trametinib
Trametinib may be used alone or in combination with another medication to treat a type of skin cancer. It is a MEK inhibitor drug with anti-cancer activity.Reference standards of Trametinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
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[pname] => Trametinib Dimethyl Sulfoxide
[catalogue_number] => PA 47 0141000
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[form] => C28H29FIN5O5S
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Trametinib Dimethyl Sulfoxide
Catalogue No.:PA 47 0141000
Molecular Formula : C28H29FIN5O5S
Molecular Weight : 693.53
stdClass Object
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[pname] => Trametinib - API Standards
[catalogue_number] => PA 47 14000
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[chemical_name] =>
[weight] => 615.39
[form] => C26H23FIN5O4
[cas] => 871700-17-3
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Trametinib - API Standards
Catalogue No.:PA 47 14000
Molecular Formula : C26H23FIN5O4
Molecular Weight : 615.39
stdClass Object
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[pname] => N-(3-(5-((4-Bromo-2-fluorophenyl)amino)-3-cyclopropyl-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
[catalogue_number] => PA 47 14510
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[chemical_name] =>
[weight] => 568.39
[form] => C26H23BrFN5O4
[cas] => NA
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N-(3-(5-((4-Bromo-2-fluorophenyl)amino)-3-cyclopropyl-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
Catalogue No.:PA 47 14510
Molecular Formula : C26H23BrFN5O4
Molecular Weight : 568.39
stdClass Object
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[pname] => 3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione
[catalogue_number] => PA 47 14520
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[form] => C14H13FIN3O2
[cas] => 871700-22-0
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3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione
Catalogue No.:PA 47 14520
Molecular Formula : C14H13FIN3O2
Molecular Weight : 401.17
stdClass Object
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[pname] => Trametinib-d4
[catalogue_number] => PA STI 084082
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[weight] => 619.42
[form] => C26H19D4FIN5O4
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Catalogue No.:PA STI 084082
Molecular Formula : C26H19D4FIN5O4
Molecular Weight : 619.42
stdClass Object
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[pname] => 1-(3-Aminophenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
[catalogue_number] => PA 47 0141001
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[weight] => 573.37
[form] => C24H21FIN5O3
[cas] => 871701-87-0
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1-(3-Aminophenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
Catalogue No.:PA 47 0141001
Molecular Formula : C24H21FIN5O3
Molecular Weight : 573.37
stdClass Object
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[pname] => 1-(3-Amino-4-hydroxyphenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
[catalogue_number] => PA 47 0141002
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1-(3-Amino-4-hydroxyphenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
Catalogue No.:PA 47 0141002
Molecular Formula : C24H21FIN5O4
Molecular Weight : 589.37
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[pname] => 3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione
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3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione
Catalogue No.:PA 47 0141005
Molecular Formula : C18H15FIN3O4
Molecular Weight : 483.24
stdClass Object
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[pname] => N-(3-((3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)amino)phenyl)acetamide
[catalogue_number] => PA 47 0141004
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[weight] => 615.4
[form] => C26H23FIN5O4
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N-(3-((3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)amino)phenyl)acetamide
stdClass Object
(
[pname] => Desiodo Trametinib
[catalogue_number] => PA 47 0141003
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[chemical_name] =>
[weight] => 489.51
[form] => C26H24FN5O4
[cas] => 871700-65-1
[pslug] => 871700-65-1-desiodo-trametinib-pa470141003
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Catalogue No.:PA 47 0141003
Molecular Formula : C26H24FN5O4
Molecular Weight : 489.51
stdClass Object
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[pname] => N-Cyclopropyl-2-((2-fluoro-4-iodophenyl)amino)-4-hydroxy-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
[catalogue_number] => PA 47 0141006
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[chemical_name] =>
[weight] => 457.24
[form] => C17H17FIN3O3
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N-Cyclopropyl-2-((2-fluoro-4-iodophenyl)amino)-4-hydroxy-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
Catalogue No.:PA 47 0141006
Molecular Formula : C17H17FIN3O3
Molecular Weight : 457.24
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[catalogue_number] => PA 47 0141007
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[weight] => 631.4
[form] => C26H23FIN5O5
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N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)imino)-8-hydroxy-6,8-dimethyl-2,4,7-trioxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
stdClass Object
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[pname] => N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)imino)-8-hydroperoxy-6,8-dimethyl-2,4,7-trioxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
[catalogue_number] => PA 47 0141008
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[weight] => 647.4
[form] => C26H23FIN5O6
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N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)imino)-8-hydroperoxy-6,8-dimethyl-2,4,7-trioxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
stdClass Object
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[pname] => 3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-1-(3-nitrophenyl)pyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
[catalogue_number] => PA 47 0141009
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[weight] => 603.35
[form] => C24H19FIN5O5
[cas] => 1279693-89-8
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3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-1-(3-nitrophenyl)pyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
Catalogue No.:PA 47 0141009
Molecular Formula : C24H19FIN5O5
Molecular Weight : 603.35
stdClass Object
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[catalogue_number] => PA 47 0141010
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N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)(nitroso)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
stdClass Object
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[pname] => N-(1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-N-methylnitrous amide
[catalogue_number] => PA 47 0141011
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[weight] => 430.18
[form] => C14H12FIN4O3
[cas] => NA
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N-(1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-N-methylnitrous amide
Catalogue No.:PA 47 0141011
Molecular Formula : C14H12FIN4O3
Molecular Weight : 430.18
stdClass Object
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N-(3-((3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)(nitroso)amino)phenyl)acetamide