ambrisentan

Metabolites - Ambrisentan is a drug indicated for use in the treatment of pulmonary hypertension. Ambrisentan was approved by the U.S. Food and Drug Administration (FDA) and European Medicines Agency, and designated an orphan drug, for the treatment of pulmonary hypertension. Reference standards of Ambrisentan API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => rac 4-Hydroxymethyl Ambrisentan-d3
    [catalogue_number] => PA STI 050030
    [category_ids] => ,80,71,98,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 397.44
    [form] => C22H19D3N2O5
    [cas] =>  1287096-42-7
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PA STI 050030
PA STI 050030

rac 4-Hydroxymethyl Ambrisentan-d3


  • Catalogue No.:PA STI 050030

  • CAS :

    1287096-42-7

  • Molecular Formula : C22H19D3N2O5

  • Molecular Weight : 397.44

stdClass Object
(
    [pname] => Ambrisentan Acyl β-D-Glucuronide
    [catalogue_number] => PA 28 46610
    [category_ids] => ,80,95,71,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 554.55
    [form] => C28H30N20O10
    [cas] => 1106685-58-8
    [pslug] => 1106685-58-8-ambrisentan-acyl-beta-d-glucuronide-pa2846610
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PA 28 46610
PA 28 46610

Ambrisentan Acyl β-D-Glucuronide


  • Catalogue No.:PA 28 46610

  • CAS :

    1106685-58-8

  • Molecular Formula : C28H30N20O10

  • Molecular Weight : 554.55

stdClass Object
(
    [pname] => 2,3-Dihydroxy-3,3-diphenylpropionic Acid Methyl Ester
    [catalogue_number] => PA 28 0461000
    [category_ids] => ,75,76,78,82,
    [chemical_name] => 
    [weight] => 272.3
    [form] => C16H16O4
    [cas] => NA
    [pslug] => -2-3-dihydroxy-3-3-diphenylpropionic-acid-methyl-ester-pa280461000
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PA 28 0461000
PA 28 0461000

2,3-Dihydroxy-3,3-diphenylpropionic Acid Methyl Ester


  • Catalogue No.:PA 28 0461000

  • CAS :

    NA

  • Molecular Formula : C16H16O4

  • Molecular Weight : 272.3

stdClass Object
(
    [pname] => (S)-4-Hydroxymethyl Ambrisentan
    [catalogue_number] => PA 28 0461001
    [category_ids] => ,82,78,76,75,70,
    [chemical_name] => 
    [weight] => 394.43
    [form] => C22H22N2O5
    [cas] => 1106685-66-8
    [pslug] => 1106685-66-8-s-4-hydroxymethyl-ambrisentan-pa280461001
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PA 28 0461001
PA 28 0461001

(S)-4-Hydroxymethyl Ambrisentan


  • Catalogue No.:PA 28 0461001

  • CAS :

    1106685-66-8

  • Molecular Formula : C22H22N2O5

  • Molecular Weight : 394.43

stdClass Object
(
    [pname] => (R,S)-Ambrisentan acyl-β-D-glucuronide
    [catalogue_number] => PA 28 0461002
    [category_ids] => ,70,75,76,78,82,95,
    [chemical_name] => 
    [weight] => 554.55
    [form] => C28H30N2O10
    [cas] => 1106685-82-8
    [pslug] => 1106685-82-8-r-s-ambrisentan-acyl-beta-d-glucuronide-pa280461002
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PA 28 0461002
PA 28 0461002

(R,S)-Ambrisentan acyl-β-D-glucuronide


  • Catalogue No.:PA 28 0461002

  • CAS :

    1106685-82-8

  • Molecular Formula : C28H30N2O10

  • Molecular Weight : 554.55

stdClass Object
(
    [pname] => Ambrisentan Hydroxy Acid Impurity (R-Isomer)
    [catalogue_number] => PA 28 0461003
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 272.3
    [form] => C16H16O4
    [cas] => 178306-49-5
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PA 28 0461003
PA 28 0461003

Ambrisentan Hydroxy Acid Impurity (R-Isomer)


  • Catalogue No.:PA 28 0461003

  • CAS :

    178306-49-5

  • Molecular Formula : C16H16O4

  • Molecular Weight : 272.3

stdClass Object
(
    [pname] => rac 4-Hydroxymethyl Ambrisentan
    [catalogue_number] => PA 28 0461004
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 394.43
    [form] => C22H22N2O5
    [cas] => 1106685-84-0
    [pslug] => 1106685-84-0-rac-4-hydroxymethyl-ambrisentan-pa280461004
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PA 28 0461004
PA 28 0461004

rac 4-Hydroxymethyl Ambrisentan


  • Catalogue No.:PA 28 0461004

  • CAS :

    1106685-84-0

  • Molecular Formula : C22H22N2O5

  • Molecular Weight : 394.43

stdClass Object
(
    [pname] => Ethyl (S)-2-((4,6-dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoate
    [catalogue_number] => PA 28 0461005
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 406.48
    [form] => C24H26N2O4
    [cas] => 1349854-31-4
    [pslug] => 1349854-31-4-ethyl-s-2-4-6-dimethylpyrimidin-2-yl-oxy-3-methoxy-3-3-diphenylpropanoate-pa280461005
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PA 28 0461005
PA 28 0461005

Ethyl (S)-2-((4,6-dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoate


  • Catalogue No.:PA 28 0461005

  • CAS :

    1349854-31-4

  • Molecular Formula : C24H26N2O4

  • Molecular Weight : 406.48

stdClass Object
(
    [pname] => 2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenyl propanoic acid ethyl ester
    [catalogue_number] => PA 28 0461006
    [category_ids] => ,75,76,78,70,82,
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    [weight] => 406.48
    [form] => C24H26N2O4
    [cas] => NA
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PA 28 0461006
PA 28 0461006

2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenyl propanoic acid ethyl ester


  • Catalogue No.:PA 28 0461006

  • CAS :

    NA

  • Molecular Formula : C24H26N2O4

  • Molecular Weight : 406.48

stdClass Object
(
    [pname] => 2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3,3-diphenylacrylic acid
    [catalogue_number] => PA 28 0461007
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 346.39
    [form] => C21H18N2O3
    [cas] => 1312092-82-2
    [pslug] => 1312092-82-2-2-4-6-dimethylpyrimidin-2-yl-oxy-3-3-diphenylacrylic-acid-pa280461007
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PA 28 0461007
PA 28 0461007

2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3,3-diphenylacrylic acid


  • Catalogue No.:PA 28 0461007

  • CAS :

    1312092-82-2

  • Molecular Formula : C21H18N2O3

  • Molecular Weight : 346.39

stdClass Object
(
    [pname] => Ambrisentan N-Oxide
    [catalogue_number] => PA 28 0461008
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 394.43
    [form] => C22H22N2O5
    [cas] => NA
    [pslug] => ambrisentan-n-oxide-pa280461008
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PA 28 0461008
PA 28 0461008

Ambrisentan N-Oxide


  • Catalogue No.:PA 28 0461008

  • CAS :

    NA

  • Molecular Formula : C22H22N2O5

  • Molecular Weight : 394.43

stdClass Object
(
    [pname] => (S)-2-((4-(Hydroxymethyl)-6-(methyl-d3)pyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid
    [catalogue_number] => PA STI 088903
    [category_ids] => ,98,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 397.45
    [form] => C22H19D3N2O5
    [cas] => NA
    [pslug] => s-2-4-hydroxymethyl-6-methyl-d3-pyrimidin-2-yl-oxy-3-methoxy-3-3-diphenylpropanoic-acid-pasti088903
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PA STI 088903
PA STI 088903

(S)-2-((4-(Hydroxymethyl)-6-(methyl-d3)pyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid


  • Catalogue No.:PA STI 088903

  • CAS :

    NA

  • Molecular Formula : C22H19D3N2O5

  • Molecular Weight : 397.45

stdClass Object
(
    [pname] => Ambrisentan D3
    [catalogue_number] => PA STI 088904
    [category_ids] => ,98,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 381.45
    [form] => C22H19D3N2O4
    [cas] => 1046116-26-0
    [pslug] => 1046116-26-0-ambrisentan-d3-pasti088904
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PA STI 088904
PA STI 088904

Ambrisentan D3


  • Catalogue No.:PA STI 088904

  • CAS :

    1046116-26-0

  • Molecular Formula : C22H19D3N2O4

  • Molecular Weight : 381.45

stdClass Object
(
    [pname] => 2-((4,6-Dimethylpyrimidin-2-yl)oxy)-1-phenylethan-1-one
    [catalogue_number] => PAI 01 016041
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 242.28
    [form] => C14H14N2O2
    [cas] => 2052996-29-7
    [pslug] => 2052996-29-7-2-4-6-dimethylpyrimidin-2-yl-oxy-1-phenylethan-1-one-pai01016041
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PAI 01 016041
PAI 01 016041

2-((4,6-Dimethylpyrimidin-2-yl)oxy)-1-phenylethan-1-one


  • Catalogue No.:PAI 01 016041

  • CAS :

    2052996-29-7

  • Molecular Formula : C14H14N2O2

  • Molecular Weight : 242.28

stdClass Object
(
    [pname] => 2-((4,6-Dimethylpyrimidin-2-yl)oxy)-1,1-diphenylethan-1-ol
    [catalogue_number] => PAI 01 016042
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 320.39
    [form] => C20H20N2O2
    [cas] => 2052996-28-6
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PAI 01 016042
PAI 01 016042

2-((4,6-Dimethylpyrimidin-2-yl)oxy)-1,1-diphenylethan-1-ol


  • Catalogue No.:PAI 01 016042

  • CAS :

    2052996-28-6

  • Molecular Formula : C20H20N2O2

  • Molecular Weight : 320.39

stdClass Object
(
    [pname] => Diphenylacetaldehyde
    [catalogue_number] => PA 28 0461009
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 196.25
    [form] => C14H12O
    [cas] => 947-91-1
    [pslug] => 947-91-1-diphenylacetaldehyde-pa280461009
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PA 28 0461009
PA 28 0461009

Diphenylacetaldehyde


  • Catalogue No.:PA 28 0461009

  • CAS :

    947-91-1

  • Molecular Formula : C14H12O

  • Molecular Weight : 196.25

stdClass Object
(
    [pname] => 4-Hydroxymethyl Ambrisentan D5
    [catalogue_number] => PA STI 089231
    [category_ids] => ,98,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 399.46
    [form] => C22H17D5N2O5
    [cas] => 2012598-50-2
    [pslug] => 2012598-50-2-4-hydroxymethyl-ambrisentan-d5-pasti089231
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PA STI 089231
PA STI 089231

4-Hydroxymethyl Ambrisentan D5


  • Catalogue No.:PA STI 089231

  • CAS :

    2012598-50-2

  • Molecular Formula : C22H17D5N2O5

  • Molecular Weight : 399.46

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