Ivabradine Hydrochloride-impurities | Pharmaffiliates

ivabradine hydrochloride

Ivabradine Hydrochloride is used for the symptomatic treatment of chronic stable angina pectoris in patients with normal sinus rhythm who cannot take beta blockers. It is marketed under the trade name Corlanor. Reference standards of Ivabradine Hydrochloride API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane
    [catalogue_number] => PA 09 0241000
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 207.27
    [form] => C12H17NO2
    [cas] => 866783-12-2
    [pslug] => 866783-12-2-1s-4-5-dimethoxy-1-methylamino-methyl-benzocyclobutane-pa090241000
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PA 09 0241000

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane


  • Catalogue No.:PA 09 0241000

  • CAS :

    866783-12-2

  • Molecular Formula : C12H17NO2

  • Molecular Weight : 207.27

stdClass Object
(
    [pname] => N-Demethyl Ivabradine Hydrochloride
    [catalogue_number] => PA 09 24520
    [category_ids] => ,79,69,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 491.02
    [form] => C26H35ClN2O5
    [cas] => 1246638-08-3
    [pslug] => 1246638-08-3-n-demethyl-ivabradine-hydrochloride-pa0924520
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PA 09 24520

N-Demethyl Ivabradine Hydrochloride


  • Catalogue No.:PA 09 24520

  • CAS :

    1246638-08-3

  • Molecular Formula : C26H35ClN2O5

  • Molecular Weight : 491.02

stdClass Object
(
    [pname] => O-Desmethyl Ivabradine
    [catalogue_number] => PA 09 24530
    [category_ids] => 79,76,75,69,70,78,82
    [chemical_name] => 
    [weight] => 454.56
    [form] => C26H34N2O5
    [cas] => 304462-60-0
    [pslug] => 304462-60-0-o-desmethyl-ivabradine-pa0924530
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PA 09 24530

O-Desmethyl Ivabradine


  • Catalogue No.:PA 09 24530

  • CAS :

    304462-60-0

  • Molecular Formula : C26H34N2O5

  • Molecular Weight : 454.56

stdClass Object
(
    [pname] => 8-Demethyl Ivabradine
    [catalogue_number] => PA 09 24540
    [category_ids] => ,79,69,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 454.56
    [form] => C26H34N2O5
    [cas] => 304464-97-9
    [pslug] => 304464-97-9-8-demethyl-ivabradine-pa0924540
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PA 09 24540

8-Demethyl Ivabradine


  • Catalogue No.:PA 09 24540

  • CAS :

    304464-97-9

  • Molecular Formula : C26H34N2O5

  • Molecular Weight : 454.56

stdClass Object
(
    [pname] => Ivabradin N-oxide
    [catalogue_number] => PA 09 24550
    [category_ids] => 82,79,78,76,75,70,69
    [chemical_name] => 
    [weight] => 484.6
    [form] => C27H36N2O6
    [cas] => 2511244-97-4
    [pslug] => 2511244-97-4-ivabradin-n-oxide-pa0924550
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PA 09 24550

Ivabradin N-oxide


  • Catalogue No.:PA 09 24550

  • CAS :

    2511244-97-4

  • Molecular Formula : C27H36N2O6

  • Molecular Weight : 484.6

stdClass Object
(
    [pname] => N-Demethyl Ivabradine
    [catalogue_number] => PA 09 24780
    [category_ids] => ,79,69,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 454.6
    [form] => C26H34N2O5
    [cas] => 215935-23-2
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PA 09 24780

N-Demethyl Ivabradine


  • Catalogue No.:PA 09 24780

  • CAS :

    215935-23-2

  • Molecular Formula : C26H34N2O5

  • Molecular Weight : 454.6

stdClass Object
(
    [pname] => Methyl (S)-2-(2-(2-((3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)amino)ethyl)-4,5-dimethoxyphenyl)Acetate
    [catalogue_number] => PA 09 24790
    [category_ids] => ,79,69,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 500.63
    [form] => C28H40N2O6
    [cas] => NA
    [pslug] => methyl-s-2-2-2-3-3-4-dimethoxybicyclo-4-2-0-octa-1-6-2-4-trien-7-yl-methyl-methyl-amino-propyl-amino-ethyl-4-5-dimethoxyphenyl-acetate-pa0924790
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PA 09 24790

Methyl (S)-2-(2-(2-((3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)amino)ethyl)-4,5-dimethoxyphenyl)Acetate


  • Catalogue No.:PA 09 24790

  • CAS :

    NA

  • Molecular Formula : C28H40N2O6

  • Molecular Weight : 500.63

stdClass Object
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    [pname] => (S)-3-(3-((3-Chloro-2-(3,4-dimethoxyphenyl)propyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
    [catalogue_number] => PA 09 24800
    [category_ids] => ,79,69,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 505.05
    [form] => C27H37ClN2O5
    [cas] => 2768438-46-4
    [pslug] => 2768438-46-4-s-3-3-3-chloro-2-3-4-dimethoxyphenyl-propyl-methyl-amino-propyl-7-8-dimethoxy-1-3-4-5-tetrahydro-2h-benzo-d-azepin-2-one-pa0924800
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PA 09 24800

(S)-3-(3-((3-Chloro-2-(3,4-dimethoxyphenyl)propyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one


  • Catalogue No.:PA 09 24800

  • CAS :

    2768438-46-4

  • Molecular Formula : C27H37ClN2O5

  • Molecular Weight : 505.05

stdClass Object
(
    [pname] => (S)-2-(2-(2-((3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)amino)ethyl)-4,5-dimethoxyphenyl)-2-oxoacetic Acid
    [catalogue_number] => PA 09 24810
    [category_ids] => ,79,69,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 500.58
    [form] => C27H36N2O7
    [cas] => NA
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PA 09 24810

(S)-2-(2-(2-((3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)amino)ethyl)-4,5-dimethoxyphenyl)-2-oxoacetic Acid


  • Catalogue No.:PA 09 24810

  • CAS :

    NA

  • Molecular Formula : C27H36N2O7

  • Molecular Weight : 500.58

stdClass Object
(
    [pname] => 1-Chloro-2-(2-(2-((3-(((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)amino)-2-hydroxyethyl)-4,5-dimethoxyphenyl)ethan-1-ol
    [catalogue_number] => PA 09 24850
    [category_ids] => ,79,69,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 523.07
    [form] => C27H39ClN2O6
    [cas] => NA
    [pslug] => 1-chloro-2-2-2-3-3-4-dimethoxybicyclo-4-2-0-octa-1-3-5-trien-7-yl-methyl-methyl-amino-propyl-amino-2-hydroxyethyl-4-5-dimethoxyphenyl-ethan-1-ol-pa0924850
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PA 09 24850

1-Chloro-2-(2-(2-((3-(((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)amino)-2-hydroxyethyl)-4,5-dimethoxyphenyl)ethan-1-ol


  • Catalogue No.:PA 09 24850

  • CAS :

    NA

  • Molecular Formula : C27H39ClN2O6

  • Molecular Weight : 523.07

stdClass Object
(
    [pname] => (E)-1-Chloro-2-(2-(2-((3-(((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)imino)ethyl)-4,5-dimethoxyphenyl)ethan-1-ol
    [catalogue_number] => PA 09 24860
    [category_ids] => ,79,69,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 505.05
    [form] => C27H37ClN2O5
    [cas] => NA
    [pslug] => e-1-chloro-2-2-2-3-3-4-dimethoxybicyclo-4-2-0-octa-1-3-5-trien-7-yl-methyl-methyl-amino-propyl-imino-ethyl-4-5-dimethoxyphenyl-ethan-1-ol-pa0924860
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PA 09 24860

(E)-1-Chloro-2-(2-(2-((3-(((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)imino)ethyl)-4,5-dimethoxyphenyl)ethan-1-ol


  • Catalogue No.:PA 09 24860

  • CAS :

    NA

  • Molecular Formula : C27H37ClN2O5

  • Molecular Weight : 505.05

stdClass Object
(
    [pname] => 3-Chloro-2-(3,4-dimethoxyphenyl)-N-methylpropan-1-amine Hydrochloride
    [catalogue_number] => PA 09 24870
    [category_ids] => ,79,69,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 280.19
    [form] => C12H19Cl2NO2
    [cas] => 2768438-48-6
    [pslug] => 2768438-48-6-3-chloro-2-3-4-dimethoxyphenyl-n-methylpropan-1-amine-hydrochloride-pa0924870
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PA 09 24870

3-Chloro-2-(3,4-dimethoxyphenyl)-N-methylpropan-1-amine Hydrochloride


  • Catalogue No.:PA 09 24870

  • CAS :

    2768438-48-6

  • Molecular Formula : C12H19Cl2NO2

  • Molecular Weight : 280.19

stdClass Object
(
    [pname] => (R)-3,4-Dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide
    [catalogue_number] => PA 09 24880
    [category_ids] => ,79,69,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 221.26
    [form] => C12H15NO3
    [cas] => NA
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PA 09 24880

(R)-3,4-Dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide


  • Catalogue No.:PA 09 24880

  • CAS :

    NA

  • Molecular Formula : C12H15NO3

  • Molecular Weight : 221.26

stdClass Object
(
    [pname] => Dehydro Ivabradine Hydrochloride
    [catalogue_number] => PA 09 24890
    [category_ids] => ,79,69,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 503.04
    [form] => C27H35ClN2O5
    [cas] => 1086026-38-1
    [pslug] => 1086026-38-1-dehydro-ivabradine-hydrochloride-pa0924890
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PA 09 24890

Dehydro Ivabradine Hydrochloride


  • Catalogue No.:PA 09 24890

  • CAS :

    1086026-38-1

  • Molecular Formula : C27H35ClN2O5

  • Molecular Weight : 503.04

stdClass Object
(
    [pname] => 3-(3-Bromopropyl)-7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2-one
    [catalogue_number] => PA 09 24900
    [category_ids] => ,79,69,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 340.22
    [form] => C15H18BrNO3
    [cas] => 1428869-91-3
    [pslug] => 1428869-91-3-3-3-bromopropyl-7-8-dimethoxy-1-3-dihydro-2h-benzo-d-azepin-2-one-pa0924900
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PA 09 24900

3-(3-Bromopropyl)-7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2-one


  • Catalogue No.:PA 09 24900

  • CAS :

    1428869-91-3

  • Molecular Formula : C15H18BrNO3

  • Molecular Weight : 340.22

stdClass Object
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    [pname] => (S)-3-(3-((2-(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)ethyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepine-1,2(3H)-dione Hydrochloride
    [catalogue_number] => PA 09 24910
    [category_ids] => ,79,69,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 519.04
    [form] => C27H35ClN2O6
    [cas] => NA
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PA 09 24910

(S)-3-(3-((2-(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)ethyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepine-1,2(3H)-dione Hydrochloride


  • Catalogue No.:PA 09 24910

  • CAS :

    NA

  • Molecular Formula : C27H35ClN2O6

  • Molecular Weight : 519.04

stdClass Object
(
    [pname] => Homoveratric Acid
    [catalogue_number] => PA 09 24920
    [category_ids] => ,80,76,75,93,78,82,70,
    [chemical_name] => 
    [weight] => 196.2
    [form] => C10H12O4
    [cas] => 93-40-3
    [pslug] => 93-40-3-homoveratric-acid-pa0924920
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PA 09 24920

Homoveratric Acid


  • Catalogue No.:PA 09 24920

  • CAS :

    93-40-3

  • Molecular Formula : C10H12O4

  • Molecular Weight : 196.2

stdClass Object
(
    [pname] => 3-(3-(((3-Hydroxy-4-methoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
    [catalogue_number] => PA 09 0241002
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 454.57
    [form] => C26H34N2O5
    [cas] => 2247881-26-9
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PA 09 0241002

3-(3-(((3-Hydroxy-4-methoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one


  • Catalogue No.:PA 09 0241002

  • CAS :

    2247881-26-9

  • Molecular Formula : C26H34N2O5

  • Molecular Weight : 454.57

stdClass Object
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    [pname] => 3-(3-((((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-5-hydroxy-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
    [catalogue_number] => PA 09 0241001
    [category_ids] => ,78,75,70,76,82,
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    [weight] => 484.59
    [form] => C27H36N2O6
    [cas] => NA
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PA 09 0241001

3-(3-((((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-5-hydroxy-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one


  • Catalogue No.:PA 09 0241001

  • CAS :

    NA

  • Molecular Formula : C27H36N2O6

  • Molecular Weight : 484.59

stdClass Object
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    [pname] => (S)-3-(3-(((3-Hydroxy-4-methoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
    [catalogue_number] => PA 09 0241003
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 454.57
    [form] => C26H34N2O5
    [cas] => 304464-98-0
    [pslug] => 304464-98-0-s-3-3-3-hydroxy-4-methoxybicyclo-4-2-0-octa-1-3-5-trien-7-yl-methyl-methyl-amino-propyl-7-8-dimethoxy-1-3-4-5-tetrahydro-2h-benzo-d-azepin-2-one-pa090241003
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PA 09 0241003

(S)-3-(3-(((3-Hydroxy-4-methoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one


  • Catalogue No.:PA 09 0241003

  • CAS :

    304464-98-0

  • Molecular Formula : C26H34N2O5

  • Molecular Weight : 454.57

stdClass Object
(
    [pname] => (S)-3-(3-(((3-Hydroxy-4-methoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one Hydrochloride
    [catalogue_number] => PA 09 0241005
    [category_ids] => ,76,75,70,82,78,
    [chemical_name] => 
    [weight] => 491.03
    [form] => C26H35ClN2O5
    [cas] => NA
    [pslug] => s-3-3-3-hydroxy-4-methoxybicyclo-4-2-0-octa-1-6-2-4-trien-7-yl-methyl-methyl-amino-propyl-7-8-dimethoxy-1-3-4-5-tetrahydro-2h-benzo-d-azepin-2-one-hydrochloride-pa090241005
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PA 09 0241005

(S)-3-(3-(((3-Hydroxy-4-methoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one Hydrochloride


  • Catalogue No.:PA 09 0241005

  • CAS :

    NA

  • Molecular Formula : C26H35ClN2O5

  • Molecular Weight : 491.03

stdClass Object
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    [pname] => (S)-3-(3-(((4-Hydroxy-3-methoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one Hydrochloride
    [catalogue_number] => PA 09 0241006
    [category_ids] => 70,75,76,78,82
    [chemical_name] => 
    [weight] => 491.03
    [form] => C26H35ClN2O5
    [cas] => NA
    [pslug] => s-3-3-4-hydroxy-3-methoxybicyclo-4-2-0-octa-1-6-2-4-trien-7-yl-methyl-methyl-amino-propyl-7-8-dimethoxy-1-3-4-5-tetrahydro-2h-benzo-d-azepin-2-one-hydrochloride-pa090241006
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PA 09 0241006

(S)-3-(3-(((4-Hydroxy-3-methoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one Hydrochloride


  • Catalogue No.:PA 09 0241006

  • CAS :

    NA

  • Molecular Formula : C26H35ClN2O5

  • Molecular Weight : 491.03

stdClass Object
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    [pname] => 3-(3-((2-(3,4-Dimethoxyphenyl)propyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one Hydrochloride
    [catalogue_number] => PA 09 0241007
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 507.07
    [form] => C27H39ClN2O5
    [cas] => NA
    [pslug] => 3-3-2-3-4-dimethoxyphenyl-propyl-methyl-amino-propyl-7-8-dimethoxy-1-3-4-5-tetrahydro-2h-benzo-d-azepin-2-one-hydrochloride-pa090241007
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PA 09 0241007

3-(3-((2-(3,4-Dimethoxyphenyl)propyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one Hydrochloride


  • Catalogue No.:PA 09 0241007

  • CAS :

    NA

  • Molecular Formula : C27H39ClN2O5

  • Molecular Weight : 507.07

stdClass Object
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    [pname] => 3-(3-((((R)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxydecahydro-2H-benzo[d]azepin-2-one Hydrochloride
    [catalogue_number] => PA 09 0241009
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 511.1
    [form] => C27H43ClN2O5
    [cas] => NA
    [pslug] => 3-3-r-3-4-dimethoxybicyclo-4-2-0-octa-1-3-5-trien-7-yl-methyl-methyl-amino-propyl-7-8-dimethoxydecahydro-2h-benzo-d-azepin-2-one-hydrochloride-pa090241009
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PA 09 0241009

3-(3-((((R)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxydecahydro-2H-benzo[d]azepin-2-one Hydrochloride


  • Catalogue No.:PA 09 0241009

  • CAS :

    NA

  • Molecular Formula : C27H43ClN2O5

  • Molecular Weight : 511.1