Trametinib-impurities | Pharmaffiliates

trametinib

Trametinib may be used alone or in combination with another medication to treat a type of skin cancer. It is a MEK inhibitor drug with anti-cancer activity.Reference standards of Trametinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => Trametinib Dimethyl Sulfoxide
    [catalogue_number] => PA 47 0141000
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 693.53
    [form] => C28H29FIN5O5S
    [cas] => 1187431-43-1
    [pslug] => 1187431-43-1-trametinib-dimethyl-sulfoxide-pa470141000
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PA 47 0141000

Trametinib Dimethyl Sulfoxide


  • Catalogue No.:PA 47 0141000

  • CAS :

    1187431-43-1

  • Molecular Formula : C28H29FIN5O5S

  • Molecular Weight : 693.53

20% OFF
stdClass Object
(
    [pname] => Trametinib - API Standards 
    [catalogue_number] => PA 47 14000
    [category_ids] => ,80,78,70,82,
    [chemical_name] => 
    [weight] => 615.39
    [form] => C26H23FIN5O4
    [cas] => 871700-17-3
    [pslug] => 871700-17-3-trametinib-api-pa4714000
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PA 47 14000

Trametinib - API Standards


  • Catalogue No.:PA 47 14000

  • CAS :

    871700-17-3

  • Molecular Formula : C26H23FIN5O4

  • Molecular Weight : 615.39

stdClass Object
(
    [pname] => N-(3-(5-((4-Bromo-2-fluorophenyl)amino)-3-cyclopropyl-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
    [catalogue_number] => PA 47 14510
    [category_ids] => ,80,78,70,82,79,89,
    [chemical_name] => 
    [weight] => 568.39
    [form] => C26H23BrFN5O4
    [cas] => NA
    [pslug] => n-3-5-4-bromo-2-fluorophenyl-amino-3-cyclopropyl-6-8-dimethyl-2-4-7-trioxo-3-4-6-7-tetrahydropyrido-4-3-d-pyrimidin-1-2h-yl-phenyl-acetamide-pa4714510
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PA 47 14510

N-(3-(5-((4-Bromo-2-fluorophenyl)amino)-3-cyclopropyl-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide


  • Catalogue No.:PA 47 14510

  • CAS :

    NA

  • Molecular Formula : C26H23BrFN5O4

  • Molecular Weight : 568.39

stdClass Object
(
    [pname] => 3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione
    [catalogue_number] => PA 47 14520
    [category_ids] => ,78,70,82,89,79,80,
    [chemical_name] => 
    [weight] => 401.17
    [form] => C14H13FIN3O2
    [cas] => 871700-22-0
    [pslug] => 871700-22-0-3-cyclopropyl-1-2-fluoro-4-iodophenyl-6-methylamino-pyrimidine-2-4-1h-3h-dione-pa4714520
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PA 47 14520

3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione


  • Catalogue No.:PA 47 14520

  • CAS :

    871700-22-0

  • Molecular Formula : C14H13FIN3O2

  • Molecular Weight : 401.17

stdClass Object
(
    [pname] => Trametinib-d4
    [catalogue_number] => PA STI 084082
    [category_ids] => ,79,80,71,78,70,82,98,
    [chemical_name] => 
    [weight] => 619.42
    [form] => C26H19D4FIN5O4
    [cas] => NA
    [pslug] => trametinib-d4-pasti084082
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PA STI 084082

Trametinib-d4


  • Catalogue No.:PA STI 084082

  • CAS :

    NA

  • Molecular Formula : C26H19D4FIN5O4

  • Molecular Weight : 619.42

stdClass Object
(
    [pname] => 1-(3-Aminophenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
    [catalogue_number] => PA 47 0141001
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 573.37
    [form] => C24H21FIN5O3
    [cas] => 871701-87-0
    [pslug] => 871701-87-0-1-3-aminophenyl-3-cyclopropyl-5-2-fluoro-4-iodophenyl-amino-6-8-dimethylpyrido-4-3-d-pyrimidine-2-4-7-1h-3h-6h-trione-pa470141001
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PA 47 0141001

1-(3-Aminophenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione


  • Catalogue No.:PA 47 0141001

  • CAS :

    871701-87-0

  • Molecular Formula : C24H21FIN5O3

  • Molecular Weight : 573.37

stdClass Object
(
    [pname] => 1-(3-Amino-4-hydroxyphenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
    [catalogue_number] => PA 47 0141002
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 589.37
    [form] => C24H21FIN5O4
    [cas] => 1620017-29-9
    [pslug] => 1620017-29-9-1-3-amino-4-hydroxyphenyl-3-cyclopropyl-5-2-fluoro-4-iodophenyl-amino-6-8-dimethylpyrido-4-3-d-pyrimidine-2-4-7-1h-3h-6h-trione-pa470141002
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PA 47 0141002

1-(3-Amino-4-hydroxyphenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione


  • Catalogue No.:PA 47 0141002

  • CAS :

    1620017-29-9

  • Molecular Formula : C24H21FIN5O4

  • Molecular Weight : 589.37

stdClass Object
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    [pname] => 3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione
    [catalogue_number] => PA 47 0141005
    [category_ids] => ,80,78,70,82,76,
    [chemical_name] => 
    [weight] => 483.24
    [form] => C18H15FIN3O4
    [cas] => 871700-24-2
    [pslug] => 871700-24-2-3-cyclopropyl-1-2-fluoro-4-iodophenyl-5-hydroxy-6-8-dimethylpyrido-2-3-d-pyrimidine-2-4-7-1h-3h-8h-trione-pa470141005
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PA 47 0141005

3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione


  • Catalogue No.:PA 47 0141005

  • CAS :

    871700-24-2

  • Molecular Formula : C18H15FIN3O4

  • Molecular Weight : 483.24

stdClass Object
(
    [pname] => N-(3-((3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)amino)phenyl)acetamide
    [catalogue_number] => PA 47 0141004
    [category_ids] => ,80,78,70,82,76,
    [chemical_name] => 
    [weight] => 615.4
    [form] => C26H23FIN5O4
    [cas] => 871700-25-3
    [pslug] => 871700-25-3-n-3-3-cyclopropyl-1-2-fluoro-4-iodophenyl-6-8-dimethyl-2-4-7-trioxo-1-2-3-4-7-8-hexahydropyrido-2-3-d-pyrimidin-5-yl-amino-phenyl-acetamide-pa470141004
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PA 47 0141004

N-(3-((3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)amino)phenyl)acetamide


  • Catalogue No.:PA 47 0141004

  • CAS :

    871700-25-3

  • Molecular Formula : C26H23FIN5O4

  • Molecular Weight : 615.4

stdClass Object
(
    [pname] => Desiodo Trametinib
    [catalogue_number] => PA 47 0141003
    [category_ids] => ,80,78,70,82,76,
    [chemical_name] => 
    [weight] => 489.51
    [form] => C26H24FN5O4
    [cas] => 871700-65-1
    [pslug] => 871700-65-1-desiodo-trametinib-pa470141003
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PA 47 0141003

Desiodo Trametinib


  • Catalogue No.:PA 47 0141003

  • CAS :

    871700-65-1

  • Molecular Formula : C26H24FN5O4

  • Molecular Weight : 489.51

stdClass Object
(
    [pname] => N-Cyclopropyl-2-((2-fluoro-4-iodophenyl)amino)-4-hydroxy-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
    [catalogue_number] => PA 47 0141006
    [category_ids] => ,78,70,82,
    [chemical_name] => 
    [weight] => 457.24
    [form] => C17H17FIN3O3
    [cas] => NA
    [pslug] => n-cyclopropyl-2-2-fluoro-4-iodophenyl-amino-4-hydroxy-1-5-dimethyl-6-oxo-1-6-dihydropyridine-3-carboxamide-pa470141006
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PA 47 0141006

N-Cyclopropyl-2-((2-fluoro-4-iodophenyl)amino)-4-hydroxy-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide


  • Catalogue No.:PA 47 0141006

  • CAS :

    NA

  • Molecular Formula : C17H17FIN3O3

  • Molecular Weight : 457.24

stdClass Object
(
    [pname] => N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)imino)-8-hydroxy-6,8-dimethyl-2,4,7-trioxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
    [catalogue_number] => PA 47 0141007
    [category_ids] => ,80,78,70,82,
    [chemical_name] => 
    [weight] => 631.4
    [form] => C26H23FIN5O5
    [cas] => 1383430-03-2
    [pslug] => 1383430-03-2-n-3-3-cyclopropyl-5-2-fluoro-4-iodophenyl-imino-8-hydroxy-6-8-dimethyl-2-4-7-trioxo-3-4-5-6-7-8-hexahydropyrido-4-3-d-pyrimidin-1-2h-yl-phenyl-acetamide-pa470141007
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PA 47 0141007

N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)imino)-8-hydroxy-6,8-dimethyl-2,4,7-trioxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide


  • Catalogue No.:PA 47 0141007

  • CAS :

    1383430-03-2

  • Molecular Formula : C26H23FIN5O5

  • Molecular Weight : 631.4

stdClass Object
(
    [pname] => N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)imino)-8-hydroperoxy-6,8-dimethyl-2,4,7-trioxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
    [catalogue_number] => PA 47 0141008
    [category_ids] => ,80,78,70,82,
    [chemical_name] => 
    [weight] => 647.4
    [form] => C26H23FIN5O6
    [cas] => 1383430-04-3
    [pslug] => 1383430-04-3-n-3-3-cyclopropyl-5-2-fluoro-4-iodophenyl-imino-8-hydroperoxy-6-8-dimethyl-2-4-7-trioxo-3-4-5-6-7-8-hexahydropyrido-4-3-d-pyrimidin-1-2h-yl-phenyl-acetamide-pa470141008
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PA 47 0141008

N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)imino)-8-hydroperoxy-6,8-dimethyl-2,4,7-trioxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide


  • Catalogue No.:PA 47 0141008

  • CAS :

    1383430-04-3

  • Molecular Formula : C26H23FIN5O6

  • Molecular Weight : 647.4

stdClass Object
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    [pname] => 3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-1-(3-nitrophenyl)pyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
    [catalogue_number] => PA 47 0141009
    [category_ids] => ,80,78,70,82,
    [chemical_name] => 
    [weight] => 603.35
    [form] => C24H19FIN5O5
    [cas] => 1279693-89-8
    [pslug] => 1279693-89-8-3-cyclopropyl-5-2-fluoro-4-iodophenyl-amino-6-8-dimethyl-1-3-nitrophenyl-pyrido-4-3-d-pyrimidine-2-4-7-1h-3h-6h-trione-pa470141009
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PA 47 0141009

3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-1-(3-nitrophenyl)pyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione


  • Catalogue No.:PA 47 0141009

  • CAS :

    1279693-89-8

  • Molecular Formula : C24H19FIN5O5

  • Molecular Weight : 603.35

stdClass Object
(
    [pname] => N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)(nitroso)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
    [catalogue_number] => PA 47 0141010
    [category_ids] => ,80,78,70,82,
    [chemical_name] => 
    [weight] => 644.4
    [form] => C26H22FIN6O5
    [cas] => NA
    [pslug] => n-3-3-cyclopropyl-5-2-fluoro-4-iodophenyl-nitroso-amino-6-8-dimethyl-2-4-7-trioxo-3-4-6-7-tetrahydropyrido-4-3-d-pyrimidin-1-2h-yl-phenyl-acetamide-pa470141010
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PA 47 0141010

N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)(nitroso)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide


  • Catalogue No.:PA 47 0141010

  • CAS :

    NA

  • Molecular Formula : C26H22FIN6O5

  • Molecular Weight : 644.4

stdClass Object
(
    [pname] => N-(1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-N-methylnitrous amide
    [catalogue_number] => PA 47 0141011
    [category_ids] => ,80,78,70,82,
    [chemical_name] => 
    [weight] => 430.18
    [form] => C14H12FIN4O3
    [cas] => NA
    [pslug] => n-1-cyclopropyl-3-2-fluoro-4-iodophenyl-2-6-dioxo-1-2-3-6-tetrahydropyrimidin-4-yl-n-methylnitrous-amide-pa470141011
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PA 47 0141011

N-(1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-N-methylnitrous amide


  • Catalogue No.:PA 47 0141011

  • CAS :

    NA

  • Molecular Formula : C14H12FIN4O3

  • Molecular Weight : 430.18

stdClass Object
(
    [pname] => N-(3-((3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)(nitroso)amino)phenyl)acetamide
    [catalogue_number] => PA 47 0141012
    [category_ids] => ,70,78,82,162,
    [chemical_name] => 
    [weight] => 644.4
    [form] => C26H22FIN6O5
    [cas] => NA
    [pslug] => n-3-3-cyclopropyl-1-2-fluoro-4-iodophenyl-6-8-dimethyl-2-4-7-trioxo-1-2-3-4-7-8-hexahydropyrido-2-3-d-pyrimidin-5-yl-nitroso-amino-phenyl-acetamide-pa470141012
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PA 47 0141012

N-(3-((3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)(nitroso)amino)phenyl)acetamide


  • Catalogue No.:PA 47 0141012

  • CAS :

    NA

  • Molecular Formula : C26H22FIN6O5

  • Molecular Weight : 644.4