regorafenib
A multikinase inhibitor, Regorafenib is used in the treatment of metastatic colorectal cancer and advanced gastrointestinal stromal tumors. Shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition.Reference standards of Regorafenib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
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[pname] => Regorafenib N-Oxide
[catalogue_number] => PA 18 49510
[category_ids] => ,79,80,71,76,75,78,70,82,
[chemical_name] =>
[weight] => 498.81
[form] => C21H15ClF4N4O4
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Catalogue No.:PA 18 49510
Molecular Formula : C21H15ClF4N4O4
Molecular Weight : 498.81
stdClass Object
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[pname] => 4-(4-Amino-3-fluorophenoxy)-N-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)picolinamide
[catalogue_number] => PA 18 49520
[category_ids] => ,79,80,71,76,75,78,70,82,89,
[chemical_name] =>
[weight] => 491.45
[form] => C25H19F2N5O4
[cas] => 2518234-85-8
[pslug] => 2518234-85-8-4-4-amino-3-fluorophenoxy-n-2-fluoro-4-2-methylcarbamoyl-pyridin-4-yl-oxy-phenyl-picolinamide-pa1849520
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4-(4-Amino-3-fluorophenoxy)-N-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)picolinamide
Catalogue No.:PA 18 49520
Molecular Formula : C25H19F2N5O4
Molecular Weight : 491.45
stdClass Object
(
[pname] => Hydroxyregorafenib
[catalogue_number] => PA 18 49530
[category_ids] => ,79,80,71,76,75,78,70,82,
[chemical_name] =>
[weight] => 498.81
[form] => C21H15ClF4N4O4
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Catalogue No.:PA 18 49530
Molecular Formula : C21H15ClF4N4O4
Molecular Weight : 498.81
stdClass Object
(
[pname] => N-Desmethyl Regorafenib
[catalogue_number] => PA 18 49580
[category_ids] => 82,80,79,78,76,75,71,70
[chemical_name] =>
[weight] => 468.79
[form] => C20H13ClF4N4O3
[cas] => 1343498-72-5
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Catalogue No.:PA 18 49580
Molecular Formula : C20H13ClF4N4O3
Molecular Weight : 468.79
stdClass Object
(
[pname] => Regorafenib Tablets EP Impurity FP-A
[catalogue_number] => PA 18 49630
[category_ids] => ,80,71,76,75,78,70,82,
[chemical_name] =>
[weight] => 333.31
[form] => C16H16FN3O4
[cas] => 2514957-39-0
[pslug] => 2514957-39-0-regorafenib-tablets-ep-impurity-fp-a-pa1849630
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Regorafenib Tablets EP Impurity FP-A
Catalogue No.:PA 18 49630
Molecular Formula : C16H16FN3O4
Molecular Weight : 333.31
stdClass Object
(
[pname] => Regorafenib - Impurity E
[catalogue_number] => PA 18 0490050
[category_ids] => ,78,75,76,82,
[chemical_name] =>
[weight] => 811.49
[form] => C35H23Cl2F7N6O5
[cas] => 2098799-13-2
[pslug] => 2098799-13-2-regorafenib-impurity-e-pa180490050
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Catalogue No.:PA 18 0490050
Molecular Formula : C35H23Cl2F7N6O5
Molecular Weight : 811.49
stdClass Object
(
[pname] => N-Desmethyl Regorafenib N-Oxide (M5 Metabolite)
[catalogue_number] => PA 18 0491000
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 484.79
[form] => C20H13ClF4N4O4
[cas] => 835621-12-0
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N-Desmethyl Regorafenib N-Oxide (M5 Metabolite)
Catalogue No.:PA 18 0491000
Molecular Formula : C20H13ClF4N4O4
Molecular Weight : 484.79
stdClass Object
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[pname] => 4-(3-Fluoro-4-(3-(3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide
[catalogue_number] => PA 18 0491001
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 448.38
[form] => C21H16F4N4O3
[cas] => 2188236-16-8
[pslug] => 2188236-16-8-4-3-fluoro-4-3-3-trifluoromethyl-phenyl-ureido-phenoxy-n-methylpicolinamide-pa180491001
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4-(3-Fluoro-4-(3-(3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide
Catalogue No.:PA 18 0491001
Molecular Formula : C21H16F4N4O3
Molecular Weight : 448.38
stdClass Object
(
[pname] => 4-(4-acetamido-3-fluorophenoxy)-N-methylpicolinamide
[catalogue_number] => PA 18 0491002
[category_ids] => ,75,76,78,70,82,
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[weight] => 303.29
[form] => C15H14FN3O3
[cas] => 2141961-84-2
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4-(4-acetamido-3-fluorophenoxy)-N-methylpicolinamide
Catalogue No.:PA 18 0491002
Molecular Formula : C15H14FN3O3
Molecular Weight : 303.29
stdClass Object
(
[pname] => Regorafenib D3
[catalogue_number] => PA STI 089099
[category_ids] => ,98,75,76,78,70,82,
[chemical_name] =>
[weight] => 485.84
[form] => C21H12D3ClF4N4O3
[cas] => 1255386-16-3
[pslug] => 1255386-16-3-regorafenib-d3-pasti089099
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Catalogue No.:PA STI 089099
Molecular Formula : C21H12D3ClF4N4O3
Molecular Weight : 485.84
stdClass Object
(
[pname] => Regorafenib 13CD3
[catalogue_number] => PA STI 089168
[category_ids] => ,98,75,76,78,70,82,
[chemical_name] =>
[weight] => 486.83
[form] => C2013CH12D3ClF4N4O3
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Catalogue No.:PA STI 089168
Molecular Formula : C2013CH12D3ClF4N4O3
Molecular Weight : 486.83
stdClass Object
(
[pname] => Regorafenib 13CD3 N-Oxide
[catalogue_number] => PA STI 089169
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[chemical_name] =>
[weight] => 502.83
[form] => C2013CH12D3ClF4N4O4
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Regorafenib 13CD3 N-Oxide
Catalogue No.:PA STI 089169
Molecular Formula : C2013CH12D3ClF4N4O4
Molecular Weight : 502.83
stdClass Object
(
[pname] => Regorafenib Dipyrimidine Impurity
[catalogue_number] => PA 18 0491003
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 380.38
[form] => C20H17FN4O3
[cas] => NA
[pslug] => regorafenib-dipyrimidine-impurity-pa180491003
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Regorafenib Dipyrimidine Impurity
Catalogue No.:PA 18 0491003
Molecular Formula : C20H17FN4O3
Molecular Weight : 380.38
