Fostamatinib

Intermediates - Fostamatinib, sold under the brand names Tavalisse and Tavlesse, is a tyrosine kinase inhibitor medication for the treatment of chronic immune thrombocytopenia. Reference standards of Fostamatinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => Fostamatinib
    [catalogue_number] => PA 06 2030000
    [category_ids] => ,76,78,70,82,
    [chemical_name] => 
    [weight] => 580.47
    [form] => C23H26FN6O9P
    [cas] => 901119-35-5
    [pslug] => 901119-35-5-fostamatinib-api-pa062030000
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PA 06 2030000
PA 06 2030000

Fostamatinib

  • Catalogue No.:PA 06 2030000

  • CAS :

    901119-35-5

  • Molecular Formula : C23H26FN6O9P

  • Molecular Weight : 580.47

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Details 
stdClass Object
(
    [pname] => 6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
    [catalogue_number] => PA 06 2031000
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 470.46
    [form] => C22H23FN6O5
    [cas] => 841290-80-0
    [pslug] => 841290-80-0-6-5-fluoro-2-3-4-5-trimethoxyphenyl-amino-pyrimidin-4-yl-amino-2-2-dimethyl-2h-pyrido-3-2-b-1-4-oxazin-3-4h-one-pa062031000
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PA 06 2031000
PA 06 2031000

6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one

  • Catalogue No.:PA 06 2031000

  • CAS :

    841290-80-0

  • Molecular Formula : C22H23FN6O5

  • Molecular Weight : 470.46

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Details 
stdClass Object
(
    [pname] => (6-((5-Fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)(nitroso)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl)methyl dihydrogen phosphate
    [catalogue_number] => PA 06 2031001
    [category_ids] => ,76,78,70,82,162,
    [chemical_name] => 
    [weight] => 609.46
    [form] => C23H25FN7O10P
    [cas] => NA
    [pslug] => 6-5-fluoro-2-3-4-5-trimethoxyphenyl-amino-pyrimidin-4-yl-nitroso-amino-2-2-dimethyl-3-oxo-2-3-dihydro-4h-pyrido-3-2-b-1-4-oxazin-4-yl-methyl-dihydrogen-phosphate-pa062031001
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PA 06 2031001
PA 06 2031001

(6-((5-Fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)(nitroso)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl)methyl dihydrogen phosphate

  • Catalogue No.:PA 06 2031001

  • CAS :

    NA

  • Molecular Formula : C23H25FN7O10P

  • Molecular Weight : 609.46

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Details 
stdClass Object
(
    [pname] => (6-((5-Fluoro-2-(nitroso(3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)(nitroso)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl)methyl dihydrogen phosphate
    [catalogue_number] => PA 06 2031002
    [category_ids] => ,76,78,70,82,162,
    [chemical_name] => 
    [weight] => 638.46
    [form] => C23H24FN8O11P
    [cas] => NA
    [pslug] => 6-5-fluoro-2-nitroso-3-4-5-trimethoxyphenyl-amino-pyrimidin-4-yl-nitroso-amino-2-2-dimethyl-3-oxo-2-3-dihydro-4h-pyrido-3-2-b-1-4-oxazin-4-yl-methyl-dihydrogen-phosphate-pa062031002
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PA 06 2031002
PA 06 2031002

(6-((5-Fluoro-2-(nitroso(3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)(nitroso)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl)methyl dihydrogen phosphate

  • Catalogue No.:PA 06 2031002

  • CAS :

    NA

  • Molecular Formula : C23H24FN8O11P

  • Molecular Weight : 638.46

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Details 
stdClass Object
(
    [pname] => (6-((5-Fluoro-2-(nitroso(3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl)methyl dihydrogen phosphate
    [catalogue_number] => PA 06 2031003
    [category_ids] => ,76,78,70,82,162,
    [chemical_name] => 
    [weight] => 609.46
    [form] => C23H25FN7O10P
    [cas] => NA
    [pslug] => 6-5-fluoro-2-nitroso-3-4-5-trimethoxyphenyl-amino-pyrimidin-4-yl-amino-2-2-dimethyl-3-oxo-2-3-dihydro-4h-pyrido-3-2-b-1-4-oxazin-4-yl-methyl-dihydrogen-phosphate-pa062031003
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PA 06 2031003
PA 06 2031003

(6-((5-Fluoro-2-(nitroso(3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl)methyl dihydrogen phosphate

  • Catalogue No.:PA 06 2031003

  • CAS :

    NA

  • Molecular Formula : C23H25FN7O10P

  • Molecular Weight : 609.46

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Details 
stdClass Object
(
    [pname] => Desmethoxy Fostamatinib Impurity
    [catalogue_number] => PA 06 2031004
    [category_ids] => ,76,78,70,82,
    [chemical_name] => 
    [weight] => 566.44
    [form] => C22H24FN6O9P
    [cas] => NA
    [pslug] => desmethoxy-fostamatinib-impurity-pa062031004
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PA 06 2031004
PA 06 2031004

Desmethoxy Fostamatinib Impurity

  • Catalogue No.:PA 06 2031004

  • CAS :

    NA

  • Molecular Formula : C22H24FN6O9P

  • Molecular Weight : 566.44

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Details 
stdClass Object
(
    [pname] => Sodium 2-((2-amino-6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)pyridin-3-yl)oxy)-2-methylpropanoate
    [catalogue_number] => PA 06 2031005
    [category_ids] => ,76,78,70,82,
    [chemical_name] => 
    [weight] => 510.46
    [form] => C22H24FN6NaO6
    [cas] => NA
    [pslug] => sodium-2-2-amino-6-5-fluoro-2-3-4-5-trimethoxyphenyl-amino-pyrimidin-4-yl-amino-pyridin-3-yl-oxy-2-methylpropanoate-pa062031005
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PA 06 2031005
PA 06 2031005

Sodium 2-((2-amino-6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)pyridin-3-yl)oxy)-2-methylpropanoate

  • Catalogue No.:PA 06 2031005

  • CAS :

    NA

  • Molecular Formula : C22H24FN6NaO6

  • Molecular Weight : 510.46

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Details 
stdClass Object
(
    [pname] => 4,4'-Methylenebis(6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one)
    [catalogue_number] => PA 06 2031006
    [category_ids] => ,76,78,70,82,
    [chemical_name] => 
    [weight] => 952.93
    [form] => C45H46F2N12O10
    [cas] => NA
    [pslug] => 4-4-methylenebis-6-5-fluoro-2-3-4-5-trimethoxyphenyl-amino-pyrimidin-4-yl-amino-2-2-dimethyl-2h-pyrido-3-2-b-1-4-oxazin-3-4h-one-pa062031006
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PA 06 2031006
PA 06 2031006

4,4'-Methylenebis(6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one)

  • Catalogue No.:PA 06 2031006

  • CAS :

    NA

  • Molecular Formula : C45H46F2N12O10

  • Molecular Weight : 952.93

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Details 
stdClass Object
(
    [pname] => tert-Butyl ((6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl)methyl) hydrogen phosphate
    [catalogue_number] => PA 06 2031007
    [category_ids] => ,76,78,70,82,
    [chemical_name] => 
    [weight] => 636.57
    [form] => C27H34FN6O9P
    [cas] => NA
    [pslug] => tert-butyl-6-5-fluoro-2-3-4-5-trimethoxyphenyl-amino-pyrimidin-4-yl-amino-2-2-dimethyl-3-oxo-2-3-dihydro-4h-pyrido-3-2-b-1-4-oxazin-4-yl-methyl-hydrogen-phosphate-pa062031007
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PA 06 2031007
PA 06 2031007

tert-Butyl ((6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl)methyl) hydrogen phosphate

  • Catalogue No.:PA 06 2031007

  • CAS :

    NA

  • Molecular Formula : C27H34FN6O9P

  • Molecular Weight : 636.57

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