Lorlatinib
Metabolites
- Lorlatinib is approved in the US and in Europe for the second- or third-line treatment of ALK-positive metastatic non-small-cell lung cancer (NSCLC). Reference standards of Lorlatinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
stdClass Object
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[pname] => Lorlatinib
[catalogue_number] => PA 12 1490000
[category_ids] => ,78,75,70,76,82,
[chemical_name] =>
[weight] => 406.42
[form] => C21H19FN6O2
[cas] => 1454846-35-5
[pslug] => 1454846-35-5-lorlatinib-api-pa121490000
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Catalogue No.:PA 12 1490000
Molecular Formula : C21H19FN6O2
Molecular Weight : 406.42
stdClass Object
(
[pname] => (S)-Lorlatinib
[catalogue_number] => PA 12 1491000
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[chemical_name] =>
[weight] => 406.42
[form] => C21H19FN6O2
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Catalogue No.:PA 12 1491000
Molecular Formula : C21H19FN6O2
Molecular Weight : 406.42
stdClass Object
(
[pname] => (R)-2-(1-((2-Amino-5-(5-cyano-1-methyl-3-((methylamino)methyl)-1H-pyrazol-4-yl)pyridin-3-yl)oxy)ethyl)-4-fluorobenzoic Acid
[catalogue_number] => PA 12 1491002
[category_ids] => ,78,75,70,76,82,
[chemical_name] =>
[weight] => 424.44
[form] => C21H21FN6O3
[cas] => 1455009-85-4
[pslug] => 1455009-85-4-r-2-1-2-amino-5-5-cyano-1-methyl-3-methylamino-methyl-1h-pyrazol-4-yl-pyridin-3-yl-oxy-ethyl-4-fluorobenzoic-acid-pa121491002
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(R)-2-(1-((2-Amino-5-(5-cyano-1-methyl-3-((methylamino)methyl)-1H-pyrazol-4-yl)pyridin-3-yl)oxy)ethyl)-4-fluorobenzoic Acid
Catalogue No.:PA 12 1491002
Molecular Formula : C21H21FN6O3
Molecular Weight : 424.44
stdClass Object
(
[pname] => (R)-2-(1-((2-Amino-5-(5-cyano-1-methyl-3-((methyl(nitroso)amino)methyl)-1H-pyrazol-4-yl)pyridin-3-yl)oxy)ethyl)-4-fluorobenzoic Acid
[catalogue_number] => PA 12 1491003
[category_ids] => ,78,75,70,76,82,162,
[chemical_name] =>
[weight] => 453.43
[form] => C21H20FN7O4
[cas] => NA
[pslug] => r-2-1-2-amino-5-5-cyano-1-methyl-3-methyl-nitroso-amino-methyl-1h-pyrazol-4-yl-pyridin-3-yl-oxy-ethyl-4-fluorobenzoic-acid-pa121491003
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(R)-2-(1-((2-Amino-5-(5-cyano-1-methyl-3-((methyl(nitroso)amino)methyl)-1H-pyrazol-4-yl)pyridin-3-yl)oxy)ethyl)-4-fluorobenzoic Acid
Catalogue No.:PA 12 1491003
Molecular Formula : C21H20FN7O4
Molecular Weight : 453.43
stdClass Object
(
[pname] => Diboc Nitrile Lorlatinib Impurity
[catalogue_number] => PA 12 1491004
[category_ids] => ,78,75,70,76,82,
[chemical_name] =>
[weight] => 687.57
[form] => C31H36BrFN6O6
[cas] => 1643141-22-3
[pslug] => 1643141-22-3-diboc-nitrile-lorlatinib-impurity-pa121491004
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Diboc Nitrile Lorlatinib Impurity
Catalogue No.:PA 12 1491004
Molecular Formula : C31H36BrFN6O6
Molecular Weight : 687.57
stdClass Object
(
[pname] => Lorlatinib tert-butyl Acetate Impurity
[catalogue_number] => PA 12 1491005
[category_ids] => ,78,75,70,76,82,
[chemical_name] =>
[weight] => 506.54
[form] => C26H27FN6O4
[cas] => 2306101-64-2
[pslug] => 2306101-64-2-lorlatinib-tert-butyl-acetate-impurity-pa121491005
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Lorlatinib tert-butyl Acetate Impurity
Catalogue No.:PA 12 1491005
Molecular Formula : C26H27FN6O4
Molecular Weight : 506.54
stdClass Object
(
[pname] => Lorlatinib Descyano Impurity
[catalogue_number] => PA 12 1491006
[category_ids] => ,78,75,70,76,82,
[chemical_name] =>
[weight] => 381.41
[form] => C20H20FN5O2
[cas] => NA
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Lorlatinib Descyano Impurity
Catalogue No.:PA 12 1491006
Molecular Formula : C20H20FN5O2
Molecular Weight : 381.41
stdClass Object
(
[pname] => Boc-Lorlatinib Impurity
[catalogue_number] => PA 12 1491007
[category_ids] => ,78,75,70,76,82,
[chemical_name] =>
[weight] => 606.66
[form] => C31H35FN6O6
[cas] => 1643141-23-4
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Catalogue No.:PA 12 1491007
Molecular Formula : C31H35FN6O6
Molecular Weight : 606.66
stdClass Object
(
[pname] => Lorlatinib Acid Impurity
[catalogue_number] => PA 12 1491008
[category_ids] => ,78,75,70,76,82,
[chemical_name] =>
[weight] => 425.42
[form] => C21H20FN5O4
[cas] => NA
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Catalogue No.:PA 12 1491008
Molecular Formula : C21H20FN5O4
Molecular Weight : 425.42
