Dacomitinib
Dacomitinib (trade name Vizimpro) is a drug candidate under development by Pfizer for the treatment of non-small-cell lung carcinoma (NSCLC). It is a selective and irreversible inhibitor of EGFR. Reference standards of Dacomitinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
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[pname] => Dacomitinib
[catalogue_number] => PA 04 2190000
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[weight] => 469.95
[form] => C24H25ClFN5O2
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Catalogue No.:PA 04 2190000
Molecular Formula : C24H25ClFN5O2
Molecular Weight : 469.95
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[pname] => 1-(4-((3-Chloro-4-fluorocyclohexyl)amino)-7-methoxyquinazolin-6-yl)-5-hydroxypyrrolidin-2-one
[catalogue_number] => PA 04 2191000
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[chemical_name] =>
[weight] => 402.81
[form] => C19H16ClFN4O3
[cas] => 2190490-31-2
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1-(4-((3-Chloro-4-fluorocyclohexyl)amino)-7-methoxyquinazolin-6-yl)-5-hydroxypyrrolidin-2-one
Catalogue No.:PA 04 2191000
Molecular Formula : C19H16ClFN4O3
Molecular Weight : 402.81
stdClass Object
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[pname] => Dacomitinib Desmethyl Impurity
[catalogue_number] => PA 04 2191001
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[chemical_name] =>
[weight] => 455.92
[form] => C23H23ClFN5O2
[cas] => 2468202-15-3
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Dacomitinib Desmethyl Impurity
Catalogue No.:PA 04 2191001
Molecular Formula : C23H23ClFN5O2
Molecular Weight : 455.92
stdClass Object
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[pname] => Dacomitinib Z-Isomer
[catalogue_number] => PA 04 2191002
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Catalogue No.:PA 04 2191002
Molecular Formula : C24H25ClFN5O2
Molecular Weight : 469.95
stdClass Object
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[pname] => (E)-N-(4-((3-Chloro-4-fluorophenyl)(nitroso)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide
[catalogue_number] => PA 04 2191003
[category_ids] => ,78,75,70,76,82,162,
[chemical_name] =>
[weight] => 498.94
[form] => C24H24ClFN6O3
[cas] => NA
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(E)-N-(4-((3-Chloro-4-fluorophenyl)(nitroso)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide
Catalogue No.:PA 04 2191003
Molecular Formula : C24H24ClFN6O3
Molecular Weight : 498.94
stdClass Object
(
[pname] => 3-((3-Chloro-4-fluorophenyl)amino)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)butanamide
[catalogue_number] => PA 04 2191004
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[chemical_name] =>
[weight] => 615.51
[form] => C30H30Cl2F2N6O2
[cas] => NA
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3-((3-Chloro-4-fluorophenyl)amino)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)butanamide
Catalogue No.:PA 04 2191004
Molecular Formula : C30H30Cl2F2N6O2
Molecular Weight : 615.51
stdClass Object
(
[pname] => N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)amino)-4-(piperidin-1-yl)butanamide
[catalogue_number] => PA 04 2191005
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[weight] => 788.68
[form] => C39H37Cl2F2N9O3
[cas] => NA
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N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)amino)-4-(piperidin-1-yl)butanamide
Catalogue No.:PA 04 2191005
Molecular Formula : C39H37Cl2F2N9O3
Molecular Weight : 788.68
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[pname] => N4-(3-Chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine
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[weight] => 318.74
[form] => C15H12ClFN4O
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N4-(3-Chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine
Catalogue No.:PA 04 2191006
Molecular Formula : C15H12ClFN4O
Molecular Weight : 318.74
stdClass Object
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[pname] => (2E)-4-(1-Piperidinyl)-2-butenoic Acid Hydrochloride
[catalogue_number] => PA 04 2191007
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[weight] => 205.68
[form] => C9H16ClNO2
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(2E)-4-(1-Piperidinyl)-2-butenoic Acid Hydrochloride
Catalogue No.:PA 04 2191007
Molecular Formula : C9H16ClNO2
Molecular Weight : 205.68
stdClass Object
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[pname] => N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
[catalogue_number] => PA 04 2191008
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[weight] => 336.68
[form] => C14H7ClF2N4O2
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N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
Catalogue No.:PA 04 2191008
Molecular Formula : C14H7ClF2N4O2
Molecular Weight : 336.68
