Nirogacestat

Intermediates - Nirogacestat is an oral gamma-secretase inhibitor used for the treatment of adults with progressing desmoid tumors, working by blocking Notch signaling to reduce tumor growth and improve disease control Reference standards of Nirogacestat API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => Nirogacestat
    [catalogue_number] => PA 14 1630000
    [category_ids] => ,70,71,78,80,82,
    [chemical_name] => 
    [weight] => 489.66
    [form] => C27H41F2N5O
    [cas] => 1290543-63-3
    [pslug] => 1290543-63-3-nirogacestat-pa141630000
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PA 14 1630000
PA 14 1630000

Nirogacestat

  • Catalogue No.:PA 14 1630000

  • CAS :

    1290543-63-3

  • Molecular Formula : C27H41F2N5O

  • Molecular Weight : 489.66

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Details 
stdClass Object
(
    [pname] => (S)-2-(((S)-6,8-Difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentyl(nitroso)amino)propan-2-yl)-1H-imidazol-4-yl)pentanamide
    [catalogue_number] => PA 14 1631000
    [category_ids] => ,70,78,79,80,82,81,162,
    [chemical_name] => 
    [weight] => 518.65
    [form] => C27H40F2N6O2
    [cas] => NA
    [pslug] => s-2-s-6-8-difluoro-1-2-3-4-tetrahydronaphthalen-2-yl-amino-n-1-2-methyl-1-neopentyl-nitroso-amino-propan-2-yl-1h-imidazol-4-yl-pentanamide-pa141631000
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PA 14 1631000
PA 14 1631000

(S)-2-(((S)-6,8-Difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentyl(nitroso)amino)propan-2-yl)-1H-imidazol-4-yl)pentanamide

  • Catalogue No.:PA 14 1631000

  • CAS :

    NA

  • Molecular Formula : C27H40F2N6O2

  • Molecular Weight : 518.65

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Details 
stdClass Object
(
    [pname] => (S)-2-(((S)-6,8-Difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(nitroso)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide
    [catalogue_number] => PA 14 1631001
    [category_ids] => ,70,78,79,80,82,81,162,
    [chemical_name] => 
    [weight] => 518.65
    [form] => C27H40F2N6O2
    [cas] => NA
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PA 14 1631001
PA 14 1631001

(S)-2-(((S)-6,8-Difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(nitroso)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide

  • Catalogue No.:PA 14 1631001

  • CAS :

    NA

  • Molecular Formula : C27H40F2N6O2

  • Molecular Weight : 518.65

Enquire
Details 
stdClass Object
(
    [pname] => N-(2-Methyl-2-(4-nitro-1H-imidazol-1-yl)propyl)-N-neopentylnitrous amide
    [catalogue_number] => PA 14 1631002
    [category_ids] => ,70,71,78,80,82,
    [chemical_name] => 
    [weight] => 283.33
    [form] => C12H21N5O3
    [cas] => NA
    [pslug] => n-2-methyl-2-4-nitro-1h-imidazol-1-yl-propyl-n-neopentylnitrous-amide-pa141631002
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PA 14 1631002
PA 14 1631002

N-(2-Methyl-2-(4-nitro-1H-imidazol-1-yl)propyl)-N-neopentylnitrous amide

  • Catalogue No.:PA 14 1631002

  • CAS :

    NA

  • Molecular Formula : C12H21N5O3

  • Molecular Weight : 283.33

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Details 
stdClass Object
(
    [pname] => (S)-2-(((S)-6,8-Difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(nitroso)amino)pentanoic Acid
    [catalogue_number] => PA 14 1631003
    [category_ids] => ,70,71,78,80,82,
    [chemical_name] => 
    [weight] => 312.32
    [form] => C15H18F2N2O3
    [cas] => NA
    [pslug] => s-2-s-6-8-difluoro-1-2-3-4-tetrahydronaphthalen-2-yl-nitroso-amino-pentanoic-acid-pa141631003
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PA 14 1631003
PA 14 1631003

(S)-2-(((S)-6,8-Difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(nitroso)amino)pentanoic Acid

  • Catalogue No.:PA 14 1631003

  • CAS :

    NA

  • Molecular Formula : C15H18F2N2O3

  • Molecular Weight : 312.32

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Details 
stdClass Object
(
    [pname] => N-(2-(4-Amino-1H-imidazol-1-yl)-2-methylpropyl)-N-neopentylnitrous amide
    [catalogue_number] => PA 14 1631004
    [category_ids] => ,70,71,78,80,82,
    [chemical_name] => 
    [weight] => 253.35
    [form] => C12H23N5O
    [cas] => NA
    [pslug] => n-2-4-amino-1h-imidazol-1-yl-2-methylpropyl-n-neopentylnitrous-amide-pa141631004
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PA 14 1631004
PA 14 1631004

N-(2-(4-Amino-1H-imidazol-1-yl)-2-methylpropyl)-N-neopentylnitrous amide

  • Catalogue No.:PA 14 1631004

  • CAS :

    NA

  • Molecular Formula : C12H23N5O

  • Molecular Weight : 253.35

Enquire
Details 
stdClass Object
(
    [pname] => (S)-2-(((S)-6,8-Difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(nitroso)amino)-N-(1-(2-methyl-1-(neopentyl(nitroso)amino)propan-2-yl)-1H-imidazol-4-yl)pentanamide
    [catalogue_number] => PA 14 1631005
    [category_ids] => ,70,71,78,80,82,
    [chemical_name] => 
    [weight] => 547.65
    [form] => C27H39F2N7O3
    [cas] => NA
    [pslug] => s-2-s-6-8-difluoro-1-2-3-4-tetrahydronaphthalen-2-yl-nitroso-amino-n-1-2-methyl-1-neopentyl-nitroso-amino-propan-2-yl-1h-imidazol-4-yl-pentanamide-pa141631005
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PA 14 1631005
PA 14 1631005

(S)-2-(((S)-6,8-Difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(nitroso)amino)-N-(1-(2-methyl-1-(neopentyl(nitroso)amino)propan-2-yl)-1H-imidazol-4-yl)pentanamide

  • Catalogue No.:PA 14 1631005

  • CAS :

    NA

  • Molecular Formula : C27H39F2N7O3

  • Molecular Weight : 547.65

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Details 
stdClass Object
(
    [pname] => Methyl (S)-2-(((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(nitroso)amino)pentanoate
    [catalogue_number] => PA 14 1631006
    [category_ids] => ,70,71,78,80,82,
    [chemical_name] => 
    [weight] => 326.34
    [form] => C16H20F2N2O3
    [cas] => NA
    [pslug] => methyl-s-2-s-6-8-difluoro-1-2-3-4-tetrahydronaphthalen-2-yl-nitroso-amino-pentanoate-pa141631006
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PA 14 1631006
PA 14 1631006

Methyl (S)-2-(((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(nitroso)amino)pentanoate

  • Catalogue No.:PA 14 1631006

  • CAS :

    NA

  • Molecular Formula : C16H20F2N2O3

  • Molecular Weight : 326.34

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Details 
stdClass Object
(
    [pname] => Nirogacestat-D5
    [catalogue_number] => PA STI 090181
    [category_ids] => ,98,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 494.69
    [form] => C27H36D5F2N5O
    [cas] => NA
    [pslug] => nirogacestat-d5-pasti090181
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PA STI 090181
PA STI 090181

Nirogacestat-D5

  • Catalogue No.:PA STI 090181

  • CAS :

    NA

  • Molecular Formula : C27H36D5F2N5O

  • Molecular Weight : 494.69

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