.55

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Details 
stdClass Object
(
    [pname] => 7-(2-Methyl-4-nitrophenoxy)-[1,2,4]triazolo[1,5-a]pyridine
    [catalogue_number] => PA 20 3361007
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 270.25
    [form] => C13H10N4O3
    [cas] => 937263-44-0
    [pslug] => 937263-44-0-7-2-methyl-4-nitrophenoxy-1-2-4-triazolo-1-5-a-pyridine-pa203361007
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PA 20 3361007

7-(2-Methyl-4-nitrophenoxy)-[1,2,4]triazolo[1,5-a]pyridine

  • Catalogue No.:PA 20 3361007

  • CAS :

    937263-44-0

  • Molecular Formula : C13H10N4O3

  • Molecular Weight : 270.25

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Details 
stdClass Object
(
    [pname] => Tucatinib D6
    [catalogue_number] => PA STI 089971
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 486.57
    [form] => C26H18D6N8O2
    [cas] => NA
    [pslug] => tucatinib-d6-pasti089971
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PA STI 089971

Tucatinib D6

  • Catalogue No.:PA STI 089971

  • CAS :

    NA

  • Molecular Formula : C26H18D6N8O2

  • Molecular Weight : 486.57

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CPHI INDIA- 28, 30 November