nintedanib
Pharmaceutical standards
- A Nintedanib is used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer. It is a small molecule kinase inhibitor. Reference standards of Nintedanib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
stdClass Object
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[pname] => (Z)-1-Acetyl-3-(ethoxy(phenyl)methylene)-2-oxoindoline-6-carboxylic Acid
[catalogue_number] => PA 14 0541076
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[chemical_name] =>
[weight] => 351.36
[form] => C20H17NO5
[cas] => 1985659-44-6
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(Z)-1-Acetyl-3-(ethoxy(phenyl)methylene)-2-oxoindoline-6-carboxylic Acid
Catalogue No.:PA 14 0541076
Molecular Formula : C20H17NO5
Molecular Weight : 351.36
stdClass Object
(
[pname] => Methyl (Z)-1-acetyl-3-(2-methoxybenzylidene)-2-oxoindoline-6-carboxylate
[catalogue_number] => PA 14 0541077
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[weight] => 351.36
[form] => C20H17NO5
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Methyl (Z)-1-acetyl-3-(2-methoxybenzylidene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541077
Molecular Formula : C20H17NO5
Molecular Weight : 351.36
stdClass Object
(
[pname] => Ethyl (Z)-1-acetyl-3-(2-ethoxybenzylidene)-2-oxoindoline-6-carboxylate
[catalogue_number] => PA 14 0541078
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[chemical_name] =>
[weight] => 379.41
[form] => C22H21NO5
[cas] => NA
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Ethyl (Z)-1-acetyl-3-(2-ethoxybenzylidene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541078
Molecular Formula : C22H21NO5
Molecular Weight : 379.41
stdClass Object
(
[pname] => N-(4-Aminophenyl)-2-(4-(2-((4-aminophenyl)amino)-2-oxoethyl)piperazin-1-yl)-N-methylacetamide
[catalogue_number] => PA 14 0541079
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[weight] => 396.50
[form] => C21H28N6O2
[cas] => NA
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N-(4-Aminophenyl)-2-(4-(2-((4-aminophenyl)amino)-2-oxoethyl)piperazin-1-yl)-N-methylacetamide
Catalogue No.:PA 14 0541079
Molecular Formula : C21H28N6O2
Molecular Weight : 396.50
stdClass Object
(
[pname] => Methyl (Z)-3-(((4-(2-(4-ethylpiperazin-1-yl)-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
[catalogue_number] => PA 14 0541067
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[weight] => 553.66
[form] => C32H35N5O4
[cas] => NA
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Methyl (Z)-3-(((4-(2-(4-ethylpiperazin-1-yl)-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541067
Molecular Formula : C32H35N5O4
Molecular Weight : 553.66
stdClass Object
(
[pname] => (Z)-2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoacetic Acid
[catalogue_number] => PA 14 0541080
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[chemical_name] =>
[weight] => 471.47
[form] => C26H21N3O6
[cas] => NA
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(Z)-2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoacetic Acid
Catalogue No.:PA 14 0541080
Molecular Formula : C26H21N3O6
Molecular Weight : 471.47
stdClass Object
(
[pname] => N-Methyl-N-(4-nitrophenyl)nitrous amide
[catalogue_number] => PA 14 0541081
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[weight] => 181.15
[form] => C7H7N3O3
[cas] => NA
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N-Methyl-N-(4-nitrophenyl)nitrous amide
Catalogue No.:PA 14 0541081
Molecular Formula : C7H7N3O3
Molecular Weight : 181.15
stdClass Object
(
[pname] => Methyl (Z)-3-(2-((4-(2-(4-ethylpiperazin-1-yl)-N-methylacetamido)phenyl)amino)benzylidene)-2-oxoindoline-6-carboxylate
[catalogue_number] => PA 14 0541082
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[weight] => 553.66
[form] => C32H35N5O4
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Methyl (Z)-3-(2-((4-(2-(4-ethylpiperazin-1-yl)-N-methylacetamido)phenyl)amino)benzylidene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541082
Molecular Formula : C32H35N5O4
Molecular Weight : 553.66
stdClass Object
(
[pname] => Methyl (E)-3-(((4-(2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
[catalogue_number] => PA 14 0541083
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[weight] => 525.61
[form] => C30H31N5O4
[cas] => NA
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Methyl (E)-3-(((4-(2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541083
Molecular Formula : C30H31N5O4
Molecular Weight : 525.61
stdClass Object
(
[pname] => Methyl (Z)-3-(((4-(methyl(nitroso)amino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
[catalogue_number] => PA 14 0541084
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[chemical_name] =>
[weight] => 428.45
[form] => C24H20N4O4
[cas] => NA
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Methyl (Z)-3-(((4-(methyl(nitroso)amino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541084
Molecular Formula : C24H20N4O4
Molecular Weight : 428.45
stdClass Object
(
[pname] => N-(4-Aminophenyl)-N-methyl-2-(piperazin-1-yl)acetamide Hydrochloride
[catalogue_number] => PA 14 0541085
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 284.79
[form] => C13H21ClN4O
[cas] => NA
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N-(4-Aminophenyl)-N-methyl-2-(piperazin-1-yl)acetamide Hydrochloride
Catalogue No.:PA 14 0541085
Molecular Formula : C13H21ClN4O
Molecular Weight : 284.79
stdClass Object
(
[pname] => Methyl (Z)-1-acetyl-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)(nitroso)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
[catalogue_number] => PA 14 0541086
[category_ids] => ,71,78,80,88,89,162,
[chemical_name] =>
[weight] => 610.67
[form] => C33H34N6O6
[cas] => NA
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Methyl (Z)-1-acetyl-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)(nitroso)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541086
Molecular Formula : C33H34N6O6
Molecular Weight : 610.67
stdClass Object
(
[pname] => (Z)-3-(((4-(N-Methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)(nitroso)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylic Acid
[catalogue_number] => PA 14 0541087
[category_ids] => ,71,78,80,88,89,162,
[chemical_name] =>
[weight] => 554.61
[form] => C30H30N6O5
[cas] => NA
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(Z)-3-(((4-(N-Methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)(nitroso)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylic Acid
Catalogue No.:PA 14 0541087
Molecular Formula : C30H30N6O5
Molecular Weight : 554.61
stdClass Object
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[pname] => Methyl (Z)-3-(((4-(2-(4-methylpiperazin-1-yl)acetamido)phenyl)(nitroso)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
[catalogue_number] => PA 14 0541088
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[weight] => 554.61
[form] => C30H30N6O5
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Methyl (Z)-3-(((4-(2-(4-methylpiperazin-1-yl)acetamido)phenyl)(nitroso)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541088
Molecular Formula : C30H30N6O5
Molecular Weight : 554.61
stdClass Object
(
[pname] => Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)(nitroso)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
[catalogue_number] => PA 14 0541089
[category_ids] => ,71,78,80,88,89,162,
[chemical_name] =>
[weight] => 568.63
[form] => C31H32N6O5
[cas] => NA
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Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)(nitroso)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541089
Molecular Formula : C31H32N6O5
Molecular Weight : 568.63
stdClass Object
(
[pname] => (Z)-1-(2-((4-(((6-Carboxy-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1,4-dioxide
[catalogue_number] => PA 14 0541091
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 557.61
[form] => C30H31N5O6
[cas] => NA
[pslug] => z-1-2-4-6-carboxy-2-oxoindolin-3-ylidene-phenyl-methyl-amino-phenyl-methyl-amino-2-oxoethyl-4-methylpiperazine-1-4-dioxide-pa140541091
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(Z)-1-(2-((4-(((6-Carboxy-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1,4-dioxide
Catalogue No.:PA 14 0541091
Molecular Formula : C30H31N5O6
Molecular Weight : 557.61
stdClass Object
(
[pname] => (S)-2-Hydroxy-2-methyl-3-(4-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)phenoxy)propyl methanesulfonate
[catalogue_number] => PA 14 0541092
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 519.53
[form] => C23H28F3NO7S
[cas] => 1318735-01-1
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(S)-2-Hydroxy-2-methyl-3-(4-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)phenoxy)propyl methanesulfonate
Catalogue No.:PA 14 0541092
Molecular Formula : C23H28F3NO7S
Molecular Weight : 519.53
stdClass Object
(
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[catalogue_number] => PA 14 0541093
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[weight] => 244.34
[form] => C14H20N4
[cas] => 677749-29-0
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1-Methyl-2-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazole
Catalogue No.:PA 14 0541093
Molecular Formula : C14H20N4
Molecular Weight : 244.34
stdClass Object
(
[pname] => (Z)-1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1-oxide 2,2,2-trifluoroacetate
[catalogue_number] => PA 14 0541094
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[chemical_name] =>
[weight] => 669.66
[form] => C33H34F3N5O7
[cas] => NA
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(Z)-1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1-oxide 2,2,2-trifluoroacetate
Catalogue No.:PA 14 0541094
Molecular Formula : C33H34F3N5O7
Molecular Weight : 669.66
