Tezacaftor is used to treat cystic fibrosis in certain people. It is a drug that is sold as a fixed-dose combination with ivacaftor as Symdeko.Reference standards of Tezacaftor API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
stdClass Object ( [pname] => Tezacaftor - API Standards [catalogue_number] => PA 47 98000 [category_ids] => ,80,79,78,70,82,89, [chemical_name] => [weight] => 520.51 [form] => C26H27F3N2O6 [cas] => 1152311-62-0 [pslug] => 1152311-62-0-tezacaftor-api-pa4798000 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 47 98000
CAS :
Molecular Formula : C26H27F3N2O6
Molecular Weight : 520.51
stdClass Object ( [pname] => 1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(8-fluoro-2-hydroxy-4-(hydroxymethyl)-1,1-dimethyl-1,2,4,5-tetrahydro-[1,4]oxazepino[4,5-a]indol-9-yl)cyclopropane-1-carboxamide [catalogue_number] => PA 47 0981000 [category_ids] => ,75,76,78,70,82, [chemical_name] => [weight] => 518.49 [form] => C26H25F3N2O6 [cas] => 1432657-04-9 [pslug] => 1432657-04-9-1-2-2-difluorobenzo-d-1-3-dioxol-5-yl-n-8-fluoro-2-hydroxy-4-hydroxymethyl-1-1-dimethyl-1-2-4-5-tetrahydro-1-4-oxazepino-4-5-a-indol-9-yl-cyclopropane-1-carboxamide-pa470981000 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 47 0981000
Molecular Formula : C26H25F3N2O6
Molecular Weight : 518.49
stdClass Object ( [pname] => (R)-1-(5-Amino-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-1-yl)-3-(benzyloxy)propan-2-ol [catalogue_number] => PA 47 0981001 [category_ids] => ,75,76,78,70,82, [chemical_name] => [weight] => 476.59 [form] => C29H33FN2O3 [cas] => 1294504-67-8 [pslug] => 1294504-67-8-r-1-5-amino-2-1-benzyloxy-2-methylpropan-2-yl-6-fluoro-1h-indol-1-yl-3-benzyloxy-propan-2-ol-pa470981001 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 47 0981001
Molecular Formula : C29H33FN2O3
Molecular Weight : 476.59
stdClass Object ( [pname] => (R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane-1-carboxamide [catalogue_number] => PA 47 0981002 [category_ids] => ,75,76,78,70,82, [chemical_name] => [weight] => 560.57 [form] => C29H31F3N2O6 [cas] => 1152311-90-4 [pslug] => 1152311-90-4-r-1-2-2-difluorobenzo-d-1-3-dioxol-5-yl-n-1-2-2-dimethyl-1-3-dioxolan-4-yl-methyl-6-fluoro-2-1-hydroxy-2-methylpropan-2-yl-1h-indol-5-yl-cyclopropane-1-carboxamide-pa470981002 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 47 0981002
Molecular Formula : C29H31F3N2O6
Molecular Weight : 560.57
stdClass Object ( [pname] => Tezacaftor Metabolite [catalogue_number] => PA 47 0981003 [category_ids] => ,75,76,78,70,82, [chemical_name] => [weight] => 518.49 [form] => C26H25F3N2O6 [cas] => 1432656-97-7 [pslug] => 1432656-97-7-tezacaftor-metabolite-pa470981003 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 47 0981003
stdClass Object ( [pname] => (R)-1-(Benzyloxy)-3-((2-bromo-5-fluoro-4-nitrophenyl)amino)propan-2-ol [catalogue_number] => PAI 47 098001 [category_ids] => ,70, [chemical_name] => [weight] => 399.22 [form] => C16H16BrFN2O4 [cas] => 1342896-73-4 [pslug] => 1342896-73-4-r-1-benzyloxy-3-2-bromo-5-fluoro-4-nitrophenyl-amino-propan-2-ol-pai47098001 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PAI 47 098001
Molecular Formula : C16H16BrFN2O4
Molecular Weight : 399.22
stdClass Object ( [pname] => (R)-1-((4-Amino-2-bromo-5-fluorophenyl)amino)-3-(benzyloxy)propan-2-ol [catalogue_number] => PAI 47 098002 [category_ids] => ,70, [chemical_name] => [weight] => 369.23 [form] => C16H18BrFN2O2 [cas] => 1294504-63-4 [pslug] => 1294504-63-4-r-1-4-amino-2-bromo-5-fluorophenyl-amino-3-benzyloxy-propan-2-ol-pai47098002 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PAI 47 098002
Molecular Formula : C16H18BrFN2O2
Molecular Weight : 369.23
stdClass Object ( [pname] => (R)-1-((4-Amino-2-(4-(benzyloxy)-3,3-dimethylbut-1-yn-1-yl)-5-fluorophenyl)amino)-3-(benzyloxy)propan-2-ol [catalogue_number] => PAI 47 098003 [category_ids] => ,70, [chemical_name] => [weight] => 476.59 [form] => C29H33FN2O3 [cas] => 1294504-66-7 [pslug] => 1294504-66-7-r-1-4-amino-2-4-benzyloxy-3-3-dimethylbut-1-yn-1-yl-5-fluorophenyl-amino-3-benzyloxy-propan-2-ol-pai47098003 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PAI 47 098003
stdClass Object ( [pname] => (R)-N-(1-(3-(Benzyloxy)-2-hydroxypropyl)-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-5-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamide [catalogue_number] => PAI 47 098004 [category_ids] => ,70, [chemical_name] => [weight] => 700.76 [form] => C40H39F3N2O6 [cas] => 1294504-68-9 [pslug] => 1294504-68-9-r-n-1-3-benzyloxy-2-hydroxypropyl-2-1-benzyloxy-2-methylpropan-2-yl-6-fluoro-1h-indol-5-yl-1-2-2-difluorobenzo-d-1-3-dioxol-5-yl-cyclopropane-1-carboxamide-pai47098004 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PAI 47 098004
Molecular Formula : C40H39F3N2O6
Molecular Weight : 700.76
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